CY1120141T1 - Παραγωγο βενζαμιδιου ως αναστολεας απακετυλασης ιστονης με ισχυρη διαφοροποιητικη και αντιπολλαπλασιαστικη δραστικοτητα - Google Patents

Παραγωγο βενζαμιδιου ως αναστολεας απακετυλασης ιστονης με ισχυρη διαφοροποιητικη και αντιπολλαπλασιαστικη δραστικοτητα

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Publication number
CY1120141T1
CY1120141T1 CY20181100243T CY181100243T CY1120141T1 CY 1120141 T1 CY1120141 T1 CY 1120141T1 CY 20181100243 T CY20181100243 T CY 20181100243T CY 181100243 T CY181100243 T CY 181100243T CY 1120141 T1 CY1120141 T1 CY 1120141T1
Authority
CY
Cyprus
Prior art keywords
collapable
benzamidi
disconnector
suspender
hygiene
Prior art date
Application number
CY20181100243T
Other languages
English (en)
Inventor
Xian-Ping Lu
Zhibin Li
Aihua Xie
Boyu Li
Zhiqiang Ning
Song Shan
Tuo Deng
Weiming Hu
Leming Shi
Original Assignee
Shenzhen Chipscreen Biosciences Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=32872046&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1120141(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Shenzhen Chipscreen Biosciences Ltd. filed Critical Shenzhen Chipscreen Biosciences Ltd.
Publication of CY1120141T1 publication Critical patent/CY1120141T1/el

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/56—Amides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/46—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/51—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyridine Compounds (AREA)

Abstract

Η παρούσα εφεύρεση αφορά την παρασκευή και φαρμακευτική χρήση νέων παραγώγων βενζαμιδίου όπως ορίζονται στην περιγραφή του τύπου (I) ως αναστολέων απακετυλάσης ιστόνης (HDACI), τις παρασκευές αυτών και τις μεθόδους χρήσης των ενώσεων αυτών ή του φαρμακευτικά αποδεκτού άλατος αυτών στην αγωγή πολλαπλασιαστικών νόσων των κυττάρων, π.χ. καρκίνου και ψωρίασης.
CY20181100243T 2003-02-14 2018-02-27 Παραγωγο βενζαμιδιου ως αναστολεας απακετυλασης ιστονης με ισχυρη διαφοροποιητικη και αντιπολλαπλασιαστικη δραστικοτητα CY1120141T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US44791503P 2003-02-14 2003-02-14
US10/770,035 US7244751B2 (en) 2003-02-14 2004-02-02 Histone deacetylase inhibitors of novel benzamide derivatives with potent differentiation and anti-proliferation activity
EP04709299A EP1592665A4 (en) 2003-02-14 2004-02-09 HISTONE DEACETYLASE INHIBITORS OF NEW POWERFUL DIFFERENTIATION BENZAMIDE DERIVATIVES WITH PROLIFERATION-INHIBITING ACTIVITY

Publications (1)

Publication Number Publication Date
CY1120141T1 true CY1120141T1 (el) 2018-12-12

Family

ID=32872046

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20181100243T CY1120141T1 (el) 2003-02-14 2018-02-27 Παραγωγο βενζαμιδιου ως αναστολεας απακετυλασης ιστονης με ισχυρη διαφοροποιητικη και αντιπολλαπλασιαστικη δραστικοτητα

Country Status (14)

Country Link
US (2) US7244751B2 (el)
EP (3) EP2860174B1 (el)
JP (1) JP4637821B2 (el)
AU (1) AU2004212345B2 (el)
CA (1) CA2511479C (el)
CY (1) CY1120141T1 (el)
DK (1) DK2860174T3 (el)
ES (1) ES2663274T3 (el)
HK (1) HK1257248A1 (el)
HU (1) HUE036127T2 (el)
PT (1) PT2860174T (el)
RU (1) RU2364589C2 (el)
SI (1) SI2860174T1 (el)
WO (1) WO2004071400A2 (el)

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Also Published As

Publication number Publication date
HK1257248A1 (zh) 2019-10-18
EP2860174A3 (en) 2015-07-08
WO2004071400A2 (en) 2004-08-26
HUE036127T2 (hu) 2018-06-28
PT2860174T (pt) 2018-03-06
EP3336078A1 (en) 2018-06-20
EP1592665A4 (en) 2007-07-18
US7550490B2 (en) 2009-06-23
US7244751B2 (en) 2007-07-17
CA2511479C (en) 2012-04-24
EP2860174A2 (en) 2015-04-15
AU2004212345B2 (en) 2009-07-23
JP4637821B2 (ja) 2011-02-23
US20040224991A1 (en) 2004-11-11
RU2364589C2 (ru) 2009-08-20
ES2663274T3 (es) 2018-04-11
SI2860174T1 (en) 2018-04-30
US20080039509A1 (en) 2008-02-14
WO2004071400A3 (en) 2005-06-16
AU2004212345A1 (en) 2004-08-26
EP2860174B1 (en) 2017-11-29
EP1592665A2 (en) 2005-11-09
JP2007527362A (ja) 2007-09-27
CA2511479A1 (en) 2004-08-26
RU2005128550A (ru) 2006-01-20
DK2860174T3 (en) 2018-03-12

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