CN219374733U

CN219374733U - Raman puncture biopsy probe for nerve biopsy operation

Info

Publication number: CN219374733U
Application number: CN202320400836.5U
Authority: CN
Inventors: 赵虎林; 孙萌涛; 孙英华; 潘越
Original assignee: Beijing Zhongyanzhi Innovation Technology Research Institute Co ltd
Current assignee: Beijing Zhongyanzhi Innovation Technology Research Institute Co ltd
Priority date: 2023-03-07
Filing date: 2023-03-07
Publication date: 2023-07-21
Anticipated expiration: 2033-03-07

Abstract

The utility model discloses a Raman puncture biopsy probe for nerve biopsy operation, which comprises a working sleeve and a Raman biopsy needle, wherein a working sleeve inner core is arranged in the working sleeve, biopsy windows and Raman windows are respectively arranged on two side walls of the lower end of the Raman biopsy needle, a biopsy channel is fixedly arranged on one side, close to the biopsy windows, of the Raman biopsy needle, a cutting tube is arranged in the biopsy channel, an optical fiber channel is fixedly arranged on one side, located in the Raman biopsy needle, of the Raman biopsy needle, and the whole optical fiber channel is filled with optical fibers. The utility model discloses a Raman puncture biopsy probe for nerve biopsy operation, which is designed to integrally biopsy and Raman fiber channel, position and identify tissues, then accurately take out the tissues of a detected part, and a beam splitting device is designed to conduct incident light and returned Raman signals along a correct path.

Description

Raman puncture biopsy probe for nerve biopsy operation

Technical Field

The utility model relates to the technical field of medical instruments, in particular to a Raman puncture biopsy probe for nerve biopsy operation.

Background

Currently, in biopsy procedures, most solid cancers are found by conventional imaging techniques such as Computed Tomography (CT), magnetic Resonance Imaging (MRI), positron Emission Tomography (PET), and Ultrasound (US). While these images describe the location and anatomical relationship of cancer, most of them have limitations in tumor grading and molecular characterization. Thus, diagnosis and treatment planning require direct sampling of histological, molecular, and genomic features. Thus, the quality of the tissue obtained for analysis is critical to guiding the clinical trajectory. Diagnosis of tumors requires high quality tumor sampling during and after treatment in order to make proper treatment decisions, and the accuracy of tissue and lesion targeting prior to acquisition by conventional imaging techniques may be affected by time elapsed after imaging and by procedural tissue shifts, or poor quality sampling during surgery.

Current methods to reduce the risk of low quality sampling include intra-operative sample analysis based on histological processing (such as tissue smears and frozen tissue sections), or the collection of multiple samples to increase the accuracy of diagnostic samples. Few hospital conditions can meet the need for rapid pathological section detection of surgery, but the fastest handling and analysis of each sample takes 20-30 minutes, greatly extending the duration of the surgery.

Therefore, the brain tissue detection device based on artificial intelligent recognition and Raman spectrum is designed, and the detection method can rapidly detect the molecular level of the target tissue in real time in the cranium by utilizing the Raman scattering principle without taking out the tissue. Meanwhile, the artificial intelligence performs real-time data analysis and large database comparison, and analyzes the tissue type of the reached target tissue. The accuracy of the localization is diagnosed in real time, thereby guiding the performance of the biopsy procedure.

Disclosure of Invention

The utility model aims to solve the defects in the prior art, and provides a Raman puncture biopsy probe for a nerve biopsy operation.

In order to achieve the above purpose, the present utility model adopts the following technical scheme: the utility model provides a Raman puncture biopsy probe for nerve biopsy operation, includes work sleeve pipe and Raman biopsy needle, the inside work sleeve pipe inner core that is provided with of work sleeve pipe, raman biopsy needle lower extreme both sides wall is provided with biopsy window and Raman window respectively, the inside biopsy channel that is close to one side of biopsy window of Raman biopsy needle is fixed to be provided with, the inside cutting tube that is provided with of biopsy channel, the inside and fixed fibre channel that is located one side of Raman window of Raman biopsy needle, fibre channel wholly is the optic fibre and packs, the optic fibre upper end stretches out the Raman biopsy needle and is fixed to be provided with beam splitting device, beam splitting device upper end is fixed to be provided with collection fiber connector, beam splitting device inside is provided with beam splitting piece.

