CN223464548U - Purification device for preparing biological polysaccharide - Google Patents

Abstract

The utility model relates to the field of bioengineering and discloses a purifying device for preparing biological polysaccharide, which comprises a filter cylinder and a purifying box, wherein a material receiving cover is fixedly connected to the upper surface of the filter cylinder, a motor is arranged on the upper surface of the filter cylinder, a rotating rod is fixedly connected to the output end of the motor, a stirring blade is fixedly connected to the outer wall of the rotating rod, an activated carbon filter plate is fixedly connected to the inner wall of the filter cylinder, a connecting ring is arranged inside the filter cylinder, a clamping rod is fixedly connected to the outer wall of the connecting ring, a clamping assembly is arranged on the outer wall of the filter cylinder, the clamping assembly is used for fixing the clamping rod, a sliding assembly is arranged inside the connecting ring, and the sliding assembly is used for assisting the connecting ring to move up and down. According to the utility model, the activated carbon filter plate is cleaned, so that the mode that the filter plate is required to be disassembled and cleaned by a traditional purifying device is avoided, the workload of operators is greatly reduced, and the waste of raw material liquid is effectively reduced by the arrangement of the scraping plate.

Description

Purification device for preparing biological polysaccharide

Technical Field

The utility model relates to the field of bioengineering, in particular to a purification device for preparing biological polysaccharide.

Background

Biological polysaccharide is a biological macromolecule with important physiological functions and wide application value. In the field of medicine, the biological polysaccharide purification device can be used as a medicine carrier, an immunomodulator, an anticoagulant and the like, provides a key material basis for the research and development of novel medicines and the treatment of diseases, and ensures the purity of raw materials and intermediate products in the preparation process of the biological polysaccharide purification device so as to ensure the quality and the performance of the final product, so that the production quality of biological polysaccharide is ensured.

The purification device for biological polysaccharide generally comprises the steps of filtration, precipitation, ion exchange chromatography, gel filtration chromatography, dialysis and the like, wherein the filtration operation is the most important link in the preparation of the biological polysaccharide, generally comprises a plurality of layers of filter screens, filter membranes or filter media, and separates impurities from a solution or a mixture in a physical interception, adsorption and other modes.

However, most of the existing biological polysaccharide purifying devices are designed with emphasis on optimizing the filtering function and neglecting the cleaning process, and because the existing devices lack a high-efficiency cleaning mechanism specific to the filtering mechanism, no suitable cleaning interface, automatic cleaning device or easy-to-disassemble structure is provided, the operators need to consume a great deal of time and effort when the filtering mechanism needs to be cleaned, and even the whole purifying device may need to be partially disassembled, thus increasing maintenance cost and downtime, and adversely affecting the continuous production process of biological polysaccharide.

Disclosure of utility model

In order to overcome the defects, the utility model provides a purifying device for preparing biological polysaccharide, which aims to solve the problems that the existing biological polysaccharide purifying device ignores a cleaning link, so that a great deal of time and energy are consumed by staff.

In order to achieve the above purpose, the purifying device for preparing biological polysaccharide comprises a filter cylinder and a purifying box, wherein the upper surface of the filter cylinder is fixedly connected with a material receiving cover, the upper surface of the filter cylinder is provided with a motor, the output end of the motor is fixedly connected with a rotating rod, the outer wall of the rotating rod is fixedly connected with a stirring blade, the inner wall of the filter cylinder is fixedly connected with an activated carbon filter plate, a connecting ring is arranged inside the filter cylinder, the outer wall of the connecting ring is fixedly connected with a clamping rod, the outer wall of the filter cylinder is provided with a clamping assembly, the clamping assembly is used for fixing the clamping rod, the inner part of the connecting ring is provided with a sliding assembly, the sliding assembly is used for assisting the connecting ring to move up and down, the clamping assembly comprises a clamping cylinder, the inner part of the clamping cylinder is fixedly connected with a spring, one end of the spring is fixedly connected with a clamping block, one side of the outer wall of the clamping block is fixedly connected with a pulling block, and the inner part of the clamping cylinder is provided with a sliding groove I.

