CO5021130A1 - AMIDINE COMPOUND CONTAIN - Google Patents

AMIDINE COMPOUND CONTAIN

Info

Publication number
CO5021130A1
CO5021130A1 CO99021315A CO99021315A CO5021130A1 CO 5021130 A1 CO5021130 A1 CO 5021130A1 CO 99021315 A CO99021315 A CO 99021315A CO 99021315 A CO99021315 A CO 99021315A CO 5021130 A1 CO5021130 A1 CO 5021130A1
Authority
CO
Colombia
Prior art keywords
carbon atoms
alkyl
alkoxy
alkoxycarbonyl
aralkyloxycarbonyl
Prior art date
Application number
CO99021315A
Other languages
Spanish (es)
Inventor
Katoh Susmo
Yokota Katsuyuki
Mikio Hayashi
Original Assignee
Japan Tobacco Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Japan Tobacco Inc filed Critical Japan Tobacco Inc
Publication of CO5021130A1 publication Critical patent/CO5021130A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyridine Compounds (AREA)

Abstract

Un compuesto de amidina de fórmula IEn donde R es un grupo de fórmulaEn donde R4 es un átomo de hidrógeno, hidroxi, alquilo inferior, alcoxi inferior o átomo de halógeno, R5 es átomo de hidrógeno, ciano, carboxi, o alcoxicarbonilo inferior, R6 es átomo de hidrógeno, cicloalquilo, hidroxi, carboxi, alcoxicarbonilo inferior, aralquiloxicarbonilo.En donde dicho alquilo inferior es un alquilo que tiene de 1 a 6 átomos de carbono, dicho alcoxi inferior es un alcoxi que tiene de 1 a 6 átomos de carbono y dicho alcoxicarbonilo inferior es un alcoxicarbonilo que tiene de 1 a 6 átomos de carbono.en donde dicho aralquiloxicarbonilo es opcionalmente sustituido por átomo de halógeno, nitro, alquilo, alcoxi o trifluorometilo, nitro, amino, alquilamino inferior, dialquilamino, arilo, heteroarilo, en donde dicho alquilamino inferior es un alquilamino que tiene de 1 a 6 átomos de carbono, en donde dicho arilo o heteroarilo es opcionalmente sustituido por 1 a 3 sustituyentes seleccionados entre alquilo inferior, hidroxi, alcoxi inferior, carboxi, alcoxicarbonilo inferior aralquiloxicarbonilo, nitro, amino, acilamino, amidino, e hidroxiamidino, un heterociclo saturado de 5 a 7 miembros con al menos un átomo de nitrógeno, en donde dicho heterociclo saturado está opcionalmente sustituido por un alquilo inferior, acilo, dialquilamino inferior alcanoilo inferior o imidoilo, en donde dicho alcanoilo inferior es un alcanoilo que tiene de 1 a 6 átomos de carbono, o ...An amidine compound of formula I Where R is a group of formula Where R 4 is a hydrogen atom, hydroxy, lower alkyl, lower alkoxy or halogen atom, R 5 is hydrogen atom, cyano, carboxy, or lower alkoxycarbonyl, R 6 is hydrogen atom, cycloalkyl, hydroxy, carboxy, lower alkoxycarbonyl, aralkyloxycarbonyl. wherein said lower alkyl is an alkyl having 1 to 6 carbon atoms, said lower alkoxy is an alkoxy having 1 to 6 carbon atoms and said Lower alkoxycarbonyl is an alkoxycarbonyl having 1 to 6 carbon atoms, wherein said aralkyloxycarbonyl is optionally substituted by halogen, nitro, alkyl, alkoxy or trifluoromethyl, nitro, amino, lower alkylamino, dialkylamino, aryl, heteroaryl, wherein said lower alkylamino is an alkylamino having 1 to 6 carbon atoms, wherein said aryl or heteroaryl is optionally substituted by 1 to 3 substituents selected os between lower alkyl, hydroxy, lower alkoxy, carboxy, lower alkoxycarbonyl aralkyloxycarbonyl, nitro, amino, acylamino, amidino, and hydroxyamidino, a saturated 5- to 7-membered heterocycle with at least one nitrogen atom, wherein said saturated heterocycle is optionally substituted by a lower alkyl, acyl, lower dialkylamino lower alkanoyl or imidoyl, wherein said lower alkanoyl is an alkanoyl having 1 to 6 carbon atoms, or ...

