CU20230045A7 - Compuestos multicíclicos que comprenden estructuras heteroaromáticos o aromáticas bicíclicos útiles como inhibidores de la peptidasa 5 relacionada con calicreína (klk5) - Google Patents
Compuestos multicíclicos que comprenden estructuras heteroaromáticos o aromáticas bicíclicos útiles como inhibidores de la peptidasa 5 relacionada con calicreína (klk5)Info
- Publication number
- CU20230045A7 CU20230045A7 CU2023000045A CU20230045A CU20230045A7 CU 20230045 A7 CU20230045 A7 CU 20230045A7 CU 2023000045 A CU2023000045 A CU 2023000045A CU 20230045 A CU20230045 A CU 20230045A CU 20230045 A7 CU20230045 A7 CU 20230045A7
- Authority
- CU
- Cuba
- Prior art keywords
- klk5
- inhibitors
- compounds
- related peptidase
- kallycrene
- Prior art date
Links
- 101001091379 Homo sapiens Kallikrein-5 Proteins 0.000 title abstract 7
- 102100034868 Kallikrein-5 Human genes 0.000 title abstract 7
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 102000035195 Peptidases Human genes 0.000 title 1
- 108091005804 Peptidases Proteins 0.000 title 1
- 235000019833 protease Nutrition 0.000 title 1
- 208000011219 Netherton syndrome Diseases 0.000 abstract 2
- 230000001594 aberrant effect Effects 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 2
- 102000001399 Kallikrein Human genes 0.000 abstract 1
- 108060005987 Kallikrein Proteins 0.000 abstract 1
- 102000057032 Tissue Kallikreins Human genes 0.000 abstract 1
- 108700022175 Tissue Kallikreins Proteins 0.000 abstract 1
- 230000004913 activation Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 230000006806 disease prevention Effects 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 208000017520 skin disease Diseases 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
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- A—HUMAN NECESSITIES
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- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
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- A61K31/33—Heterocyclic compounds
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- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
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- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
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- A—HUMAN NECESSITIES
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- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
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- A—HUMAN NECESSITIES
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- A61K31/4196—1,2,4-Triazoles
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- A61K31/42—Oxazoles
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- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
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- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/443—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
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- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
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- A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
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- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
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- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/26—Oxygen atoms
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- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
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- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D307/80—Radicals substituted by oxygen atoms
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- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
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- C—CHEMISTRY; METALLURGY
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- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
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- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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Abstract