Further, the sliding component comprises a guide groove, the guide groove is formed in the connecting ring, a guide rod is fixedly connected in the filter cartridge, and the outer wall of the guide rod is slidably connected with the inner wall of the guide groove.

Further, the dwang outer wall fixedly connected with connecting rod, connecting rod outer wall sliding connection has the loop bar, loop bar outer wall one side fixedly connected with scraper blade, connecting rod upper surface fixedly connected with slide nail.

Further, a second sliding groove is formed in the sleeve rod, and the outer wall of the slide nail is connected to the inner wall of the second sliding groove in a sliding mode.

Further, a clamping groove is formed in the clamping rod, and the clamping groove is used for being clamped with the clamping block.

Further, the lower surface of the filter cartridge is fixedly connected with a flow guide pipe, and the outer wall of the flow guide pipe is provided with a water pump.

Further, a purifying cylinder is fixedly connected inside the purifying box, and a chromatographic column and a gel column are arranged inside the purifying cylinder.

Further, the purifying box is connected with a dialysis box in a sliding mode, and the dialysis box is used for further purifying polysaccharide.

The utility model has the following beneficial effects:

1. According to the utility model, the connecting ring can slide upwards along the guide rod by pulling upwards, so that the clamping rod at the outer side of the connecting ring moves upwards, the clamping rod can slide along the first sliding groove in the clamping cylinder, the clamping block is extruded when the clamping rod slides, the clamping block moves inwards of the clamping cylinder, meanwhile, the spring can be extruded and contracted by the clamping block until the clamping groove slides to a position opposite to the clamping block, the clamping block is clamped with the clamping groove by the elastic action of the spring until the clamping groove slides to a position opposite to the clamping block, the connecting ring is fixed, and the activated carbon filter plate is cleaned by moving the notch opened by the connecting ring upwards, so that the mode that the traditional purifying device needs to disassemble and clean the filter plate is avoided, and the workload of operators is greatly reduced.

2. According to the utility model, the rotating rod is driven by the motor, so that the plurality of stirring blades on the outer side of the rotating rod can be driven to rotate, the raw materials are fully contacted with the precipitant, and when the rotating rod rotates, the connecting rod is driven to rotate, so that the sleeve rod on the outer side of the connecting rod extends outwards under the limit of the slide nail and the slide groove, the full contact of the inner wall of the scraper filter cylinder is realized, and the scraper can scrape the raw material liquid on the inner wall of the filter cylinder by the driving rotation of the connecting rod, so that the waste of the raw material liquid is effectively reduced.

Drawings

FIG. 1 is a schematic perspective view of a purification device for preparing biological polysaccharide according to the present utility model;

FIG. 2 is a schematic diagram of a filter cartridge of a purification device for preparing biological polysaccharide according to the present utility model;

FIG. 3 is a schematic diagram of a connecting ring structure of a purifying device for preparing biological polysaccharide according to the present utility model;

Fig. 4 is a schematic diagram of a structure of a cartridge of a purifying device for preparing biological polysaccharide according to the present utility model;

FIG. 5 is a schematic diagram of a connecting box of a purifying device for preparing biological polysaccharide;

Fig. 6 is a schematic diagram of a scraper structure of a purifying device for preparing biological polysaccharide according to the present utility model.

Legend description:

1. The filter cartridge comprises a filter cartridge body, a motor, a material receiving cover, a rotating rod, a filter plate 5, an activated carbon filter plate 6, a connecting ring, a guide rod 7, a guide rod 8, a guide groove 9, a clamping rod 10, a clamping groove 11, a stirring blade 12, a clamping cylinder 13, a first sliding groove, a 14, a clamping block 15, a spring 16, a pulling block 17, a purifying box 18, a purifying cylinder 19, a dialysis box 20, a guide pipe 21, a water pump 22, a scraping plate 23, a connecting rod 24, a loop bar 25, a second sliding groove 26 and a slide nail.

Detailed Description

The following description of the embodiments of the present utility model will be made clearly and completely with reference to the accompanying drawings, in which it is apparent that the embodiments described are only some embodiments of the present utility model, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the utility model without making any inventive effort, are intended to be within the scope of the utility model.

