CU24002B1 - Método para la resolución de una mezcla de isómeros ópticos de pinocembrina, específicamente un racemato de pinocembrina - Google Patents

Método para la resolución de una mezcla de isómeros ópticos de pinocembrina, específicamente un racemato de pinocembrina

Info

Publication number
CU24002B1
CU24002B1 CU2010000086A CU20100086A CU24002B1 CU 24002 B1 CU24002 B1 CU 24002B1 CU 2010000086 A CU2010000086 A CU 2010000086A CU 20100086 A CU20100086 A CU 20100086A CU 24002 B1 CU24002 B1 CU 24002B1
Authority
CU
Cuba
Prior art keywords
pinocembrine
racemate
resolution
mixture
optical isomers
Prior art date
Application number
CU2010000086A
Other languages
English (en)
Other versions
CU20100086A7 (es
Inventor
Song Wu
Guanhua Du
Yue Yuan
Qingyun Yang
Mei Gao
Yan Qi
Yuanfeng Tong
Yuehua Wang
Original Assignee
Inst Materia Medica
Cspc Zhongqi Pharmaceutical Technology Shaijiazhuang Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inst Materia Medica, Cspc Zhongqi Pharmaceutical Technology Shaijiazhuang Co filed Critical Inst Materia Medica
Publication of CU20100086A7 publication Critical patent/CU20100086A7/es
Publication of CU24002B1 publication Critical patent/CU24002B1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
    • C07D311/34—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 3 only
    • C07D311/36—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 3 only not hydrogenated in the hetero ring, e.g. isoflavones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B57/00—Separation of optically-active compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
    • C07D311/28—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only
    • C07D311/32—2,3-Dihydro derivatives, e.g. flavanones

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)

Abstract

La presente invención se relaciona con un método para la resolución de una mezcla de isómeros ópticos de pinocembrina, en particular, de racemato de pinocembrina, mediante el uso de una amina primaria quiral o una sulfinamida quiral. La presente invencióna también se relaciona co la (R)- (+)- pinocembrina obtenida por el método ESPACIO PARA FÓRMULA
CU2010000086A 2007-11-08 2010-05-05 Método para la resolución de una mezcla de isómeros ópticos de pinocembrina, específicamente un racemato de pinocembrina CU24002B1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN200710177016XA CN101429186B (zh) 2007-11-08 2007-11-08 松属素外消旋体的拆分方法
PCT/CN2008/072983 WO2009067904A1 (fr) 2007-11-08 2008-11-07 Procédés de résolution du mélange d'isomères optiques, notamment du racémate de pinocembrine

Publications (2)

Publication Number Publication Date
CU20100086A7 CU20100086A7 (es) 2011-10-05
CU24002B1 true CU24002B1 (es) 2014-06-27

Family

ID=40644852

Family Applications (1)

Application Number Title Priority Date Filing Date
CU2010000086A CU24002B1 (es) 2007-11-08 2010-05-05 Método para la resolución de una mezcla de isómeros ópticos de pinocembrina, específicamente un racemato de pinocembrina

Country Status (16)

Country Link
US (1) US8399691B2 (es)
EP (1) EP2221300B1 (es)
JP (1) JP5436438B2 (es)
KR (1) KR101569081B1 (es)
CN (1) CN101429186B (es)
BR (1) BRPI0817382A2 (es)
CA (1) CA2703927C (es)
CO (1) CO6491120A2 (es)
CU (1) CU24002B1 (es)
ES (1) ES2453970T3 (es)
HK (1) HK1146541A1 (es)
MX (1) MX2010005026A (es)
MY (1) MY158919A (es)
RU (1) RU2480460C2 (es)
SG (1) SG185957A1 (es)
WO (1) WO2009067904A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101154803B1 (ko) 2010-09-30 2012-06-18 현대자동차주식회사 시트 래치 구조
CN113341053A (zh) * 2021-04-13 2021-09-03 河北科技大学 一种1-萘乙胺手性纯度的分析方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU168753B (es) * 1974-05-03 1976-07-28
WO2002088048A1 (fr) 2001-04-27 2002-11-07 Daicel Chemical Industries, Ltd. Agent de separation comprenant un derive de polysaccharide a structure polycyclique
JP2005176758A (ja) 2003-12-22 2005-07-07 Sanwa Kagaku Kenkyusho Co Ltd 光学活性を有する４−オキソクロマン−２−カルボン酸誘導体の製法

Also Published As

Publication number Publication date
CU20100086A7 (es) 2011-10-05
SG185957A1 (en) 2012-12-28
CN101429186A (zh) 2009-05-13
CA2703927C (en) 2015-09-15
CN101429186B (zh) 2012-11-21
EP2221300A1 (en) 2010-08-25
RU2010122601A (ru) 2011-12-20
MX2010005026A (es) 2010-05-27
US20100261916A1 (en) 2010-10-14
US8399691B2 (en) 2013-03-19
EP2221300A4 (en) 2011-11-30
JP5436438B2 (ja) 2014-03-05
EP2221300B1 (en) 2014-01-08
BRPI0817382A2 (pt) 2015-03-31
MY158919A (en) 2016-11-30
CO6491120A2 (es) 2012-07-31
WO2009067904A1 (fr) 2009-06-04
KR101569081B1 (ko) 2015-11-27
RU2480460C2 (ru) 2013-04-27
JP2011503015A (ja) 2011-01-27
KR20100095547A (ko) 2010-08-31
AU2008329376A1 (en) 2009-06-04
ES2453970T3 (es) 2014-04-09
CA2703927A1 (en) 2009-06-04
HK1146541A1 (en) 2011-06-17

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FG Grant of patent