CN217438181U - Gene sequencer and sequencing chip loading device thereof - Google Patents
Gene sequencer and sequencing chip loading device thereof Download PDFInfo
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- CN217438181U CN217438181U CN202221455542.4U CN202221455542U CN217438181U CN 217438181 U CN217438181 U CN 217438181U CN 202221455542 U CN202221455542 U CN 202221455542U CN 217438181 U CN217438181 U CN 217438181U
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Abstract
本实用新型公开了一种基因测序仪及其测序芯片装载装置，测序芯片装载装置包括测序元件、芯片平台、定位机构和压紧机构，所述芯片平台的表面设置有真空槽道，所述测序元件放置于所述芯片平台，所述定位机构使所述测序元件定位，所述压紧机构将所述测序元件中的测序芯片压紧在所述芯片平台上。上述测序芯片装载装置，结合真空吸附及压紧固定两种方式，提高了测序元件中测序芯片的固定效果。
The utility model discloses a gene sequencer and a sequencing chip loading device thereof. The sequencing chip loading device comprises a sequencing element, a chip platform, a positioning mechanism and a pressing mechanism. A vacuum channel is arranged on the surface of the chip platform. The element is placed on the chip platform, the positioning mechanism positions the sequencing element, and the pressing mechanism compresses the sequencing chip in the sequencing element on the chip platform. The above-mentioned sequencing chip loading device, combined with two methods of vacuum adsorption and pressing and fixing, improves the fixing effect of the sequencing chip in the sequencing element.
Description
Technical Field
The utility model relates to a medical equipment technical field, in particular to sequencing chip loading attachment. Also relates to a gene sequencer.
Background
A gene sequencer is an instrument in the biochemical and medical fields and is used for sequencing DNA. The basic structure of the chip comprises a sequencing element and a chip platform for loading the sequencing element, wherein an etched microfluid flow channel is arranged in the sequencing chip of the sequencing element, and two ends of the flow channel are respectively provided with an opening, so that a reagent or a sample flows in and out from the openings, and then a sequencing reaction is carried out in the flow channel.
Generally, most sequencing components include a sequencing chip and a housing for holding the sequencing chip, and the housing is generally accessible to a user and also facilitates positioning of the sequencing chip. In the process of testing the sequencing chip, the sequencing chip is difficult to accurately position due to the small chip size, so that the sequencing error is caused, and the sequencing chip needs to be accurately positioned. At present, most of sequencing chips loaded on a chip platform only adopt a mechanical pressing mode, and a cover component is utilized to tightly press the sequencing chip on the chip platform, so that the following defects exist: the bending of the sequencing chip and the deterioration of the flatness are easily caused, and the subsequent sequencing work is influenced.
Therefore, how to provide a sequencing chip loading device that solves the above technical problems is a technical problem that needs to be solved urgently by those skilled in the art.
SUMMERY OF THE UTILITY MODEL
The utility model aims at providing a sequencing chip loading attachment for gene sequencer combines vacuum adsorption and compresses tightly fixed dual mode, has improved sequencing element's fixed effect. Another object of the utility model is to provide a gene sequencer, adopt above-mentioned sequencing chip loading attachment.
In order to realize the above object, the utility model provides a sequencing chip loading attachment, including sequencing component, chip platform, positioning mechanism and hold-down mechanism, the surface of chip platform is provided with the vacuum channel, the sequencing component place in the chip platform, positioning mechanism makes the sequencing component location, hold-down mechanism will sequencing chip in the sequencing component compresses tightly on the chip platform.
Preferably, the positioning mechanism is used for positioning the peripheral side of the sequencing element, and the pressing mechanism is used for fixing the upper side of the sequencing element.
Preferably, the positioning mechanism comprises a top member and at least two sets of positioning members arranged on the chip platform, wherein the top member is used for elastically pushing the sequencing element so as to enable at least two non-parallel side surfaces of the sequencing element to be positioned and attached to the positioning members.
Preferably, the sequencing component is including installing the casing of sequencing chip, the inboard of casing is provided with the confession the constant head tank that the setting element penetrated, the outside of casing is provided with the confession the tight notch in top tight piece top, top tight piece elasticity top during the casing sequencing chip's side with the setting element location laminating.
