CO6300950A2 - Un compuesto de benzodiazepina que bloquea la corriente ikur o el canal kv 1.5 en forma potente y mas selectiva que otros canales de k+ o la corriente i kach (canal girk 1/4) - Google Patents
Un compuesto de benzodiazepina que bloquea la corriente ikur o el canal kv 1.5 en forma potente y mas selectiva que otros canales de k+ o la corriente i kach (canal girk 1/4)Info
- Publication number
- CO6300950A2 CO6300950A2 CO10117060A CO10117060A CO6300950A2 CO 6300950 A2 CO6300950 A2 CO 6300950A2 CO 10117060 A CO10117060 A CO 10117060A CO 10117060 A CO10117060 A CO 10117060A CO 6300950 A2 CO6300950 A2 CO 6300950A2
- Authority
- CO
- Colombia
- Prior art keywords
- channel
- current
- channels
- blocks
- compound
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2008041296 | 2008-02-22 | ||
| JP2008227368 | 2008-09-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO6300950A2 true CO6300950A2 (es) | 2011-07-21 |
Family
ID=40600203
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO10117060A CO6300950A2 (es) | 2008-02-22 | 2010-09-22 | Un compuesto de benzodiazepina que bloquea la corriente ikur o el canal kv 1.5 en forma potente y mas selectiva que otros canales de k+ o la corriente i kach (canal girk 1/4) |
Country Status (26)
| Country | Link |
|---|---|
| US (2) | US8338406B2 (https=) |
| EP (1) | EP2254873B1 (https=) |
| JP (1) | JP5355582B2 (https=) |
| KR (1) | KR101332948B1 (https=) |
| CN (2) | CN101952259B (https=) |
| AR (1) | AR070449A1 (https=) |
| AU (1) | AU2009216079B2 (https=) |
| BR (1) | BRPI0908132A2 (https=) |
| CA (1) | CA2715872A1 (https=) |
| CO (1) | CO6300950A2 (https=) |
| CY (1) | CY1115220T1 (https=) |
| DK (1) | DK2254873T3 (https=) |
| ES (1) | ES2494366T3 (https=) |
| HR (1) | HRP20140796T1 (https=) |
| IL (1) | IL207276A (https=) |
| MX (1) | MX2010009269A (https=) |
| MY (1) | MY156226A (https=) |
| NZ (1) | NZ587157A (https=) |
| PL (1) | PL2254873T3 (https=) |
| PT (1) | PT2254873E (https=) |
| RU (1) | RU2496775C2 (https=) |
| SI (1) | SI2254873T1 (https=) |
| TW (1) | TWI413522B (https=) |
| UA (1) | UA103018C2 (https=) |
| WO (1) | WO2009104819A1 (https=) |
| ZA (1) | ZA201005469B (https=) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2494366T3 (es) | 2008-02-22 | 2014-09-15 | Otsuka Pharmaceutical Co., Ltd. | Compuesto de benzodiacepina y composición farmacéutica |
| TWI481601B (zh) | 2009-08-21 | 2015-04-21 | Otsuka Pharma Co Ltd | 含氮化合物及藥學組成物 |
| US8796447B2 (en) | 2009-08-21 | 2014-08-05 | Otsuka Pharmaceutical Co., Ltd. | Process for producing benzo[B][1,4]diazepine-2,4-dione compound |
| JP2012184225A (ja) * | 2011-02-18 | 2012-09-27 | Otsuka Pharmaceut Co Ltd | 医薬組成物 |
| CA2834548C (en) | 2011-04-28 | 2021-06-01 | The Broad Institute, Inc. | Inhibitors of histone deacetylase |
| AR090037A1 (es) | 2011-11-15 | 2014-10-15 | Xention Ltd | Derivados de tieno y/o furo-pirimidinas y piridinas inhibidores de los canales de potasio |
| JP2014533258A (ja) | 2011-11-15 | 2014-12-11 | ゼンション・リミテッドＸｅｎｔｉｏｎ Ｌｉｍｉｔｅｄ | カリウムチャネル阻害剤としてのチエノ［２，３−ｃ］ピラゾールの使用 |
| EP2877444B1 (en) | 2012-07-27 | 2020-09-02 | The Broad Institute, Inc. | Inhibitors of histone deacetylase |
| US9914717B2 (en) | 2012-12-20 | 2018-03-13 | The Broad Institute, Inc. | Cycloalkenyl hydroxamic acid derivatives and their use as histone deacetylase inhibitors |
| JOP20190086A1 (ar) * | 2016-10-21 | 2019-04-18 | Novartis Ag | مشتقات نافثيريدينون جديدة واستخدامها في معالجة عدم انتظام ضربات القلب |
| EA038455B1 (ru) * | 2016-10-26 | 2021-08-31 | Новартис Аг | Новые производные нафтиридинона и их применение в лечении аритмии |
| RU2764243C2 (ru) | 2017-09-22 | 2022-01-14 | ДЖУБИЛАНТ ЭПИПЭД ЭлЭлСи | Гетероциклические соединения в качестве ингибиторов PAD |
