CN221982223U - A biopharmaceutical powder mixing device - Google Patents

A biopharmaceutical powder mixing device Download PDF

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Publication number
CN221982223U
CN221982223U CN202323469009.0U CN202323469009U CN221982223U CN 221982223 U CN221982223 U CN 221982223U CN 202323469009 U CN202323469009 U CN 202323469009U CN 221982223 U CN221982223 U CN 221982223U
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China
Prior art keywords
powder
tank body
mixing tank
stirring
mounting hole
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CN202323469009.0U
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Chinese (zh)
Inventor
夏若金
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Shanghai Aopumai Bioengineering Co ltd
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Shanghai Aopumai Bioengineering Co ltd
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Abstract

本实用新型涉及生物制药技术领域,且公开了一种生物制药粉料混合装置,包括混合罐体,所述混合罐体内部分为两层,所述混合罐体内部的上方设有压碎仓,所述压碎仓的下方设有搅拌仓,所述压碎仓与搅拌仓之间通过中阻隔板分开,所述阻隔板的中间开设有圆孔,所述混合罐体的上方开设有用于加入药粉的加料口,所述混合罐体的下方开设有用于倒出药粉的出料口,所述混合罐体的内部转动安装有用于将药粉进行混合搅拌的搅拌组件,所述混合罐体的上方安装有用于给设备传递动力的传动组件,所述混合罐体的下方固定连接有支撑组件,该设备的结构简单、构造合理,能够满足对药粉的搅拌均匀,且能压碎成块的药粉。

The utility model relates to the technical field of biopharmaceuticals, and discloses a biopharmaceutical powder mixing device, comprising a mixing tank body, wherein the mixing tank body is internally divided into two layers, a crushing bin is provided above the inner part of the mixing tank body, a stirring bin is provided below the crushing bin, the crushing bin and the stirring bin are separated by a middle barrier plate, a circular hole is provided in the middle of the barrier plate, a feeding port for adding medicine powder is provided above the mixing tank body, a discharge port for pouring out medicine powder is provided below the mixing tank body, a stirring assembly for mixing and stirring medicine powder is rotatably installed inside the mixing tank body, a transmission assembly for transmitting power to the device is installed above the mixing tank body, a supporting assembly is fixedly connected to the lower part of the mixing tank body, the device has a simple structure and a reasonable construction, can meet the requirements of uniform stirring of medicine powder, and can crush medicine powder into blocks.