Preferably, the sequencing element is substantially rectangular in shape, the positioning members include at least one first positioning member for longitudinal positioning and at least one second positioning member for lateral positioning, and the housing is provided with a first positioning slot matching with the first positioning member and a second positioning slot matching with the second positioning member.
Preferably, two sides of the chip platform are provided with sealing blocks, the sequencing element further comprises a sealing member mounted on the housing, the sealing blocks are provided with first fluid ports, the sealing member is provided with second fluid ports, the sequencing chip is provided with third fluid ports, and the first fluid ports, the second fluid ports and the third fluid ports are aligned.
Preferably, a third driving member is arranged on one side of the chip platform, the third driving member is connected with and drives a second transmission shaft, the second transmission shaft is provided with a first cam piece and a second cam piece, the first cam piece and the second cam piece are both connected with a moving piece, and the sealing block is arranged on the moving piece; the sealing piece is further provided with a positioning hole, and the sealing block is provided with a third positioning piece matched with the positioning hole in a positioning mode.
Preferably, the compressing mechanism comprises a compressing piece and a driving piece for driving the compressing piece to compress the sequencing element; the pressing piece is connected with an induction piece, and the induction piece is subjected to induction detection by the detection piece.
Preferably, the pressing mechanism further comprises a first transmission shaft, the first transmission shaft is used for installing the pressing piece, and the first transmission shaft is connected through a transmission piece and driven by the driving piece; the driving part comprises a first driving part and a second driving part which are respectively positioned on two sides of the chip platform.
The utility model also provides a gene sequencer, including image acquisition device and above-mentioned sequencing chip loading attachment.
Compared with the prior art, the utility model provides a sequencing chip loading attachment includes sequencing component, chip platform, positioning mechanism and hold-down mechanism, and the surface of chip platform is provided with the vacuum channel, and the sequencing component is placed in the chip platform, and positioning mechanism makes the sequencing component location, and the sequencing chip of hold-down mechanism in with the sequencing component compresses tightly on the chip platform.
In the working process of the sequencing chip loading device, a vacuum channel on the surface of a chip platform is vacuumized, so that a sequencing chip in a sequencing element on the chip platform is vacuum-absorbed, and a first fixing effect is provided; the sequencing element on the chip platform is also positioned by the positioning mechanism, and a sequencing chip in the sequencing element is also tightly pressed on the chip platform to provide a second fixing function. Above-mentioned sequencing chip loading attachment combines vacuum adsorption and compresses tightly fixed two kinds of modes, has improved the fixed effect of sequencing chip among the sequencing component: the vacuum adsorption solves the problem of bending caused by a mechanical compression mode, improves the flatness and facilitates the smooth proceeding of subsequent sequencing work; moreover, the process can realize automation, and the operation is simple and convenient.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings required to be used in the description of the embodiments or the prior art will be briefly described below, it is obvious that the drawings in the following description are only embodiments of the present invention, and for those skilled in the art, other drawings can be obtained according to the provided drawings without creative efforts.
Fig. 1 is a schematic diagram illustrating an effect of a sequencing chip loading device according to an embodiment of the present invention;
fig. 2 is a schematic structural diagram of a sequencing chip loading apparatus according to an embodiment of the present invention;
FIG. 3 is a schematic structural diagram of a gene sequencer according to an embodiment of the present invention;
FIG. 4 is a top view of FIG. 1;
FIG. 5 is a top view of FIG. 2;
FIG. 6 is a top view of FIG. 3;
FIG. 7 is a schematic diagram of a partial enlargement at the sequencing element of FIG. 1;
FIG. 8 is a schematic bottom view of the structure of FIG. 1;
FIG. 9 is a right side view of FIG. 1;
FIG. 10 is a schematic diagram of the sequencing element of FIG. 1;
FIG. 11 is an exploded view of the sequencing element of FIG. 1;
FIG. 12 is a schematic view of the housing of FIG. 10;
fig. 13 is a front view of fig. 12.
Wherein:
1-a chip platform, 2-a first positioning member, 3-a second positioning member, 4-a sequencing chip, 5-a shell assembly, 6-a top clamping member, 7-a pressing member, 8-an elastic member, 9-a first driving member, 10-a second driving member, 11-a third driving member, 12-a first driving member, 13-a second driving member, 14-a first transmission shaft, 15-a sealing block, 16-a third positioning member, 17-a sensing member, 18-a first detection member, 19-a second detection member, 20-a first fluid port, 21-an image acquisition device, 22-a first groove surface, 23-a second groove surface, 24-a second transmission shaft, 25-a first cam member, 26-a second cam member, 27-a motion member, 28-a sealing member, 29-a second fluid port, 30-a positioning hole, 31-a shell, 32-a third fluid port, 33-a mounting piece, 34-a first positioning groove, 35-a second positioning groove, 36-a first limiting part, 37-a second limiting part and 38-a boss.
