CN221433315U - Grinding device is used in clofarabine raw materials production - Google Patents
Grinding device is used in clofarabine raw materials production Download PDFInfo
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- CN221433315U CN221433315U CN202323437150.2U CN202323437150U CN221433315U CN 221433315 U CN221433315 U CN 221433315U CN 202323437150 U CN202323437150 U CN 202323437150U CN 221433315 U CN221433315 U CN 221433315U
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- Prior art keywords
- grinding
- clofarabine
- raw materials
- hopper
- groups
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- 238000000227 grinding Methods 0.000 title claims abstract description 95
- 239000002994 raw material Substances 0.000 title claims abstract description 49
- WDDPHFBMKLOVOX-AYQXTPAHSA-N clofarabine Chemical compound C1=NC=2C(N)=NC(Cl)=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@@H]1F WDDPHFBMKLOVOX-AYQXTPAHSA-N 0.000 title claims abstract description 25
- 229960000928 clofarabine Drugs 0.000 title claims abstract description 25
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 12
- 230000007246 mechanism Effects 0.000 claims abstract description 26
- 238000005520 cutting process Methods 0.000 claims abstract description 14
- 238000007599 discharging Methods 0.000 claims abstract description 7
- 238000009826 distribution Methods 0.000 claims description 3
- 239000000463 material Substances 0.000 description 13
- 235000017166 Bambusa arundinacea Nutrition 0.000 description 9
- 235000017491 Bambusa tulda Nutrition 0.000 description 9
- 241001330002 Bambuseae Species 0.000 description 9
- 235000015334 Phyllostachys viridis Nutrition 0.000 description 9
- 239000011425 bamboo Substances 0.000 description 9
- 238000001125 extrusion Methods 0.000 description 3
- 238000001914 filtration Methods 0.000 description 2
- 230000008676 import Effects 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- 208000024893 Acute lymphoblastic leukemia Diseases 0.000 description 1
- 208000014697 Acute lymphocytic leukaemia Diseases 0.000 description 1
- GFFGJBXGBJISGV-UHFFFAOYSA-N Adenine Chemical compound NC1=NC=NC2=C1N=CN2 GFFGJBXGBJISGV-UHFFFAOYSA-N 0.000 description 1
- 229930024421 Adenine Natural products 0.000 description 1
- 208000006664 Precursor Cell Lymphoblastic Leukemia-Lymphoma Diseases 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 229960000643 adenine Drugs 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 150000003834 purine nucleoside derivatives Chemical class 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02W—CLIMATE CHANGE MITIGATION TECHNOLOGIES RELATED TO WASTEWATER TREATMENT OR WASTE MANAGEMENT
- Y02W30/00—Technologies for solid waste management
- Y02W30/50—Reuse, recycling or recovery technologies
- Y02W30/62—Plastics recycling; Rubber recycling
Landscapes
- Crushing And Pulverization Processes (AREA)
Abstract
The utility model provides a grinding device for producing clofarabine raw materials, which relates to the technical field of clofarabine production and comprises a grinding box, wherein two groups of grinding rollers are rotatably arranged in the middle of the inner side of the grinding box, the two groups of grinding rollers are driven by a motor to rotate relatively, and a crushing mechanism and a uniform blanking mechanism are arranged in the middle of the upper end of the grinding box; the crushing mechanism comprises a crushing cylinder, a rotating shaft is rotatably arranged at the bottom of the inner side of the crushing cylinder, a plurality of groups of cutting knives are arranged at the middle parts of the two ends of the rotating shaft, and the rotating shaft is driven by a motor; the even unloading mechanism is provided with the discharge gate including the unloading hopper in the middle of the bottom of unloading hopper. According to the utility model, the crushing mechanism is arranged in the middle of the upper end of the grinding box, so that the clofarabine raw materials can be cut and crushed, and then the finely crushed raw materials are uniformly discharged through the uniform discharging mechanism, so that the situation that a large amount of raw materials are accumulated in two groups of grinding rollers to cause blockage to the running of the grinding rollers is effectively avoided.
Description
Technical Field
The utility model relates to the technical field of clofarabine production, in particular to a grinding device for clofarabine raw material production.
Background
Clofarabine is a second generation purine nucleoside analogue, and has a chemical name of 2-chloro-9- (2-deoxy-2-fluoro-beta-D-arabino) adenine, a molecular formula of C10H11ClFN O3 and a relative molecular mass of 303.68. Clinically used for treating acute lymphoblastic leukemia of children.