Referring to fig. 1-2, one embodiment provided by the present utility model is: A purifying device for preparing biological polysaccharide comprises a filter cartridge 1 and a purifying box 17, wherein the upper surface of the filter cartridge 1 is fixedly connected with a material receiving cover 3, raw material liquid firstly enters the filter cartridge 1 through the material receiving cover 3, a filter screen arranged in the filter cartridge 1 intercepts large particle impurities in the raw material liquid, an activated carbon filter plate 5 arranged in the filter cartridge 1 performs preliminary filtration on the entered raw material, activated carbon adsorbs and filters small molecular impurities in the raw material liquid, a precipitator is slowly added into the filter cartridge 1 according to a certain proportion after filtration is completed, a motor 2 is started, the output end of the motor 2 is fixedly connected with a rotating rod 4, the outer wall of the rotating rod 4 is fixedly connected with a stirring blade 11, the stirring blade 11 arranged on the outer wall of the rotating rod 4 can be driven by the motor 2 to stir the raw material, so that the raw material is fully contacted with the precipitator, thereby realizing the separation of polysaccharide and impurity, the polysaccharide solution after separation can flow out through the honeycomb duct 20 below the filter cartridge 1, and then the power is provided by the water pump 21, can guide the polysaccharide solution into the purifying tube 18, the upper surface of the filter cartridge 1 is provided with the motor 2, the inner wall of the filter cartridge 1 is fixedly connected with the activated carbon filter plate 5, the inside of the filter cartridge 1 is provided with the connecting ring 6, the outer wall of the connecting ring 6 is fixedly connected with the clamping rod 9, the outer wall of the filter cartridge 1 is provided with the clamping assembly, the clamping assembly is used for fixing the clamping rod 9, the inside of the connecting ring 6 is provided with the sliding assembly, the sliding assembly is used for assisting the connecting ring 6 to move up and down, the lower surface of the filter cartridge 1 is fixedly connected with the honeycomb duct 20, the outer wall of the honeycomb duct 20 is provided with the water pump 21, the inside of the purifying box 17 is fixedly connected with the purifying tube 18, the inside of the purifying tube 18 is provided with the chromatographic column and the gel column, through purifying section of thick bamboo 18 inside is provided with chromatographic column and gel column, can effectively get rid of the impurity that molecular weight and polysaccharide difference are great, thereby obtain the polysaccharide component through further purification, make the impurity that molecular weight and polysaccharide difference are great get rid of in the polysaccharide solution, the polysaccharide solution that is purified through preceding step gets into dialysis box 19, because there is the concentration gradient inside and outside the dialysis box 19, micromolecular impurity can diffuse into the dialysate through the semipermeable membrane, and the polysaccharide molecule is then kept in dialysis box 19, thereby realized further purification to the polysaccharide, the inside sliding connection of purifying box 17 has dialysis box 19, dialysis box 19 is used for can doing further purification to the polysaccharide.

Referring to fig. 2-4, the clamping assembly comprises a clamping cylinder 12, a spring 15 is fixedly connected inside the clamping cylinder 12, one end of the spring 15 is fixedly connected with a clamping block 14, one side of the outer wall of the clamping block 14 is fixedly connected with a pulling block 16, a chute I13 is formed inside the clamping cylinder 12, when the activated carbon filter plate 5 needs to be cleaned, the connecting ring 6 can be pulled upwards firstly, the connecting ring 6 can slide upwards along the guide rod 7, meanwhile, the connecting ring 6 can drive the clamping rod 9 on the outer side of the connecting ring to move upwards, the guide rod 7 is fixed inside the filter cylinder 1, a guide groove 8 is formed inside the connecting ring 6, the outer wall of the guide rod 7 is connected with the inner wall of the guide groove 8 in a sliding manner, so that a guiding effect is provided for the up-down sliding of the connecting ring 6, when the clamping rod 9 moves upwards, the clamping rod 9 can enter the clamping cylinder 12, the clamping rod 9 can slide along the first chute 13 in the clamping cylinder 12, meanwhile, the clamping rod 9 can squeeze the clamping block 14 when sliding, so that the clamping block 14 can move towards the inside of the clamping cylinder 12, meanwhile, the spring 15 can be squeezed and contracted by the clamping block 14 until the clamping groove 10 in the clamping rod 9 slides to a position opposite to the clamping block 14, the clamping block 14 can be completely clamped in the clamping groove 10 through the elastic effect of the spring 15, the fixing of the connecting ring 6 is realized, the cleaning of the activated carbon filter plate 5 is realized through the notch of the upward moving opening of the connecting ring 6, the sliding assembly comprises a guide groove 8, and the guide groove 8 is formed in the connecting ring 6.

