CO2018001460A2 - Método para mejorar la solubilidad acuosa de fármacos insolubles o ligeramente solubles en agua - Google Patents
Método para mejorar la solubilidad acuosa de fármacos insolubles o ligeramente solubles en aguaInfo
- Publication number
- CO2018001460A2 CO2018001460A2 CONC2018/0001460A CO2018001460A CO2018001460A2 CO 2018001460 A2 CO2018001460 A2 CO 2018001460A2 CO 2018001460 A CO2018001460 A CO 2018001460A CO 2018001460 A2 CO2018001460 A2 CO 2018001460A2
- Authority
- CO
- Colombia
- Prior art keywords
- water
- insoluble
- dissolved
- organic compound
- aqueous solvent
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0291—Micelles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/602—Glycosides, e.g. rutin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/10—General cosmetic use
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Birds (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Molecular Biology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Dermatology (AREA)
- Oncology (AREA)
- Rheumatology (AREA)
- Ophthalmology & Optometry (AREA)
- Anesthesiology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Dispersion Chemistry (AREA)
- Transplantation (AREA)
- Hematology (AREA)
- Communicable Diseases (AREA)
- Pulmonology (AREA)
- Psychiatry (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201514801578A | 2015-07-16 | 2015-07-16 | |
| PCT/EP2016/066999 WO2017009480A1 (en) | 2015-07-16 | 2016-07-15 | Method for improving aqueous solubility of water-insoluble or slightly water-soluble drugs |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO2018001460A2 true CO2018001460A2 (es) | 2018-05-10 |
Family
ID=56418519
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CONC2018/0001460A CO2018001460A2 (es) | 2015-07-16 | 2018-02-14 | Método para mejorar la solubilidad acuosa de fármacos insolubles o ligeramente solubles en agua |
Country Status (29)
| Country | Link |
|---|---|
| EP (1) | EP3324933B1 (https=) |
| JP (1) | JP6836825B2 (https=) |
| KR (1) | KR102615005B1 (https=) |
| CN (1) | CN107847440B (https=) |
| AU (1) | AU2016293125B2 (https=) |
| CA (1) | CA2992376C (https=) |
| CL (1) | CL2018000032A1 (https=) |
| CO (1) | CO2018001460A2 (https=) |
| CY (1) | CY1124322T1 (https=) |
| DK (1) | DK3324933T3 (https=) |
| EA (1) | EA036233B1 (https=) |
| ES (1) | ES2844581T3 (https=) |
| HR (1) | HRP20210333T1 (https=) |
| HU (1) | HUE053116T2 (https=) |
| IL (1) | IL256882B (https=) |
| LT (1) | LT3324933T (https=) |
| MA (1) | MA42472B1 (https=) |
| MX (1) | MX379341B (https=) |
| MY (1) | MY196065A (https=) |
| NZ (1) | NZ738592A (https=) |
| PH (1) | PH12018500042A1 (https=) |
| PL (1) | PL3324933T3 (https=) |
| PT (1) | PT3324933T (https=) |
| RS (1) | RS61561B1 (https=) |
| SA (1) | SA518390688B1 (https=) |
| SI (1) | SI3324933T1 (https=) |
| UA (1) | UA123312C2 (https=) |
| WO (1) | WO2017009480A1 (https=) |
| ZA (1) | ZA201708594B (https=) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108143713A (zh) * | 2018-01-04 | 2018-06-12 | 南方医科大学南方医院 | 一种增加羟喜树碱溶解度的方法 |
| US12377046B1 (en) | 2019-04-24 | 2025-08-05 | Wellomics LLC | Delivery system matrices |
| CN110074385B (zh) * | 2019-05-21 | 2022-05-31 | 绥化市蓝源生物工程有限公司 | 一种生物碱溶解纳他霉素的生物溶剂及其应用 |
| KR20220022829A (ko) * | 2020-08-19 | 2022-02-28 | 주식회사 모든바이오 | 글리시리진 및 수용성 약물을 포함하는 나노 입자, 이를 포함하는 약제학적 조성물 및 이들의 제조 방법 |
| CN114588118B (zh) * | 2022-01-25 | 2023-05-23 | 武汉爱民制药股份有限公司 | 一种注射用七叶皂苷钠复方制剂 |
| KR102922176B1 (ko) * | 2022-07-08 | 2026-02-04 | 한국생산기술연구원 | 소수성 약물 전달을 위한 금-히알루론산 나노입자의 제조방법 |
