CN219385126U - Fermentation tank for preparing acetylated glucosamine - Google Patents

Fermentation tank for preparing acetylated glucosamine Download PDF

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Publication number
CN219385126U
CN219385126U CN202320395347.5U CN202320395347U CN219385126U CN 219385126 U CN219385126 U CN 219385126U CN 202320395347 U CN202320395347 U CN 202320395347U CN 219385126 U CN219385126 U CN 219385126U
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inner tank
electric heating
tank
wall
support frames
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CN202320395347.5U
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闫福根
石勇
林荣业
林昌宇
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Zhejiang Golden Shell Pharmaceutical Co ltd
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Zhejiang Golden Shell Pharmaceutical Co ltd
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    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/10Process efficiency

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Abstract

The utility model discloses a fermentation tank for preparing acetylated glucosamine, which is characterized in that a controller controls electric push rods on a plurality of supporting frames to enable an electric heating plate or a heat absorbing plate to be pressed against the outer wall of an inner tank. After the electric heating plate is pressed against the outer wall of the inner tank, the electric heating wires of the electric heating plate generate heat and transfer the heat to the culture medium fermentation broth in the inner tank through the pipe wall of the inner tank, so that the temperature of the culture medium fermentation broth of the inner tank rises. On the other hand, through the jar wall of inner tank set up stirring protruding edge, avoid traditional stirring mode that sets up (mixing) shaft and stirring vane for whether the cleanness of inner tank is convenient and convenient, has reduced the health dead angle, provides the guarantee for the stable quality of product. The utility model solves the problems of poor temperature control performance and slow response to temperature regulation of some fermentation tanks used in the existing production of N-acetylglucosamine.

