CS231474B1 - Method of preparation of water extract from matericaria chamomilla l. - Google Patents

Abstract

A method of treating an aqueous extract of chamomile / Matricaria chamomilla L. / za in order to obtain an aqueous ethanolic solution no turbidity, miscible with water, 1 with ethyl alcohol. This is accomplished by bringing it to water of an extract having a water content of 30 to 70 wt. percent with stirring at 18-40 ° C adds as much ethanol as the resulting concentrate ethyl alcohol in the mixture is 60-90 wt. %, the resulting suspension is allowed to settle and the clear aqueous ethanolic solution is separated. Field of application: Pharmaceutical and space industry

Description

The present invention relates to a process for the treatment of an aqueous extract of chamomile (Matrcarcar chamomilla).

Chamomile is a medicinal plant, its extracts have antiphlogistic, spasmolytic effects, and are also used as a stomachic and carminative / Becker H. a sp. Dtsch. Apoth. Ztg.

121, 1285 (1981)].

It has been found that the lipophilic part of the extract (en-in-dicycloethers, bisabolol, bisabololoxides etc.) and the hydrophilic part (mainly the aglycones apigenin, luteolin, to a lesser extent the coumarins herniarin and umbelliferone) have pharmacodynamic effects / (Isaac Oi Dtsch .

Apoth. Ztg. 120, 567 (1980); Cesk. farm. 27, 359 (1978)].

Several procedures have been developed to obtain valuable camomile substances: eg, the drug is extracted with dichloromethane, then with water, the extracts combined and supplemented with ethanol / Hungarian pat. from the drug with steam distillation, essential oil is obtained, the residue is extracted with water, the aqueous extract is concentrated and mixed with the essential oil / hungarian. U.S. Pat. U.S. Pat. No. 15,020 (further procedure (US Pat. No. 1,095,931)) utilizes extraction with ethyl alcohol alone, a mixture of isopropyl alcohol and water (US Pat. U.S. Pat. No. 2,249,433), organic solvents (U.S. Pat. Germany 2 165 633,

227 292, 2 316 363 /, supercritical gases / pat. No. 2,709,033 / etc.

The disadvantage of these processes is that they either contain only the lipophilic portion of the drug - in the case of extraction with organic solvents, or they are quenched as a result of the polymer dropping out of solution - in the case of aqueous or aqueous organic extracts. The disadvantages of these processes have been eliminated by the process according to the invention in such a way that to the aqueous extract of camomile with a water content of 30 to 70% by weight. With stirring at a temperature of 18 to 40 ° C, enough ethanol was added so that the final concentration of ethanol in the solution was 60 to 90 wt. The resulting suspension was allowed to sediment and the clear aqueous ethanol solution was separated.

Further details of the method of treating the aqueous extract are evident from the examples.

He did

To 100 g of aqueous chamomile extract, with a water content of 30% by weight. 50 ml of distilled water are added, 300 g of ethyl alcohol are added under vigorous stirring at 25 ° C, the mixture is stirred for a further 15 minutes and allowed to settle. The clear aqueous ethanol solution is poured. This procedure gave a clear extract, free from undesirable polymeric substances of a sugar nature, which does not become stagnant on standing, miscible with water and ethyl alcohol without turbidity, having the following parameters: density d ³⁰ 866 kg. m ³ , refractive index n ³⁰ 1.3736, umbelliferone content 0.06 mg / ml, herniarin 0.14 mg / ml, apigenin 0.037 mg / ml.

Example 2

To 100 g of aqueous chamomile extract with a water content of 70% by weight. After stirring vigorously at 40 [deg.] C., 800 g of ethyl alcohol are added and the mixture is stirred at 40 [deg.] C. for a further hour, then left to sediment and the clear aqueous ethanol solution is poured off. The prepared extract is clear, devoid of undesirable, mainly sugar, non-turbid miscible with water and ethyl alcohol, with the following parameters: d ^ 847 kg. m, np 1.3711, umbelliferone content 0.015 mg / ml, herniarin 0.03 mg / ml, apigenin 0.009 mg / ml.

Claims (1)

pWhen you create A process for treating an aqueous extract of chamomile (Matricaria chamomilla L.), characterized in that to an aqueous extract having a water content of 30 to 70 wt. % so much ethyl alcohol is added with stirring at a temperature of 18 to 40 ° C that the final concentration of ethanol in the mixture is 60 to 90 wt. The resulting suspension was allowed to sediment and the clear aqueous ethanol solution was separated.