CN217366207U - Flexible digital cardiovascular stent - Google Patents

Flexible digital cardiovascular stent Download PDF

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Publication number
CN217366207U
CN217366207U CN202220318585.1U CN202220318585U CN217366207U CN 217366207 U CN217366207 U CN 217366207U CN 202220318585 U CN202220318585 U CN 202220318585U CN 217366207 U CN217366207 U CN 217366207U
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flexible
flexible digital
digital system
cardiovascular stent
stent
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CN202220318585.1U
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赵照
闻棕择
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Beijing Xinfu Ankang Technology Co ltd
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Beijing Xinfu Ankang Technology Co ltd
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    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02EREDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
    • Y02E60/00Enabling technologies; Technologies with a potential or indirect contribution to GHG emissions mitigation
    • Y02E60/13Energy storage using capacitors

Abstract

The application discloses flexible digital cardiovascular support includes: a cardiovascular stent consisting of a single or multiple wires; a flexible digital system comprising a flexible substrate, a microelectronic device, and an encapsulation layer; the microelectronic device is disposed on the flexible substrate; the encapsulation layer covers the microelectronic device; the packaging layer is formed by stacking a plurality of layers of flexible films and has deformation capacity; the flexible digital system is arranged on the metal wire of the cardiovascular stent. The flexible digital cardiovascular stent is implanted into a blood vessel of a person under guardianship, so that various physiological data of the blood vessel of the person under guardianship can be acquired in real time, the physiological data are wirelessly transmitted to external equipment for analysis and processing, the health state of the blood vessel can be monitored in real time, and vascular diseases are prevented.

Description

Flexible digital cardiovascular stent
Technical Field
The application relates to the field of medical equipment, in particular to a flexible digital cardiovascular stent.
Background
The intravascular stent is a stent structure implanted at a lesion position on the basis of the expansion molding of a lumen balloon, is used for achieving the purposes of supporting a stenotic occlusion section blood vessel, reducing the elastic retraction and the plasticity of the blood vessel and keeping the blood flow of the lumen unobstructed, and is mainly divided into a coronary stent, a cerebrovascular stent, a renal artery stent, an aorta stent and the like. The cardiovascular stent has the main functions of improving myocardial blood supply, preventing myocardial ischemia, enabling the stenotic coronary artery to be in an expanded state and enabling the far-end myocardial to obtain better blood supply.
However, 6-8 months after the intervention of the stent in some patients, the patient can have the situation of cardiovascular restenosis and even reocclusion at the stent implantation position. Restenosis was likely to occur in 20% of patients using metal stents and in 9% of patients using drug stents. Restenosis and reocclusion can seriously impair the efficacy of the operation and even threaten the life safety of the patient. The lack of detection of the physiological state of blood vessels and body health monitoring after operation is a difficult problem to be solved urgently at present.
Disclosure of Invention
In view of this, the present application provides a flexible digital cardiovascular stent, which adopts the following technical scheme:
a flexible digital cardiovascular stent, comprising:
a cardiovascular stent comprised of a metal wire;
a flexible digital system comprising a flexible substrate, a microelectronic device, and an encapsulation layer;
the microelectronic device is disposed on the flexible substrate;
the encapsulation layer covers the microelectronic device;
the packaging layer is formed by stacking a plurality of layers of flexible films and has deformation capacity;
the flexible digital system is arranged on the metal wire of the cardiovascular stent.
Optionally, the microelectronic device comprises a sensor, an integrated circuit, an antenna, and a supercapacitor;
the sensor comprises at least one of a ph sensor, a temperature sensor, a pressure sensor or a flow sensor for sensing blood physiological data;
the integrated circuit is used for acquiring, storing and modulating physiological data and converting a wireless power supply line signal into electric energy;
the antenna is used for sending physiological data and receiving wireless power supply signals;
the super capacitor is configured to store electrical energy.
Optionally, the integrated circuit comprises an acquisition module, a controller, an RF data transmitter, a memory, an encryption circuit, an RF rectifier, and a power supply circuit.
Optionally, the flexible digital system is disposed on a single wire of a cardiovascular stent.
Optionally, the flexible digital system is disposed over a plurality of wires of a cardiovascular stent.