Description

Biopharmaceutical powder mixing device
Technical Field
The utility model relates to the technical field of bio-pharmaceuticals, in particular to a bio-pharmaceutical powder mixing device.
Background
The biopharmaceutical powder mixing device is equipment for mixing powder raw materials in a biopharmaceutical process. Biopharmaceuticals are processes for preparing drugs by the synthesis or recombinant expression of biological macromolecules such as proteins and nucleic acids using biotechnology means. In the biopharmaceutical process, powder blending is an important step for blending drug substance powders, preparing pharmaceutical formulations or blending other pharmaceutical ingredients.
The background of biopharmaceutical powder mixing devices can be traced to the development of the biopharmaceutical industry. With the continued advancement of biotechnology and the rapid growth of the biopharmaceutical market, there is an increasing demand for biopharmaceutical powder mixing devices.
However, if the powder to be mixed is agglomerated during processing, the agglomeration is difficult to crush, and the stirring rod is single, so that the uniformity of mixing is affected, and the final quality of the medicine is affected; therefore, the existing requirements are not met, and a biopharmaceutical powder mixing device is provided for this purpose.
Disclosure of utility model
The utility model provides a biopharmaceutical powder mixing device, which has the beneficial effects of solving the problems mentioned in the background art.
The utility model provides the following technical scheme: the utility model provides a bio-pharmaceuticals powder mixing arrangement, includes the mixing tank body, the internal portion of mixing tank is two-layer, the inside top of mixing tank is equipped with crushing storehouse, the below of crushing storehouse is equipped with the stirring storehouse, separate through well baffle between crushing storehouse and the stirring storehouse, the round hole has been seted up in the centre of baffle, the charge door that is used for adding the powder has been seted up to the top of the mixing tank body, the discharge gate that is used for pouring the powder has been seted up to the below of the mixing tank body, the inside rotation of the mixing tank body is installed and is used for carrying out the stirring subassembly of mixing with the powder, the transmission subassembly that is used for equipment transmission power is installed to the top of the mixing tank body, the below fixedly connected with supporting component of the mixing tank body.
As an alternative to the biopharmaceutical powder mixing apparatus of the present utility model, wherein: the stirring assembly comprises a rotating pipe rotationally connected with the mixing tank body, a transmission rod is rotationally connected in the rotating pipe, a first belt pulley is fixedly connected with the upper side of the rotating pipe, a rotating shaft is fixedly connected with the lower side of the rotating pipe, the rotating shaft is rotationally connected with the lower side of the mixing tank body, an upper mounting hole, a middle mounting hole and a lower mounting hole are sequentially formed in the two sides of the rotating pipe from top to bottom, a spiral pressing pipe used for crushing and pushing medicine powder in the middle is rotationally connected in the upper mounting hole, the spiral pressing pipe is located in the crushing bin, a first bevel gear is fixedly arranged at one end of the spiral pressing pipe, and a soft cushion used for preventing the medicine powder from entering the pipe is arranged at the rotating joint of the upper mounting hole.
As an alternative to the biopharmaceutical powder mixing apparatus of the present utility model, wherein: the utility model discloses a powder stirring device, including well mounting hole, fixed mounting, short puddler, wherein all rotate in the well mounting hole and be connected with the short puddler that is used for carrying out mixing stirring with the powder, fixed mounting has the puddler that is used for supplementary stirring on the short puddler, the one end fixed mounting of short puddler has the second bevel gear, the short puddler with well mounting hole rotates the junction and is equipped with the cushion that is used for preventing the powder entering intraductal.
As an alternative to the biopharmaceutical powder mixing apparatus of the present utility model, wherein: a long stirring rod for mixing and stirring the medicinal powder is rotationally connected in the lower mounting hole, an auxiliary rod for further stirring is fixedly arranged on the long stirring rod, one end of the long stirring rod is fixedly provided with a third bevel gear, and a soft cushion for preventing the medicinal powder from entering the pipe is arranged at the rotating connection part of the long stirring rod and the lower mounting hole.
