CY1112328T1 - Νεα διαδικασια συνθεσης της moguisteine - Google Patents

Νεα διαδικασια συνθεσης της moguisteine

Info

Publication number
CY1112328T1
CY1112328T1 CY20111100811T CY111100811T CY1112328T1 CY 1112328 T1 CY1112328 T1 CY 1112328T1 CY 20111100811 T CY20111100811 T CY 20111100811T CY 111100811 T CY111100811 T CY 111100811T CY 1112328 T1 CY1112328 T1 CY 1112328T1
Authority
CY
Cyprus
Prior art keywords
moguisteine
new
methoxyphenoxy
methyl
composition procedure
Prior art date
Application number
CY20111100811T
Other languages
English (en)
Inventor
Enrico Vigano'
Massimiliano Arrighi
Renato Molteni
Simona Lanfranconi
Ernesto Landonio
Original Assignee
A.M.S.A. Anonima Materie Sintetiche E Affini S.P.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by A.M.S.A. Anonima Materie Sintetiche E Affini S.P.A. filed Critical A.M.S.A. Anonima Materie Sintetiche E Affini S.P.A.
Publication of CY1112328T1 publication Critical patent/CY1112328T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/04—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/14—Antitussive agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
    • C07D317/22—Radicals substituted by singly bound oxygen or sulfur atoms etherified

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)

Abstract

Η εφεύρεση αναφέρεται σε μια διαδικασία σύνθεσης της moguisteine, η οποία είναι ο αιθυλ εστέρας του (R,S)-3-[2-[(2-μεθοξυφαινοξυ) μεθυλ]-1,3- θειαζολιδιν-3- υλ]-3- οξυπροπανοϊκού οξέος, η οποία περιλαμβάνει τα στάδια σχηματισμού ενός νέου κυκλικού ενδιάμεσου προϊόντος του χημικού τύπου της 2-[(2-μεθοξυφαινοξυ) μεθυλ]-1,3- διοξολάνης (4), σχηματισμού της (R,S)-2-[(2-μεθοξυφαινοξυ) μεθυλ]-1,3- θειαζολιδίνης (6) και αντίδρασης της τελευταίας με μονοαιθυλομηλονικό οξύ (7) ή ένα άλας του. Η moguisteine της εφεύρεσης προκύπτει με μεγάλη απόδοση και καθαρότητα.
CY20111100811T 2007-12-03 2011-08-24 Νεα διαδικασια συνθεσης της moguisteine CY1112328T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07425770A EP2070915A1 (en) 2007-12-03 2007-12-03 New process for the synthesis of moguisteine
EP08857548A EP2231627B1 (en) 2007-12-03 2008-12-02 New process for the synthesis of moguisteine

Publications (1)

Publication Number Publication Date
CY1112328T1 true CY1112328T1 (el) 2015-12-09

Family

ID=39450286

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20111100811T CY1112328T1 (el) 2007-12-03 2011-08-24 Νεα διαδικασια συνθεσης της moguisteine

Country Status (12)

Country Link
EP (2) EP2070915A1 (el)
KR (1) KR20110086503A (el)
CN (1) CN101883761B (el)
AT (1) ATE511505T1 (el)
CY (1) CY1112328T1 (el)
ES (1) ES2367466T3 (el)
PL (1) PL2231627T3 (el)
PT (1) PT2231627E (el)
RS (1) RS51931B (el)
RU (1) RU2492165C2 (el)
SI (1) SI2231627T1 (el)
WO (1) WO2009071528A2 (el)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102653527A (zh) * 2011-12-22 2012-09-05 东莞达信生物技术有限公司 一种莫吉司坦合成工艺
CN105399701A (zh) * 2013-01-06 2016-03-16 天津市汉康医药生物技术有限公司 噻唑烷衍生物、其制备方法和用途

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU195492B (en) * 1984-07-27 1988-05-30 Boehringer Biochemia Srl Process for producing 2-substituted thiazolidine derivatives with antitussive and mucus regulating action and pharmaceuticals comprising these compounds as active ingredient
IT1216119B (it) * 1988-03-17 1990-02-22 Boehringer Biochemia Srl Beta_carbonil_carbossiamidi di 1,3_tiazolidine.
IT1318650B1 (it) * 2000-07-28 2003-08-27 Dompe Spa 1,3-diossolani ad attivita' antitosse.

Also Published As

Publication number Publication date
EP2231627B1 (en) 2011-06-01
WO2009071528A2 (en) 2009-06-11
CN101883761A (zh) 2010-11-10
ATE511505T1 (de) 2011-06-15
CN101883761B (zh) 2013-03-27
RU2010127348A (ru) 2012-01-10
KR20110086503A (ko) 2011-07-28
RU2492165C2 (ru) 2013-09-10
PT2231627E (pt) 2011-09-13
EP2231627A2 (en) 2010-09-29
EP2070915A1 (en) 2009-06-17
ES2367466T3 (es) 2011-11-03
WO2009071528A3 (en) 2009-08-13
SI2231627T1 (sl) 2011-10-28
PL2231627T3 (pl) 2011-11-30
RS51931B (en) 2012-02-29

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