Detailed Description
The technical solutions in the embodiments of the present invention will be described clearly and completely with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only some embodiments of the present invention, not all embodiments. Based on the embodiments in the present invention, all other embodiments obtained by a person skilled in the art without creative work belong to the protection scope of the present invention.
In order to make the technical field of the present invention better understand, the present invention will be described in detail with reference to the accompanying drawings and the detailed description.
Please refer to fig. 1 to 13, wherein fig. 1 is a schematic diagram illustrating an effect of a sequencing chip loading device according to an embodiment of the present invention, fig. 2 is a schematic diagram illustrating a structure of a sequencing chip loading device according to an embodiment of the present invention, fig. 3 is a schematic diagram illustrating a structure of a gene sequencer according to an embodiment of the present invention, fig. 4 is a top view of fig. 1, fig. 5 is a top view of fig. 2, fig. 6 is a top view of fig. 3, fig. 7 is a schematic diagram illustrating a portion of a sequencing element in fig. 1 in an enlarged manner, fig. 8 is a schematic diagram illustrating a bottom structure of fig. 1, fig. 9 is a right side view of fig. 1, fig. 10 is a schematic diagram illustrating a structure of a sequencing element in fig. 1, fig. 11 is an exploded schematic diagram of a sequencing element in fig. 1, fig. 12 is a schematic diagram illustrating a structure of a housing in fig. 10, and fig. 13 is a front view of fig. 12.
In a first specific implementation mode, the utility model provides a sequencing chip loading attachment includes sequencing component, chip platform 1, positioning mechanism and hold-down mechanism, and chip platform 1's surface is provided with the vacuum channel, and the sequencing component is placed in chip platform 1, and positioning mechanism makes the sequencing component location, and hold-down mechanism compresses tightly sequencing chip 4 in the sequencing component on chip platform 1.
In the embodiment, the positioning and pressing mechanism provides positioning and pressing and fixing functions for the sequencing element; the vacuum channel can be connected with a vacuum device through a gas pipe, such as a vacuum pump, and a vacuum environment is constructed through the vacuum channel to provide an adsorption fixing function for the sequencing chip 4 in the sequencing element.
In the working process of the sequencing chip loading device, a vacuum channel on the surface of the chip platform 1 is vacuumized, so that a sequencing chip 4 in a sequencing element on the chip platform 1 is vacuum-absorbed, and a first fixing effect is provided; the sequencing element on the chip platform 1 is also acted by a positioning and pressing mechanism, and the positioning and pressing mechanism presses the sequencing element after positioning to provide a second fixing action. Above-mentioned sequencing chip loading attachment combines vacuum adsorption and compresses tightly fixed two kinds of modes, has improved the fixed effect of sequencing component: the vacuum adsorption solves the problem that the sequencing element is bent due to a mechanical compression mode, improves the flatness of the sequencing element and facilitates the smooth operation of subsequent sequencing work; moreover, the process can realize automation, and the operation is simple and convenient.
In the vacuum adsorption principle, at least one shallow groove communicated with each other is formed in the surface of the chip platform 1, when a sequencing element is arranged on the chip platform 1, a closed cavity is formed by the lower surface of the sequencing chip 4 and the shallow groove on the chip platform 1, then a vacuum pump is used for pumping air in the cavity away to form a negative pressure condition, and the sequencing chip 4 in the sequencing element can be adsorbed on the chip platform 1 by utilizing atmospheric pressure.
It should be noted that, the sequencing element can be adsorbed on the chip platform 1 only by using a vacuum adsorption mode, but in the actual processing process, the cavity formed by the lower surface of the sequencing element and the shallow groove on the chip platform 1 is actually gapped, so that the adsorption is not firm, and therefore, the two fixing modes of pressing down and fixing and vacuum adsorption need to be combined, and the stability of positioning and pressing of the sequencing element is improved.
