CN222466954U

CN222466954U - Body fluid collection container assembly

Info

Publication number: CN222466954U
Application number: CN202420624581.5U
Authority: CN
Inventors: 林子奥; 邵明; 陈国梅
Original assignee: Aomingcheng Hangzhou Biotechnology Co ltd
Current assignee: Aomingcheng Hangzhou Biotechnology Co ltd
Priority date: 2024-03-28
Filing date: 2024-03-28
Publication date: 2025-02-14
Anticipated expiration: 2034-03-28

Abstract

The application relates to a body fluid collecting container assembly which comprises a body fluid collecting container structure, a body fluid collecting container cover structure, a body fluid storage container structure and a body fluid collecting container assembly, wherein the outer wall of the body fluid collecting container cover structure is in sealing fit with an opening of the body fluid collecting container structure, and the body fluid storage container structure can be matched with the inner wall of the body fluid collecting container cover structure. The technical scheme of the application effectively solves the problem that errors are easy to form in body fluid sampling and collecting in the prior art.

Description

Body fluid collection container assembly

Technical Field

The application relates to the technical field of body fluid collection containers, in particular to a body fluid collection container assembly.

Background

CfDNA (cell-free DNA) refers to degraded cell-free DNA molecules released by cells, free in body fluids (blood, urine, saliva, cerebrospinal fluid, etc.). The content of cfDNA in the blood of healthy people is extremely low, but the content of cfDNA in the body is gradually increased along with the development of diseases such as tumors, inflammations and the like. cfDNA includes circulating tumor DNA, mitochondrial DNA and fetal DNA, and has important applications in noninvasive/minimally invasive liquid biopsies, particularly in the field of early screening of cancer.

Traditional cfDNA studies use plasma samples, while urine cfDNA studies and applications are less. Although the urine collection has the advantages of convenient sampling, large urine sample volume and the like compared with blood, the urine collection is limited by the following points that the urine contains complex components and more impurities, especially the DNase has higher activity and is easier to degrade cfDNA of the urine, the urine contains shed cells, the released somatic cell DNA of the shed cells can influence the analysis of the cfDNA, and the urine contains microorganisms which possibly cause the deterioration of the urine sample. Therefore, there is a need to solve these problems, facilitating the popularization of clinical applications of urine cfDNA.

Body fluid detection can be adopted in the body detection, and the body fluid is put into a container for reaction, separation and other operations.

In some prior art, body fluids, reagents, and the like are placed in a container to perform a reaction. When the body fluid is collected, the body fluid is directly collected for use or is directly poured into the container after collection, and the collection mode leads to larger sample collection error.

Disclosure of utility model

The application provides a body fluid collecting container assembly, which solves the problem that errors are easy to form in body fluid sampling and collecting in the prior art.

The body fluid collecting container assembly comprises a body fluid collecting container structure, a body fluid collecting container cover structure, a body fluid storage container structure and a body fluid collecting container structure, wherein the outer wall of the body fluid collecting container cover structure is in sealing fit with an opening of the body fluid collecting container structure, and the body fluid storage container structure can be matched with the inner wall of the body fluid collecting container cover structure.

Further, the body fluid collection container lid structure includes body fluid collection container cooperation body, isolation part, straw and lid, and the outer wall of body fluid collection container cooperation body cooperatees with the container mouth of body fluid collection container structure, and isolation part sets up in the inside of body fluid collection container cooperation body, and the straw setting is in body fluid collection container cooperation body, and the both ends of straw are located the both sides of isolation part respectively, and the outer end at body fluid collection container cooperation body is established to the lid.

Further, the body fluid collection container matching body is a matching pipe, the edge of the isolation part is matched with the inner wall of the matching pipe in a sealing way, and the suction pipe is positioned in the matching pipe and passes through the isolation part in a sealing way.

Further, the cooperation pipe includes drum section and frustum section, and drum section's first end links to each other with the tip of frustum section, and the big head end of frustum section is located the outside of body fluid collection container structure, and the isolation part sets up the junction at drum section and frustum section.

Further, the body fluid collection container cover structure further comprises a filter disposed at the second end of the cylindrical section, the inner end of the straw being in communication with the filter.