Referring to fig. 5-6, the outer wall of the rotating rod 4 is fixedly connected with a connecting rod 23, the outer wall of the connecting rod 23 is slidably connected with a sleeve rod 24, one side of the outer wall of the sleeve rod 24 is fixedly connected with a scraping plate 22, the upper surface of the connecting rod 23 is fixedly connected with a slide pin 26, a sliding groove II 25 is formed in the sleeve rod 24, the outer wall of the slide pin 26 is slidably connected with the inner wall of the sliding groove II 25, when the rotating rod 4 rotates, the connecting rod 23 and the sleeve rod 24 are slidably connected, the slide pin 26 on the connecting rod 23 slides in the sliding groove II 25 of the sleeve rod 24, and the connecting rod 23 is driven to rotate under the action of centrifugal force generated by rotation of the rotating rod 4, so that the sleeve rod 24 on the outer wall of the connecting rod 23 extends outwards, the scraping plate 22 on the outer wall of the sleeve rod 24 can be fully contacted with the inner wall of the filter cartridge 1, and the scraping plate 22 can clean the inner wall of the filter cartridge 1 through the driving rotation of the connecting rod 23, so that the waste of raw material liquid is effectively reduced.

When the device is used, firstly, raw material liquid enters a filter cylinder 1 through a material receiving cover 3, a filter screen arranged in the filter cylinder 1 intercepts large-particle impurities in the raw material liquid, an activated carbon filter plate 5 arranged in the filter cylinder 1 carries out preliminary filtration on the entered raw material, activated carbon carries out adsorption filtration on small-molecule impurities in the raw material liquid, a precipitator is slowly added into the filter cylinder 1 according to a certain proportion after filtration is finished, a motor 2 is started, a stirring blade 11 on the outer wall of a rotating rod 4 can be driven by the motor 2 to stir the raw material, the raw material is fully contacted with the precipitator, thereby realizing separation of polysaccharide and impurities, a separated polysaccharide solution flows out through a guide pipe 20 below the filter cylinder 1, then provides power through a water pump 21, the polysaccharide solution can be led into a purification cylinder 18, and a chromatographic column and a gel column are arranged in the purification cylinder 18, so that impurities with larger molecular weight and polysaccharide difference can be effectively removed, further purified polysaccharide components are obtained, the polysaccharide solution with larger molecular weight and polysaccharide difference in the polysaccharide solution is removed through a dialysis box 19, and the polysaccharide solution purified through the previous dialysis box is filled into a dialysis box 19, and the concentration gradient of the polysaccharide molecules are further purified through the dialysis box, and the polysaccharide molecules are further purified inside and outside the dialysis box is realized;

When the activated carbon filter plate 5 needs to be cleaned, the connecting ring 6 can be pulled upwards, so that the connecting ring 6 can slide upwards along the guide rod 7, meanwhile, the connecting ring 6 can drive the clamping rod 9 on the outer side of the connecting ring to move upwards, when the clamping rod 9 moves upwards, the clamping rod 9 can enter the clamping cylinder 12, and can slide along the first sliding groove 13 in the clamping cylinder 12, meanwhile, the clamping rod 9 can squeeze the clamping block 14 when sliding, so that the clamping block 14 can move towards the inside of the clamping cylinder 12, meanwhile, the spring 15 can be squeezed and contracted by the clamping block 14, and the clamping block 14 can be clamped inside the clamping groove 10 completely through the elastic effect of restoration of the spring 15 until the clamping groove 10 in the clamping rod 9 slides to a position opposite to the clamping block 14, so that the fixing of the connecting ring 6 is realized, and the cleaning of the activated carbon filter plate 5 is realized through the notch opened by the upward movement of the connecting ring 6;