As a further description of the above technical solution:

the upper end of the working sleeve is fixedly provided with a working sleeve handle.

As a further description of the above technical solution:

and an inner core handle is fixedly arranged at the upper end of the inner core of the working sleeve.

As a further description of the above technical solution:

a cutting groove is fixedly formed in one side of the lower end of the cutting tube, and the cutting groove is matched with the biopsy window.

As a further description of the above technical solution:

the upper end of the cutting pipe is fixedly provided with a cutting handle, and two side walls of the cutting handle are respectively fixedly provided with an opening mark and a closing mark.

As a further description of the above technical solution:

the collection optical fiber connector is connected with a spectrometer and an artificial intelligent computer through a collection optical fiber, and the artificial intelligent computer comprises a computer, a display, raman spectrum identification software, a Raman spectrum database, raman spectrum data comparison software, laser emission control software, system control software and an artificial intelligent spectrum learning system.

As a further description of the above technical solution:

one side of the beam splitting device is fixedly provided with an excitation optical fiber connector, and the excitation optical fiber connector is fixedly connected with a laser emitter through an excitation optical fiber.

As a further description of the above technical solution:

the upper end of the Raman biopsy needle is fixedly provided with a biopsy handle.

The utility model has the following beneficial effects:

1. the Raman puncture biopsy probe for the nerve biopsy operation provided by the utility model has the advantages that the detection in the closed living tissue is realized, the operation efficiency is improved, the operation is guided in real time, the operation is ensured to be effective, and the injury of the secondary operation is avoided.

2. The utility model provides a Raman puncture biopsy probe for a nerve biopsy operation, which is designed to integrally form biopsy and Raman fiber channel, position and identify tissues, then accurately take out the tissues of a detected part, and a beam splitting device is designed to conduct incident light and returned Raman signals along a correct path.

Drawings

FIG. 1 is a schematic diagram of the working structure of a Raman biopsy probe for nerve biopsy operation according to the present utility model;

FIG. 2 is a schematic view of a working cannula of a Raman biopsy probe for nerve biopsy according to the present utility model;

FIG. 3 is a top view of a Raman biopsy needle of the Raman biopsy probe for nerve biopsy operation according to the present utility model;

FIG. 4 is a schematic view of the internal structure of a Raman biopsy needle of the Raman biopsy probe for nerve biopsy operation according to the present utility model;

FIG. 5 is a schematic view of a cutting tube structure of a Raman biopsy probe for nerve biopsy according to the present utility model;

fig. 6 is a schematic diagram of an optical fiber structure of a raman needle biopsy probe for a nerve biopsy operation according to the present utility model.

Legend description:

1. a working sleeve; 2. a raman biopsy needle; 3. a working sleeve handle; 4. a working cannula inner core; 5. an inner core handle; 6. a biopsy window; 7. a raman window; 8. a biopsy channel; 9. cutting the tube; 10. cutting a groove; 11. cutting the handle; 12. a fiber channel; 13. an optical fiber; 14. a beam splitting device; 15. collecting the optical fiber connector; 16. exciting the fiber optic connector; 17. splitting the beam slice; 18. a biopsy handle.

Detailed Description

The following description of the embodiments of the present utility model will be made clearly and completely with reference to the accompanying drawings, in which it is apparent that the embodiments described are only some embodiments of the present utility model, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the utility model without making any inventive effort, are intended to be within the scope of the utility model.