CO99021315A 1998-04-10 1999-04-12 AMIDINE COMPOUND CONTAIN CO5021130A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP11623398 1998-04-10
JP23786998 1998-08-25

Publications (1)

Publication Number Publication Date
CO5021130A1 true CO5021130A1 (en) 2001-03-27

Family

ID=26454606

Family Applications (1)

Application Number Title Priority Date Filing Date
CO99021315A CO5021130A1 (en) 1998-04-10 1999-04-12 AMIDINE COMPOUND CONTAIN

Country Status (23)

Country Link
US (2) US6562828B1 (en)
EP (1) EP1070714B1 (en)
KR (1) KR100416111B1 (en)
CN (1) CN1305470A (en)
AR (1) AR015269A1 (en)
AT (1) ATE272630T1 (en)
AU (1) AU752588B2 (en)
BR (1) BR9910122A (en)
CA (1) CA2327488A1 (en)
CO (1) CO5021130A1 (en)
DE (1) DE69919149D1 (en)
HU (1) HUP0101137A3 (en)
ID (1) ID28266A (en)
IL (1) IL138899A0 (en)
NO (1) NO20005083L (en)
NZ (1) NZ508101A (en)
PE (1) PE20000422A1 (en)
PL (1) PL343424A1 (en)
RU (1) RU2201927C2 (en)
SG (1) SG74717A1 (en)
SK (1) SK15072000A3 (en)
TR (1) TR200002904T2 (en)
WO (1) WO1999052895A1 (en)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT813525E (en) 1995-03-10 2004-02-27 Berlex Lab BENZAMIDINE DERIVATIVES AND THEIR USE AS ANTICOAGULANTS
US6686364B2 (en) 1997-12-08 2004-02-03 Berlex Laboratories, Inc. Benzamidine derivatives and their use as anti-coagulants
AU6123699A (en) * 1998-10-16 2000-05-08 Takeda Chemical Industries Ltd. Nitrogenous fused heterocycle compounds, process for the preparation thereof andagents containing the same
US6262088B1 (en) 1998-11-19 2001-07-17 Berlex Laboratories, Inc. Polyhydroxylated monocyclic N-heterocyclic derivatives as anti-coagulants
US6350761B1 (en) 1999-07-30 2002-02-26 Berlex Laboratories, Inc. Benzenamine derivatives as anti-coagulants
US20020065303A1 (en) * 2000-02-01 2002-05-30 Bing-Yan Zhu Bivalent phenylene inhibitors of factor Xa
AU2001249399A1 (en) * 2000-03-24 2001-10-08 Cor Therapeutics, Inc. Isoquinolone inhibitors of factor xa
US20020019394A1 (en) * 2000-03-24 2002-02-14 Wenhao Li Bicyclic sulfonyl amino inhibitors of factor Xa
US7879840B2 (en) * 2005-08-25 2011-02-01 The Trustees Of Columbia University In The City Of New York Agents for preventing and treating disorders involving modulation of the RyR receptors
US20060293266A1 (en) * 2000-05-10 2006-12-28 The Trustees Of Columbia Phosphodiesterase 4D in the ryanodine receptor complex protects against heart failure
US20040229781A1 (en) * 2000-05-10 2004-11-18 Marks Andrew Robert Compounds and methods for treating and preventing exercise-induced cardiac arrhythmias