Further, the filter comprises a shell and a filter element arranged in the shell, and the inner end of the suction pipe is matched with the shell and communicated with the inside of the shell.

Further, the body fluid collection container structure comprises a body fluid container and a body fluid collection cup, the body fluid container is provided with a container opening, the body fluid collection cup comprises a liquid inlet and a liquid outlet, the liquid outlet is connected with the body fluid container in a sealing way, and the liquid inlet is larger than the liquid outlet.

Further, the body fluid collection cup comprises a cup body, the cup body comprises a first arc-shaped section and a second arc-shaped section which are connected in sequence, the curvature radius of the first arc-shaped section is larger than that of the second arc-shaped section, a liquid inlet is formed in one side, far away from the second arc-shaped section, of the first arc-shaped section, and a liquid outlet is formed in one side, far away from the first arc-shaped section, of the second arc-shaped section.

Further, the body fluid collection cup further comprises a valve and a branch pipe, the branch pipe is arranged between the cup body and the liquid outlet, and the valve is arranged between the branch pipe and the liquid outlet.

Further, the body fluid storage container structure comprises a test tube and a cork, and the cork is arranged at the opening of the test tube in a sealing manner.

By applying the technical scheme of the application, after the body fluid collection container structure collects body fluid, the body fluid in the body fluid collection container structure is transferred into the body fluid storage container structure through the body fluid collection thermal container cover structure, and the collection, transfer and storage of the body fluid are accurate. The technical scheme of the application effectively solves the problem that errors are easy to form in body fluid sampling and collecting in the prior art.

Drawings

The accompanying drawings, which are incorporated in and constitute a part of this specification, illustrate embodiments consistent with the application and together with the description, serve to explain the principles of the application.

In order to more clearly illustrate the embodiments of the application or the technical solutions of the prior art, the drawings which are used in the description of the embodiments or the prior art will be briefly described, and it will be obvious to a person skilled in the art that other drawings can be obtained from these drawings without inventive effort.

FIG. 1 shows a schematic view of a body fluid collection container structure of a body fluid collection container assembly according to an embodiment of the present application;

FIG. 2 shows a schematic structural view of a body fluid collection container cap structure of the body fluid collection container assembly of FIG. 1;

FIG. 3 shows a schematic diagram of the body fluid storage container of the body fluid collection container assembly of FIG. 1;

Fig. 4 shows a schematic structural view of a filter of the liquid collection container assembly of fig. 1.

Wherein the above figures include the following reference numerals:

10. The body fluid collecting container structure comprises 11 parts of body fluid container, 12 parts of body fluid collecting cup, 121 parts of cup body, 122 parts of valve, 123 parts of branch pipe, 20 parts of body fluid collecting container cover structure, 21 parts of body fluid collecting container matched body, 22 parts of suction pipe, 23 parts of cover body, 24 parts of filter, 30 parts of body fluid storing container structure, 31 parts of test tube, 32 parts of soft plug.

Detailed Description

It should be noted that, without conflict, the embodiments of the present application and features of the embodiments may be combined with each other. The application will be described in detail below with reference to the drawings in connection with embodiments.

It should be noted that the following detailed description is illustrative and is intended to provide further explanation of the application. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this application belongs.

Spatially relative terms, such as "above," "upper" and "upper surface," "above" and the like, may be used herein for ease of description to describe one device or feature's spatial relationship to another device or feature as illustrated in the figures. It will be understood that the spatially relative terms are intended to encompass different orientations in use or operation in addition to the orientation depicted in the figures. For example, if the device in the figures is turned over, elements described as "above" or "over" other devices or structures would then be oriented "below" or "beneath" the other devices or structures. Thus, the process is carried out, the exemplary term "above" may be included. Upper and lower. Two orientations below. The device may also be oriented 90 degrees or at other orientations and the spatially relative descriptors used herein interpreted accordingly.

As shown in fig. 1 to 3, the body fluid collection container assembly of the present embodiment includes a body fluid collection container structure 10, a body fluid collection container cover structure 20, and a body fluid storage container structure 30. The outer wall of the body fluid collection container cover structure 20 sealingly engages the opening of the body fluid collection container structure 10. The body fluid storage container structure 30 may be mated with the inner wall of the body fluid collection container cap structure 20.