Description

Fermentation tank for preparing acetylated glucosamine
Technical Field
The utility model relates to the technical field of acetylated glucosamine production equipment, in particular to a fermentation tank for preparing acetylated glucosamine.
Background
N-acetylglucosamine is an important functional monosaccharide, and is present in various microorganisms and animal plants. N-acetamido glucose has the effects of resisting aging, stimulating the growth of bifidobacteria in the intestinal tracts of infants, regulating endocrine, relieving joint pain, promoting cartilage tissue regeneration and the like, and is widely applied to the fields of medicines, food ingredients and cosmetics.
The existing preparation method of the N-acetylglucosamine comprises three methods, namely a chitin hydrolysis method, an enzymolysis method and a microbial synthesis method. The microbial fermentation method (such as the Chinese patent with the application number of CN 202111680766.5) has the advantages of high production efficiency, little pollution, no anaphylactic reaction and high economic benefit due to no limitation of seasons, regions, raw material sources and the like.
The fermentation tank is used as an important device in the production process of N-acetylglucosamine, and the fermentation quality of the fermentation tank has an influence on the production process of the N-acetylglucosamine. Some of the prior fermentation has poor temperature control performance and slow response to temperature regulation.
Disclosure of Invention
In order to overcome the defects existing in the prior art, a fermentation tank for preparing acetylated glucosamine is provided, so that the problems of poor temperature control performance and slow response to temperature regulation of some fermentation tanks used in the existing production of N-acetylglucosamine are solved.
To achieve the above object, there is provided a fermenter for preparing acetylated glucosamine, comprising:
the outer tank sleeve is internally provided with a driving motor;
the inner tank is arranged in the outer tank sleeve, the upper end and the lower end of the inner tank are respectively rotatably arranged in the outer tank sleeve through bearings, the driving motor is connected to the inner tank, a plurality of stirring ribs are formed on the inner wall of the inner tank along the circumferential direction of the inner tank, and a containing space is formed between the outer wall of the inner tank and the inner wall of the outer tank sleeve;
the electric heating device comprises an inner tank, a plurality of rows of support frames, a plurality of electric push rods and a plurality of heat absorbing plates, wherein the support frames are connected to the outer wall of the inner tank, each row of support frames comprises a plurality of support frames arranged along the circumferential direction of the inner tank, the plurality of rows of support frames are arranged along the axial direction of the inner tank, the support frames are connected with the electric heating plates or the heat absorbing plates through the electric push rods, the electric heating plates and the heat absorbing plates are alternately arranged, and the electric heating plates on two adjacent rows of support frames and the heat absorbing plates are arranged in a staggered manner;
a temperature sensor installed in the inner tank;
and the controller is connected with a plurality of rows of electric push rods on the supporting frame and the temperature sensor.
Further, the output end of the driving motor is coaxially connected to the lower end of the inner tank.
Further, the stirring ridge has a first side close to the inner wall of the inner tank and a second side far away from the inner wall of the inner tank, and the thickness of the stirring ridge gradually decreases from the first side to the second side.
Further, the opposite sides of the stirring convex edges are concave and arc-shaped.
Further, a duct is formed inside the electric heating plate, and an electric heating wire is embedded in the duct.
Further, a containing cavity is formed in the heat absorbing plate, and a heat conducting medium is contained in the containing cavity.
Further, the heat conducting medium is water.
The fermentation tank for preparing the acetylated glucosamine has the beneficial effects that the controller of the fermentation tank enables the electric heating plate or the heat absorbing plate to be pressed against the outer wall of the inner tank by controlling the electric push rods on the supporting frames. After the electric heating plate is pressed against the outer wall of the inner tank, the electric heating wires of the electric heating plate generate heat and transfer the heat to the culture medium fermentation broth in the inner tank through the pipe wall of the inner tank, so that the temperature of the culture medium fermentation broth of the inner tank rises.
When the heat absorbing plate is pressed against the outer wall of the inner tank, the heat absorbing plate absorbs heat of the culture medium fermentation broth of the inner tank through the heat conducting glue, and heat is transferred through the heat radiating fins, so that the temperature of the culture medium fermentation broth of the inner tank is lowered.
On the other hand, the controller adjusts the lifting speed of the culture medium fermentation liquor in the inner tank by controlling the number of electric heating plates or heat absorbing plates which are pressed against and attached to the tank wall of the inner tank, so that the temperature of the culture medium fermentation liquor in the inner tank can be quickly adjusted and adjusted to the set temperature.
According to the fermentation tank for preparing the acetylated glucosamine, disclosed by the utility model, the stirring ribs are arranged on the tank wall of the inner tank, so that the traditional stirring mode of arranging the stirring shaft and the stirring blades is avoided, the inner tank is convenient and fast to clean, the sanitary dead angle is reduced, and the guarantee is provided for the quality stability of products.
Drawings
Other features, objects and advantages of the present application will become more apparent upon reading of the detailed description of non-limiting embodiments, made with reference to the following drawings, in which:
FIG. 1 is a schematic diagram of a fermenter for producing acetylated glucosamine according to an embodiment of the present utility model.
Fig. 2 is a cross-sectional view at A-A in fig. 1.
Fig. 3 is a schematic structural view of an electric heating plate according to an embodiment of the present utility model.
Fig. 4 is a schematic structural view of a heat absorbing plate according to an embodiment of the present utility model.
Detailed Description
The present application is described in further detail below with reference to the drawings and examples. It is to be understood that the specific embodiments described herein are merely illustrative of the utility model and are not limiting of the utility model. It should be noted that, for convenience of description, only the portions related to the utility model are shown in the drawings.
It should be noted that, in the case of no conflict, the embodiments and features in the embodiments may be combined with each other. The present application will be described in detail below with reference to the accompanying drawings in conjunction with embodiments.
A microbial process for preparing N-acetylglucosamine includes such steps as inoculating the primary strain (MGLCN) of colibacillus, culturing in the culture medium with resistance by streaking, and culturing at 30-37 deg.C for 9-12 hr. The strain is inoculated into a 250mL seed bottle for secondary seed culture, and the culture conditions are as follows: the temperature is 30-36 ℃, the rotating speed of the shaking table is 200rcf, and the culture time is 9-12 h; when the OD value is about 1.0-2.0, inoculating the strain into a fermentation tank, and culturing under the condition that: the volume of the culture medium in the fermentation tank is 1.5L; inoculation amount: 10-15%, and culturing conditions: the initial fermentation temperature is 30-36 ℃, the air flow is 5-50L/min, the stirring speed is 300-600 r/min, the dissolved oxygen is maintained at 30-80%, when the fermentation OD is 0-30, na2CO3 with the concentration of 10% is added to adjust the pH value to 7.2, when the fermentation OD is 30-90, a mixed solution of Na2CO3 with the concentration of 10% and tryptophan with the concentration of 2g/L is added to adjust the pH value in a tank to 7.8, and after the stable period is reached, 60% glycerol and 2g/L tryptophan are fed in per hour to 50-200 ml, and the culture is continued until the fermentation is finished.