| AU2018352142B2 (en) | 2017-10-18 | 2022-08-25 | Jubilant Epipad LLC | Imidazo-pyridine compounds as PAD inhibitors |
| US11629135B2 (en) | 2017-11-06 | 2023-04-18 | Jubilant Prodell Llc | Pyrimidine derivatives as inhibitors of PD1/PD-L1 activation |
| PT3704120T (pt) | 2017-11-24 | 2024-07-03 | Jubilant Episcribe Llc | Compostos heterocíclicos como inibidores de prmt5 |
| EP3737362B1 (en) | 2018-01-12 | 2025-10-15 | Kdac Therapeutics, Inc. | Combination of a selective histone deacetylase 3 (hdac3) inhibitor and an immunotherapy agent for the treatment of cancer |
| MX2020009517A (es) | 2018-03-13 | 2021-01-20 | Jubilant Prodel LLC | Compuestos biciclicos como inhibidores de la interaccion/activacio n de pdl/pd-l1. |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3133056A (en) | 1961-05-15 | 1964-05-12 | May & Baker Ltd | N-phenylpiperazine derivatives of tetrahydrobenzodiazepines |
| US4001408A (en) | 1966-12-14 | 1977-01-04 | Roussel-Uclaf | Substituted heterocyclic compounds, processes and composition including those |
| US3984398A (en) | 1966-12-14 | 1976-10-05 | Roussel-Uclaf | 1,5-Benzodiazepine-2,4-diones |
| BE707667A (https=) | 1966-12-14 | 1968-06-07 | ||
| JPH0296133A (ja) * | 1988-10-01 | 1990-04-06 | Fuji Photo Film Co Ltd | ハロゲン化銀カラー写真感光材料 |
| BR9200951A (pt) | 1991-03-21 | 1992-11-17 | Hoffmann La Roche | Compostos, processo para sua producao,preparacoes farmaceuticas e uso |
| US5428031A (en) * | 1991-12-03 | 1995-06-27 | Merck & Co., Inc. | Methods of treating cardiac arrhythmia |
| US5700797A (en) | 1995-06-07 | 1997-12-23 | Merck & Co, Inc. | N-(2,4-dioxo-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-3-yl)-3-amides |
| US5691331A (en) | 1995-06-07 | 1997-11-25 | Merck & Co., Inc. | N-(2,4-Dioxo-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-3yl) -3- amides |
| GB0008179D0 (en) | 2000-04-05 | 2000-05-24 | Glaxo Group Ltd | Chemical process |
| AU6895000A (en) | 1999-08-09 | 2001-03-05 | Merck & Co., Inc. | Antiarrhythmic compounds |
| NZ532463A (en) * | 2001-11-13 | 2007-02-23 | Dimensional Pharm Inc | Substituted 1,4-benzodiazepines and uses thereof for the treatment of cancer |
| PL377314A1 (pl) | 2002-12-20 | 2006-01-23 | Amgen Inc. | Modulatory astmy i zapaleń na tle alergicznym |
| AR055203A1 (es) | 2005-08-31 | 2007-08-08 | Otsuka Pharma Co Ltd | Derivados de benzotiofeno con propiedades antipsicoticas |
| JP4785881B2 (ja) * | 2007-02-27 | 2011-10-05 | 大塚製薬株式会社 | 医薬 |
| ES2494366T3 (es) | 2008-02-22 | 2014-09-15 | Otsuka Pharmaceutical Co., Ltd. | Compuesto de benzodiacepina y composición farmacéutica |
-
2009
- 2009-02-20 ES ES09713382.1T patent/ES2494366T3/es active Active
- 2009-02-20 PT PT97133821T patent/PT2254873E/pt unknown
- 2009-02-20 NZ NZ587157A patent/NZ587157A/en not_active IP Right Cessation
- 2009-02-20 JP JP2010533351A patent/JP5355582B2/ja not_active Expired - Fee Related
- 2009-02-20 SI SI200930958T patent/SI2254873T1/sl unknown
- 2009-02-20 MY MYPI2010003603A patent/MY156226A/en unknown
- 2009-02-20 BR BRPI0908132-1A patent/BRPI0908132A2/pt not_active IP Right Cessation
- 2009-02-20 PL PL09713382T patent/PL2254873T3/pl unknown
- 2009-02-20 EP EP09713382.1A patent/EP2254873B1/en not_active Not-in-force
- 2009-02-20 WO PCT/JP2009/053623 patent/WO2009104819A1/en not_active Ceased
- 2009-02-20 HR HRP20140796AT patent/HRP20140796T1/hr unknown
- 2009-02-20 CN CN200980105883XA patent/CN101952259B/zh not_active Expired - Fee Related
- 2009-02-20 UA UAA201011248A patent/UA103018C2/uk unknown
- 2009-02-20 AU AU2009216079A patent/AU2009216079B2/en not_active Ceased
- 2009-02-20 CN CN201310203728.XA patent/CN103554088B/zh not_active Expired - Fee Related