In the description of the present utility model, it should be noted that, directions or positional relationships indicated by terms such as "center", "upper", "lower", "left", "right", "vertical", "horizontal", "inner", "outer", etc., are based on directions or positional relationships shown in the drawings, are merely for convenience of description and simplification of description, and do not indicate or imply that the apparatus or element to be referred to must have a specific direction, be constructed and operated in the specific direction, and thus should not be construed as limiting the present utility model; the terms "first," "second," "third," and the like, are used for descriptive purposes only and are not to be construed as indicating or implying relative importance, and furthermore, unless explicitly specified and limited otherwise, the terms "mounted," "connected," "coupled," and the like are to be construed broadly, and may be fixedly coupled, detachably coupled, or integrally coupled, for example; can be mechanically or electrically connected; can be directly connected or indirectly connected through an intermediate medium, and can be communication between two elements. The specific meaning of the above terms in the present utility model will be understood in specific cases by those of ordinary skill in the art.

Referring to fig. 1-6, one embodiment provided by the present utility model is: a Raman puncture biopsy probe for nerve biopsy operation comprises a working sleeve 1 and a Raman biopsy needle 2, wherein a working sleeve inner core 4 is arranged in the working sleeve 1, biopsy windows 6 and Raman windows 7 are respectively arranged on two side walls of the lower end of the Raman biopsy needle 2, a biopsy channel 8 is fixedly arranged on one side, close to the biopsy windows 6, of the inside of the Raman biopsy needle 2, a cutting tube 9 is arranged in the biopsy channel 8, an optical fiber channel 12 is fixedly arranged on one side, located in the Raman windows 7, of the inside of the Raman biopsy needle 2, the whole optical fiber channel 12 is filled with optical fibers 13, the upper end of each optical fiber 13 extends out of the Raman biopsy needle 2 and is fixedly provided with a beam splitting device 14, a collecting optical fiber connector 15 is fixedly arranged at the upper end of the beam splitting device 14, and a beam splitting piece 17 is arranged in the beam splitting device 14 and can separate excitation laser light from a received Raman scattered light path;

the working sleeve 1 is fixedly provided with a working sleeve handle 3 at the upper end, the working sleeve inner core 4 is fixedly provided with an inner core handle 5, one side of the lower end of a cutting tube 9 is fixedly provided with a cutting groove 10, the cutting groove 10 is matched with a biopsy window 6, the upper end of the cutting tube 9 is fixedly provided with a cutting handle 11, two side walls of the cutting handle 11 are respectively fixedly provided with an opening and closing mark, a collecting optical fiber connector 15 is connected with a spectrometer and an artificial intelligent computer through a collecting optical fiber, the artificial intelligent computer comprises a computer, a display, raman spectrum identification software, a Raman spectrum database, raman spectrum data comparison software, laser emission control software, system control software and an artificial intelligent spectrum learning system, one side of a beam splitting device 14 is fixedly provided with an excitation optical fiber connector 16, the excitation optical fiber connector 16 is fixedly connected with a laser emitter through an excitation optical fiber, and the upper end of a Raman biopsy needle 2 is fixedly provided with a biopsy handle 18.

Working principle: when the Raman puncture biopsy probe for neurosurgery biopsy is used, the operation starts to disinfect an operation part, a stereotactic or robot and other positioning technologies are used for determining and positioning an operation access according to an operation plan performed before the operation, a drill bit is used for drilling a drill hole with a size for a working cannula 1 on a skull, the working cannula 1 and a working cannula inner core 4 are assembled together, a cutting tube 9 is inserted into a Raman biopsy needle 2, a direction mark on a cutting handle 11 is aligned to a 'off', the combined working cannula 1 and the working cannula inner core 4 are advanced along the drilled hole and advanced to a target tissue according to a designated direction and an angle of the pre-operation plan, the fixed position of the working cannula 1 is kept unchanged, the working cannula inner core 4 is pulled out, the Raman biopsy needle 2 is inserted into the bottom along the working cannula handle 3, a collection optical fiber and an excitation optical fiber are connected with a beam splitting device 14, loading system control software in computer, collecting Raman spectrum by computer software, automatically exciting laser, collecting spectrometer data, comparing collected data with database data, intelligently judging and identifying tissue contacted with Raman window according to comparison result, storing data, displaying identification result on display, if the identification result is not target tissue to be extracted, manually adjusting depth and angle, repeatedly identifying, if the identification result is target tissue to be extracted, holding working sleeve 1, rotating Raman biopsy needle 2 by 180 degrees, holding biopsy handle 18, rotating cutting handle 11 to "on", connecting injector behind cutting groove 10, the negative pressure state in the cutting groove 10 is realized by air suction, the cutting groove 10 is rotated to be closed, the injector is taken down, the cutting tube 9 is pulled out, at the moment, the tissue in the cutting tube 9 is the target tissue identified by Raman spectrum, and the biopsy tissue can be identified and sampled for a plurality of times according to the actual situation after being taken out.