Furthermore, the positioning and pressing mechanism comprises a positioning mechanism and a pressing mechanism, the positioning mechanism is used for positioning the periphery of the sequencing element, and the pressing mechanism is used for fixing the upper side of the sequencing element.
In this embodiment, the positioning and pressing mechanism is divided into two parts, one of which is a positioning mechanism for providing a positioning function, and the positioning mechanism performs positioning when being installed on the peripheral side of the sequencing element; and the second is a pressing mechanism for providing a fixing effect, and the pressing mechanism is used for fixing the sequencing element after positioning.
In a specific embodiment, the positioning mechanism comprises a holding member 6 and at least two sets of positioning members disposed on the chip platform 1, wherein the holding member 6 is used for elastically holding the sequencing element so that at least two non-parallel sides of the sequencing element are positioned and attached to the positioning members.
In this embodiment, the tightening member 6 serves as a plug to provide a tightening action to the sequencing element on the periphery of the sequencing element, so that the acted sequencing element is contacted with the positioning member, and the sequencing element is contacted and positioned by the positioning member.
It should be noted that, in order to accurately position the sequencing element in the plane XOY, at least two faces of the sequencing element are positioned, and the two faces need to be in a non-parallel state, so that at least two sets of positioning elements corresponding to the faces are required.
In the present embodiment, the sequencing element includes a sequencing chip 4 and a housing assembly 5, the housing assembly 5 having a housing 31 for mounting the sequencing chip 4, and the positioning and fixing of the sequencing element is substantially the positioning and fixing of the sequencing chip 4.
Illustratively, a positioning groove is formed in the inner side of the housing 31, and the positioning groove is used for the positioning element to penetrate through, so that the setting position of the positioning groove corresponds to the setting position of the positioning element; the positioning slot is communicated with an opening of the casing 31 for installing the sequencing chip 4, so that the sequencing chip 4 in the casing 31 is positioned by the contact of the positioning piece when the pushing piece 6 pushes the sequencing element tightly.
Specifically, a notch is formed on the outer side of the housing 31, and the notch is used for tightly pushing the tightening piece 6 and is an action point of the tightening piece 6 on the sequencing element; the notch has the groove face of slope to the quantity of setting element is two sets of examples, and when the tight piece 6 in notch department top tight casing 31 in the top, receive the slope effect of groove face, casing 31's motion can be decomposed into the motion to two sets of setting elements, and casing 31 drives sequencing chip 4 again and removes, and then realizes the contact positioning effect of two sets of setting elements to sequencing chip 4.
Illustratively, as shown in fig. 7, the notch has a trapezoidal shape, and has a horizontal groove surface and a first groove surface 22 and a second groove surface 23 located on both sides of the groove surface, and both the first groove surface 22 and the second groove surface 23 are inclined; when the tightening member 6 is tightened and pushed at the first groove surface 22, the housing 31 moves to the left and back; when the tightening member 6 is pushed and tightened at the second groove surface 23, the housing 31 moves to the right and backward. In addition, other shapes such as a triangle, as long as the hypotenuse is not parallel to the X and Y directions, should also fall within the scope of the present embodiment.
Further, the tightening member 6 is an elastic plug which can be elastically compressed to maintain a proper force.
Illustratively, the shape of the sequencing element is substantially rectangular, and the shapes of the sequencing chip 4 and the housing 31 are both substantially rectangular, that is, the shapes of regular rectangles and irregular rectangles such as unfilled corners should also fall within the scope of the present embodiment.
Illustratively, the positioning members are two groups, one of which is a first positioning member 2 for longitudinal positioning, and the number may be at least one; two of them are second positioning members 3 for transverse positioning, and the number can be at least one.
Correspondingly, the housing 31 is provided with a first positioning groove 34 matching with the first positioning element 2 and a second positioning groove 35 matching with the second positioning element 3.
Further, the housing 31 is provided with a first position-limiting portion 36 and a second position-limiting portion 37 for limiting the position of the sequencing chip 4 at two vertical sides.
In the present embodiment, the first position-limiting portion 36 is located at the upper portion, and functions to prevent the sequencing chip 4 from separating upwards; the second position-limiting portion 37 is located at the lower portion and is used for preventing the sequencing chip 4 from falling off downwards.
Besides, it should be noted that there are various driving manners of the tightening unit 6, including but not limited to manual and automatic, and automatic driving manners, including but not limited to electric, start and hydraulic, etc., and shall also fall within the scope of the present embodiment.
