CN221904828U - Wet granulation equipment for improving medicine mixing uniformity - Google Patents

Abstract

The utility model relates to the field of wet granulation, and discloses a wet granulation device for improving the uniformity of drug mixing, comprising a preparation tube, wherein the bottom of the preparation tube is a truncated cone structure, a feed port is fixed on the top of the preparation tube, a delivery pipe is fixed at an angle on the top of the preparation tube, and the delivery pipe is connected to the feed port, a box is fixed on the side wall of the preparation tube, a water inlet is fixed on the top of the box, a delivery mechanism for delivering drugs is arranged inside the box, a rotating shaft is rotatably connected to the top of the preparation tube, and one end of the rotating shaft passes through the top of the preparation tube, and a dispersion net is sleeved on the side wall of the rotating shaft. The utility model drives the dispersion net to rotate through a rotating mechanism in conjunction with the rotating shaft, and when the drug passes through the surface of the dispersion net, it will be more evenly dispersed into the inside of the preparation tube, so that the drug powder and the drug solution are in contact more fully and thoroughly, and at the same time, through the rotation of the auger, the sleeve can output the wet drug accumulated at the bottom of the preparation tube from the top of the sleeve, and the stirring mechanism is cooperated to make the drug mixed more evenly.

Description

A wet granulation device for improving drug mixing uniformity

Technical Field

The utility model relates to the technical field of wet granulation, in particular to a wet granulation device for improving the mixing uniformity of medicines.

Background Art

Wet granulation is a commonly used granulation method, which is suitable for the process of mixing drug ingredients with wetting agents and forming granules. This method is to mix the drug ingredients with an appropriate amount of solvent or wetting agent to form a bondable paste, then extrude or spray the paste into granules through mechanical force or pressure, and finally remove the solvent or wetting agent through a drying process to obtain the desired drug particles.

In the prior art wet granulation equipment, during drug mixing, the drug powder is poured centrally, and the drug liquid is only sprayed above the inside of the equipment, so the contact between the drug powder and the drug liquid is insufficient. In addition, during the granulation production process, the mixed wet drug is easily accumulated at the bottom of the granulation chamber, causing material agglomeration, making the drug mixing uneven, reducing the quality of the granulation product, and the drug is easily attached to the inner wall of the equipment during the mixing process, which not only causes drug waste, but also is difficult to clean, reducing the practicality of the device.

Utility Model Content

The utility model aims to solve the shortcomings in the prior art and proposes a wet granulation device for improving the uniformity of drug mixing.

In order to achieve the above purpose, the utility model adopts the following technical solutions:

A wet granulation device for improving the uniformity of drug mixing comprises a preparation barrel, the bottom of the preparation barrel is a truncated cone structure, a feed port is fixed on the top of the preparation barrel, a delivery pipe is fixed obliquely on the top of the preparation barrel, and the delivery pipe is connected to the feed port, a box is fixed on the side wall of the preparation barrel, a water inlet is fixed on the top of the box, a delivery mechanism for delivering drugs is arranged inside the box, a rotating shaft is rotatably connected to the top of the preparation barrel, and one end of the rotating shaft passes through the top of the preparation barrel, a dispersion net is sleeved on the side wall of the rotating shaft, and the dispersion net is located below the delivery pipe, a rotating mechanism for rotating the rotating shaft is arranged on the top of the preparation barrel, a stirring mechanism for stirring drugs is arranged on the side wall of the rotating shaft, and the preparation barrel is provided with a rotating mechanism for rotating the rotating shaft. A cleaning mechanism for cleaning the inner wall of the preparation cylinder is provided inside the preparation cylinder, and a plurality of brackets are fixed in a circular shape at equal distances at the bottom of the inner wall of the preparation cylinder, and the same sleeve is fixed on the top of the plurality of brackets, and the bottom of the sleeve does not contact the bottom of the preparation cylinder, and an auger is sleeved on the side wall of the rotating shaft, and the auger is located in the sleeve. During use of the device, the dispersion net is driven to rotate by the rotating mechanism in cooperation with the rotating shaft. When the drug passes through the surface of the dispersion net, it will be more evenly dispersed into the interior of the preparation cylinder, so that the contact between the drug powder and the drug solution is more sufficient and thorough. At the same time, through the rotation of the auger, the sleeve can output the wet drug accumulated at the bottom of the preparation cylinder from the top of the sleeve, and the stirring mechanism is used to make the drug mixed more evenly.