After the body fluid is collected by the body fluid collecting container structure 10, the body fluid in the body fluid collecting container structure 10 is transferred into the body fluid storage container structure 30 through the body fluid collecting container cover structure 20, and the collection, transfer and storage are accurate, so that the body fluid is not easy to pollute. The technical scheme of the embodiment effectively solves the problem that errors are easy to form in body fluid sampling and collecting in the prior art.

As shown in fig. 2, in the technical scheme of the present embodiment, the body fluid collecting container cover structure 20 includes a body fluid collecting container matching body 21, a partition, a straw 22 and a cover 23, the outer wall of the body fluid collecting container matching body 21 is matched with the container mouth of the body fluid collecting container structure 10, the partition is disposed in the body fluid collecting container matching body 21, the straw 22 is disposed in the body fluid collecting container matching body 21, two ends of the straw 22 are respectively located at two sides of the partition, and the cover 23 is covered on the outer end of the body fluid collecting container matching body 21. In use, the body fluid storage container structure 30 is inserted into the straw 22, and the straw 22 draws body fluid within the body fluid collection container structure 10to the body fluid storage container structure 30, thus avoiding contact of the body fluid with the outside, such as the outside air. The outer end refers to an end located outside the body fluid collecting container structure 10 after the body fluid collecting container assembly 21 is assembled with the body fluid collecting container structure 10, and the inner end refers to an end located inside the body fluid collecting container structure 10 after the body fluid collecting container assembly 21 is assembled with the body fluid collecting container structure 10.

As shown in fig. 2, in the technical solution of this embodiment, the body fluid collection container matching body 21 is a matching tube, the edge of the isolation portion is in sealing fit with the inner wall of the matching tube, and the straw 22 is located in the matching tube and passes through the isolation portion in a sealing manner. The structure is compact and convenient to use. When in use, the matching tube is in sealing connection with the body fluid container 11 through threads, the outer end of the suction tube 22 is inserted into the soft plug 32, and body fluid in the body fluid container 11 is sucked into the test tube 31 through negative pressure. The structure has higher operation efficiency.

As shown in fig. 2, in the technical solution of this embodiment, the mating tube includes a cylindrical section and a conical section, a first end of the cylindrical section is connected to a small end of the conical section, a large end of the conical section is located outside the body fluid collection container structure 10, and the isolation portion is disposed at a junction between the cylindrical section and the conical section. The arrangement of the frustum section enables the body fluid storage container structure 30 to be sealed easily when matched with the frustum section, and the universality is stronger. For example, a larger model of the soft plug 32 may be more shallow than the frustum section, a smaller model of the soft plug 32 may be more deep than the frustum section. If a better seal is desired, it can be mated deeper.

As shown in fig. 2 and 4, in the technical solution of the present embodiment, the body fluid collecting container cover structure 20 further includes a filter 24, the filter 24 is disposed at the second end of the cylindrical section, and the inner end of the straw 22 is in communication with the filter 24. The arrangement of the filter 24 allows better impurities and higher purity of the body fluid sucked into the test tube 31, which further improves the accuracy of the body fluid test.

As shown in fig. 4, in the technical solution of the present embodiment, the filter 24 includes a housing and a filter element disposed in the housing, and the inner end of the suction pipe 22 is matched with the housing and communicates with the interior of the housing. The structure is convenient to set, and the filter element is not easy to damage or fail under the protection of the shell. The housing may be made of plastic or the like which does not cause test errors.