- 2009-02-20 RU RU2010138928/04A patent/RU2496775C2/ru not_active IP Right Cessation
- 2009-02-20 US US12/918,226 patent/US8338406B2/en not_active Expired - Fee Related
- 2009-02-20 AR ARP090100589A patent/AR070449A1/es unknown
- 2009-02-20 CA CA2715872A patent/CA2715872A1/en active Pending
- 2009-02-20 MX MX2010009269A patent/MX2010009269A/es active IP Right Grant
- 2009-02-20 KR KR1020107021117A patent/KR101332948B1/ko not_active Expired - Fee Related
- 2009-02-20 TW TW098105587A patent/TWI413522B/zh not_active IP Right Cessation
- 2009-02-20 DK DK09713382.1T patent/DK2254873T3/da active
-
2010
- 2010-07-29 IL IL207276A patent/IL207276A/en not_active IP Right Cessation
- 2010-07-30 ZA ZA2010/05469A patent/ZA201005469B/en unknown
- 2010-09-22 CO CO10117060A patent/CO6300950A2/es active IP Right Grant
-
2012
- 2012-08-22 US US13/591,361 patent/US8664217B2/en not_active Expired - Fee Related
-
2014
- 2014-07-01 CY CY20141100482T patent/CY1115220T1/el unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CO6300950A2 (es) | Un compuesto de benzodiazepina que bloquea la corriente ikur o el canal kv 1.5 en forma potente y mas selectiva que otros canales de k+ o la corriente i kach (canal girk 1/4) | |
| CO6440511A2 (es) | Compuesto que contienen nitrogeno y composicion farmaceutica | |
| CO2019000686A2 (es) | Compuestos de indol sustituidos con [1,2,4]triazolo[1,5-a]piridinilo | |
| DOP2011000217A (es) | Nuevas bencenosulfonamidas como bloqueadores de canales de calcio | |
| ECSP14013245A (es) | Nuevos derivados dihidroquinolina-2-ona | |
| GT200500185A (es) | Moduladores del receptor de progesterona que comprenden derivados de pirrol-oxindol y sus usos | |
| ATE527693T1 (de) | Feldeffekttransistor mit einer oxydschicht als kanalschicht und verfahren zu dessen herstellung | |
| CO2017007635A2 (es) | Nuevos compuestos bicíclicos | |
| MX360301B (es) | Moleculas pequeñas que contienen boro como agentes antiinflamatorios. | |
| ME01532B (me) | Jedinjenja | |
| CO6561782A2 (es) | Polipetidos factor viii-fc quimericos e hibridos y metodos de uso de los mismos | |
| PE20121065A1 (es) | Compuestos tetraciclicos | |
| MX2019009763A (es) | Metodos para tratar esquizofrenia. | |
| PA8795601A1 (es) | Derivados de azaciclilisoquinolinona e isoindolinona como antagonistas de histamina-3 | |
| BRPI0814772A2 (pt) | Indazóis substituídos por 5-piridinona | |
| CL2008002767A1 (es) | Compuestos derivados de heterociclico triciclico; composicion farmaceutica; y su uso para el tratamiento de un trastorno mediado por serotonina tal como obesidad, esquizofrenia y disfuncion cognitiva. | |
| AR099071A1 (es) | Antagonistas selectivos de nr2b | |
| BRPI0412629A (pt) | método de tratamento de disfunção ocular em mamìferos | |
| PA8790101A1 (es) | Derivados de aminoalquilazol como antagonistas de histamina-3 | |
| CU23853B1 (es) | Pirimidinil-piperazinas útiles como ligandos del receptor d3/d2 | |
| CL2007000773A1 (es) | Uso de compuestos derivados de diazepina condensada para el tratamiento de un desorden cognitivo como add o adhd;o su uso para tratar spm o pmdd. | |
| CO6280532A2 (es) | Derivados de isoquinolinona como antagonistas de nk3 | |
| CR20110348A (es) | Derivados de piperidina | |
| ES2533990T3 (es) | Antagonistas de receptores opioides de arilpiperazina | |
| CL2008003932A1 (es) | Compuestos derivados de 2-heteroaroil-imidazo[1,2-a]piridina, moduladores de los receptores nucleares nurr1; compuestos intermediarios; composicion farmaceutica; y uso par el tratamiento y prevencion de enfermedades neurodegenerativas, psiquiatricas, inflamatorias, osteoporosis, cancer, entre otras. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Application granted |