CN219048521U - High-efficient blood sampling and collection device of big mouse fundus - Google Patents
High-efficient blood sampling and collection device of big mouse fundus Download PDFInfo
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- CN219048521U CN219048521U CN202222752047.6U CN202222752047U CN219048521U CN 219048521 U CN219048521 U CN 219048521U CN 202222752047 U CN202222752047 U CN 202222752047U CN 219048521 U CN219048521 U CN 219048521U
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- 238000010241 blood sampling Methods 0.000 title claims description 13
- 239000008280 blood Substances 0.000 claims abstract description 79
- 210000004369 blood Anatomy 0.000 claims abstract description 79
- 241000699666 Mus <mouse, genus> Species 0.000 claims description 25
- 238000007789 sealing Methods 0.000 claims description 7
- 241000699670 Mus sp. Species 0.000 claims description 6
- 238000000034 method Methods 0.000 description 9
- 238000001125 extrusion Methods 0.000 description 5
- 238000010172 mouse model Methods 0.000 description 5
- 230000008569 process Effects 0.000 description 5
- 230000001681 protective effect Effects 0.000 description 5
- 230000006378 damage Effects 0.000 description 4
- 230000008859 change Effects 0.000 description 3
- 230000001739 rebound effect Effects 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- 208000027418 Wounds and injury Diseases 0.000 description 2
- 238000010171 animal model Methods 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 210000004220 fundus oculi Anatomy 0.000 description 2
- 208000014674 injury Diseases 0.000 description 2
- 230000009471 action Effects 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000004796 pathophysiological change Effects 0.000 description 1
- 238000005086 pumping Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000001360 synchronised effect Effects 0.000 description 1
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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Abstract
The utility model relates to the technical field of experimental mouse blood collection, in particular to a high-efficiency blood collection and collection device for the fundus of a large mouse, which comprises a collection cavity, wherein a piston block is arranged in the collection cavity, one side of the piston block is fixedly connected with a piston rod and a first reset spring respectively, the right end of the piston rod is provided with a fixed plate, one side of the fixed plate is fixedly connected with a capacity control rod, one side of the capacity control rod is provided with a plurality of clamping grooves, the outer side of the collection cavity is provided with a mounting plate, one side of the mounting plate is fixedly connected with a second reset spring, one end of the second reset spring is fixedly connected with a bolt, and the improved blood collection and collection device is used for collecting blood of the experimental mouse through the piston block.
Description
Technical Field
The utility model relates to the technical field of experimental mouse blood sampling, in particular to a high-efficiency blood sampling and collecting device for fundus oculi of a large mouse.
Background
In the biomedical basic research field, an animal model is generally required to verify an experiment, and a mouse model is the most commonly used experimental animal model; in the experiment, a few experimental conditions are usually applied to a mouse model, the influence of the experimental conditions on a living body is judged by observing the behavior change, the blood index change and the pathophysiological change in a tissue specimen, and when the blood index change of the mouse model is judged, the blood specimen needs to be reserved.
The mouse model has smaller volume, so the blood content is smaller; in order to obtain more blood samples, the blood sampling methods commonly used at present are as follows: the tail blood taking, the eye blood taking and the large blood vessel blood taking, wherein the blood volume obtained by taking the blood with the eyes is more and about several milliliters, so the eye blood taking becomes a blood taking method which is more commonly used for a mouse model, a blood taking and collecting device is required to be used when a laboratory mouse is subjected to blood taking, the blood taking and collecting device is required to have the basic functions of blood taking and collecting, the damage to the laboratory mouse is reduced as much as possible, the follow-up observation to the laboratory mouse is convenient, and therefore, the high-efficiency blood taking and collecting device for the fundus of the rat is an essential device in the blood taking process of the laboratory mouse.
The prior patent (publication number: CN 207444952U) discloses a high-efficiency blood collection device for the fundus of a rat and a mouse, which comprises a blood collection part and a blood collection part, wherein the blood collection part and the blood collection part are communicated through a hose; the blood sampling part comprises a blunt end metal pipe part, the lower half part of the blood sampling part is fixedly provided with a hand-held part, the hand-held part comprises a central piece and fins connected with one side or two sides of the central piece, and anti-skid salient points are arranged on the surfaces of the central piece and the fins; the blood collecting part comprises an elastic plastic blood collecting tube, and the blood collecting tube comprises an upper end part with a blood collecting nozzle and a cylindrical lower end part; the blood collecting nozzle is detachably and tightly connected with the end part of the hose; the upper end part is connected with a mouth cover which is matched with the blood collection mouth; the upper end part and the cylindrical lower end part are detachably connected through a buckle; the lower end of the column is provided with a flat bottom, a conical bottom or an arc bottom; the blood collecting tube generates negative pressure in the manual squeezing and loosening processes to collect blood, and the utility model can be used for efficiently and conveniently collecting blood and blood, has good controllability, improves the success rate of primary blood collection and the blood collecting efficiency, and is beneficial to reducing the risks of operation failure and repeated damage. The inventors found that the following problems exist in the prior art in the process of implementing the present utility model: 1. in the technical scheme, the blood collection is carried out by means of instantaneous negative pressure generated by extrusion of the blood collection tube in a rebound manner, but the rebound effect can be reduced in the long-time use process of the blood collection tube, the negative pressure pumping capacity is reduced, and the blood collection effect is affected; 2. and the quantity of blood collection depends on the extrusion degree of the fingers of the staff on the blood collection tube, so that the staff is required to judge by experience, and the blood volume error of each collection is larger.