| EP4431082A1 (en) * | 2023-03-13 | 2024-09-18 | Marinomed Biotech AG | Aqueous composition comprising budesonide |
| EP4516289A1 (en) | 2023-08-30 | 2025-03-05 | SPH Sine Pharmaceutical Laboratories Co., Ltd | Antiviral nasal spray comprising favipiravir |
| CN117562911B (zh) * | 2023-12-07 | 2024-06-04 | 海南医学院 | 化合物tigloside在制备治疗和/或预防骨关节炎药物中的用途 |
| WO2025133675A1 (en) * | 2023-12-20 | 2025-06-26 | Melikoglu, Ahmet | Method for producing nasal formulation comprising aescin and rutin |
| EP4696300A1 (en) | 2024-08-14 | 2026-02-18 | Marinomed Biotech AG | Aqueous composition comprising fluticasone |
| KR102907892B1 (ko) * | 2025-01-09 | 2026-01-12 | 주식회사 한바이오 | 가용성을 높인 피레스로이드계의 보건용 스프레이 살충제 제조방법 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1119957A (en) | 1979-12-04 | 1982-03-16 | Martin Whitefield | Steroid compositions |
| US4782047A (en) | 1986-05-22 | 1988-11-01 | Syntex Pharmaceuticals International Ltd. | Aqueous steroid formulations for nasal administration |
| US4868170A (en) | 1987-11-13 | 1989-09-19 | E. R. Squibb & Sons, Inc. | Steriod lotion formulation |
| JPH1025255A (ja) * | 1996-07-11 | 1998-01-27 | Taisho Pharmaceut Co Ltd | 溶解性の改善された難溶性薬剤 |
| FR2799369B1 (fr) | 1999-10-08 | 2001-12-21 | Oreal | Association d'escine et de sulfate de dextran et son utilisation |
| US7125564B2 (en) | 2001-02-16 | 2006-10-24 | Lavipharm Laboratories, Inc. | Water soluble and palatable complexes |
| JP4000283B2 (ja) * | 2002-08-07 | 2007-10-31 | 丸善製薬株式会社 | 甘草油性抽出物の可溶化組成物、並びに飲料、液状調味料、化粧品及び医薬部外品 |
| US7897587B2 (en) | 2004-09-03 | 2011-03-01 | Nycomed Us Inc. | Topical dermatological formulations and use thereof |
| JP5128801B2 (ja) * | 2006-10-16 | 2013-01-23 | フロイント産業株式会社 | 高水分散性粉末とその製造方法 |
| JP6265624B2 (ja) * | 2012-05-11 | 2018-01-24 | ロート製薬株式会社 | ルリコナゾール含有外用医薬組成物 |
| US9907846B2 (en) * | 2013-04-01 | 2018-03-06 | Mx Adjuvac Ab | Nanoparticles, composed of sterol and saponin from Quillaja saponaria Molina for use in pharmaceutical compositions |
| CN103271891B (zh) * | 2013-04-28 | 2016-01-06 | 福建南方制药股份有限公司 | 人参皂苷纳米胶束及其制备方法、应用和药物组合物 |
| CN103520081B (zh) * | 2013-09-27 | 2015-10-28 | 无限极（中国）有限公司 | 一种调节皮肤免疫力、延缓皮肤老化的外用护肤品 |
-
2016
- 2016-07-15 SI SI201631114T patent/SI3324933T1/sl unknown
- 2016-07-15 MX MX2018000286A patent/MX379341B/es unknown
- 2016-07-15 EA EA201890194A patent/EA036233B1/ru unknown
- 2016-07-15 DK DK16739477.4T patent/DK3324933T3/da active
- 2016-07-15 MY MYPI2017704929A patent/MY196065A/en unknown
- 2016-07-15 HR HRP20210333TT patent/HRP20210333T1/hr unknown
- 2016-07-15 PT PT167394774T patent/PT3324933T/pt unknown
- 2016-07-15 KR KR1020187004268A patent/KR102615005B1/ko active Active
- 2016-07-15 NZ NZ738592A patent/NZ738592A/en unknown
- 2016-07-15 PL PL16739477T patent/PL3324933T3/pl unknown
- 2016-07-15 CN CN201680039722.5A patent/CN107847440B/zh active Active
- 2016-07-15 ES ES16739477T patent/ES2844581T3/es active Active
- 2016-07-15 HU HUE16739477A patent/HUE053116T2/hu unknown
- 2016-07-15 WO PCT/EP2016/066999 patent/WO2017009480A1/en not_active Ceased
- 2016-07-15 AU AU2016293125A patent/AU2016293125B2/en active Active
- 2016-07-15 EP EP16739477.4A patent/EP3324933B1/en active Active
- 2016-07-15 CA CA2992376A patent/CA2992376C/en active Active
- 2016-07-15 UA UAA201712614A patent/UA123312C2/uk unknown
- 2016-07-15 LT LTEP16739477.4T patent/LT3324933T/lt unknown
- 2016-07-15 JP JP2017566080A patent/JP6836825B2/ja active Active
- 2016-07-15 RS RS20210293A patent/RS61561B1/sr unknown
