CN218566996U - Sample collection system is used in antibody production - Google Patents
Sample collection system is used in antibody production Download PDFInfo
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- CN218566996U CN218566996U CN202222761876.0U CN202222761876U CN218566996U CN 218566996 U CN218566996 U CN 218566996U CN 202222761876 U CN202222761876 U CN 202222761876U CN 218566996 U CN218566996 U CN 218566996U
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- 230000016784 immunoglobulin production Effects 0.000 title claims abstract description 12
- 238000007789 sealing Methods 0.000 claims abstract description 44
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- 230000007246 mechanism Effects 0.000 claims abstract description 13
- 230000002146 bilateral effect Effects 0.000 claims abstract description 9
- 230000009471 action Effects 0.000 claims description 14
- 238000001514 detection method Methods 0.000 abstract description 9
- 238000005070 sampling Methods 0.000 description 12
- 238000001125 extrusion Methods 0.000 description 4
- 230000001105 regulatory effect Effects 0.000 description 4
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- 230000008901 benefit Effects 0.000 description 1
- 230000001276 controlling effect Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
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- 230000009545 invasion Effects 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 230000033001 locomotion Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
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- 230000003472 neutralizing effect Effects 0.000 description 1
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- 230000001717 pathogenic effect Effects 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
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- 231100000765 toxin Toxicity 0.000 description 1
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Abstract
The utility model discloses a sample collecting device for antibody production, which comprises a needle tube, wherein the lower end surface of the needle tube is fixed with a needle head, the upper end of the needle tube is fixed with a support handle in bilateral symmetry, a fixed plate is arranged above the needle tube, the lower end surface of the fixed plate is fixed with a piston rod, and the piston rod is arranged at the inner side of the needle tube and can move up and down; the needle tube fixing device is characterized by also comprising a scale rod fixed on the lower end surface of the fixing plate, wherein the scale rod is arranged on the outer side of the needle tube and penetrates through the limiting ring, and the limiting ring is penetrated by the needle tube to enable the limiting ring to move up and down; the fixing box is fixed at the lower end of the inner side of the needle tube, a sealing plug is arranged above the fixing box, and the sealing plug is contacted with the fixing box to realize sealing; the movable ring is arranged below the needle tube, and a needle head in the movable ring penetrates through the needle tube to form a sliding mechanism; the utility model discloses can accomplish the back at the sample, realize avoiding external environment to cause the pollution to the sample to the automatic sealing effect of inlet, guarantee later stage detection data accuracy, and can adjust the sample volume, satisfy the actual detection demand, avoid extravagant.
Description
Technical Field
The utility model relates to an antibody sample collection system technical field specifically is an antibody sample collection system for production.
Background
The antibody is a protein with protective effect, mainly used for distinguishing bacteria and germs invading into human body from the outside, thereby realizing neutralizing toxin or preventing pathogen invasion, and further ensuring human health, with the development of science and technology, artificially synthesized antibody is also widely used, after the antibody is produced, the efficacy of the antibody needs to be detected, so as to ensure the treatment effect of the antibody, when the detection is carried out, the sampling effect on a sample needs to be realized through a sampling device, the existing sampling device for the antibody, such as a novel sampling device for detecting the antibody of the publication No. CN213372004U, comprises a needle tube, a sample tube is slidably mounted at the top of the inner end of the needle tube, 8230, a baffle ring is fixedly mounted at the top of the inner end of the needle tube, a plug is mounted at the bottom thread of the inner end of the needle tube, and the existing sampling device has certain defects when in actual use:
above-mentioned current sampling device is taking a sample the back, the syringe needle directly exposes outside and air contact, be difficult to realize sealed protection, thereby lead to dust or bacterium in the air to get into in the syringe needle with the antibody contact, and then influence the accuracy that the antibody detected, and when taking a sample, need confirm how much of sample volume according to actual need, and what of sample volume is mainly controlled through the manual work to current device, be difficult to guarantee the accuracy of sample volume, so need improve in order to satisfy the in-service use demand to above-mentioned literary composition.