As a further solution of the utility model, the conveying mechanism includes a connecting pipe, one end of the connecting pipe is fixedly connected to the bottom of the box body, a water pump is fixed to the bottom of the box body, one end of the connecting pipe is fixed to the water outlet of the water pump, and the other end of the connecting pipe is connected to the preparation cylinder. A plurality of branch pipes are fixed linearly at equal distances on the side wall of the connecting pipe, and the plurality of branch pipes are connected to the preparation cylinder. When the power switch of the water pump is turned on, the medicine liquid in the box body is input into the preparation cylinder through the connecting pipe and the branch pipe by the water pump, so that the medicine liquid and the medicine are mixed more evenly.

As a further solution of the utility model, the rotating mechanism includes a motor, which is fixedly connected to the top of the preparation cylinder, the output shaft of the motor is sleeved with a first bevel gear, the top end of the rotating shaft is sleeved with a second bevel gear, and the second bevel gear is meshed with the first bevel gear. The driving motor drives the first bevel gear to rotate, and cooperates with the second bevel gear to drive the rotating shaft to rotate.

As a further solution of the utility model, the stirring mechanism includes a plurality of stirring rods, which are fixedly connected to the side wall of the rotating shaft at equal distances, and the plurality of stirring rods are located below the dispersion net. The cleaning mechanism includes a scraper, which is fixedly connected to the ends of the plurality of stirring rods, and the scraper is adapted to the preparation barrel. When the rotating shaft rotates, the stirring rods and the scraper are driven to rotate. The stirring rods rotate to stir and mix the medicine and the medicine solution, and the scraper rotates to clean the inner wall of the preparation barrel.

As a further solution of the utility model, a discharge port is fixed at the bottom of the preparation cylinder, and the mixed medicine is taken out through the discharge port and sent to a granulator for granulation.

The beneficial effects of the utility model are:

1. During use, the rotating mechanism drives the rotating shaft to rotate, thereby driving the dispersion net to rotate. When the drug enters the surface of the dispersion net through the conveying tube, the drug will be more evenly dispersed into the interior of the preparation cylinder, so that the contact between the drug powder and the drug solution is more complete and thorough.

2. During the rotation of the shaft, the auger is driven to rotate, and the sleeve can be used to output the wet medicine accumulated at the bottom of the preparation cylinder from the top of the sleeve to prevent the medicine from accumulating at the bottom of the preparation cylinder. At the same time, the stirring mechanism is used to make the medicine mixed more evenly.

3. During the rotation of the shaft, the cleaning mechanism can clean the medicine adhered to the inner wall of the preparation tube to avoid wasting medicine and improve the practicality of the device.

BRIEF DESCRIPTION OF THE DRAWINGS

FIG1 is a schematic structural diagram of a wet granulation device for improving drug mixing uniformity proposed by the present invention;

FIG2 is a schematic cross-sectional view of a preparation barrel and a box of a wet granulation device for improving drug mixing uniformity proposed by the present invention;

FIG3 is a schematic diagram of a scraper, a sleeve, a bracket and a stirring rod of a wet granulation device for improving the uniformity of drug mixing proposed by the utility model;

FIG4 is a schematic cross-sectional view of a sleeve of a wet granulation device for improving drug mixing uniformity proposed by the present invention.