In a specific explanation, reference may be made to fig. 1, in which the tightening member 6 as an elastic plug is pushed out, the tightening member 6 pushes the bevel edge of the housing 31 as an outer frame to move to the upper right (in a non-specific direction), a boss 38 is disposed on the inner side of the outer frame, and the boss 38 brings the sequencing chip 4 into contact with the first positioning member 2 and the second positioning member 3 as positioning pins in the XY directions, so as to accurately position the sequencing chip 4.
It should be noted that there are many arrangements of the bosses 38, which may be in the illustrated form, or at least 2 non-parallel groups, each group including at least one boss 38, and the bosses 38 may be in an arc shape, a spherical shape, or a rectangular shape, and the like, and the present invention also belongs to the description scope of the present embodiment.
In a specific embodiment, the pressing mechanism comprises a pressing member 7 and a driving member for driving the pressing member 7 to press the sequencing element; the pressing piece 7 is connected with a sensing piece 17, and the sensing piece 17 is sensed and detected by a detecting piece.
In the embodiment, the pressing member 7 is used for pressing and fixing the sequencing element and the sequencing chip 4 thereof under the action of the driving member; the sensing piece 17 moves along with the pressing piece 7, and the sensing piece 17 is detected by the detection piece, so that the pressing piece 7 reaches a preset position by detecting the movement change of the pressing piece 7, and automatic control is realized.
Illustratively, the detecting member comprises a first detecting member 18 and a second detecting member 19 which are arranged at the left and right sides separately, and the position of the sensing member 17 is detected through the separated first detecting member 18 and second detecting member 19, so as to judge the motion change of the pressing member 7; after the detection piece detects that the pressing piece 7 moves in place, the driving piece stops acting, and at the moment, the pressing piece 7 just presses the sequencing chip 4 on the chip platform 1 with proper force.
Specifically, taking two sets of pressing mechanisms as an example, the driving members include a first driving member 9 and a second driving member 10 respectively located at two sides of the chip platform 1, and the two sides of the sequencing chip 4 are pressed down and fixed by the two sets of pressing mechanisms.
On the basis, for each group of pressing mechanisms, the pressing mechanism further comprises a first transmission shaft 14, the pressing piece 7 is arranged on the first transmission shaft 14, and the first transmission shaft 14 is connected through a transmission piece and driven by a driving piece.
In this embodiment, the first driving element 9 and the second driving element 10 are used as power sources, and under the action of the driving element, the first transmission shaft 14 is driven to rotate around the shaft, and the pressing element 7 is driven by the first transmission shaft 14 to move together, so that the rotation of the pressing element 7 is utilized to realize downward pressing and fixing of the sequencing chip 4.
It should be noted that there are various types of the above-mentioned transmission members, including but not limited to the first transmission member 12 and the second transmission member 13 in the form of gears shown in fig. 1, and may also be a synchronous belt, or a direct drive, and shall fall within the scope of the present embodiment; the first drive element 9 and the second drive element 10 should be synchronized during operation.
Furthermore, compressing tightly piece 7 still is provided with elastic component 8, and elastic component 8's effect lies in guaranteeing compressing tightly piece 7 and sequencing chip 4 and contacting at appropriate power, avoids compressing tightly the too big damage sequencing chip 4 of the pressure of piece 7.
Besides, the chip platform 1 is provided with sealing blocks 15 on both sides, the sequencing element further comprises a sealing member 28 mounted on the housing 31, the sealing block 15 is provided with a first fluid port 20, the sealing member 28 is provided with a second fluid port 29, the sequencing chip 4 is provided with a third fluid port 32, and the first fluid port 20, the second fluid port 29 and the third fluid port 32 are aligned.
It should be noted that the sealing member 28 may be disposed in association with the housing 31 or in association with the sealing block 15, and it is within the scope of the present embodiment as long as the sealing member 28 is pressed to be closely attached to the sequencing chip 4 by the ascending of the sealing block 15, so that the second fluid port 29 and the third fluid port 32 are completely aligned to form a high-quality sealing state.
On the basis, the sealing block 15 can move up and down, and is in contact with and sealed communication with the sealing piece 28 of the shell 31 after the sealing block 15 moves upwards.