SUMMERY OF THE UTILITY MODEL
An object of the utility model is to provide a sample collection system is used in antibody production to propose inconvenient realization sealed protection and influence the accuracy of antibody detection and the problem of the uncontrollable sample volume in solving above-mentioned background art.
In order to achieve the purpose, the sample collecting device for antibody production comprises a needle tube, wherein a needle head is fixed on the lower end face of the needle tube, supporting handles are symmetrically fixed at the upper end of the needle tube in a left-right mode, a fixing plate is arranged above the needle tube, and a piston rod is fixed on the lower end face of the fixing plate and is arranged on the inner side of the needle tube and can move up and down; the needle tube fixing device is characterized by further comprising a scale rod, a fixing box and a movable ring, wherein the scale rod is fixed on the lower end face of the fixing plate and arranged on the outer side of the needle tube, the scale rod penetrates through the limiting ring, and meanwhile the limiting ring is penetrated by the needle tube to enable the limiting ring to move up and down; the fixing box is fixed at the lower end of the inner side of the needle tube, a sealing plug is arranged above the fixing box, and the sealing plug is in contact with the fixing box to realize a sealing effect; the movable ring is arranged below the needle tube, and the needle head in the movable ring penetrates through the movable ring to form a sliding mechanism.
Furthermore, the piston head is fixed at the lower end of the piston rod, the piston head is in contact with the inner wall of the needle tube and can slide up and down, and negative pressure can be formed in the needle tube through the contact sliding effect between the piston head and the needle tube, so that a sample can be extracted, and the normal use of the device is ensured.
Further, the scale rod runs through the support handle and can slide from top to bottom, and the scale rod runs through the spacing ring and constitute slide mechanism, the scale rod distributes for bilateral symmetry about the central line of spacing ring, when the scale rod removes, through the scale rod with support handle and spacing ring between the slip direction effect, can guarantee the stability that the scale rod removed.
Further, still be provided with otic placode and positioning bolt on the spacing ring, the otic placode bilateral symmetry is fixed the spacing ring outside, positioning bolt through the screw thread with spacing ring interconnect, and positioning bolt and the contact of scale rod can realize the positioning action, constitute stop gear through above-mentioned mechanism, adjust through the position to the spacing ring, can adjust the spacing ring to the distance between the support handle to realize the regulation and control effect of sample volume, cooperation positioning bolt produces the extrusion force to the scale rod, can realize the positioning action, guarantees to adjust the stability of back spacing ring.
Furthermore, a vertical rod and a spring are further arranged on the sealing plug; the vertical rod is vertically fixed on the lower end face of the sealing plug and penetrates through the upper end face of the fixing box to slide up and down; the spring is fixed on the montant, and fixes in fixed box on the spring, the montant passes through to constitute elastic mechanism between spring and the fixed box, when the sealing plug does not receive exogenic action, through the effect of spring, can make sealing plug automatic re-setting realize the sealed to fixed box to avoid the sample to be contaminated, the stability that the sealing plug removed can be guaranteed in the sliding guide effect of cooperation montant.
Furthermore, the up end of the movable ring is vertically fixed with a mandril, the mandril is distributed in bilateral symmetry with the center line of the movable ring, the upper end of the mandril penetrates through the needle tube and the lower end face of the fixed box and can slide, when a sample is taken out, the movable ring moves upwards to drive the mandril to move, the mandril is jacked up the vertical rod, the sealing plug is further moved, and the normal discharge effect of the sample is ensured.