In the figure: 1. preparation cylinder; 2. box body; 3. feed port; 4. water inlet; 5. motor; 6. first bevel gear; 7. second bevel gear; 8. connecting pipe; 9. branch pipe; 10. conveying pipe; 11. rotating shaft; 12. dispersion net; 13. water pump; 14. discharge port; 15. scraper; 16. sleeve; 17. bracket; 18. stirring rod; 19. auger.

DETAILED DESCRIPTION

The technical solutions in the embodiments of the present invention will be described clearly and completely below in conjunction with the drawings in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, rather than all of the embodiments.

Referring to Figures 1 to 4, a wet granulation device for improving the uniformity of drug mixing includes a preparation barrel 1, the bottom of the preparation barrel 1 is a truncated cone structure, a feed port 3 is fixed on the top of the preparation barrel 1, a delivery pipe 10 is fixed at an angle on the top of the preparation barrel 1, and the delivery pipe 10 is connected to the feed port 3, a box body 2 is fixed on the side wall of the preparation barrel 1, a water inlet 4 is fixed on the top of the box body 2, a delivery mechanism for delivering drugs is provided inside the box body 2, a rotating shaft 11 is rotatably connected to the top of the preparation barrel 1, and one end of the rotating shaft 11 passes through the top of the preparation barrel 1, a dispersing net 12 is sleeved on the side wall of the rotating shaft 11, and the dispersing net 12 is located below the delivery pipe 10, a rotating mechanism for rotating the rotating shaft 11 is provided on the top of the preparation barrel 1, and a stirring mechanism for stirring drugs is provided on the side wall of the rotating shaft 11, and the inside of the preparation barrel 1 A cleaning mechanism for cleaning the inner wall of the preparation tube 1 is provided. A plurality of brackets 17 are fixed in a circular shape at equal distances at the bottom of the inner wall of the preparation tube 1. A same sleeve 16 is fixed on the top of the plurality of brackets 17, and the bottom of the sleeve 16 does not contact the bottom of the preparation tube 1. An auger 19 is sleeved on the side wall of the rotating shaft 11, and the auger 19 is located in the sleeve 16. During use of the device, the rotating mechanism cooperates with the rotating shaft 11 to drive the dispersion net 12 to rotate. When the drug passes through the surface of the dispersion net 12, it will be more evenly dispersed into the interior of the preparation tube 1, so that the contact between the drug powder and the drug solution is more sufficient and thorough. At the same time, the auger 19 rotates, and the sleeve 16 can be used to output the wet drug accumulated at the bottom of the preparation tube 1 from the top of the sleeve 16, and the stirring mechanism is used to make the drug mixed more evenly.

1 and 2, in a preferred embodiment, the conveying mechanism includes a connecting pipe 8, one end of which is fixedly connected to the bottom of the box body 2, a water pump 13 is fixed at the bottom of the box body 2, one end of the connecting pipe 8 is fixed to the water outlet of the water pump 13, the other end of the connecting pipe 8 is connected to the preparation barrel 1, a plurality of branch pipes 9 are fixed in a linear manner at equal distances on the side wall of the connecting pipe 8, and the plurality of branch pipes 9 are connected to the preparation barrel 1, the power switch of the water pump 13 is turned on, and the medicine liquid in the box body 2 is input into the preparation barrel 1 through the connecting pipe 8 and the branch pipe 9 by the water pump 13, so that the medicine liquid and the medicine are mixed more evenly.

1 and 3 , in a preferred embodiment, the rotating mechanism includes a motor 5, which is fixedly connected to the top of the preparation cylinder 1, and the output shaft of the motor 5 is sleeved with a first bevel gear 6, and the top end of the rotating shaft 11 is sleeved with a second bevel gear 7, and the second bevel gear 7 is meshed with the first bevel gear 6. The driving motor 5 drives the first bevel gear 6 to rotate, and cooperates with the second bevel gear 7 to drive the rotating shaft 11 to rotate.