Optionally, the integrated circuit, the antenna and the super capacitor are arranged in an area where a plurality of metal wires are attached in the flexible digital system, and the at least one sensor is arranged in an area where a single metal wire is attached in the flexible digital system.
Compared with the prior art, the method has the following beneficial effects:
based on the technical scheme, the flexible digital cardiovascular support provided by the application realizes a flexible digital system with flexibility and deformation capability by manufacturing the integrated circuit, the antenna and the super capacitor on the flexible substrate and adopting a multilayer flexible thin film packaging technology. The flexible digital system is fixed on the metal wire of the cardiovascular stent, and in the cardiovascular stent unfolding process of the interventional operation, the flexible digital system with the deformation capability enters the blood vessel along with the cardiovascular stent, so that various physiological data of the blood vessel of the person under guardianship can be collected in real time, the physiological data is wirelessly transmitted to external equipment for analysis and processing, the real-time monitoring of the health state of the blood vessel is met, and the pathological changes of the blood vessel are prevented.
Drawings
In order to more clearly illustrate the embodiments of the present application or the technical solutions in the prior art, the drawings needed to be used in the description of the embodiments or the prior art will be briefly described below, it is obvious that the drawings in the following description are only some embodiments described in the present application, and other drawings can be obtained by those skilled in the art without creative efforts.
Fig. 1 and fig. 2 are flexible digital cardiovascular stent structures provided by embodiments of the present application.
Fig. 3 and 4 show another flexible digital cardiovascular stent structure provided by embodiments of the present application.
Fig. 5 is a partial regional structure diagram of a flexible cardiovascular stent provided by an embodiment of the application.
Fig. 6 is a schematic view of the working principle of the flexible digital cardiovascular stent provided by the embodiment of the application.
Detailed Description
In order to make the aforementioned objects, features and advantages of the present invention more comprehensible, embodiments accompanied with figures are described in detail below.
In the following description, numerous specific details are set forth in order to provide a thorough understanding of the present invention, but the present invention may be implemented in other ways different from the specific details set forth herein, and one skilled in the art may similarly generalize the present invention without departing from the spirit of the present invention, and therefore the present invention is not limited to the specific embodiments disclosed below.
The application provides a flexible digital cardiovascular stent comprising a cardiovascular stent and a flexible digital system.
The flexible digital system comprises a sensor, an integrated circuit, an antenna and a super capacitor.
Because the cardiovascular stent needs to be opened at an artery in the interventional operation, the cardiovascular stent is guided into a vascular lesion part through a catheter and then supported, the vessel is possibly bent in the guiding process, and the stent can be physically deformed to a certain degree in the supporting process, a flexible digital system needs to be manufactured and formed based on a flexible semiconductor process, and the cardiovascular stent can be made of materials such as nickel-titanium alloy, cobalt-chromium alloy or medical stainless steel.
Considering that the flexible digital system substrate material needs to have good biocompatibility, stability and non-toxic characteristics in vitro cytotoxicity test, and also needs to be able to withstand high temperature and corrosive environment in semiconductor process, and simultaneously has good flexible deformation capability, the flexible digital system substrate material can be selected from polyimide or flexible glass, and the thickness of the substrate is preferably less than 0.1 mm.
Thin Film Transistors (TFTs) made of a material such as metal oxide indium, gallium and zinc mixture (IGZO) or Low Temperature Polysilicon (LTPS) may be manufactured on a flexible substrate through deposition, patterning, etching, and the like using conventional semiconductor processing equipment. MEMS devices, such as supercapacitors and antennas, can also be formed by using appropriate MEMS processes on flexible substrates. Sensors and integrated circuits in flexible digital systems are realized by fabricating metal layers that can be routed so that the individual transistors or MEMS devices are electrically connected.
The flexible digital system is packaged by adopting a multilayer thin film packaging technology, the packaging layer comprises a plurality of inorganic layers and a plurality of organic layers which are alternately stacked, and each organic/inorganic layer is stacked to form a pair. The packaging layer that the flexible thin film of multilayer piled up can play the cushioning effect to physical deformation to satisfy flexible deformation ability of flexible when the protection flexible digital system does not receive the destruction, the packaging layer still plays the effect of separation water oxygen. The outermost layer of the packaging layer is made of a biocompatible material, so that rejection reaction of a human body can be avoided. Wherein, the inorganic layer material can be one or more of silicon nitride, silicon oxide, aluminum oxide or titanium oxide, and the organic layer material can be one or more of polydimethylsiloxane, polyimide, ultraviolet curing optical cement or organic resin.