Compared with the prior art, the utility model, have following advantage:
(1) The utility model discloses be provided with the spacing ring, when controlling the sample volume, through adjusting the spacing ring to the distance between the support handle to realize the control to piston head displacement, and then realize the regulating action of feeding volume, and after the regulation is accomplished, produce the extrusion force through positioning bolt to the scale rod and can realize fixing the spacing ring, guarantee the stability of spacing ring after the regulation;
(2) The utility model is provided with the sealing plug, after sampling is completed, the air pressure in the needle tube is restored to be balanced at the moment, so that the sealing plug is restored to be in situ under the action of the spring and is contacted with the upper opening of the fixing box to realize sealing, thereby realizing the isolation effect inside and outside the needle tube, avoiding the influence of external environmental factors on antibodies in the needle tube and ensuring the accuracy of antibody detection data;
(3) The utility model discloses an elasticity is from seal mechanism can realize the self-sealing effect to the inlet after the sample is accomplished to avoid external environment to cause the pollution to the sample, guarantee the accuracy of later stage detection data, cooperation adjustment mechanism can adjust the sample volume according to the actual demand, so that satisfy the actual detection demand, avoid extravagant.
Drawings
Fig. 1 is a schematic overall front view structure diagram of the present invention;
FIG. 2 is a schematic view of the front cross-sectional structure of the needle tube of the present invention;
FIG. 3 is a schematic top view of the needle cannula of the present invention;
FIG. 4 is a schematic view of the front cross-sectional structure of the fixing box of the present invention;
fig. 5 is an enlarged schematic view of a portion a in fig. 4 according to the present invention.
In the figure: 1. a needle tube; 2. a needle head; 3. a support handle; 4. a fixing plate; 5. a piston rod; 6. a piston head; 7. a graduated rod; 8. a limiting ring; 801. an ear plate; 802. positioning the bolt; 9. a fixing box; 10. a sealing plug; 1001. a vertical rod; 1002. a spring; 11. a movable ring; 1101. and a push rod.
Detailed Description
The invention is further described below with reference to the accompanying drawings:
as shown in the accompanying drawings 1 to 5, the utility model provides a sample collecting device for antibody production, which comprises a needle tube 1, wherein the lower end surface of the needle tube 1 is fixed with a needle head 2, the upper end of the needle tube 1 is fixed with a support handle 3 in a bilateral symmetry way, a fixing plate 4 is arranged above the needle tube 1, meanwhile, the lower end surface of the fixing plate 4 is fixed with a piston rod 5, and the piston rod 5 is arranged at the inner side of the needle tube 1 and can move up and down; the needle tube fixing device further comprises a scale rod 7, a fixing box 9 and a movable ring 11, wherein the scale rod 7 is fixed on the lower end face of the fixing plate 4, the scale rod 7 is arranged on the outer side of the needle tube 1, the scale rod 7 penetrates through the limiting ring 8, and meanwhile the limiting ring 8 is penetrated through by the needle tube 1 to enable the limiting ring 8 to move up and down; the fixing box 9 is fixed at the lower end of the inner side of the needle tube 1, a sealing plug 10 is arranged above the fixing box 9, and the sealing plug 10 is contacted with the fixing box 9 to realize a sealing effect; the movable ring 11 is arranged below the needle tube 1, and the needle head 2 in the movable ring 11 penetrates through to form a sliding mechanism.
Wherein, the lower end of the piston rod 5 is fixed with a piston head 6, and the piston head 6 is contacted with the inner wall of the needle tube 1 to slide up and down; the scale rod 7 penetrates through the support handle 3 to slide up and down, the scale rod 7 penetrates through the limiting ring 8 to form a sliding mechanism, and the scale rod 7 is distributed in bilateral symmetry about the central line of the limiting ring 8; the limiting ring 8 is also provided with an ear plate 801 and a positioning bolt 802; the ear plates 801 are symmetrically fixed at the outer side of the limit ring 8; the positioning bolt 802 is connected with the limiting ring 8 through threads, and the positioning bolt 802 is in contact with the scale rod 7 to achieve the positioning effect.
The utility model discloses when using, at first adjust the sample volume according to actual need, through not hard up positioning bolt 802, make positioning bolt 802 and the separation of scale rod 7, remove the positioning action to spacing ring 8, promote otic placode 801 again, the sliding action between cooperation spacing ring 8 and the scale rod 7, can adjust the position of spacing ring 8, thereby adjust spacing ring 8 to the distance between the support handle 3, and then realize the regulating action of sample volume, after adjusting, through rotating positioning bolt 802, make positioning bolt 802 and the contact of scale rod 7 produce the extrusion force, thereby realize the fixed action to spacing ring 8, guarantee the stability of spacing ring 8.