2 and 3 , in a preferred embodiment, the stirring mechanism includes a plurality of stirring rods 18, which are fixedly connected to the side wall of the rotating shaft 11 at equal distances, and the plurality of stirring rods 18 are located below the dispersion net 12, and the cleaning mechanism includes a scraper 15, which is fixedly connected to the ends of the plurality of stirring rods 18, and the scraper 15 is adapted to the preparation tube 1, and the rotation of the rotating shaft 11 drives the stirring rods 18 and the scraper 15 to rotate, the stirring rods 18 rotate to stir and mix the medicine and the medicine solution, and the scraper 15 rotates to clean the inner wall of the preparation tube 1.

2 , in a preferred embodiment, a discharge port 14 is fixed at the bottom of the preparation cylinder 1 , and the mixed medicine is taken out through the discharge port 14 and sent to a granulator for granulation.

Working principle of this embodiment: During use of this device, a certain amount of liquid medicine is pre-injected into the box body 2 through the water inlet 4, and the powder to be mixed is input into the preparation tube 1 through the feed port 3. The powder entering the preparation tube 1 falls onto the surface of the dispersion net 12 through the conveying pipe 10, and the power switch of the motor 5 is turned on. The driving motor 5 drives the first bevel gear 6 to rotate, and cooperates with the second bevel gear 7 to drive the rotating shaft 11 to rotate, and then drives the dispersion net 12 to rotate. When the dispersion net 12 rotates, the powder falls into the bottom of the preparation tube 1, and the medicine will be more evenly dispersed into the interior of the preparation tube 1, so that the powder and the liquid medicine are in contact more fully and thoroughly. At the same time, the power switch of the water pump 13 is turned on, and the liquid medicine in the box body 2 is input into the preparation tube 1 through the connecting pipe 8 and the branch pipe 9 through the water pump 13. At the same time, the rotating shaft 11 rotates. At the same time, the stirring rod 18 and the auger 19 are driven to rotate simultaneously to stir and mix the medicine and the liquid medicine. After a period of time, the mixed viscous medicine at the bottom of the preparation tube 1 falls into the bottom of the preparation tube 1. At this time, the auger 19 rotates to cooperate with the sleeve 16 to flip the viscous medicine at the bottom of the preparation tube 1 from the bottom of the sleeve 16 to the top of the sleeve 16, and transport it out from the top of the sleeve 16 to avoid the accumulation of medicine at the bottom of the preparation tube 1. In this way, the medicine can be mixed more evenly and the quality of the medicine can be improved. When the stirring rod 18 rotates, the scraper 15 is driven to rotate along the inner wall of the preparation tube 1 to scrape and clean the medicine on the inner wall of the preparation tube 1 to avoid wasting medicine and improve the practicality of the device. After the stirring is completed, the mixed medicine is taken out through the discharge port 14 and sent to the granulator for granulation.

For ease of description, spatially relative terms such as "above", "above", "on the upper surface of", "above", etc. may be used here to describe the spatial positional relationship between a device or feature and other devices or features as shown in the figure. It should be understood that spatially relative terms are intended to include different orientations of the device in use or operation in addition to the orientation described in the figure. For example, if the device in the accompanying drawings is inverted, the device described as "above other devices or structures" or "above other devices or structures" will be positioned as "below other devices or structures" or "below other devices or structures". Thus, the exemplary term "above" can include both "above" and "below". The device can also be positioned in other different ways (rotated 90 degrees or in other orientations), and the spatially relative descriptions used here are interpreted accordingly.

It should be noted that the terms used herein are only for describing specific embodiments and are not intended to limit the exemplary embodiments according to the present application. As used herein, unless the context clearly indicates otherwise, the singular form is also intended to include the plural form. In addition, it should be understood that when the terms "comprise" and/or "include" are used in this specification, it indicates the presence of features, steps, operations, devices, components and/or combinations thereof.