US20040048780A1 (en) * 2000-05-10 2004-03-11 The Trustees Of Columbia University In The City Of New York Method for treating and preventing cardiac arrhythmia
US7718644B2 (en) * 2004-01-22 2010-05-18 The Trustees Of Columbia University In The City Of New York Anti-arrhythmic and heart failure drugs that target the leak in the ryanodine receptor (RyR2) and uses thereof
US7393652B2 (en) * 2000-05-10 2008-07-01 The Trustees Of Columbia University In The City Of New York Methods for identifying a chemical compound that directly enhances binding of FKBP12.6 to PKA-phosphorylated type 2 ryanodine receptor (RyR2)
US8022058B2 (en) 2000-05-10 2011-09-20 The Trustees Of Columbia University In The City Of New York Agents for preventing and treating disorders involving modulation of the RyR receptors
US6489125B1 (en) * 2000-05-10 2002-12-03 The Trustees Of Columbia University In The City Of New York Methods for identifying chemical compounds that inhibit dissociation of FKBP12.6 binding protein from type 2 ryanodine receptor
AU2001269531A1 (en) * 2000-07-17 2002-01-30 Takeda Chemical Industries Ltd. Sulfone derivatives, process for their production and use thereof
DE10110325A1 (en) * 2001-03-03 2002-09-05 Merck Patent Gmbh Phenyl derivatives 2
JP2005532991A (en) 2002-01-10 2005-11-04 ニューロジェン・コーポレーション Melanin-concentrating hormone receptor ligand: substituted 2- (4-benzyl-piperazin-1-ylmethyl)-and 2- (4-benzyl-diazepan-1-ylmethyl) -1H-benzimidazole analogs
JPWO2003095446A1 (en) * 2002-05-09 2005-09-15 持田製薬株式会社 Process for producing 1- (4-pyridyl) -4-piperidone
US7544678B2 (en) * 2002-11-05 2009-06-09 The Trustees Of Columbia University In The City Of New York Anti-arrythmic and heart failure drugs that target the leak in the ryanodine receptor (RyR2)
AU2003284596A1 (en) * 2002-11-22 2004-06-18 Takeda Pharmaceutical Company Limited Imidazole derivative, process for producing the same, and use
AU2003302238A1 (en) 2002-12-03 2004-06-23 Axys Pharmaceuticals, Inc. 2-(2-hydroxybiphenyl-3-yl)-1h-benzoimidazole-5-carboxamidine derivatives as factor viia inhibitors
WO2004080283A2 (en) 2003-03-07 2004-09-23 The Trustees Of Columbia University, In The City Of New York Type 1 ryanodine receptor-based methods
EP1479676A1 (en) * 2003-05-19 2004-11-24 Aventis Pharma Deutschland GmbH Benzimidazole-derivatives as factor xa inhibitors
US7741341B2 (en) * 2003-05-19 2010-06-22 Sanofi-Aventis Deutschland Gmbh Benzimidazole-derivatives as factor Xa inhibitors