As shown in fig. 1, in the technical solution of this embodiment, a body fluid collecting container structure 10 includes a body fluid container 11 and a body fluid collecting cup 12, the body fluid container 11 has a container opening, the body fluid collecting cup 12 includes a liquid inlet and a liquid outlet, the liquid outlet is hermetically connected with the body fluid container 11, and the liquid inlet is larger than the liquid outlet. The body fluid collection cup 12 is configured to more easily collect body fluid. The body fluid may be blood, urine, saliva, cerebrospinal fluid, etc. cfDNA (cell-free DNA) refers to degraded cell-free DNA molecules released by cells, free in body fluids (blood, urine, saliva, cerebrospinal fluid, etc.). The content of cfDNA in the blood of healthy people is extremely low, but the content of cfDNA in the body is gradually increased along with the development of diseases such as tumors, inflammations and the like. cfDNA includes circulating tumor DNA, mitochondrial DNA and fetal DNA, and has important applications in noninvasive/minimally invasive liquid biopsies, particularly in the field of early screening of cancer. Traditional cfDNA studies use plasma samples, while urine cfDNA studies and applications are less. Although the urine collection has the advantages of convenient sampling, large urine sample volume and the like compared with blood, the urine collection is limited by the following points that the urine contains complex components and more impurities, especially the DNase has higher activity and is easier to degrade cfDNA of the urine, the urine contains shed cells, the released somatic cell DNA of the shed cells can influence the analysis of the cfDNA, and the urine contains microorganisms which possibly cause the deterioration of the urine sample. In this embodiment, taking urine as an example, urine is collected into the body fluid container 11 through the body fluid collecting cup 12, so that the collection is easier, more convenient and more sanitary than the collection directly through the body fluid container 11.

As shown in fig. 1, in the technical solution of this embodiment, the body fluid collecting cup 12 includes a cup body 121, the cup body 121 includes a first arc section and a second arc section that are sequentially connected, a curvature radius of the first arc section is larger than a curvature radius of the second arc section, a fluid inlet is formed on one side of the first arc section far away from the second arc section, and a fluid outlet is formed on one side of the second arc section far away from the first arc section. The structure avoids the splashing of urine, so that the urine collection is more convenient.

As shown in fig. 1, in the technical solution of this embodiment, the body fluid collection cup 12 further includes a valve 122 and a branch pipe 123, the branch pipe 123 is disposed between the cup body 121 and the liquid outlet, and the valve 122 is disposed between the branch pipe 123 and the liquid outlet. During collection, the valve 122 is closed, so that the beginning urine flows out of the branch pipe 123, and when middle-section urine is taken, the valve 122 is opened, because the urine flows into the body fluid container 11 more easily than flows out of the branch pipe 123, the urine cannot enter the branch pipe and can enter the body fluid container 11. The valve 122 is located close to the inlet of the branch pipe 123, so that the low-quality portion of the urine can be discharged as much as possible. The lower portion of the cup 121 has a main pipe section, and the valve 122 is easily disposed on the main pipe section, which will not be described herein.

As shown in fig. 3, in the technical solution of the present embodiment, the body fluid storage container structure 30 includes a test tube 31 and a cork 32, and the cork 32 is sealingly disposed at an opening of the test tube 31. The stopper 32 has a certain deformability, and the needle portion of the straw 22 pierces the stopper 32, so that the stopper 32 can be restored to a sealed state after the body fluid is collected. The outer end of the suction tube 22 has a needling portion, which is a needling tip formed by the inclined surface of the suction tube 22. The cork is rubber stopper, silica gel stopper, wood stopper etc. can all be enough, and body fluid storage container structure 30 still includes the medicament, and the medicament is placed in the test tube, and the test tube is inside to be negative pressure state.

The body fluid storage container structure 30 and the body fluid collection container cover structure 20 are hermetically packaged by a sealing film or the like before use. Taking urine collection as an example, the fore-stage urine is directly discharged through the urination tube, and then the middle-stage urine enters the urine cup (body fluid container 11) by toggling the valve 122. After mid-section urine is collected, the switch is turned off, the residual urine is continuously discharged through the urination pipe (the branch pipe 123), and the whole urination process is not required to be interrupted. Subsequently, the urine receiving device (body fluid collecting container structure 10) is unscrewed, the urine cup cover (body fluid collecting container cover structure 20) is covered with the urine cup (body fluid container 11), and the urine cup is gently shaken to mix urine. Tearing the protective film on the urine cup cover, inverting the urine collecting tube and inserting the urine collecting tube into the groove of the urine cup cover to ensure that the needle pierces the urine collecting tube plug cover (soft plug 32), allowing middle-section urine to enter the collecting tube (test tube 31), slightly inverting and uniformly mixing the urine and the protective agent, and standing at normal temperature.

It is noted that the terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting of exemplary embodiments according to the present application. As used herein, the singular is also intended to include the plural unless the context clearly indicates otherwise, and furthermore, it is to be understood that the terms "comprises" and/or "comprising" when used in this specification are taken to specify the presence of stated features, steps, operations, devices, components, and/or combinations thereof.