After forming the flexible digital system on the flexible substrate, the flexible digital system is secured to the cardiovascular stent wire surface. If the substrate of the flexible digital system is flexible glass, a metal brazing process can be adopted, and a plurality of brazing transition layers are manufactured between the flexible glass substrate and the cardiovascular stent metal wire, so that the flexible digital system is fixed on the surface of the cardiovascular stent metal wire; if the substrate of the flexible digital system is polyimide, a proper coupling agent is arranged in the polyimide film, a coupling transition layer which is the same as the metal wire material is sputtered on the surface of the metal wire, and a part of the coupling agent in the polyimide film is combined with the surface of the coupling transition layer through hydrogen bonds or chemical bonds by utilizing heating coupling reaction, so that the flexible digital system is fixed on the transition layer on the surface of the metal wire of the cardiovascular stent, and the flexible digital system is fixed on the cardiovascular stent, wherein the coupling agent can be a titanate coupling agent, an organic chromium complex coupling agent, a silane coupling agent or an aluminate coupling agent.
Referring to fig. 1 and 2, fig. 1 and 2 are flexible digital cardiovascular stent structures provided by embodiments of the present application.
Fig. 2 shows a flexible digital cardiovascular stent structure corresponding to the dashed line in fig. 1.
The flexible digital system 202 may be attached to a single wire 201 of a reticulated cardiovascular stent. The flexible digital cardiovascular stent 200 is a double-layer structure consisting of a cardiovascular stent metal wire 201 and a flexible digital system 202, wherein the outer layer (close to a blood vessel wall after implantation) is the cardiovascular stent metal wire 201 made of nickel-titanium alloy, cobalt-chromium alloy or medical stainless steel and the like, and the inner layer is the flexible digital system 202 based on a flexible substrate.
The length of the flexible digital system 202 is less than the length of the single cardiovascular stent wire 201, the width of the flexible digital system 202 does not exceed the width of the cardiovascular stent wire 201, the thickness of the flexible digital system 202 is preferably less than 100 μm, and the width and the thickness can be set appropriately according to the size of the wire 201, so as to reduce the obstructive influence of the flexible digital system 202 on blood circulation as much as possible.
Referring to fig. 3 and 4, fig. 3 and 4 are views of another flexible digital cardiovascular stent structure provided by an embodiment of the present application.
Fig. 4 shows the flexible digital cardiovascular stent structure corresponding to the dotted line in fig. 3.
The flexible digital system 402 may be attached to the plurality of wires 401 of the reticulated cardiovascular stent. The flexible digital cardiovascular stent 400 is a double-layer structure consisting of a cardiovascular stent metal wire 401 and a flexible digital system 402, wherein the outer layer (close to the vascular wall after implantation) is the cardiovascular stent metal wire 401 made of nickel-titanium alloy, cobalt-chromium alloy or medical stainless steel and the like, and the inner layer is the flexible digital system 402 based on a flexible substrate.
The integrated circuits, antennas and supercapacitors in the flexible digital system 402 may be disposed in an area 403 of the flexible digital system 402 where the plurality of wires meet, and the at least one sensor may be disposed in an area 404 of the flexible digital system 402 where the single wire is attached, it being understood that the area 404 is shown by way of example only and that there are many areas of the flexible digital system 402 where the single wire is attached. The area 403 has lower physical deformation capability requirements than the area 404, and the integrated circuit, the antenna and the super capacitor are arranged in the area 403, and the sensor is arranged in the area 404, so that the flexible digital system has higher reliability.
The application provides a flexible digital system among flexible digital cardiovascular support is parasitized on cardiovascular support wire, intervene in the operation through the pipe with flexible digital cardiovascular support leading-in vasculopathy part back, flexible digital system expands along with cardiovascular support wire together, flexible digital cardiovascular support is network structure after the expansion, cardiovascular support wire is located the one side of attached vascular wall, flexible digital system does not contact with the vascular wall. After the flexible digital cardiovascular stent is unfolded, the length, the width and the thickness of the flexible digital system are hardly changed, the length of the flexible digital system is less than the length of a single cardiovascular stent wire, the width of the flexible digital system does not exceed the width of the cardiovascular stent wire, the thickness of the flexible digital system is preferably less than 100 mu m, and the width and the thickness can be properly set according to the size of the wire, so that the influence of the flexible digital system on the reticular cardiovascular stent on the blood circulation obstruction is reduced as much as possible.