In the manufacturing process of the clofarabine, a grinding device is needed to grind production raw materials into powder, however, the traditional grinding device is simpler in structure, a feeding hopper is arranged in the middle of the upper end of a grinding box and used for discharging, two groups of grinding rollers are arranged in the middle of the inner side of the grinding box and used for extrusion grinding of raw materials, and raw materials to be processed can be guided into the two groups of grinding rollers through the feeding hopper for extrusion grinding; however, during the production process, the grinding rolls often suffer from clogging due to the accumulation of large amounts of raw materials.
In order to solve the above problems, we propose a grinding device for producing clofarabine raw material to solve the above problems.
Disclosure of utility model
In order to solve the problems in the background technology, the utility model provides a grinding device for producing clofarabine raw materials.
In order to achieve the above purpose, the technical scheme adopted by the utility model is as follows:
The grinding device for the clofarabine raw material production comprises a grinding box and two groups of grinding rollers which are rotatably arranged in the middle of the inner side of the grinding box, wherein the two groups of grinding rollers are driven by a motor to rotate relatively so as to realize extrusion grinding of the raw material to be fed, and a crushing mechanism and a uniform feeding mechanism are arranged in the middle of the upper end of the grinding box; wherein, broken mechanism is including a broken section of thick bamboo, the inboard bottom of a broken section of thick bamboo rotates and installs the axis of rotation, the both ends middle part of axis of rotation all is provided with the multiunit cutting knife, the axis of rotation is driven by the motor, drives the axis of rotation through the motor and rotates to make multiunit cutting knife carry out rotary motion in the inboard bottom of a broken section of thick bamboo, thereby realize cutting broken to the clofarabine raw materials.
The even unloading mechanism is including the unloading hopper, the bottom middle part of unloading hopper is provided with the discharge gate, the discharge gate is located the upper end middle part of two sets of grinding rollers to and, rotate at the inboard middle part of discharge gate and install the rotary drum, the outward appearance of rotary drum is all around with the central point array distribution has multiunit flitch down, the end of flitch is close to the inner wall of discharge gate, the rotary drum is rotated at the inboard middle part of discharge gate by the motor drive, thereby realizes carrying out even unloading to the raw materials of accomplishing the breakage, avoids a large amount of raw materials to pile up in two sets of grinding rollers, leads to the operation to the grinding roller to cause the jam.
Preferably, the bottom middle part of broken section of thick bamboo is provided with the filter screen, the filter screen is located the upper end middle part of hopper down, filter screen fixed mounting is in the upper end middle part of grinding case, can carry out the filtration separation to broken raw materials through the filter screen.
Preferably, the lower hopper is located the bottom middle part of filter screen, lower hopper fixed mounting is in the inboard upper end of grinding case, the upper end import of lower hopper is circular, the bottom discharge gate of lower hopper is the groove type, and lower hopper can guide the raw materials to two sets of grinding roller middle part positions.
Preferably, a feeding hopper is arranged in the middle of the top end of the crushing cylinder and used for adding materials, and an outlet at the bottom end of the feeding hopper is positioned in the middle of the upper end of the crushing mechanism.
Preferably, the inboard bottom of grinding case is provided with the guide plate of funnel shape, the guide plate is located the bottom middle part of two sets of grinding rollers to and be provided with the discharging pipe in the bottom middle part of guide plate, the discharging pipe is located the bottom middle part of grinding case, can guide the raw materials of accomplishing the grinding through the guide plate, then discharges through discharging pipe department.
Preferably, circular support columns are arranged around the bottom end of the grinding box and play a role in supporting, and anti-slip pads are arranged in the middle of the bottom end of the support columns.
Compared with the prior art, the utility model has the beneficial effects that:
in this scheme, through being provided with broken mechanism in the upper end middle part of grinding the case, can cut the breakage to the clofarabine raw materials, then carry out even unloading to the raw materials of breaking into pieces through even unloading mechanism to effectually avoided a large amount of raw materials to pile up in two sets of grinding rollers, lead to the condition production that causes the jam to the operation of grinding roller.
Drawings
FIG. 1 is a schematic perspective view of the present utility model;
FIG. 2 is a side cross-sectional view of the present utility model;
FIG. 3 is a side cross-sectional view of the grinding chamber of the present utility model;
fig. 4 is an exploded view of the crushing drum and filter screen of the present utility model.
In the figure: 1. a grinding box; 2. a grinding roller; 3. a crushing cylinder; 4. a feed hopper; 5. a rotating shaft; 6. a cutting knife; 7. a filter screen; 8. discharging a hopper; 9. a rotating drum; 10. a blanking plate; 11. a material guide plate; 12. a discharge pipe; 13. and (5) supporting the column.