US7378409B2 (en) 2003-08-21 2008-05-27 Bristol-Myers Squibb Company Substituted cycloalkylamine derivatives as modulators of chemokine receptor activity
JP4355917B2 (en) 2003-10-29 2009-11-04 信越化学工業株式会社 Nitrogen-containing organic compound, resist material, and pattern forming method
US8710045B2 (en) * 2004-01-22 2014-04-29 The Trustees Of Columbia University In The City Of New York Agents for preventing and treating disorders involving modulation of the ryanodine receptors
DE102004016605A1 (en) * 2004-04-03 2005-10-20 Merck Patent Gmbh Thiocarbamoylproline
TWI396686B (en) * 2004-05-21 2013-05-21 Takeda Pharmaceutical Cyclic amide derivative, and its production and use
FR2870846B1 (en) 2004-05-25 2006-08-04 Sanofi Synthelabo TETRAHYDROISOQUINOLYLSULFONAMIDE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC USE
JPWO2006016637A1 (en) * 2004-08-11 2008-05-01 杏林製薬株式会社 New cyclic aminobenzoic acid derivatives
WO2006083003A1 (en) 2005-02-02 2006-08-10 Ajinomoto Co., Inc. Novel benzamidine compound
CN101189231B (en) * 2005-03-23 2011-05-18 杏林制药株式会社 Novel cyclic aminophenylalkanoic acid derivative
US7709516B2 (en) * 2005-06-17 2010-05-04 Endorecherche, Inc. Helix 12 directed non-steroidal antiandrogens
US7704990B2 (en) * 2005-08-25 2010-04-27 The Trustees Of Columbia University In The City Of New York Agents for preventing and treating disorders involving modulation of the RyR receptors
EP1790646A1 (en) * 2005-11-24 2007-05-30 Sanofi-Aventis Isoquinoline und benzo[h]isoquinoline derivatives, their preparation and their therapeutical application as antagonists of histamine H3 receptor .
US20080186971A1 (en) * 2007-02-02 2008-08-07 Tarari, Inc. Systems and methods for processing access control lists (acls) in network switches using regular expression matching logic
JPWO2010005087A1 (en) * 2008-07-11 2012-01-05 味の素株式会社 Amidine derivatives
AR080375A1 (en) 2010-03-05 2012-04-04 Sanofi Aventis PROCEDURE FOR THE PREPARATION OF 2- (CYCLOHEXIMETHYL) -N- {2 - [(2S) -1-METHYLPIRROLIDIN-2-IL] ETIL} -1,2,3,4-TETRAHYDROISOCHINOLINE- 7-SULFONAMIDE
KR101499696B1 (en) * 2013-10-16 2015-03-09 한국식품연구원 Enterococcus sp. microorganisms from salted fish and mass production method of s-adenosyl-l-methionine using the same
CN103965113A (en) * 2014-05-06 2014-08-06 四川大学 1-ethoxyl-2-substituted phenoxymethyl benzimidazole compound and preparation method thereof
SG11202003005PA (en) * 2017-10-04 2020-04-29 Japan Tobacco Inc Nitrogen-containing heteroaryl compound, and pharmaceutical use thereof