It should be noted that the terms "first," "second," and the like in the description and the claims of the present application and the above figures are used for distinguishing between similar objects and not necessarily for describing a particular sequential or chronological order. It is to be understood that the data so used may be interchanged where appropriate such that embodiments of the application described herein may be capable of being practiced otherwise than as specifically illustrated and described. Furthermore, the terms "comprises," "comprising," and "having," and any variations thereof, are intended to cover a non-exclusive inclusion, such that a process, method, system, article, or apparatus that comprises a list of steps or elements is not necessarily limited to those steps or elements expressly listed but may include other steps or elements not expressly listed or inherent to such process, method, article, or apparatus.

The above is only a preferred embodiment of the present application, and is not intended to limit the present application, but various modifications and variations can be made to the present application by those skilled in the art. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present application should be included in the protection scope of the present application.

Claims

1. A body fluid collection container assembly comprising:

a body fluid collection container structure (10);

A body fluid collection container cover structure (20), wherein the outer wall of the body fluid collection container cover structure (20) is in sealing fit with an opening of the body fluid collection container structure (10);

A body fluid storage container structure (30), the body fluid storage container structure (30) being cooperable with an inner wall of the body fluid collection container cover structure (20).

2. The body fluid collecting container assembly according to claim 1, wherein the body fluid collecting container cover structure (20) comprises a body fluid collecting container matching body (21), a separation part, a suction pipe (22) and a cover body (23), the outer wall of the body fluid collecting container matching body (21) is matched with a container opening of the body fluid collecting container structure (10), the separation part is arranged in the body fluid collecting container matching body (21), the suction pipe (22) is arranged in the body fluid collecting container matching body (21), two ends of the suction pipe (22) are respectively positioned at two sides of the separation part, and the cover body (23) is covered on the outer end of the body fluid collecting container matching body (21).

3. Body fluid collection container assembly according to claim 2, wherein the body fluid collection container fitting (21) is a fitting tube, the edge of the partition being in sealing engagement with the inner wall of the fitting tube, the suction tube (22) being located within the fitting tube and being sealed through the partition.

4. A body fluid collection container assembly according to claim 3, wherein the mating tube comprises a cylindrical section and a frustum section, a first end of the cylindrical section being connected to a small end of the frustum section, a large end of the frustum section being located outside the body fluid collection container structure (10), the partition being provided at a junction of the cylindrical section and the frustum section.

5. The body fluid collection container assembly of claim 4, wherein the body fluid collection container cap structure (20) further comprises a filter (24), the filter (24) being disposed at the second end of the cylindrical section, the inner end of the straw (22) being in communication with the filter (24).

6. The body fluid collection container assembly of claim 5, wherein the filter (24) comprises a housing and a cartridge disposed within the housing, the inner end of the straw (22) being mated to the housing and in communication with the housing.

7. Body fluid collection container assembly according to claim 1, wherein the body fluid collection container structure (10) comprises a body fluid container (11) and a body fluid collection cup (12), the body fluid container (11) having a container mouth, the body fluid collection cup (12) comprising a liquid inlet and a liquid outlet, the liquid outlet being sealingly connected to the body fluid container (11), the liquid inlet being larger than the liquid outlet.

8. The body fluid collection container assembly of claim 7, wherein the body fluid collection cup (12) comprises a cup body (121), the cup body (121) comprises a first arcuate segment and a second arcuate segment connected in sequence, the radius of curvature of the first arcuate segment is greater than the radius of curvature of the second arcuate segment, the fluid inlet is formed on a side of the first arcuate segment remote from the second arcuate segment, and the fluid outlet is formed on a side of the second arcuate segment remote from the first arcuate segment.

9. The body fluid collection container assembly of claim 8, wherein the body fluid collection cup (12) further comprises a valve (122) and a branch tube (123), the branch tube (123) being disposed between the cup (121) and the outlet, the valve (122) being disposed between the branch tube (123) and the outlet.

10. Body fluid collection container assembly according to any of claims 1 to 9, wherein the body fluid storage container structure (30) comprises a test tube (31) and a cork (32), the cork (32) being sealingly arranged at an opening of the test tube (31).