Detailed Description
The embodiment of the application provides a grinding device for producing clofarabine raw materials, which can cut and crush the clofarabine raw materials by arranging a crushing mechanism in the middle of the upper end of a grinding box 1, and then uniformly blanking the finely crushed raw materials by using a uniform blanking mechanism, thereby effectively avoiding the situation that a large amount of raw materials are accumulated in two groups of grinding rollers 2 to cause blockage to the running of the grinding rollers 2.
Examples: referring to fig. 1-4, a grinding device for producing clofarabine raw materials in this embodiment includes a grinding box 1, and two sets of grinding rollers 2 rotatably mounted in the middle of the inner side of the grinding box 1, where the two sets of grinding rollers 2 are driven by a motor to rotate relatively, so as to squeeze and grind raw materials entering the middle of the two sets of grinding rollers 2.
The grinding case 1's upper end middle part is provided with crushing mechanism and even unloading mechanism, wherein crushing mechanism is including broken section of thick bamboo 3, rotate in the inboard bottom of broken section of thick bamboo 3 and install axis of rotation 5, the both ends middle part of axis of rotation 5 all is provided with multiunit cutting knife 6, axis of rotation 5 is driven by the motor, drive axis of rotation 5 through the motor, thereby make multiunit cutting knife 6 can carry out rotary cutting to the clofarabine raw materials that enters into in the broken section of thick bamboo 3, thereby realize cutting up big raw materials, thereby make things convenient for two sets of grinding rollers 2 to finely grind the raw materials, avoid appearing the condition of jam to produce.
The even unloading mechanism is including unloading hopper 8, the bottom middle part of unloading hopper 8 is provided with the discharge gate, the discharge gate is located the upper end middle part of two sets of grinding roller 2, can guide the raw materials of accomplishing the breakage to the upper end middle part of two sets of grinding roller 2 through unloading hopper 8, in this process, through rotating at the inboard middle part of discharge gate and installing rotary drum 9, the outward appearance of rotary drum 9 is all around with central point array distribution has multiunit flitch 10, the end of flitch 10 is close to the inner wall of discharge gate, rotary drum 9 is rotated at the inboard middle part of discharge gate by the motor drive, drive multiunit flitch 10 through rotary drum 9 and rotate, thereby realize carrying out even unloading to the raw materials in the unloading hopper 8, avoid a large amount of raw materials to pile up between two sets of grinding roller 2, lead to causing the condition that blocks up grinding roller 2.
Wherein, be provided with filter screen 7 in the bottom middle part of broken section of thick bamboo 3, filter screen 7 is located the upper end middle part of hopper 8 down, and filter screen 7 fixed mounting carries out filtering separation to the raw and other materials of accomplishing the cutting through filter screen 7, and the raw and other materials that accord with the standard can fall into down in hopper 8 and carry out even unloading, and the raw and other materials that do not accord then can pile up in broken section of thick bamboo 3, continue to cut the breakage through crushing mechanism.
The lower hopper 8 is located the bottom middle part of filter screen 7, and lower hopper 8 fixed mounting is in the inboard upper end of grinding case 1, and the upper end import of lower hopper 8 is circular, makes things convenient for the raw materials that filter screen 7 department falls to guide the unloading, and the bottom discharge gate of lower hopper 8 is the cell type, and the raw materials can fall to the middle part of two sets of grinding roller 2 through the discharge gate of cell type, then carries out relative rotation through two sets of grinding roller 2 to the realization is extruded the grinding to the raw materials.
The top middle part of a crushing cylinder 3 is provided with a feed hopper 4, and the bottom outlet of the feed hopper 4 is positioned at the middle part of the upper end of the crushing mechanism and is provided with a feed hopper 4, so that the production raw materials are conveniently added into the crushing cylinder 3 by workers.
In some examples, the bottom of the inner side of the grinding box 1 is provided with a funnel-shaped material guide plate 11, the material guide plate 11 is located in the middle of the bottom ends of the two groups of grinding rollers 2, and a material discharge pipe 12 is arranged in the middle of the bottom ends of the material guide plate 11, the material which is ground is guided to the bottom through the material guide plate 11, and then discharged through the material discharge pipe 12, so that the material can be conveniently collected by workers, and then the next processing procedure is performed.
In some examples, circular support columns 13 are arranged around the bottom end of the grinding box 1, so that the grinding box 1 is stably supported, and anti-slip pads are arranged in the middle of the bottom end of the support columns 13, so that the stability of the grinding box 1 in running is improved.