As an alternative to the biopharmaceutical powder mixing apparatus of the present utility model, wherein: the two ends of the transmission rod are rotationally connected with the rotating tube through bearings, a second belt pulley is fixedly connected to the top end of the transmission rod, a first conical tooth is fixedly arranged above the transmission rod and meshed with the first bevel gear, a second conical tooth is fixedly arranged in the middle of the transmission rod and meshed with the second conical gear, a third conical tooth is fixedly arranged below the transmission rod and meshed with the third conical gear.
As an alternative to the biopharmaceutical powder mixing apparatus of the present utility model, wherein: the transmission assembly comprises a first transmission belt connected with the first belt pulley, the first transmission belt is connected with a transmission column, the second belt pulley is connected with a second transmission belt, the second transmission belt is also connected with the transmission column, and the transmission column is rotationally connected with the upper part of the mixing tank body.
As an alternative to the biopharmaceutical powder mixing apparatus of the present utility model, wherein: the lower part of the transmission column is connected with a main transmission belt, the main transmission belt is rotationally connected with a power motor, a motor seat for fixing the power motor is arranged below the power motor, and the motor seat is fixedly connected with the mixing tank body.
As an alternative to the biopharmaceutical powder mixing apparatus of the present utility model, wherein: the supporting component comprises supporting legs fixed below the mixing tank body, and leg pads used for increasing contact area with the ground are fixedly connected below the supporting legs.
The utility model has the following beneficial effects:
1. The biopharmaceutical powder mixing device is provided with a screw-type pressing pipe, after powder is poured from a charging hole, the powder which is formed into blocks can be crushed through rotation of the screw-type pressing pipe, and then the powder is pushed into a round hole through rotation of the screw-type pressing pipe, so that stirring is performed.
2. This bio-pharmaceuticals powder mixing arrangement is equipped with long puddler and short puddler, and long puddler and short puddler can both realize the rotation through the transmission of transfer line, and stirring rod and auxiliary rod on rethread long puddler and the short puddler carry out abundant stirring with the powder.
Drawings
Fig. 1 is a schematic diagram of the overall structure of the present utility model.
Fig. 2 is a schematic view of another view overall structure of the present utility model.
Fig. 3 is a schematic cross-sectional view of the present utility model.
Fig. 4 is a schematic overall sectional structure of the present utility model.
Fig. 5 is an enlarged schematic view of the structure of fig. 4 a according to the present utility model.
In the figure: 1. a mixing tank; 11. crushing bin; 12. a stirring bin; 13. a baffle plate; 14. a round hole; 15. a feed inlet; 16. a discharge port; 2. a stirring assembly; 21. a rotary tube; 22. a rotating shaft; 23. an upper mounting hole; 24. a middle mounting hole; 25. a lower mounting hole; 26. screwing the pipe; 27. a first bevel gear; 28. a soft cushion; 29. a short stirring rod; 210. a stirring rod; 211. a second bevel gear; 212. a long stirring rod; 213. an auxiliary rod; 214. a third bevel gear; 215. a first pulley; 3. a transmission assembly; 31. a first belt; 32. a drive column; 33. a second belt; 34. a main belt; 35. a power motor; 36. a motor base; 4. a transmission rod; 41. a bearing; 42. a second pulley; 43. a first conical tooth; 44. a second conical tooth; 45. a third conical tooth; 5. a support assembly; 51. support legs; 52. leg pads.
Detailed Description
The following description of the embodiments of the present utility model will be made clearly and completely with reference to the accompanying drawings, in which it is apparent that the embodiments described are only some embodiments of the present utility model, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the utility model without making any inventive effort, are intended to be within the scope of the utility model.
Example 1
