CY1123138T1 - Κυτταροτοξικες πρωτεϊνες που περιλαμβανουν περιοχες δεσμευσης στοχευσης-κυtταρων και περιοχες α υπομοναδας τοξινης shiga για επιλεκτικη θανατωση συγκεκριμενων κυτταρικων τυπων - Google Patents

Κυτταροτοξικες πρωτεϊνες που περιλαμβανουν περιοχες δεσμευσης στοχευσης-κυtταρων και περιοχες α υπομοναδας τοξινης shiga για επιλεκτικη θανατωση συγκεκριμενων κυτταρικων τυπων

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Publication number
CY1123138T1
CY1123138T1 CY20201100456T CY201100456T CY1123138T1 CY 1123138 T1 CY1123138 T1 CY 1123138T1 CY 20201100456 T CY20201100456 T CY 20201100456T CY 201100456 T CY201100456 T CY 201100456T CY 1123138 T1 CY1123138 T1 CY 1123138T1
Authority
CY
Cyprus
Prior art keywords
shiga toxin
regions
cytotoxic proteins
cell types
proteins containing
Prior art date
Application number
CY20201100456T
Other languages
Greek (el)
English (en)
Inventor
Eric POMA
Erin WILLERT
Jason Kim
Jack Higgins
Original Assignee
Molecular Templates, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Molecular Templates, Inc. filed Critical Molecular Templates, Inc.
Publication of CY1123138T1 publication Critical patent/CY1123138T1/el

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    • C07K16/2887—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
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    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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    • C07K2319/55—Fusion polypeptide containing a fusion with a toxin, e.g. diphteria toxin

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CY20201100456T 2013-03-12 2020-05-19 Κυτταροτοξικες πρωτεϊνες που περιλαμβανουν περιοχες δεσμευσης στοχευσης-κυtταρων και περιοχες α υπομοναδας τοξινης shiga για επιλεκτικη θανατωση συγκεκριμενων κυτταρικων τυπων CY1123138T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361777130P 2013-03-12 2013-03-12
PCT/US2014/023231 WO2014164693A2 (en) 2013-03-12 2014-03-11 Cytotoxic proteins comprising cell-targeting binding regions and shiga toxin a subunit regions for selective killing of specific cell types

Publications (1)

Publication Number Publication Date
CY1123138T1 true CY1123138T1 (el) 2021-10-29

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ID=50625074

Family Applications (1)

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CY20201100456T CY1123138T1 (el) 2013-03-12 2020-05-19 Κυτταροτοξικες πρωτεϊνες που περιλαμβανουν περιοχες δεσμευσης στοχευσης-κυtταρων και περιοχες α υπομοναδας τοξινης shiga για επιλεκτικη θανατωση συγκεκριμενων κυτταρικων τυπων

Country Status (21)

Country Link
US (4) US20160068577A1 (https=)
EP (4) EP2970478B1 (https=)
JP (6) JP6548630B2 (https=)
KR (2) KR102110127B1 (https=)
CN (2) CN111363047A (https=)
AU (1) AU2014249107C1 (https=)
CA (2) CA2902324A1 (https=)
CY (1) CY1123138T1 (https=)
DK (1) DK2970487T3 (https=)
ES (2) ES2800630T3 (https=)
HR (1) HRP20200553T1 (https=)
HU (1) HUE049470T2 (https=)
IL (3) IL240433B (https=)
LT (1) LT2970487T (https=)
MX (1) MX378807B (https=)
PL (1) PL2970487T3 (https=)
PT (1) PT2970487T (https=)
RS (1) RS60280B1 (https=)
SI (1) SI2970487T1 (https=)
SM (1) SMT202000266T1 (https=)
WO (2) WO2014164680A1 (https=)

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CN111909278B (zh) 2014-01-27 2024-04-09 分子模板公司 Mhc i类表位递送多肽
WO2017019623A2 (en) 2015-07-26 2017-02-02 Molecular Templates, Inc. Cell-targeting molecules comprising shiga toxin a subunit effectors and cd8+ t-cell epitopes
US20210138076A2 (en) * 2014-01-27 2021-05-13 Molecular Templates, Inc. Cell-targeting molecules comprising shiga toxin a subunit effectors and cd8+ t-cell epitopes
US10421958B2 (en) 2014-02-05 2019-09-24 Molecular Templates, Inc. Methods of screening, selecting, and identifying cytotoxic recombinant polypeptides based on an interim diminution of ribotoxicity
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AU2015229583B2 (en) 2014-03-11 2020-07-09 Molecular Templates, Inc. Proteins comprising amino-terminal proximal Shiga toxin A Subunit effector regions and cell-targeting immunoglobulin-type binding regions
ES2723774T3 (es) * 2014-03-11 2019-09-02 Molecular Templates Inc Proteínas que comprenden regiones de unión, regiones efectoras de la subunidad A de toxina Shiga y motivos señal de localización de retículo endoplasmático carboxi terminal
US20150328263A1 (en) 2014-05-14 2015-11-19 University Of Maryland, Baltimore Cardiac stem cells for cardiac repair
ES2919749T3 (es) 2014-06-11 2022-07-28 Molecular Templates Inc Moléculas dirigidas a células citotóxicas resistentes a la escisión por proteasa
CN107001459B (zh) 2014-09-19 2021-11-23 Siwa有限公司 用于治疗炎症和自身免疫紊乱的抗age抗体
US10387178B2 (en) * 2014-10-29 2019-08-20 Red Hat Israel, Ltd. Idle based latency reduction for coalesced interrupts
JP6882978B2 (ja) 2014-10-29 2021-06-02 バイスクルアールディー・リミテッド Ｍｔ１−ｍｍｐに特異的な二環性ペプチドリガンド
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