Referring to fig. 5, fig. 5 is a schematic view of a partial region structure of a flexible cardiovascular stent provided by an embodiment of the present application.
Referring to fig. 6, fig. 6 is a schematic view illustrating an operation principle of a flexible digital cardiovascular stent provided by an embodiment of the present application.
Fig. 5 shows that the flexible cardiovascular stent region corresponds to region 403 in fig. 4.
The integrated circuit 504, antenna 505, supercapacitor 506, sensor interface 507, and sensors (not shown in fig. 5) in the flexible digital system 502 are all disposed on a flexible substrate 503. The encapsulation layer 508 covers the integrated circuit 504, the antenna 505, the super capacitor 506, the sensor interface 507 and the sensor (not shown in fig. 5) and prevents exposure of the electronic components to blood.
It should be noted that the sensor interface 507 may be part of the integrated circuit 504, and since the sensor is not shown, the sensor interface 507 is shown separately here for ease of understanding the connection relationship of the sensor to the integrated circuit.
The integrated circuit 504 in the flexible digital system 502 may specifically include an acquisition module, a controller, an RF data transmitter, memory, encryption circuitry, an RF rectifier, and power supply circuitry.
The sensor includes at least one of a ph sensor, a temperature sensor, a pressure sensor, and a flow sensor, the at least one sensor disposed on the flexible substrate.
The ph sensor includes: a working electrode, a reference electrode, and a ph sensitive material. The ph sensitive material is disposed on the working electrode, and the ph sensitive material may be a nitrogen-doped carbon material loaded with metal nanoparticles that is sensitive to hydrogen ions. A hydrogen ion permeable membrane may be used for a partial region of the encapsulation layer so that the ph sensitive material can contact hydrogen ions in blood. By measuring the open-circuit potential between the working electrode and the reference electrode, the functional group of the ph sensitive material arranged on the working electrode reacts with hydrogen ions, so that the hydrogen ions move to the ph sensitive material, and the potential of the working electrode changes.
The pressure sensor includes a pressure sensitive layer, a first electrode layer, and a second motor layer. A pressure sensitive layer whose deformation amount changes with a change in blood pressure; the first electrode layer and the second electrode layer are respectively formed on two sides of the pressure sensitive layer to form a capacitor structure, and the distance between the capacitor structure and the capacitor structure changes along with the deformation of the pressure sensitive layer; the packaging layer wraps the outer sides of the pressure sensitive layer, the first electrode layer and the second electrode layer, the packaging layer is in contact with blood, and the capacitance value of the pressure sensitive capacitor changes along with the change of blood flow pressure.
The temperature sensor includes a thermally sensitive material. The thermosensitive material can be manufactured on the flexible substrate through electron beam processing evaporation and wet etching, when the temperature of blood outside the packaging layer changes, heat energy is conducted to the thermosensitive material through the packaging layer, the resistance value of the thermosensitive material changes, the change of temperature is reflected through the change of the measured resistance value, and finally the relation between the resistance value and the temperature value is calibrated to obtain the actually measured temperature.
The flow sensor comprises an ultrasonic flow meter. The ultrasonic flow meter may be based on various types such as a propagation velocity difference method, a doppler method, a beam offset method, and a noise method.
In the flexible digital system 502, the acquisition module is electrically connected to the sensors through the sensor interface 507, and each sensor is electrically connected to one acquisition module, for example, the ph sensor is electrically connected to the ph acquisition module, the temperature sensor is electrically connected to the temperature acquisition module, the pressure sensor is electrically connected to the pressure acquisition module, and the flow sensor is electrically connected to the flow acquisition module. A plurality of sensors can also be electrically connected with one acquisition module, for example, the ph sensor, the temperature sensor, the pressure sensor and the flow sensor are all electrically connected with the same acquisition module.