When the rotating rod 4 rotates, the connecting rod 23 which can drive the outer wall of the rotating rod rotates, so that the sleeve rod 24 which can enable the outer wall of the connecting rod 23 to extend outwards through the driving rotation of the rotating rod 4, the scraping plate 22 which can be arranged on the outer wall of the sleeve rod 24 can be fully contacted with the inner wall of the filter cartridge 1, and the scraping plate 22 can clean the inner wall of the filter cartridge 1 through the driving rotation of the connecting rod 23, so that the waste of raw material liquid is effectively reduced.

It should be noted that the foregoing description is only a preferred embodiment of the present utility model, and although the present utility model has been described in detail with reference to the foregoing embodiments, it should be understood that modifications, equivalents, improvements and modifications to the technical solution described in the foregoing embodiments may occur to those skilled in the art, and all modifications, equivalents, and improvements are intended to be included within the spirit and principle of the present utility model.

Claims (8)

1. The purifying device for preparing biological polysaccharide comprises a filter cartridge (1) and a purifying box (17), and is characterized in that the upper surface of the filter cartridge (1) is fixedly connected with a material receiving cover (3), the upper surface of the filter cartridge (1) is provided with a motor (2), the output end of the motor (2) is fixedly connected with a rotating rod (4), the outer wall of the rotating rod (4) is fixedly connected with a stirring blade (11), the inner wall of the filter cartridge (1) is fixedly connected with an activated carbon filter plate (5), a connecting ring (6) is arranged in the filter cartridge (1), the outer wall of the connecting ring (6) is fixedly connected with a clamping rod (9), the outer wall of the filter cartridge (1) is provided with a clamping assembly, the clamping assembly is used for fixing the clamping rod (9), and a sliding assembly is arranged in the connecting ring (6) and is used for assisting the connecting ring (6) to move up and down;

the clamping assembly comprises a clamping cylinder (12), a spring (15) is fixedly connected inside the clamping cylinder (12), a clamping block (14) is fixedly connected to one end of the spring (15), a pulling block (16) is fixedly connected to one side of the outer wall of the clamping block (14), and a first sliding groove (13) is formed inside the clamping cylinder (12).

2. The purification device for preparing biological polysaccharide according to claim 1, wherein the sliding component comprises a guide groove (8), the guide groove (8) is formed in the connecting ring (6), a guide rod (7) is fixedly connected in the filter cartridge (1), and the outer wall of the guide rod (7) is slidably connected with the inner wall of the guide groove (8).

3. The purification device for preparing biological polysaccharide according to claim 1, wherein the outer wall of the rotating rod (4) is fixedly connected with a connecting rod (23), the outer wall of the connecting rod (23) is slidably connected with a sleeve rod (24), one side of the outer wall of the sleeve rod (24) is fixedly connected with a scraper blade (22), and the upper surface of the connecting rod (23) is fixedly connected with a slide nail (26).

4. The purification device for preparing biological polysaccharide according to claim 3, wherein a second chute (25) is formed in the sleeve rod (24), and the outer wall of the slide nail (26) is slidably connected to the inner wall of the second chute (25).

5. The purification device for preparing biological polysaccharide according to claim 1, wherein a clamping groove (10) is formed in the clamping rod (9), and the clamping groove (10) is used for being clamped with a clamping block (14).

6. The purification device for preparing biological polysaccharide according to claim 1, wherein a flow guide pipe (20) is fixedly connected to the lower surface of the filter cartridge (1), and a water pump (21) is arranged on the outer wall of the flow guide pipe (20).

7. The purification device for preparing biological polysaccharide according to claim 1, wherein a purification cylinder (18) is fixedly connected inside the purification box (17), and a chromatographic column and a gel column are arranged inside the purification cylinder (18).

8. The purification device for preparing biological polysaccharide according to claim 1, wherein a dialysis box (19) is slidably connected inside the purification box (17), and the dialysis box (19) is used for further purifying polysaccharide.