This embodiment is intended to promote solving the problem that current bio-pharmaceuticals powder mixing arrangement is difficult to crush the powder that will agglomerate to and the stirring is inhomogeneous enough, please refer to fig. 1-5, a bio-pharmaceuticals powder mixing arrangement, including mixing tank 1, mixing tank 1 internal portion is two-layer, mixing tank 1 inside top is equipped with crushing storehouse 11, the powder that will agglomerate is crushed in crushing storehouse 11, crushing storehouse 11 below is equipped with stirring storehouse 12, separate through middle baffle 13 between crushing storehouse 11 and the stirring storehouse 12, can separate the powder and carry out the layering through the layering and handle, can realize smashing and the substep operation of mixing to the powder like this, improve effect and quality of mixing, round hole 14 has been seted up in the centre of baffle 13, the powder after the crushing is guided into round hole 14 through the cooperation of each subassembly, fall into in the stirring storehouse 12 from the round hole 14, the charge door 15 that is used for adding is seted up to mixing tank 1's top, the discharge gate 16 that is used for pouring out the powder has been seted up to mixing tank 1's below, mixing tank 1's internal rotation is installed and is used for carrying out the powder 2 to mix tank 1, the transmission subassembly is used for the fixed transmission device is connected with mixing tank 1 below the stirring 1, the stirring assembly is installed to the stirring assembly is used for the mixed device is equipped with 5.
In this embodiment: the stirring subassembly 2 includes the rotation pipe 21 of rotating with mixing tank 1 and being connected, the rotation is connected with transfer line 4 in rotation pipe 21, the top fixedly connected with first belt pulley 215 of rotation pipe 21, the below fixedly connected with axis of rotation 22 of rotation pipe 21, the axis of rotation 22 rotates with the below of mixing tank 1 and is connected, upward mounting hole 23 has been seted up in proper order from last to lower in the rotation pipe 21 both sides, well mounting hole 24, lower mounting hole 25, upward all rotate in the mounting hole 23 and be connected with the spiral swage pipe 26 that is used for crushing powder and push in the middle of in the past, spiral swage pipe 26 is located crushing storehouse 11, the spiral swage pipe 26 in the last mounting hole 23 can crush the powder, push the powder after the crushing in round hole 14 simultaneously, be favorable to the improvement of mixing effect, the one end fixedly mounted of spiral swage pipe 26 has first bevel gear 27, spiral swage pipe 26 rotates the junction with last mounting hole 23 and is equipped with the cushion 28 that is used for preventing the powder from getting into intraductally, can effectually prevent through the design of cushion 28 that the powder from getting into the inside of rotation pipe 21.
In this embodiment: the short stirring rod 29 used for mixing and stirring the powder is rotationally connected in the middle mounting hole 24, the stirring rod 210 used for assisting in stirring is fixedly mounted on the short stirring rod 29, the second bevel gear 211 is fixedly mounted at one end of the short stirring rod 29, the soft cushion 28 used for preventing the powder from entering the pipe is arranged at the rotational connection position of the short stirring rod 29 and the middle mounting hole 24, the stirring rod 210 is fixedly mounted on the short stirring rod 29, the stirring rod 210 can assist in stirring, so that the mixing is more uniform, the short stirring rod 210 can rotate, and the stirring rod 210 can be driven to rotate when rotating, thereby effectively improving the stirring effect.
In this embodiment: the long stirring rod 212 for mixing and stirring the powder is rotationally connected in the lower mounting hole 25, the auxiliary rod 213 for further stirring is fixedly mounted on the long stirring rod 212, a third bevel gear 214 is fixedly mounted at one end of the long stirring rod 212, a soft cushion 28 for preventing the powder from entering the tube is arranged at the rotary joint of the long stirring rod 212 and the lower mounting hole 25, the auxiliary rod 213 is fixedly mounted on the long stirring rod 212, and meanwhile the long stirring rod 212 can rotate through transmission, so that the powder can be further stirred through driving the auxiliary rod 213, and the mixing is more uniform.
In this embodiment: both ends of transfer line 4 all rotate with rotation pipe 21 through bearing 41 and are connected, the top fixedly connected with second belt pulley 42 of transfer line 4, the top fixed mounting of transfer line 4 has first conical tooth 43, first conical tooth 43 and first bevel gear 27 meshing, the middle fixed mounting of transfer line 4 has second conical tooth 44, second conical tooth 44 and second bevel gear 211 meshing, the below fixed mounting of transfer line 4 has third conical tooth 45, third conical tooth 45 and third bevel gear 214 meshing, transfer line 4 passes through bearing 41 and rotates with rotation pipe 21 to be connected, can guarantee the stability of transmission, deviation or resistance appear in the transmission process, second belt pulley 42 rotates and drives transfer line 4 and rotate, thereby drive first conical tooth 43 when transfer line 4 rotates, second conical tooth 44 and third conical tooth 45 rotate together, thereby first conical tooth 43 and first bevel gear 27 meshing drive first bevel gear 27 rotate, first bevel gear 27 rotates and drives spiral shell spinning pipe 26 simultaneously, second conical tooth 44 and third bevel gear 211 drive third conical gear 214 and rotate, thereby drive third conical gear 214 rotates, and second conical tooth 44 and third bevel gear 211 rotates, thereby drive third bevel gear 214 rotates and rotates, and second conical gear 211 rotates and third bevel gear 214 simultaneously, thereby stirring rod 45 rotates and third bevel gear 214.