It should be noted that the terms "first", "second", etc. in the specification and claims of the present application and the above-mentioned drawings are used to distinguish similar objects, and are not necessarily used to describe a specific order or sequence. It should be understood that the data used in this way can be interchangeable where appropriate, so that the embodiments of the present application described herein can be implemented in an order other than those illustrated or described herein, for example. In addition, the terms "including" and "having" and any of their variations are intended to cover non-exclusive inclusions, for example, a process, method, system, product or device that includes a series of steps or units is not necessarily limited to those steps or units that are clearly listed, but may include other steps or units that are not clearly listed or inherent to these processes, methods, products or devices.

The above description is only the preferred embodiment of the utility model, and is not intended to limit the utility model. For those skilled in the art, the utility model can have various modifications and changes. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the utility model shall be included in the protection scope of the utility model.

Claims (6)

1. A wet granulation device for improving the uniformity of drug mixing, comprising a preparation barrel (1), characterized in that the bottom of the preparation barrel (1) is a truncated cone structure, a feed port (3) is fixed on the top of the preparation barrel (1), a conveying pipe (10) is fixed at an angle on the top of the preparation barrel (1), and the conveying pipe (10) and the feed port (3) are connected, a box (2) is fixed on the side wall of the preparation barrel (1), a water inlet (4) is fixed on the top of the box (2), a conveying mechanism for conveying drugs is provided inside the box (2), a rotating shaft (11) is rotatably connected to the top of the preparation barrel (1), and one end of the rotating shaft (11) passes through the top of the preparation barrel (1), and the rotating shaft (11) A dispersion net (12) is sleeved on the side wall, and the dispersion net (12) is located below the conveying tube (10); a rotating mechanism for rotating the rotating shaft (11) is provided on the top of the preparation cylinder (1); a stirring mechanism for stirring the medicine is provided on the side wall of the rotating shaft (11); a cleaning mechanism for cleaning the inner wall of the preparation cylinder (1) is provided inside the preparation cylinder (1); a plurality of brackets (17) are fixed to the bottom of the inner wall of the preparation cylinder (1) at equal distances in a circle; the tops of the plurality of brackets (17) are fixed with the same sleeve (16), and the bottom of the sleeve (16) does not contact the bottom of the preparation cylinder (1); a screw auger (19) is sleeved on the side wall of the rotating shaft (11), and the screw auger (19) is located inside the sleeve (16). 2. The wet granulation equipment for improving the uniformity of drug mixing according to claim 1 is characterized in that the conveying mechanism includes a connecting pipe (8), one end of the connecting pipe (8) is fixedly connected to the bottom of the box (2), a water pump (13) is fixed to the bottom of the box (2), one end of the connecting pipe (8) is fixed to the water outlet of the water pump (13), the other end of the connecting pipe (8) is connected to the preparation barrel (1), and a plurality of branch pipes (9) are fixed to the side wall of the connecting pipe (8) at equal distances in a linear manner, and the plurality of branch pipes (9) are all connected to the preparation barrel (1). 3. The wet granulation equipment for improving the uniformity of drug mixing according to claim 1 is characterized in that the rotating mechanism includes a motor (5), the motor (5) is fixedly connected to the top of the preparation cylinder (1), the output shaft of the motor (5) is sleeved with a first bevel gear (6), the top end of the rotating shaft (11) is sleeved with a second bevel gear (7), and the second bevel gear (7) and the first bevel gear (6) are meshed. 4. The wet granulation equipment for improving the uniformity of drug mixing according to claim 1 is characterized in that the stirring mechanism includes a plurality of stirring rods (18), the plurality of stirring rods (18) are fixedly connected to the side wall of the rotating shaft (11) at equal distances, and the plurality of stirring rods (18) are all located below the dispersion net (12). 5. The wet granulation equipment for improving the uniformity of drug mixing according to claim 4 is characterized in that the cleaning mechanism comprises a scraper (15), the scraper (15) is fixedly connected to the ends of a plurality of stirring rods (18), and the scraper (15) is adapted to the preparation cylinder (1). 6. The wet granulation equipment for improving drug mixing uniformity according to claim 1, characterized in that a discharge port (14) is fixed at the bottom of the preparation cylinder (1).