- 2016-07-15 MA MA42472A patent/MA42472B1/fr unknown
-
2017
- 2017-12-18 ZA ZA2017/08594A patent/ZA201708594B/en unknown
-
2018
- 2018-01-03 SA SA518390688A patent/SA518390688B1/ar unknown
- 2018-01-04 PH PH12018500042A patent/PH12018500042A1/en unknown
- 2018-01-05 CL CL2018000032A patent/CL2018000032A1/es unknown
- 2018-01-11 IL IL256882A patent/IL256882B/en unknown
- 2018-02-14 CO CONC2018/0001460A patent/CO2018001460A2/es unknown
-
2021
- 2021-03-12 CY CY20211100218T patent/CY1124322T1/el unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CO2018001460A2 (es) | Método para mejorar la solubilidad acuosa de fármacos insolubles o ligeramente solubles en agua | |
| AR098857A1 (es) | Adhesivo | |
| CR20150287A (es) | Composición farmacéutica con biodisponibilidad mejorada | |
| BR112015017246A2 (pt) | formulação farmacêutica que compreende um corticosteroide insolúvel e um corticosteroide solúvel | |
| MX2018011881A (es) | Sistema de administracion. | |
| IN2014MN02213A (https=) | ||
| MX391778B (es) | Composición farmacéutica que comprende fibras obtenidas electrohidrodinámicamente y que tiene tiempo de residencia mejorado en el sitio de aplicación. | |
| JP2015110565A5 (https=) | ||
| BR112017026287A2 (pt) | composições de hidroxipropil beta-ciclodextrina e métodos | |
| MX387005B (es) | Nanocápsula para la administración de un compuesto lipófilo y proceso de preparación de la misma. | |
| CO2019013342A2 (es) | Formulaciones de medicamentos de moleculas pequeñas resistentes a la precipitación | |
| MX2017009482A (es) | Formulación farmacéutica. | |
| FR3058059B1 (fr) | Composition pharmaceutique comprenant le beta-elemene, le lupeol et le 2-hydroxycinnamaldehyde et/ou le 2'-benzoyloxycinnalmaldehyde et/ou le beta-sitosterol et/ou la curcumine. | |
| DOP2019000128A (es) | Composición para el tratamiento y/o prevención de la enfermedad fúngica sigatoka negra en los cultivos de banana | |
| BR112018067918A2 (pt) | formulações livres de solvente de substâncias ativas com baixo ponto de fusão | |
| BR112015027112A2 (pt) | uso de uma mistura, e, formulação de ingrediente ativo aquoso | |
| AR089132A1 (es) | Composicion microbicida y su proceso de obtencion | |
| ECSP15037180A (es) | Extracto de café que contiene ácido protocatecuico y su uso en agroquímica contra patógenos de plantas | |
| BR112015024825A2 (pt) | polímero com base em glicogênio, complexo, composições farmacêutica, nutracêutica e cosmética, e, usos dos polímeros com base em glicogênio e de um complexo | |
| EA201691825A1 (ru) | Стабилизированный раствор на основе активных веществ, способ получения стабилизированного раствора активных веществ, фармацевтическая композиция на основе стабилизированного раствора активных веществ (два варианта) | |
| EP2826497A3 (en) | Intra-articular injection and implant attachment of molecules consisting of lubricin and extracellular superoxide dismutase or hyaluronic acid and extracellular superoxide dismutase | |
| AR086576A1 (es) | Composiciones de cb-183,315 y metodos relacionados | |
| BR112016016700A2 (pt) | Composição para acelerar a penetração através da pele, preparação para administração transdérmica, e preparação de emplastro de pele | |
| BR112016028412A2 (pt) | composição farmacêutica, método para a preparação de uma composição farmacêutica, e kit | |
| FR3058060B1 (fr) | Composition pharmaceutique comprenant le beta-elemene, le lupeol, le cinnamaldehyde et/ou le 2-hydroxycinnamaldehyde et/ou le 2'-benzoyloxycinnalmaldehyde et/ou le beta-sitosterol et/ou la curcumine. |