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Léková forma anorganických komplexních sloučenin čtyřmocné platiny
CS237017B1
Czechoslovakia
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English - Inventor
Jaroslav Drobnik Dagmar Noskova Jaroslav Obrovsky Natalija N Zeligovskaya Elena P Krasovskaya Frantisek Kiss Jaroslav Salamoun Eduard Hajek
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Description
translated from
| Čerstvý roztok | 87 | 99.56 |
| Čerstvý roztok | 87 | 99.45 |
| zahř. 30 min 100 °C | ||
| 45 °C | 92 | 99.21 |
| 60 °C | 95 | 99.93 |
| 90 °C | 91 | 90.16 |
| 355 | 0.023 | |
| 477 | 4.53 | |
| 539 | 5.28 |
Claims (2)
Hide Dependent
translated from
- PREDMET1, Léková forma anorganických komplexních sloučenin čtyřmocné platiny určených pro léčení lidských chorob, zejména rakovinného původu pomocí parenterálního podání, vyznačená tím, že je tvořena stabilním vodným roztokem anorganické komplexní sloučeniny čtyřmocné platiny vzorce INH3 OH Cl \l /Pt /1 \NHs OH Cl (I) ve sterilní apyrogenní vodě v koncentraci od 0,1 mg/ml do 25 mg/ml.
- 2. Způsob přípravy lékové formy podle bodu 1, vyznačený tím, že anorganická komplexní sloučenina čtyřmocné platiny vzorce I se rozpustí ve sterilní apyrogenní vodě obsahující popřípadě hydrogenperoxíd H2O2 o koncentraci až 5 mmolů, s výhodou 1,5 až 2,5 mmolu v litru a sterilizuje při teplotě 100 °C až 120 °C, výhodně ponořením do vroucí vodní lázně na dobu 20 až 50 minut.