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3725388A (en) 1970-06-25 1973-04-03 Boehringer Sohn Ingelheim N-acyl-7-(n{41 -cycloalkyl-ureido-n{40 -sulfonyl)-isoquinolines and -benzazepines and alkali metal salts thereof
US4324794A (en) 1980-08-26 1982-04-13 Research Triangle Institute Inhibition of respiratory syncytial virus-induced cell fusion by amidino compounds
JPS59139357A (en) 1983-01-28 1984-08-10 Torii Yakuhin Kk Amidine derivative
DE4035961A1 (en) 1990-11-02 1992-05-07 Thomae Gmbh Dr K CYCLIC IMINODERIVATES, MEDICAMENTS CONTAINING SUCH COMPOUNDS AND METHOD FOR THE PRODUCTION THEREOF
US5710158A (en) 1991-05-10 1998-01-20 Rhone-Poulenc Rorer Pharmaceuticals Inc. Aryl and heteroaryl quinazoline compounds which inhibit EGF and/or PDGF receptor tyrosine kinase
CA2102780C (en) 1991-05-10 2007-01-09 Alfred P. Spada Bis mono-and bicyclic aryl and heteroaryl compounds which inhibit egf and/or pdgf receptor tyrosine kinase
US5721237A (en) 1991-05-10 1998-02-24 Rhone-Poulenc Rorer Pharmaceuticals Inc. Protein tyrosine kinase aryl and heteroaryl quinazoline compounds having selective inhibition of HER-2 autophosphorylation properties
DE4127404A1 (en) 1991-08-19 1993-02-25 Thomae Gmbh Dr K CYCLIC IMINODERIVATES, MEDICAMENTS CONTAINING SUCH COMPOUNDS AND METHOD FOR THE PRODUCTION THEREOF
JP3048698B2 (en) 1991-09-19 2000-06-05 第一製薬株式会社 Amidino-substituted aromatic compounds and salts thereof
ZA928276B (en) * 1991-10-31 1993-05-06 Daiichi Seiyaku Co Aromatic amidine derivates and salts thereof.
JP3457694B2 (en) * 1993-02-04 2003-10-20 第一製薬株式会社 Influenza prophylaxis and treatment
JP3388803B2 (en) 1993-05-20 2003-03-24 第一製薬株式会社 Method for producing optically active 7-amidinonaphthalene derivative
JPH09506335A (en) 1993-09-22 1997-06-24 ザ、ウェルカム、ファンデーション、リミテッド Bis (aminobenzimidazolyl) alkanes as antiviral agents
JPH07179407A (en) 1993-11-12 1995-07-18 Green Cross Corp:The New condensed cyclic compound or its salt and its medicinal use
US6815461B1 (en) 1994-01-20 2004-11-09 The University Of North Carolina At Chapel Hill Method of inhibiting retroviral integrase
JPH0820532A (en) 1994-07-05 1996-01-23 Dai Ichi Seiyaku Co Ltd Anti-pancreatitic agent
JP3004362B2 (en) 1994-12-02 2000-01-31 山之内製薬株式会社 Novel amidinonaphthyl derivative or salt thereof
US5693515A (en) 1995-04-28 1997-12-02 Arris Pharmaceutical Corporation Metal complexed serine protease inhibitors
US5612363A (en) 1995-06-02 1997-03-18 Berlex Laboratories, Inc. N,N-di(aryl) cyclic urea derivatives as anti-coagulants
JPH092977A (en) 1995-06-21 1997-01-07 Dai Ichi Seiyaku Co Ltd Medicine composition for oral administration
DE19530996A1 (en) * 1995-08-23 1997-02-27 Boehringer Mannheim Gmbh Cyclic guanidines, process for their preparation and pharmaceuticals
PL193686B1 (en) 1995-09-07 2007-03-30 Hoffmann La Roche Novel 4-(oxyalkoxyphenyl)-3-oxy piperisiden for treating cardiac and recal insufficiency
DK0796623T3 (en) 1996-03-20 2005-08-01 Baxter Ag Pharmaceutical composition for the treatment of blood clotting disorders
WO1997045424A1 (en) 1996-05-31 1997-12-04 C & C Research Laboratories Aromatic amidine derivatives useful as selective thrombin inhibitors
HU224315B1 (en) 1996-06-05 2005-07-28 Gyógyszerkutató Intézet Kft. Peptidyl-arginin-aldehyde derivatives of anticoagulant activity and pharmaceutical compositions containing them
JPH1017549A (en) 1996-07-02 1998-01-20 Banyu Pharmaceut Co Ltd Bicyclic aromatic amidine derivative
HN1998000118A (en) 1997-08-27 1999-02-09 Pfizer Prod Inc 2 - AMINOPYRIDINES CONTAINING SUBSTITUTES FOR CONDENSED RINGS.
US5942532A (en) * 1997-09-05 1999-08-24 Ortho Pharmaceutical Corporation 2-substituted phenyl-benzimidazole antibacterial agents
KR20020048977A (en) 1999-10-27 2002-06-24 딘 테일러 Tissue factor antagonists and methods of use thereof
US20020173507A1 (en) 2000-08-15 2002-11-21 Vincent Santora Urea compounds and methods of uses