Specifically, a third driving member 11 is disposed on one side of the chip platform 1, the third driving member 11 is connected to and drives a second transmission shaft 24, the second transmission shaft 24 is provided with a first cam member 25 and a second cam member 26, the first cam member 25 and the second cam member 26 are both connected to a moving member 27, and the sealing block 15 is mounted on the moving member 27.
In the embodiment, the cam piece is in the form of a cam, has the characteristics of eccentricity and diameter variation, and can jump up and down during rotation, so that the effect of converting the rotation action into the up-and-down action is realized; when the third driving member 11 is actuated, the third driving member 11 drives the second transmission shaft 24 to rotate, and the first cam member 25 and the second cam member 26 drive the respective moving member 27 to move up and down, thereby driving the sealing block 15 to move.
It should be noted that there are various assembling manners of the sealing block 15 and the moving element 27, including but not limited to separate assembling or integral molding, and the assembling manner should also fall within the scope of the present embodiment.
Wherein, the sealing elements 28 are respectively arranged on the lower surfaces of two sides of the shell 31, the shell 31 is provided with a mounting part 33 matched with the positioning hole 30, the mounting part 33 is preferably a hook, and the sealing elements 28 are mounted and fixed through the hook; the sealing member 28 has two second fluid ports 29, and after the sequencing chip 4 is positioned and pressed on the chip platform 1, the second fluid ports 29 of the sealing member 28 are aligned with the third fluid ports 32 on the sequencing chip 4, so that a better sealing effect is formed, and a foundation is laid for subsequent sequencing work.
On the basis, the sealing element 28 is also provided with a positioning hole 30, and the upper side of the sealing block 15 is provided with a third positioning element 16 matched with the positioning hole 30; after the sealing block 15 is driven by the third driving member 11 to move upwards, the third positioning member 16 is positioned and matched with the positioning hole 30, and at this time, the first fluid port 20 of the sealing block 15, the second fluid port 29 of the sealing member 28 and the third fluid port 32 of the sequencing chip 4 are aligned, so that the sealing performance is ensured.
It should be noted that the seal 28 is a compressible material, and that the seal 28 is compressed to a maximum amount or a predetermined range of compression when the cam member rotates the seal block 15 up to the uppermost position.
The sequencing chip loading device is also provided with a control system, and the control system is connected with the mechanisms and the components thereof to realize an automatic control process.
The sequencing chip loading device can realize the positioning of the sequencing chip 4 and the close abutment of the sequencing chip 4 on the chip platform 1. After the sequencing chip 4 is positioned by the positioning mechanism, the control system obtains a signal to turn on the vacuum pump, the sequencing chip 4 is adsorbed on the chip platform 1 by utilizing vacuum adsorption, then the control system controls the first driving piece 9 and the second driving piece 10 to synchronously act, the pressing piece 7 is driven to rotate, then the first side surface of the sequencing chip 4 is pressed downwards, and the sequencing chip 4 is abutted against the chip platform 1; then, the third driving member 11 is controlled to move to drive the sealing block 15 to ascend, so that the sequencing chip 4, the sealing member 28 and the sealing block 15 abut against each other, and the first fluid port 20, the second fluid port 29 and the third fluid port 32 are aligned, thereby completing the positioning and compressing functions of the sequencing chip 4.
The utility model also provides a gene sequencer, which comprises an image acquisition device 21 and the sequencing chip loading device, and in addition, other parts of the existing gene sequencer are required to be arranged, which are not described again; the gene sequencer should have all the beneficial effects of the sequencing chip loading device, and the description is omitted.
It is noted that, in this specification, relational terms such as first and second, and the like are used solely to distinguish one entity from another entity without necessarily requiring or implying any actual such relationship or order between such entities.
The gene sequencer and the sequencing chip loading device thereof provided by the utility model are introduced in detail. The principles and embodiments of the present invention have been explained herein using specific examples, and the above descriptions of the embodiments are only used to help understand the method and its core ideas of the present invention. It should be noted that, for those skilled in the art, without departing from the principle of the present invention, the present invention can be further modified and modified, and such modifications and modifications also fall within the scope of the appended claims.
Claims (10)
1. The sequencing chip loading device is characterized by comprising a sequencing element, a chip platform (1), a positioning mechanism and a pressing mechanism, wherein a vacuum channel is arranged on the surface of the chip platform (1), the sequencing element is placed on the chip platform (1), the positioning mechanism enables the sequencing element to be positioned, and the pressing mechanism presses a sequencing chip (4) in the sequencing element onto the chip platform (1).