The sealing plug 10 is also provided with a vertical rod 1001 and a spring 1002; the vertical rod 1001 is vertically fixed on the lower end face of the sealing plug 10, and the vertical rod 1001 penetrates through the upper end face of the fixing box 9 and can slide up and down; the spring 1002 is fixed on the vertical rod 1001, the upper end of the spring 1002 is fixed in the fixed box 9, and the vertical rod 1001 and the fixed box 9 form an elastic mechanism through the spring 1002; the top end face of the movable ring 11 is vertically fixed with a push rod 1101, the push rod 1101 is distributed symmetrically with the center line of the movable ring 11, and the top end of the push rod 1101 penetrates through the needle tube 1 and the lower end face of the fixing box 9 to slide.
After the sampling amount is adjusted, when sampling is carried out, the needle head 2 is penetrated into the antibody storage tank, the needle head 2 is immersed in the antibody solution, the fixing plate 4 is pulled, so that the piston rod 5, the piston head 6, the scale rod 7 and the limiting ring 8 are driven to move, negative pressure can be formed in the needle tube 1 through the contact sliding action of the piston head 6 and the inner wall of the needle tube 1, at the moment, the sealing plug 10 is forced to move upwards under the action of the negative pressure, the stability of the movement of the sealing plug 10 can be ensured by matching the sliding action between the vertical rod 1001 and the fixing box 9, the spring 1002 is forced to contract, at the moment, the sealing plug 10 is separated from the fixing box 9, the sealing action on the opening of the fixing box 9 is released, at the moment, the antibody solution enters the needle tube 1 through the needle head 2, so that the collection effect of the antibody sample is realized, until 8 move to with the contact of support handle 3 of spacing ring, thereby accomplish the sample collection effect, be full of by the antibody sample in the needle tubing 1 this moment, pressure resumes the balance, through the effect of spring 1002, can make sealing plug 10 resume the normal position and realize sealedly with fixed box 9 upper shed contact, thereby realize the isolated effect of air, guarantee the sealed effect of sample, avoid the sample to be contaminated by external factors and influence the accuracy of detection data, when needs take out the sample in the needle tubing 1, only need through pressing down movable ring 11, thereby drive ejector pin 1101 rebound, when ejector pin 1101 and montant 1001 contact, can make montant 1001 rebound, thereby make sealing plug 10 and fixed box 9 separation, press down fixed plate 4 again and drive piston rod 5 and piston head 6 and move down, can realize the effect of taking out of antibody, conveniently detect.
The utility model discloses a theory of operation does: when the sample collection device for antibody production is used, firstly, the sampling amount is regulated according to actual needs, the distance between the limiting ring 8 and the support handle 3 is regulated, the regulation effect of the sampling amount can be realized, the positioning bolt 802 is matched with the scale rod 7 to generate extrusion force in a contact manner, the fixing effect on the limiting ring 8 can be realized, the stability of the limiting ring 8 is ensured, after the regulation is completed, when the sampling is carried out, the needle 2 is immersed in an antibody storage tank, the needle 2 is immersed in an antibody solution at the moment, and then the fixing plate 4 is pulled, so that the piston rod 5, the piston head 6, the scale rod 7 and the limiting ring 8 are driven to move, negative pressure can be formed in the needle tube 1 through the action of the piston head 6, so that the sealing plug 10 is forced to move upwards, the sealing effect on the opening of the fixing box 9 is relieved, at the antibody solution enters the needle tube 1 through the needle 2 at the moment, the collection effect of the antibody sample is realized, the limiting ring 8 moves to be in contact with the support handle 3 until the sealing plug 8 is in contact with the sealing plug, so that the sample collection effect is completed, the pressure in the balance in the sealing plug 1 is restored, the sealing effect is realized through the action of restoring the sealing plug 10, the sealing plug to realize the accurate sealing effect of the air sealing plug for sample collection, and the detection principle of the sample collection device, thereby the sample collection device, and the sample collection effect is prevented from being polluted by the external pollution.