Disclosure of Invention
The utility model aims to provide a high-efficiency blood collection device for fundus oculi of a rat and a mouse, which aims to solve the problem that the blood collection effect is reduced due to poor rebound effect along with the increase of the service time of a traditional extrusion type rubber blood collection tube in the background technology; and the blood sampling amount is completely dependent on the experience of staff, so that the control error is larger. In order to achieve the above purpose, the present utility model provides the following technical solutions: the utility model provides a high-efficient blood sampling blood collection device of big mouse fundus, includes gathers the chamber, the inside that gathers the chamber is equipped with the piston piece, one side of piston piece is fixedly connected with piston rod and first reset spring respectively, the right-hand member of piston rod is equipped with the fixed plate, one side fixedly connected with capacity control rod of fixed plate, a plurality of draw-in groove has been seted up to one side of capacity control rod, the outside that gathers the chamber is equipped with the mounting panel, one side fixedly connected with second reset spring of mounting panel, the one end fixedly connected with bolt of second reset spring, the one end middle part swing joint in gathering the chamber has the syringe needle, be connected through the connecting wire between gathering chamber and the shutoff stopper, be connected through annular fixture block between the left end in gathering the chamber and the one end of protective cover.
Further preferably, the right end of the first return spring is welded on the right inner wall of the collecting cavity, and an elastic structure is formed between the collecting cavity and the piston block through the first return spring.
Further preferably, the side surface of the collection cavity is provided with scale marks, the capacity of the collection cavity between two adjacent scale marks is 0.1ml, and the distance between the adjacent scale marks is equal to the distance between the adjacent clamping grooves on the capacity control rod.
Further preferably, a circle of sealing rings is arranged on the side face of the piston block, and the outer size structure of the sealing rings is consistent with the inner size structure of the collecting cavity.
Further preferably, the left end side of the collecting cavity and the inner side of the right end of the protecting cover are respectively provided with an annular clamping block, and the collecting cavity is clamped with the protecting cover through the clamping blocks.
Further preferably, the number of the mounting plates is two, wherein the capacity control rod and the bolt are respectively inserted into the mounting plates above, and the bolt is inserted into the clamping groove on the capacity control rod.
Compared with the prior art, the utility model has the beneficial effects that:
according to the utility model, the blood collection of the laboratory mice is realized by moving the piston block in the collection cavity, the collection mode of the traditional extrusion collection cavity is replaced, compared with the traditional extrusion collection method, the situation that the rebound effect of the collection cavity is poor due to the fact that the collection cavity is extruded for a long time in the piston type collection mode, and the collection cavity is affected by the fact that the instantaneous negative pressure is reduced when the collection cavity rebounds is avoided, the needle head can be protected inside by utilizing the protective cover, and meanwhile the probability of injury caused by careless contact between an experimenter and the needle head is reduced.
According to the utility model, the scale marks are arranged on the side surface of the collection cavity, the distance between the adjacent clamping grooves on the capacity control rod is equal to the distance between the two adjacent scale marks, the capacity control rod can be moved towards the needle head before the test mouse is subjected to blood collection, the plug is inserted into the number of the clamping grooves according to the capacity required for blood collection, the distance of each scale mark moved by the plug block in the collection cavity is 0.1ml capacity because the diameter of the collection cavity is unchanged, and when the test mouse fundus is subjected to blood collection, a rat can collect blood by about 0.4 to 0.6ml, and a mouse can collect blood by about 0.2 to 0.3ml, so that the capacity of the collection cavity is completely sufficient, and the test mouse is very convenient and can accurately control the blood collection amount.
Drawings
FIG. 1 is a schematic diagram of a front cross-sectional structure of the present utility model;
FIG. 2 is an enlarged schematic view of the structure of the utility model at A in FIG. 1;
fig. 3 is a schematic diagram of the front view structure of the present utility model.