2. The sequencing chip loading apparatus of claim 1, wherein the positioning mechanism is configured to position a peripheral side of the sequencing element, and the clamping mechanism is configured to secure an upper side of the sequencing element.
3. The sequencing chip loading device according to claim 2, wherein the positioning mechanism comprises a top member (6) and at least two sets of positioning members arranged on the chip platform (1), and the top member (6) is used for elastically pushing the sequencing element so as to position and attach at least two non-parallel sides of the sequencing element to the positioning members.
4. The sequencing chip loading device according to claim 3, wherein the sequencing element comprises a housing (31) for installing the sequencing chip (4), a positioning groove for the positioning member to penetrate is formed in the inner side of the housing (31), a notch for the fastening member (6) to fasten is formed in the outer side of the housing (31), and the side surface of the sequencing chip (4) is positioned and attached to the positioning member when the fastening member (6) elastically fastens the housing (31).
5. The sequencing chip loading device according to claim 4, wherein the sequencing element is substantially rectangular in shape, the positioning members comprise at least one first positioning member (2) for longitudinal positioning and at least one second positioning member (3) for lateral positioning, and the housing (31) is provided with a first positioning slot (34) matching with the first positioning member (2) and a second positioning slot (35) matching with the second positioning member (3).
6. The sequencing chip loading device according to claim 4, wherein a sealing block (15) is disposed on two sides of the chip platform (1), the sequencing element further comprises a sealing member (28) mounted on the housing (31), the sealing block (15) is provided with a first fluid port (20), the sealing member (28) is provided with a second fluid port (29), the sequencing chip (4) is provided with a third fluid port (32), and the first fluid port (20), the second fluid port (29) and the third fluid port (32) are aligned.
7. The sequencing chip loading device according to claim 6, wherein a third driving member (11) is provided at one side of the chip platform (1), the third driving member (11) is connected with and drives a second transmission shaft (24), the second transmission shaft (24) is provided with a first cam member (25) and a second cam member (26), the first cam member (25) and the second cam member (26) are both connected with a moving member (27), and the sealing block (15) is mounted on the moving member (27); the sealing element (28) is further provided with a positioning hole (30), and the sealing block (15) is provided with a third positioning piece (16) matched with the positioning hole (30) in a positioning mode.
8. The sequencing chip loading device according to any one of claims 2 to 7, wherein the pressing mechanism comprises a pressing member (7) and a driving member for driving the pressing member (7) to press the sequencing element; the pressing piece (7) is connected with an induction piece (17), and the induction piece (17) is subjected to induction detection by the detection piece.
9. The sequencing chip loading device according to claim 8, wherein the pressing mechanism further comprises a first transmission shaft (14), the first transmission shaft (14) is provided for the pressing member (7), and the first transmission shaft (14) is connected through a transmission member and driven by the driving member; the driving parts comprise a first driving part (9) and a second driving part (10) which are respectively positioned at two sides of the chip platform (1).
10. A gene sequencer comprising an image acquisition device (21) and a sequencing chip loading device according to any one of claims 1 to 9.
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| CN202221455542.4U CN217438181U (en) | 2022-06-10 | 2022-06-10 | Gene sequencer and sequencing chip loading device thereof |
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| CN202221455542.4U CN217438181U (en) | 2022-06-10 | 2022-06-10 | Gene sequencer and sequencing chip loading device thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116536145A (en) * | 2023-06-13 | 2023-08-04 | 郑州思昆生物工程有限公司 | Chip outer frame device for gene sequencer |
| WO2024255812A1 (en) * | 2023-06-13 | 2024-12-19 | 郑州思昆生物工程有限公司 | Chip positioning apparatus, chip outer frame apparatus for gene sequencer, and gene sequencer |
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2022
- 2022-06-10 CN CN202221455542.4U patent/CN217438181U/en active Active
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116536145A (en) * | 2023-06-13 | 2023-08-04 | 郑州思昆生物工程有限公司 | Chip outer frame device for gene sequencer |
| WO2024255812A1 (en) * | 2023-06-13 | 2024-12-19 | 郑州思昆生物工程有限公司 | Chip positioning apparatus, chip outer frame apparatus for gene sequencer, and gene sequencer |
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