Referring to fig. 1 to 4, the present utility model provides a fermenter for preparing acetylated glucosamine, comprising: the device comprises an outer tank sleeve 1, an inner tank 2, a plurality of rows of supporting frames 3, a temperature sensor and a controller.
In this embodiment, the outer can 1 and the inner can 2 are respectively cylindrical. A driving motor 11 is installed in the outer can 1. The inner tank 2 is arranged in the outer tank cover 1. The inner tank is made of a material with good heat conductivity. The inner tank is used for accommodating the culture medium fermentation broth. Wherein the upper and lower ends of the inner tank 2 are rotatably mounted in the outer tank cover 1 through bearings 21, respectively. The drive motor is connected to the inner tank 2.
As a preferred embodiment, the inner tank is coaxially arranged in the outer tank jacket. The output end of the driving motor 11 is coaxially connected to the lower end of the inner tank 2.
The inner wall of the inner tank 2 is formed with a plurality of stirring ribs 22 provided along the circumferential direction of the inner tank 2. An accommodating space is formed between the outer wall of the inner tank 2 and the inner wall of the outer tank cover 1.
The support frame 3 is detachably connected to the outer wall of the inner tank 2. The support frame 3 is provided with a plurality of rows. Each row of support frames 3 comprises a plurality of support frames 3. The plurality of support frames 3 of each row are disposed along the circumferential direction of the inner tank 2. The multiple rows of support frames 3 are arranged in the axial direction of the inner tank 2.
Each support frame 3 is connected with an electric heating plate 32 or a heat absorbing plate 33 through an electric push rod 31. The electric heating plates 32 are alternately arranged with the heat absorbing plates 33. The electric heating plates 32 and the heat absorbing plates 33 on the two adjacent rows of supporting frames 3 are arranged in a staggered way.
In the present embodiment, the electric heating plate 32 is internally formed with a duct. The electric heating wires are embedded in the holes of the electric heating plate 32. The electric heating wire is connected with a power supply.
The electric heating plate and the heat absorbing plate are respectively prepared from plates with good heat conductivity. The electric heating plate and the heat absorbing plate are arc-shaped.
When the temperature of the culture medium fermentation broth in the inner tank needs to be increased, the electric push rod provided with the electric heating plate stretches out to press the electric heating plate against the outer wall of the inner tank so as to compensate the heat of the culture medium fermentation broth in the inner tank. When the temperature of the culture medium fermentation broth in the inner tank needs to be reduced, the electric push rod provided with the heat absorbing plate stretches out to press the heat absorbing plate against the outer wall of the inner tank so as to absorb heat in the culture medium fermentation broth in the inner tank.
As a preferred embodiment, the absorber plate is a hollow plate. The heat absorbing plate 33 has a receiving cavity formed therein. The accommodating cavity is internally provided with a heat conducting medium. The heat conducting medium is water.
Referring to fig. 4, the heat absorbing plate is in a grid shape. The mesh of the absorber plate is filled with a heat conductive adhesive 332. And a radiating fin is formed on one side of the heat absorbing plate far away from the inner tank.
In this embodiment, the support frame is fitted with a fan. In high temperature weather, blow towards the radiating fin through the fan in order to take away the heat that the absorber plate absorbed fast.
As a preferred embodiment, the side wall of the outer tank sleeve is provided with an air inlet and an air outlet. When the temperature in the accommodating space is higher, the high-temperature air flow in the accommodating space is discharged to the outer side of the outer tank sleeve through the exhaust fan arranged in the air outlet.
The temperature sensor is installed in the inner tank 2. The temperature sensor is used for collecting the culture medium fermentation liquor accommodated in the inner tank in real time. The controller is connected to the electric push rods 31 and the temperature sensor on the multi-row support frame 3.
According to the fermentation tank for preparing the acetylated glucosamine, the controller controls the electric push rods on the supporting frames to enable the electric heating plate or the heat absorbing plate to be pressed against the outer wall of the inner tank. After the electric heating plate is pressed against the outer wall of the inner tank, the electric heating wires of the electric heating plate generate heat and transfer the heat to the culture medium fermentation broth in the inner tank through the pipe wall of the inner tank, so that the temperature of the culture medium fermentation broth of the inner tank rises.
When the heat absorbing plate is pressed against the outer wall of the inner tank, the heat absorbing plate absorbs heat of the culture medium fermentation broth of the inner tank through the heat conducting glue, and heat is transferred through the heat radiating fins, so that the temperature of the culture medium fermentation broth of the inner tank is lowered.
On the other hand, the controller adjusts the lifting speed of the culture medium fermentation liquor in the inner tank by controlling the number of electric heating plates or heat absorbing plates which are pressed against and attached to the tank wall of the inner tank, so that the temperature of the culture medium fermentation liquor in the inner tank can be quickly adjusted and adjusted to the set temperature.
According to the fermentation tank for preparing the acetylated glucosamine, disclosed by the utility model, the stirring ribs are arranged on the tank wall of the inner tank, so that the traditional stirring mode of arranging the stirring shaft and the stirring blades is avoided, the inner tank is convenient and fast to clean, the sanitary dead angle is reduced, and the guarantee is provided for the quality stability of products.
As a preferred embodiment, the stirring rib 22 has a first side close to the inner wall of the inner tank 2 and a second side far from the inner wall of the inner tank 2, and the thickness of the stirring rib 22 is gradually reduced from the first side to the second side.
In this embodiment, referring to fig. 2, the opposite sides of the plurality of stirring ribs 22 are concave in an arc shape.
Through the stirring protruding edge of arc side for the culture medium zymotic fluid of inner tank is when the inner tank rotates, and stirring misce bene improves the temperature uniformity of culture medium zymotic fluid.
The foregoing description is only of the preferred embodiments of the present application and is presented as a description of the principles of the technology being utilized. It will be appreciated by persons skilled in the art that the scope of the utility model referred to in this application is not limited to the specific combinations of features described above, but it is intended to cover other embodiments in which any combination of features described above or equivalents thereof is possible without departing from the spirit of the utility model. Such as the above-described features and technical features having similar functions (but not limited to) disclosed in the present application are replaced with each other.