In the figure: 1. a collection chamber; 2. a piston block; 3. a piston rod; 4. a first return spring; 5. a fixing plate; 6. a capacity control lever; 7. a clamping groove; 8. a mounting plate; 9. a second return spring; 10. a plug pin; 11. a needle; 12. sealing the plug; 13. and a protective cover.
Detailed Description
The following description of the embodiments of the present utility model will be made clearly and completely with reference to the accompanying drawings, in which it is apparent that the embodiments described are only some embodiments of the present utility model, but not all embodiments. All other embodiments, which are obtained by a worker of ordinary skill in the art without creative efforts, are within the protection scope of the present utility model based on the embodiments of the present utility model.
Referring to fig. 1 to 3, the present utility model provides a technical solution: the utility model provides a high-efficient blood sampling blood collection device of big mouse fundus, including gathering chamber 1, the inside of gathering chamber 1 is equipped with piston piece 2, one side of piston piece 2 is fixedly connected with piston rod 3 and first reset spring 4 respectively, the right-hand member of piston rod 3 is equipped with fixed plate 5, one side fixedly connected with capacity control rod 6 of fixed plate 5, a plurality of draw-in groove 7 has been seted up to one side of capacity control rod 6, the outside of gathering chamber 1 is equipped with mounting panel 8, one side fixedly connected with second reset spring 9 of mounting panel 8, the one end fixedly connected with bolt 10 of second reset spring 9, the one end middle part swing joint of gathering chamber 1 has syringe needle 11, be connected through the connecting wire between gathering chamber 1 and the shutoff stopper 12, be connected through annular fixture block between the left end of gathering chamber 1 and the one end of protecting cover 13.
In this embodiment, as shown in fig. 1, the right end of the first return spring 4 is welded on the right inner wall of the collection cavity 1, and an elastic structure is formed between the collection cavity 1 and the piston block 2 through the first return spring 4; the piston block 2 can rebound to generate instantaneous negative pressure, and blood is sucked into the collection cavity 1 from the fundus of the laboratory mouse.
In this embodiment, as shown in fig. 1 and fig. 3, the side surface of the collecting cavity 1 is provided with scale marks, the capacity of the collecting cavity between two adjacent scale marks is 0.1ml, and the distance between the adjacent scale marks is equal to the distance between the adjacent clamping grooves 7 on the capacity control rod 6; the accurate control of blood sampling volume of user of being convenient for avoids producing great error, generally the rat can take blood 0.4 to 0.6ml about, and the mouse can take blood 0.2 to 0.3ml about, only need according to the fixed position of capacity control lever 6 of scale mark can.
In this embodiment, as shown in fig. 1, a circle of sealing ring is arranged on the side surface of the piston block 2, and the external dimension structure of the sealing ring is consistent with the internal dimension structure of the collection cavity 1; can prevent that blood from spilling in the gap of piston piece 2 and collection chamber 1, keep the laboratory mouse blood of gathering in collection chamber 1.
In this embodiment, as shown in fig. 1, the left end side surface of the collecting cavity 1 and the inner side of the right end of the protecting cover 13 are respectively provided with an annular clamping block, and the collecting cavity 1 is clamped with the protecting cover 13 through the clamping blocks; the protective cover 13 can be covered at one end of the collection cavity 1 with the needle 11 when the device is not used, so that the injury caused by careless touching of the needle 11 by a user is reduced.
In this embodiment, as shown in fig. 1 and 2, the number of the mounting plates 8 is two, wherein the capacity control rod 6 and the latch 10 are respectively inserted into the mounting plates 8 positioned above, and the latch 10 is inserted into the clamping groove 7 on the capacity control rod 6; the plug pin 10 can clamp the capacity control rod 6, so that the capacity control rod 6 can be conveniently fixed at the blood capacity scale to be collected.