The working principle of the utility model is as follows:
The grinding box comprises a grinding cylinder 3, a plurality of groups of cutting knives 6 are rotatably arranged at the bottom of the inner side of the grinding cylinder 3, and the cutting knives 6 are driven to rotate, so that the cutting and crushing of the clofarabine raw materials are realized, wherein finely crushed raw materials fall into a blanking hopper 8 through a filter screen 7 to be converged, and then a plurality of groups of blanking plates 10 are driven to rotate through a rotary drum 9, so that the finely crushed raw materials can be evenly fed into two groups of grinding rollers 2 to be extruded and ground.
The foregoing has shown and described the basic principles and main features of the present utility model and the advantages of the present utility model. It will be understood by those skilled in the art that the present utility model is not limited to the embodiments described above, and that the above embodiments and descriptions are merely illustrative of the principles of the present utility model, and various changes and modifications may be made without departing from the spirit and scope of the utility model, which is defined in the appended claims. The scope of the utility model is defined by the appended claims and equivalents thereof.
Claims (6)
1. The grinding device for the clofarabine raw material production comprises a grinding box (1), and two groups of grinding rollers (2) are rotatably arranged in the middle of the inner side of the grinding box (1), and the two groups of grinding rollers (2) are driven by a motor to rotate relatively, and the grinding device is characterized in that a crushing mechanism and a uniform blanking mechanism are arranged in the middle of the upper end of the grinding box (1);
The crushing mechanism comprises a crushing cylinder (3), a rotating shaft (5) is rotatably arranged at the bottom of the inner side of the crushing cylinder (3), a plurality of groups of cutting knives (6) are arranged at the middle parts of the two ends of the rotating shaft (5), and the rotating shaft (5) is driven by a motor;
The even unloading mechanism is including unloading hopper (8), the bottom middle part of unloading hopper (8) is provided with the discharge gate, the discharge gate is located the upper end middle part of two sets of grinding roller (2) to and, rotate at the inboard middle part of discharge gate and install rotary drum (9), the outward appearance of rotary drum (9) is all around with central point array distribution has multiunit flitch (10), the end of flitch (10) is close to the inner wall of discharge gate, rotary drum (9) are rotated at the inboard middle part of discharge gate by the motor drive.
2. The grinding device for producing the clofarabine raw material according to claim 1, wherein a filter screen (7) is arranged in the middle of the bottom end of the crushing cylinder (3), the filter screen (7) is positioned in the middle of the upper end of the discharging hopper (8), and the filter screen (7) is fixedly arranged in the middle of the upper end of the grinding box (1).
3. The grinding device for producing the clofarabine raw material according to claim 2, wherein the blanking hopper (8) is located in the middle of the bottom end of the filter screen (7), the blanking hopper (8) is fixedly installed at the upper end of the inner side of the grinding box (1), an inlet at the upper end of the blanking hopper (8) is circular, and a discharge hole at the bottom end of the blanking hopper (8) is of a groove shape.
4. The grinding device for producing the clofarabine raw material according to claim 2, wherein a feeding hopper (4) is arranged in the middle of the top end of the crushing cylinder (3), and a bottom end outlet of the feeding hopper (4) is positioned in the middle of the upper end of the crushing mechanism.
5. A grinding device for producing clofarabine raw materials according to claim 3, characterized in that a funnel-shaped guide plate (11) is arranged at the bottom of the inner side of the grinding box (1), the guide plate (11) is positioned at the middle of the bottom ends of the two groups of grinding rollers (2), a discharge pipe (12) is arranged at the middle of the bottom ends of the guide plate (11), and the discharge pipe (12) is positioned at the middle of the bottom ends of the grinding box (1).
6. The grinding device for producing the clofarabine raw material according to claim 5, wherein round support columns (13) are arranged around the bottom end of the grinding box (1), and anti-slip pads are arranged in the middle of the bottom end of the support columns (13).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202323437150.2U CN221433315U (en) | 2023-12-18 | 2023-12-18 | Grinding device is used in clofarabine raw materials production |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202323437150.2U CN221433315U (en) | 2023-12-18 | 2023-12-18 | Grinding device is used in clofarabine raw materials production |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN221433315U true CN221433315U (en) | 2024-07-30 |
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ID=92065162
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202323437150.2U Active CN221433315U (en) | 2023-12-18 | 2023-12-18 | Grinding device is used in clofarabine raw materials production |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN221433315U (en) |
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2023
- 2023-12-18 CN CN202323437150.2U patent/CN221433315U/en active Active
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