Claims (7)

1. A fermenter for preparing acetylated glucosamine, comprising:
the outer tank sleeve is internally provided with a driving motor;
the inner tank is arranged in the outer tank sleeve, the upper end and the lower end of the inner tank are respectively rotatably arranged in the outer tank sleeve through bearings, the driving motor is connected to the inner tank, a plurality of stirring ribs are formed on the inner wall of the inner tank along the circumferential direction of the inner tank, and a containing space is formed between the outer wall of the inner tank and the inner wall of the outer tank sleeve;
the electric heating device comprises an inner tank, a plurality of rows of support frames, a plurality of electric push rods and a plurality of heat absorbing plates, wherein the support frames are connected to the outer wall of the inner tank, each row of support frames comprises a plurality of support frames arranged along the circumferential direction of the inner tank, the plurality of rows of support frames are arranged along the axial direction of the inner tank, the support frames are connected with the electric heating plates or the heat absorbing plates through the electric push rods, the electric heating plates and the heat absorbing plates are alternately arranged, and the electric heating plates on two adjacent rows of support frames and the heat absorbing plates are arranged in a staggered manner;
a temperature sensor installed in the inner tank;
and the controller is connected with a plurality of rows of electric push rods on the supporting frame and the temperature sensor.
2. The fermenter for preparing acetylated glucosamine according to claim 1, wherein the output of the drive motor is coaxially connected to the lower end of the inner vessel.
3. The fermenter for producing acetylated glucosamine according to claim 1, wherein the stirring ridge has a first side close to the inner wall of the inner tank and a second side remote from the inner wall of the inner tank, the thickness of the stirring ridge gradually decreasing from the first side to the second side.
4. A fermenter for use in the preparation of acetylated glucosamine according to claim 3, wherein the opposing sides of the plurality of agitating ridges are concave in an arc.
5. The fermenter for preparing acetylated glucosamine according to claim 1, wherein the electric heating plate has a hole formed therein, and the electric heating wire is embedded in the hole.
6. The fermenter for producing acetylated glucosamine according to claim 1, wherein a receiving cavity is formed in the heat absorbing plate, and a heat conducting medium is contained in the receiving cavity.
7. The fermenter for producing acetylated glucosamine according to claim 6, wherein the heat transfer medium is water.
CN202320395347.5U 2023-02-28 2023-02-28 Fermentation tank for preparing acetylated glucosamine Active CN219385126U (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202320395347.5U CN219385126U (en) 2023-02-28 2023-02-28 Fermentation tank for preparing acetylated glucosamine

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN202320395347.5U CN219385126U (en) 2023-02-28 2023-02-28 Fermentation tank for preparing acetylated glucosamine

Publications (1)

Publication Number Publication Date
CN219385126U true CN219385126U (en) 2023-07-21

Family

ID=87194863

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202320395347.5U Active CN219385126U (en) 2023-02-28 2023-02-28 Fermentation tank for preparing acetylated glucosamine

Country Status (1)

Country Link
CN (1) CN219385126U (en)

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