The application method and the advantages of the utility model are as follows: when the high-efficiency blood sampling and collecting device for the fundus of the rat and the mouse is rolled, the working process is as follows:
as shown in fig. 1, 2 and 3, firstly, the needle 11 is screwed into the left end of the collection cavity 1, when not in use, the protective cover 13 can be covered on the collection cavity 1 to prevent the needle 11 from exposing and hurting people, before the blood collection of a laboratory mouse is carried out, the volume control rod 6 is moved according to whether the collection object is a rat or a mouse, generally about 0.4 ml to 0.6ml can be collected by the rat, about 0.2 ml to 0.3ml can be collected by the mouse, then the plug pin 10 is pulled out outwards, the fixed plate 5 is pushed towards the needle 11, the fixed plate 5 simultaneously pushes the volume control rod 6 and the piston rod 3 to move, the left end of the volume control rod 6 is moved to the scale position which is the same as the volume of blood to be collected, then the plug pin 10 is released, under the action of the second reset spring 9, the plug pin 10 is inserted into the clamping groove 7 on one side of the volume control rod 6 to fix the volume control rod 6, the volume control rod 2 in the synchronous collection cavity 1 is also moved into the corresponding volume space under the pushing of the piston rod 3, then after the laboratory mouse is fixed, the needle 11 is inserted into the laboratory mouse, then the plug pin 10 is pulled out outwards, the plug pin 10 is pulled outwards, the piston rod 3 is pulled out, the blood is sucked into the cavity 1 by the piston rod 3, the volume control rod is sealed, the blood is sealed by the piston rod 1, the left end is closed by the piston rod is simultaneously, the volume of the piston rod is sealed by the piston rod 3, the needle is closed, the blood can be sucked into the volume by the volume 1, and the volume is immediately, the blood can be collected by the piston rod 1, and the blood can be recovered by the piston rod 1, and the vacuum is completely, and the blood can be collected by the blood by the piston rod is in the vacuum.
The foregoing has shown and described the basic principles, principal features and advantages of the utility model. It will be understood by those skilled in the art that the present utility model is not limited to the above-described embodiments, and that the above-described embodiments and descriptions are only preferred embodiments of the present utility model, and are not intended to limit the utility model, and that various changes and modifications may be made therein without departing from the spirit and scope of the utility model as claimed. The scope of the utility model is defined by the appended claims and equivalents thereof.
Claims (6)
1. The utility model provides a high-efficient blood sampling collection blood device of big mouse fundus, includes collection chamber (1), its characterized in that: the inside of gathering chamber (1) is equipped with piston piece (2), one side of piston piece (2) is fixedly connected with piston rod (3) and first reset spring (4) respectively, the right-hand member of piston rod (3) is equipped with fixed plate (5), one side fixedly connected with capacity control rod (6) of fixed plate (5), a plurality of draw-in groove (7) have been seted up to one side of capacity control rod (6), the outside of gathering chamber (1) is equipped with mounting panel (8), one side fixedly connected with second reset spring (9) of mounting panel (8), one end fixedly connected with bolt (10) of second reset spring (9), one end middle part swing joint of gathering chamber (1) has syringe needle (11), be connected through the connecting wire between gathering chamber (1) and the shutoff stopper (12), be connected through annular fixture block between the one end of the left end of gathering chamber (1) and protecting cover (13).
2. The high-efficiency blood collection device for fundus of mice according to claim 1, wherein: the right end of the first reset spring (4) is welded on the right inner wall of the collecting cavity (1), and an elastic structure is formed between the collecting cavity (1) and the piston block (2) through the first reset spring (4).
3. The high-efficiency blood collection device for fundus of mice according to claim 1, wherein: the side of collection chamber (1) is equipped with the scale mark, and the collection chamber capacity between two adjacent scale marks is 0.1ml, and the distance between the adjacent scale mark equals with the distance between adjacent draw-in groove (7) on capacity control lever (6).
4. The high-efficiency blood collection device for fundus of mice according to claim 1, wherein: the side of the piston block (2) is provided with a circle of sealing ring, and the outer dimension structure of the sealing ring is consistent with the inner dimension structure of the collecting cavity (1).
5. The high-efficiency blood collection device for fundus of mice according to claim 1, wherein: the left end side of collection chamber (1) and the right-hand member inboard of protecting cover (13) are equipped with annular fixture block respectively, gather through fixture block joint between chamber (1) and the protecting cover (13).
6. The high-efficiency blood collection device for fundus of mice according to claim 1, wherein: the number of the mounting plates (8) is two, wherein the capacity control rods (6) and the bolts (10) are respectively inserted into the mounting plates (8) above, and the bolts (10) are inserted into the clamping grooves (7) on the capacity control rods (6).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202222752047.6U CN219048521U (en) | 2022-10-19 | 2022-10-19 | High-efficient blood sampling and collection device of big mouse fundus |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202222752047.6U CN219048521U (en) | 2022-10-19 | 2022-10-19 | High-efficient blood sampling and collection device of big mouse fundus |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN219048521U true CN219048521U (en) | 2023-05-23 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202222752047.6U Expired - Fee Related CN219048521U (en) | 2022-10-19 | 2022-10-19 | High-efficient blood sampling and collection device of big mouse fundus |
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| Country | Link |
|---|---|
| CN (1) | CN219048521U (en) |
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2022
- 2022-10-19 CN CN202222752047.6U patent/CN219048521U/en not_active Expired - Fee Related
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| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20230523 |
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| CF01 | Termination of patent right due to non-payment of annual fee |