Finally, it should be noted that: the foregoing description is only illustrative of the preferred embodiments of the present utility model, and although the present utility model has been described in detail with reference to the foregoing embodiments, it will be apparent to those skilled in the art that modifications may be made to the embodiments described, or equivalents may be substituted for elements thereof, and any modifications, equivalents, improvements or changes may be made without departing from the spirit and principles of the present utility model.

Claims

1. The Raman puncture biopsy probe for the nerve biopsy operation comprises a working sleeve (1) and a Raman biopsy needle (2), and is characterized in that: the novel Raman biopsy device comprises a working sleeve (1), wherein a working sleeve inner core (4) is arranged inside the working sleeve, a biopsy window (6) and a Raman window (7) are respectively arranged on two side walls of the lower end of a Raman biopsy needle (2), a biopsy channel (8) is fixedly arranged on one side, close to the biopsy window (6), of the interior of the Raman biopsy needle (2), a cutting tube (9) is arranged inside the biopsy channel (8), an optical fiber channel (12) is fixedly arranged inside the Raman biopsy needle (2) and on one side, located in the Raman window (7), the optical fiber channel (12) is integrally filled with an optical fiber (13), a beam splitting device (14) is fixedly arranged at the upper end of the optical fiber (13), a collection optical fiber connector (15) is fixedly arranged at the upper end of the beam splitting device (14), and a beam splitting piece (17) is fixedly arranged inside the beam splitting device (14).

2. A raman needle biopsy probe for nerve biopsy surgery according to claim 1, wherein: the upper end of the working sleeve (1) is fixedly provided with a working sleeve handle (3).

3. A raman needle biopsy probe for nerve biopsy surgery according to claim 1, wherein: an inner core handle (5) is fixedly arranged at the upper end of the inner core (4) of the working sleeve.

4. A raman needle biopsy probe for nerve biopsy surgery according to claim 1, wherein: a cutting groove (10) is fixedly formed in one side of the lower end of the cutting tube (9), and the cutting groove (10) is matched with the biopsy window (6).

5. A raman needle biopsy probe for nerve biopsy surgery according to claim 1, wherein: the upper end of the cutting pipe (9) is fixedly provided with a cutting handle (11), and two side walls of the cutting handle (11) are respectively fixedly provided with an opening mark and a closing mark.

6. A raman needle biopsy probe for nerve biopsy surgery according to claim 1, wherein: the collection optical fiber connector (15) is connected with a spectrometer and an artificial intelligent computer through a collection optical fiber, and the artificial intelligent computer comprises a computer, a display, raman spectrum identification software, a Raman spectrum database, raman spectrum data comparison software, laser emission control software, system control software and an artificial intelligent spectrum learning system.

7. A raman needle biopsy probe for nerve biopsy surgery according to claim 1, wherein: an excitation optical fiber connector (16) is fixedly arranged on one side of the beam splitting device (14), and the excitation optical fiber connector (16) is fixedly connected with a laser emitter through an excitation optical fiber.

8. A raman needle biopsy probe for nerve biopsy surgery according to claim 1, wherein: a biopsy handle (18) is fixedly arranged at the upper end of the Raman biopsy needle (2).