In this embodiment: the transmission assembly 3 comprises a first transmission belt 31 connected with a first belt pulley 215, the first transmission belt 31 is connected with a transmission column 32, the second belt pulley 42 is connected with a second transmission belt 33, the second transmission belt 33 is also connected with the transmission column 32, and the transmission column 32 is rotatably connected with the upper part of the mixing tank body 1.
In this embodiment: the below of drive post 32 is connected with main drive belt 34, main drive belt 34 rotates and is connected with motor 35, motor cabinet 36 that is used for fixed motor 35 is installed to the below of motor 35, motor cabinet 36 and hybrid tank 1 fixed connection, drive main drive belt 34 through motor 35 and rotate, main drive belt 34 drives drive post 32 and rotates, simultaneously first belt 31 drives first belt pulley 215 and rotates, first belt pulley 215 rotates and drives rotation pipe 21 and rotate, rotation pipe 21 rotates and drives spiral pressing pipe 26 together with short puddler 29 and long puddler 212, drive post 32 rotates and drives second drive belt 33 and rotate, this second drive belt 33 rotates second belt pulley 42, the drive transfer line 4 rotates when second belt pulley 42 rotates.
In this embodiment: the support assembly 5 comprises support legs 51 fixed below the mixing tank 1, and leg pads 52 for increasing the contact area with the ground are fixedly connected below the support legs 51.
Working principle: firstly, the powder to be mixed is poured into the mixing tank body 1 through the charging hole 15, the powder firstly enters one side of the crushing bin 11, the power motor 35 is turned on, the power motor 35 drives the main driving belt 34 to rotate, the main driving belt 34 drives the driving column 32 to rotate, the driving column 32 rotates and drives the first driving belt 31 to rotate, the first driving belt 31 rotates and drives the first belt pulley 215 to rotate, the first belt pulley 215 rotates and drives the rotating pipe 21 to rotate, the rotating pipe 21 rotates and drives the screw 26, the short stirring rod 29 and the long stirring rod 212 to rotate together, the driving column 32 rotates and drives the second driving belt 33 to rotate, the second driving belt 33 rotates and drives the driving rod 4 to rotate, the driving rod 4 rotates and drives the first conical tooth 43, the second conical tooth 44 and the third conical tooth 45 to rotate together, the first conical tooth 43 is meshed with the first conical gear 27 to drive the first conical gear 27, the first conical gear 27 rotates and drives the screw 26 to rotate, the second conical tooth 44 is meshed with the third conical gear 211 to rotate and drives the second conical gear 214 to rotate, and the second conical gear 211 rotates and drives the second conical gear 214 to rotate simultaneously, and the second conical gear 211 rotates and the third conical gear 214 rotates and the second conical gear 211 rotates simultaneously. Thereby realizing that after crushing the powder, the powder is pushed into the round hole 14 by the rotation of the spiral pressing pipe 26, so that the powder enters the stirring bin 12, and then the powder is fully stirred by the short stirring rod 29 and the long stirring rod 212 which rotate, and the powder is poured out through the discharge hole 16 after the stirring is finished.
It is noted that relational terms such as first and second, and the like are used solely to distinguish one entity or action from another entity or action without necessarily requiring or implying any actual such relationship or order between such entities or actions. Moreover, the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or apparatus.
The foregoing is merely a preferred embodiment of the present utility model, and it should be noted that it will be apparent to those skilled in the art that several modifications and variations can be made without departing from the technical principle of the present utility model, and these modifications and variations should also be regarded as the scope of the utility model.