The present invention is not limited by the above embodiments, and any other changes, modifications, substitutions, combinations, and simplifications which do not depart from the spirit and principle of the present invention should be equivalent replacement modes, and are all included in the protection scope of the present invention.
Claims (6)
1. A sample collecting device for antibody production comprises a needle tube (1), wherein a needle head (2) is fixed on the lower end face of the needle tube (1), supporting handles (3) are symmetrically fixed on the upper end of the needle tube (1) in a left-right mode, a fixing plate (4) is arranged above the needle tube (1), a piston rod (5) is fixed on the lower end face of the fixing plate (4), and the piston rod (5) is arranged on the inner side of the needle tube (1) and can move up and down; it is characterized by also comprising a scale rod (7), a fixed box (9) and a movable ring (11), wherein,
the scale rod (7) is fixed on the lower end face of the fixing plate (4), the scale rod (7) is arranged on the outer side of the needle tube (1), the scale rod (7) penetrates through the limiting ring (8), and meanwhile the limiting ring (8) is penetrated through by the needle tube (1) to enable the limiting ring (8) to move up and down;
the fixing box (9) is fixed at the lower end of the inner side of the needle tube (1), a sealing plug (10) is arranged above the fixing box (9), and the sealing plug (10) is in contact with the fixing box (9) to realize a sealing effect;
the movable ring (11) is arranged below the needle tube (1), and the needle head (2) in the movable ring (11) penetrates through the needle tube to form a sliding mechanism.
2. The antibody production sample collection device according to claim 1, wherein: the lower end of the piston rod (5) is fixed with a piston head (6), and the piston head (6) is in contact with the inner wall of the needle tube (1) and can slide up and down.
3. The antibody production sample collection device according to claim 1, wherein: the scale rod (7) penetrates through the support handle (3) and can slide up and down, the scale rod (7) penetrates through the limiting ring (8) to form a sliding mechanism, and the scale rod (7) is distributed in a bilateral symmetry mode about the central line of the limiting ring (8).
4. The antibody production sample collection device according to claim 1, wherein: still be provided with otic placode (801) and positioning bolt (802) on spacing ring (8), otic placode (801) bilateral symmetry is fixed spacing ring (8) outside, positioning bolt (802) pass through screw thread and spacing ring (8) interconnect, and positioning bolt (802) and scale rod (7) contact can realize the positioning action.
5. The antibody production sample collection device according to claim 1, wherein: the sealing plug (10) is also provided with a vertical rod (1001) and a spring (1002), the vertical rod (1001) is vertically fixed on the lower end face of the sealing plug (10), and the vertical rod (1001) penetrates through the upper end face of the fixing box (9) to slide up and down; the spring (1002) is fixed on the vertical rod (1001), the upper end of the spring (1002) is fixed in the fixed box (9), and the vertical rod (1001) and the fixed box (9) form an elastic mechanism through the spring (1002).
6. An antibody-producing sample collection device according to any one of claims 1 to 5, wherein: ejector rods (1101) are vertically fixed on the upper end face of the movable ring (11), the ejector rods (1101) are distributed in a bilateral symmetry mode about the center line of the movable ring (11), and the upper end of the ejector rods (1101) penetrates through the needle tube (1) and the lower end face of the fixing box (9) to be capable of sliding.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202222761876.0U CN218566996U (en) | 2022-10-17 | 2022-10-17 | Sample collection system is used in antibody production |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202222761876.0U CN218566996U (en) | 2022-10-17 | 2022-10-17 | Sample collection system is used in antibody production |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN218566996U true CN218566996U (en) | 2023-03-03 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202222761876.0U Active CN218566996U (en) | 2022-10-17 | 2022-10-17 | Sample collection system is used in antibody production |
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| Country | Link |
|---|---|
| CN (1) | CN218566996U (en) |
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2022
- 2022-10-17 CN CN202222761876.0U patent/CN218566996U/en active Active
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