CU20898L - DERIVATIVES OF ISOINDOL - Google Patents
DERIVATIVES OF ISOINDOLInfo
- Publication number
- CU20898L CU20898L CU7534404A CU34404A CU20898L CU 20898 L CU20898 L CU 20898L CU 7534404 A CU7534404 A CU 7534404A CU 34404 A CU34404 A CU 34404A CU 20898 L CU20898 L CU 20898L
- Authority
- CU
- Cuba
- Prior art keywords
- group
- alkyl
- atom
- cycloalkylalkyl
- alkoxyalkyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
- C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
- C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
- C07D243/24—Oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Indole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Los derivados de isoindol de la fórmula general I en la que A representa un grupo de alquileno que contiene de 2 a 10 átomos de carbono, Z representa el grupo - R representa un grupo de alquilo, cicloalquilo, cicloalquilalquilo, alcoxialquilo, alilo o aralquilo, R1, R2, R3 y R4 representan cada uno, independientemente, un átomo de hidrógeno o de halógeno o un grupo de alquilo, alcoxilo o trifluorometilo y R5 y R6 representan cada uno independiente, un átomo de hidrógeno o un grupo de alquilo, cicloalquilo, cicloalquilalquilo, hidroxialquilo, alcoxialquilo, arilo o aralquilo o R5 y R6 juntos representan el grupo - (CH2)n-, en donde n representa un número entero comprendido entre 2 y 7, 0 R5 y R6 juntos con el átomo heterocíclico pentagonal o hexagonal conteniendo un átomo de oxígeno o un átomo de nitrógeno adicional que puede estar sustituido por un grupo de alquilo o hidroxialquilo y R7 y R8 representa cada uno, independientemente, un átomo de hidrógeno o un grupo de alquilo, cicloalquilo, cicloalquilalquilo, alcoxialquilo o aralquilo con la salvedad de que uno, por lo menos, de R7 y R8 tiene un significado distinto a un átomo de hidrógeno, y sus sales de adición de ácido aceptables en farmacia.The isoindole derivatives of the general formula I in which A represents an alkylene group containing from 2 to 10 carbon atoms, Z represents the group - R represents an alkyl, cycloalkyl, cycloalkylalkyl, alkoxyalkyl, allyl or aralkyl group, R1, R2, R3 and R4 each independently represent a hydrogen or halogen atom or an alkyl, alkoxy or trifluoromethyl group and R5 and R6 each independently represent a hydrogen atom or an alkyl, cycloalkyl group, cycloalkylalkyl, hydroxyalkyl, alkoxyalkyl, aryl or aralkyl or R5 and R6 together represent the group - (CH2) n-, where n represents an integer between 2 and 7, or R5 and R6 together with the pentagonal or hexagonal heterocyclic atom containing an additional oxygen atom or nitrogen atom that may be substituted by an alkyl or hydroxyalkyl group and R7 and R8 each independently represent a hydrogen atom or an alkyl, cycloalkyl group yl, cycloalkylalkyl, alkoxyalkyl or aralkyl with the proviso that at least one of R7 and R8 has a meaning other than a hydrogen atom, and their pharmaceutically acceptable acid addition salts.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH1579574A CH605749A5 (en) | 1974-11-28 | 1974-11-28 | 2-Aminoalkyl-3-phenyl isoindole derivs |
Publications (2)
Publication Number | Publication Date |
---|---|
CU20898L true CU20898L (en) | 1979-01-16 |
CU34404A CU34404A (en) | 1982-08-24 |
Family
ID=4412019
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CU34404A CU34404A (en) | 1974-11-28 | 1975-11-27 | DERIVATIVES OF ISOINDOL |
Country Status (4)
Country | Link |
---|---|
BE (1) | BE836009A (en) |
CH (1) | CH605749A5 (en) |
CU (1) | CU34404A (en) |
ZA (1) | ZA757051B (en) |
-
1974
- 1974-11-28 CH CH1579574A patent/CH605749A5/en not_active IP Right Cessation
-
1975
- 1975-11-27 CU CU34404A patent/CU34404A/en unknown
- 1975-11-27 BE BE162224A patent/BE836009A/en unknown
-
1976
- 1976-09-28 ZA ZA757051A patent/ZA757051B/en unknown
Also Published As
Publication number | Publication date |
---|---|
ZA757051B (en) | 1976-11-24 |
CU34404A (en) | 1982-08-24 |
CH605749A5 (en) | 1978-10-13 |
BE836009A (en) | 1976-05-28 |
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