Claims (8)

1. The utility model provides a bio-pharmaceuticals powder mixing arrangement, includes the mixing tank body (1), its characterized in that: the utility model discloses a powder mixing tank, including mixing tank body (1), crushing storehouse (11) are equipped with to the inside top of mixing tank body (1), the below of crushing storehouse (11) is equipped with stirring storehouse (12), separate through baffle (13) between crushing storehouse (11) and stirring storehouse (12), round hole (14) have been seted up in the centre of baffle (13), charge door (15) that are used for adding the powder have been seted up to the top of mixing tank body (1), discharge gate (16) that are used for pouring the powder have been seted up to the below of mixing tank body (1), stirring subassembly (2) that are used for carrying out mixing stirring with the powder are installed in the inside rotation of mixing tank body (1), drive assembly (3) for equipment transmission power are installed to the top of mixing tank body (1), the below fixedly connected with supporting component (5) of mixing tank body (1).
2. The biopharmaceutical powder mixing device according to claim 1, wherein: the stirring assembly (2) comprises a rotating pipe (21) which is rotationally connected with the mixing tank body (1), a transmission rod (4) is rotationally connected to the rotating pipe (21), a first belt pulley (215) is fixedly connected to the upper part of the rotating pipe (21), a rotating shaft (22) is fixedly connected to the lower part of the rotating pipe (21), the rotating shaft (22) is rotationally connected with the lower part of the mixing tank body (1), an upper mounting hole (23), a middle mounting hole (24) and a lower mounting hole (25) are sequentially formed in two sides of the rotating pipe (21), a spiral pressing pipe (26) which is used for crushing and pushing medicine powder in the middle is rotationally connected to the upper mounting hole (23), the spiral pressing pipe (26) is located in the crushing bin (11), a first bevel gear (27) is fixedly arranged at one end of the spiral pressing pipe (26), and a soft cushion (28) which is used for preventing medicine powder from entering the pipe is arranged at the rotating connection position of the upper mounting hole (23).
3. A biopharmaceutical powder mixing device according to claim 2, wherein: the utility model discloses a powder stirring device, including well mounting hole (24), well mounting hole (24) are gone up, all rotate in being connected with in the well mounting hole (24) and be used for carrying out mixed stirring's short puddler (29), fixed mounting has stirring rod (210) that are used for supplementary stirring on short puddler (29), one end fixed mounting of short puddler (29) has second bevel gear (211), short puddler (29) with well mounting hole (24) rotate junction and are equipped with and are used for preventing powder entering intraductal cushion (28).
4. A biopharmaceutical powder mixing device according to claim 3, wherein: all rotate in lower mounting hole (25) and be connected with long puddler (212) that are used for carrying out mixed stirring with the powder, fixed mounting has auxiliary rod (213) that are used for further stirring on long puddler (212), the one end fixed mounting of long puddler (212) has third bevel gear (214), long puddler (212) with lower mounting hole (25) rotates junction and is equipped with cushion (28) that are used for preventing the powder entering intraductal.
5. The biopharmaceutical powder mixing device of claim 4, wherein: both ends of transfer line (4) all rotate through bearing (41) and pivoted tube (21) and are connected, top fixedly connected with second belt pulley (42) of transfer line (4), the top fixed mounting of transfer line (4) has first toper tooth (43), first toper tooth (43) with first bevel gear (27) meshing, the middle fixed mounting of transfer line (4) has second toper tooth (44), second toper tooth (44) with second toper tooth (211) meshing, the below fixed mounting of transfer line (4) has third toper tooth (45), third toper tooth (45) with third toper tooth (214) meshing.
6. The biopharmaceutical powder mixing device of claim 5, wherein: the transmission assembly (3) comprises a first transmission belt (31) connected with the first belt pulley (215), the first transmission belt (31) is connected with a transmission column (32), the second belt pulley (42) is connected with a second transmission belt (33), the second transmission belt (33) is also connected with the transmission column (32), and the transmission column (32) is rotationally connected with the upper part of the mixing tank body (1).
7. The biopharmaceutical powder mixing device of claim 6, wherein: the utility model discloses a hybrid tank, including main drive belt (34), drive post (32), motor cabinet (36) that are used for fixed power motor (35) are installed to the below of drive post (32), main drive belt (34) rotate and are connected with power motor (35), motor cabinet (36) and hybrid tank (1) fixed connection.
8. The biopharmaceutical powder mixing device according to claim 1, wherein: the support assembly (5) comprises support legs (51) fixed below the mixing tank body (1), and leg pads (52) used for increasing contact area with the ground are fixedly connected below the support legs (51).
CN202323469009.0U 2023-12-18 2023-12-18 A biopharmaceutical powder mixing device Active CN221982223U (en)

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Application Number Priority Date Filing Date Title
CN202323469009.0U CN221982223U (en) 2023-12-18 2023-12-18 A biopharmaceutical powder mixing device

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN202323469009.0U CN221982223U (en) 2023-12-18 2023-12-18 A biopharmaceutical powder mixing device

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CN221982223U true CN221982223U (en) 2024-11-12

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN119837011A (en) * 2025-01-10 2025-04-18 内蒙古自治区烟草公司赤峰市公司 Mushroom dreg seedling raising matrix manufacturing equipment and application method thereof

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN119837011A (en) * 2025-01-10 2025-04-18 内蒙古自治区烟草公司赤峰市公司 Mushroom dreg seedling raising matrix manufacturing equipment and application method thereof

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