Also Published As

Publication number Publication date
EP1070714A4 (en) 2002-10-30
US6562828B1 (en) 2003-05-13
HUP0101137A2 (en) 2001-10-28
HUP0101137A3 (en) 2003-03-28
AU752588B2 (en) 2002-09-26
DE69919149D1 (en) 2004-09-09
US20040006099A1 (en) 2004-01-08
PL343424A1 (en) 2001-08-13
TR200002904T2 (en) 2001-02-21
EP1070714A9 (en) 2005-10-19
RU2201927C2 (en) 2003-04-10
CN1305470A (en) 2001-07-25
CA2327488A1 (en) 1999-10-21
SG74717A1 (en) 2000-08-22
NZ508101A (en) 2002-12-20
ID28266A (en) 2001-05-10
IL138899A0 (en) 2001-11-25
AR015269A1 (en) 2001-04-18
WO1999052895A1 (en) 1999-10-21
KR100416111B1 (en) 2004-01-31
AU3167799A (en) 1999-11-01
ATE272630T1 (en) 2004-08-15
EP1070714B1 (en) 2004-08-04
BR9910122A (en) 2001-10-16
EP1070714A1 (en) 2001-01-24
PE20000422A1 (en) 2000-05-19
NO20005083D0 (en) 2000-10-09
NO20005083L (en) 2000-12-08
SK15072000A3 (en) 2001-08-06
KR20010042606A (en) 2001-05-25

Similar Documents

Publication Publication Date Title
CO5021130A1 (en) AMIDINE COMPOUND CONTAIN
TR200101893T2 (en) 4-oxo-1,4 dihydro -3-quinolinecarboxamides as antiviral agents.
YU20199A (en) Heteroaryl succinamides and their use as metalloproteinase inhibitors
CO5640140A2 (en) AKT ACTIVITY INHIBITORS
TR200102957T2 (en) Method for the preparation of citalopram.
ES8701173A1 (en) Thienyl condensed-pyrazole derivatives.
ES2191484T3 (en) HETEROCICLICAL COMPOUNDS AS INHIBITORS OF ROTAMASA ENZYMES.
WO2003106628A3 (en) Benzodiazepine inhibitors of mitochondial f¿1<f¿0? atp hydrolase and methods of inhibiting f¿1?f¿0? atp hydrolase
EA199900591A1 (en) NITROGEN-CONTAINING HETEROAROMATIC COMPOUNDS AS INHIBITOR FACTOR XA
BG103980A (en) 4-phenylpiperidine compounds
ES2139079T3 (en) IMMUNOSUPPRESSIVE AND ANTIALLERGIC COMPOUNDS, SUCH AS N- (3-OXOHEXANOIL) -HOMOSERINE-LACTONE.
AR014868A1 (en) A COMPOUND DERIVED FROM N, N (REPLACED) PHENYL (ARYL OR HETEROARILE) PROPANAMINE, A PHARMACEUTICAL COMPOSITION, USE OF THE SUCH COMPOUND AND A METHOD TO PREPARE IT.
CO5160347A1 (en) CARBAMIC ACID DERIVATIVES
DE3879522D1 (en) PROLINAL DERIVATIVES.
ES2086326T3 (en) METHOD FOR INTENSIFYING CHEMILUMINESCENCE.
DK249089D0 (en) BENZAMIDE COMPOUNDS USED AS PROTEASE INHIBITORS
ES2038678T3 (en) PROCEDURE FOR THE PREPARATION OF N- (2-ALQUIL-3-MERCAPTO-GLUTARIL) -ALFAMINO-ACIDOS.
RS49965B (en) Substituted bisindolymaleimides for the inhibition of cell proliferation
MX9301045A (en) PROCEDURE FOR PREPARING FIBRINOGEN RECEIVING ANTAGONISTS.
DE69329084D1 (en) Benzoxazepine derivatives as cholinesterase inhibitors
SE8008555L (en) TIOETYLAMIDDERIVAT
ATE196137T1 (en) THIAZOLINE DERIVATIVES
TR200003652T2 (en) Tetrahydroquinoline derivatives as glycine antagonists.
ATE247660T1 (en) FUROPYRIDINE DERIVATIVES AND THEIR THERAPEUTIC USE
PE20020687A1 (en) IMIDAZOLES AND THIAZOLS SUBSTITUTED AS INHIBITORS OF FARNESIL TRANSFERASE