<p>La activación inadecuada de las calicreínas tisulares (KLK), incluida la peptidasa 5 relacionada con la calicreína (KLK5), está implicada en una serie de enfermedades y afecciones humanas. En particular, las enfermedades de la piel como el síndrome de Netherton se caracterizan por una actividad aberrante de KLK5. En el presente documento se describen compuestos de fórmulas (I) - (IV) y sales farmacéuticamente aceptables de los mismos, que son inhibidores de Ia peptidasa 5 relacionada con calicreína (KLK5), y útiles en el tratamiento o prevención de enfermedades o afecciones que presentan actividad aberrante de KLK5, inlcuido el síndrome de Netherton.</p>
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US202163174860P | 2021-04-14 | 2021-04-14 | |
PCT/US2022/024805 WO2022221526A1 (en) | 2021-04-14 | 2022-04-14 | Bicyclic heteroaromatic inhibitors of klk5 |
Publications (1)
Publication Number | Publication Date |
---|---|
CU20230045A7 true CU20230045A7 (es) | 2024-05-07 |
Family
ID=83640779
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CU2023000045A CU20230045A7 (es) | 2021-04-14 | 2022-04-14 | Compuestos multicíclicos que comprenden estructuras heteroaromáticos o aromáticas bicíclicos útiles como inhibidores de la peptidasa 5 relacionada con calicreína (klk5) |
Country Status (21)
Country | Link |
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US (1) | US20240239752A1 (es) |
EP (1) | EP4323344A1 (es) |
JP (1) | JP2024513943A (es) |
KR (1) | KR20230171455A (es) |
CN (1) | CN117120419A (es) |
AR (1) | AR125358A1 (es) |
AU (1) | AU2022258575A1 (es) |
BR (1) | BR112023021030A2 (es) |
CA (1) | CA3216032A1 (es) |
CL (1) | CL2023003036A1 (es) |
CO (1) | CO2023015244A2 (es) |
CR (1) | CR20230522A (es) |
CU (1) | CU20230045A7 (es) |
DO (1) | DOP2023000221A (es) |
EC (1) | ECSP23084907A (es) |
IL (1) | IL307597A (es) |
MX (1) | MX2023012120A (es) |
PE (1) | PE20241352A1 (es) |
TW (1) | TW202304890A (es) |
UY (1) | UY39727A (es) |
WO (1) | WO2022221526A1 (es) |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MX2007016463A (es) * | 2005-06-22 | 2008-03-04 | Plexxikon Inc | Derivados de pirrolo [2,3-b] piridina como inhibidores de proteina cinasa. |
TW202128637A (zh) * | 2019-10-09 | 2021-08-01 | 美商百歐克斯製藥公司 | 口服補體因子d抑制劑 |
-
2022
- 2022-04-13 TW TW111114038A patent/TW202304890A/zh unknown
- 2022-04-14 WO PCT/US2022/024805 patent/WO2022221526A1/en active Application Filing
- 2022-04-14 CN CN202280028558.3A patent/CN117120419A/zh active Pending
- 2022-04-14 CA CA3216032A patent/CA3216032A1/en active Pending
- 2022-04-14 US US18/286,615 patent/US20240239752A1/en active Pending
- 2022-04-14 KR KR1020237038881A patent/KR20230171455A/ko unknown
- 2022-04-14 AU AU2022258575A patent/AU2022258575A1/en active Pending
- 2022-04-14 CU CU2023000045A patent/CU20230045A7/es unknown
- 2022-04-14 JP JP2023562223A patent/JP2024513943A/ja active Pending
- 2022-04-14 IL IL307597A patent/IL307597A/en unknown
- 2022-04-14 CR CR20230522A patent/CR20230522A/es unknown
- 2022-04-14 EP EP22788930.0A patent/EP4323344A1/en active Pending
- 2022-04-14 MX MX2023012120A patent/MX2023012120A/es unknown
- 2022-04-14 PE PE2023002838A patent/PE20241352A1/es unknown
- 2022-04-14 BR BR112023021030A patent/BR112023021030A2/pt unknown
- 2022-04-18 AR ARP220100970A patent/AR125358A1/es unknown
- 2022-04-19 UY UY0001039727A patent/UY39727A/es unknown
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2023
- 2023-10-11 DO DO2023000221A patent/DOP2023000221A/es unknown
- 2023-10-11 CL CL2023003036A patent/CL2023003036A1/es unknown
- 2023-11-10 EC ECSENADI202384907A patent/ECSP23084907A/es unknown
- 2023-11-10 CO CONC2023/0015244A patent/CO2023015244A2/es unknown
Also Published As
Publication number | Publication date |
---|---|
BR112023021030A2 (pt) | 2023-12-12 |
MX2023012120A (es) | 2023-10-24 |
JP2024513943A (ja) | 2024-03-27 |
KR20230171455A (ko) | 2023-12-20 |
TW202304890A (zh) | 2023-02-01 |
PE20241352A1 (es) | 2024-07-03 |
CL2023003036A1 (es) | 2024-03-22 |
CR20230522A (es) | 2024-02-20 |
CN117120419A (zh) | 2023-11-24 |
EP4323344A1 (en) | 2024-02-21 |
AU2022258575A1 (en) | 2023-11-23 |
AR125358A1 (es) | 2023-07-12 |
UY39727A (es) | 2022-11-30 |
US20240239752A1 (en) | 2024-07-18 |
CA3216032A1 (en) | 2022-10-20 |
WO2022221526A1 (en) | 2022-10-20 |
DOP2023000221A (es) | 2023-11-15 |
ECSP23084907A (es) | 2023-12-29 |
IL307597A (en) | 2023-12-01 |
CO2023015244A2 (es) | 2023-11-30 |
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