The acquisition module is used for sampling the input signals from the sensors and converting the physiological data in the analog signal format into the physiological data in the digital signal format. The acquisition module comprises an analog-to-digital conversion circuit, an amplifying circuit or a filtering circuit. The memory is used for storing the physiological data output by the acquisition module. The controller may control the sampling frequency of the sampling module, which may be collected continuously or periodically. The physiological data may include blood ph, pressure, temperature, or flow data.
The RF data transmitter is used for encoding and modulating the physiological data to be transmitted, the encrypted identity information and the flexible digital cardiovascular stent identifier stored in the memory to generate a radio frequency signal, and the radio frequency signal is transmitted through the antenna 505 and penetrates through the human body to reach an external device. The modulation mode can be bidirectional frequency shift keying or bidirectional phase shift keying and the like, the external equipment demodulates the received radio frequency signal to obtain the collected blood ph, pressure, temperature or flow data sent by the flexible digital cardiovascular stent, and the aim of monitoring the condition of the blood vessel is fulfilled by processing the data through a proper algorithm.
The antenna 505 is further used for receiving a wireless power supply signal transmitted from an external device and outputting the wireless power supply signal to the RF rectifier, and the RF rectifier amplifies and converts the wireless power supply signal into electric energy and then outputs the electric energy to the power supply circuit, so as to supply the electric energy to the flexible cardiovascular stent. The antenna 505 may be manufactured using a MEMS process.
The power supply circuit is used for receiving the electric energy converted by the RF rectifier, and then the electric energy is subjected to processing such as boosting or voltage stabilization to supply working electricity for each electric module in the flexible digital cardiovascular stent, and part of the electric energy can be used for charging the super capacitor 506.
The super capacitor 506 is used for storing energy converted by a wireless power supply signal, and the super capacitor 506 is manufactured by adopting an MEMS (micro electro mechanical system) process so as to meet the requirements of large capacity, high reliability, no temperature rise and the like.
The power supply process may specifically be to capture a wireless power supply signal sent by the external device and convert the wireless power supply signal into a direct current voltage so as to supply power to other circuits or modules in the system. The method comprises the steps of firstly amplifying weak wireless power supply signals collected from the outside through an RF rectifier in a mode of amplifying and accumulating step by step and converting the signals into electric energy, then boosting the electric energy to reach a rated voltage value of a driving circuit, then stabilizing the voltage to output stable direct current voltage to supply to each electronic component in a flexible digital cardiovascular support, and storing a part of the electric energy to a super capacitor to be used as a standby voltage source.
The encryption circuit is electrically connected with the RF data transmitter and the memory, and the digital identity information and the flexible digital cardiovascular stent identification can be stored in the memory. The encryption circuit can encrypt the physiological data to be sent stored in the memory and can also encrypt the digital identity information or the flexible digital cardiovascular stent identification, and the external equipment carries out decryption processing after receiving the encrypted physiological data, the digital identity information or the flexible digital cardiovascular stent identification. The digital identity information can conveniently and quickly identify the identity, and an optimal condition is created for the digital treatment of the external terminal. In the case where multiple implantable devices (such as flexible digital cardiovascular stents) are included within a person being monitored (such as blood vessels, nerves or muscles), the implantable device identification can be used to confirm the source of the data when the data is sent from the implantable devices, to identify and/or verify which implantable devices transmitted the data.
In some embodiments, the external device has a wireless communication module that can send a physiological data request signal or a wireless power signal to the flexible digital cardiovascular stent indicating that the external device is ready to receive physiological data from the flexible digital cardiovascular stent or provide power to the flexible digital cardiovascular stent.
In some embodiments, the external device has a module capable of receiving the physiological data transmitted by the flexible digital cardiovascular stent, and the controller of the flexible digital cardiovascular stent is used for controlling the RF data transmitter to transmit the physiological data after confirming the reception of the data request signal from the external device.
In some embodiments, the external device has a decryption module for decrypting the received encrypted physiological data, digital identity information or flexible digital cardiovascular stent identification for subsequent processing.
In some embodiments, the controller is requested to send data in a 12 hour period, and the ph collection module, pressure collection module, temperature collection module, and flow collection module are configured to collect blood ph, pressure, temperature, and flow data no more than every 20 milliseconds per period.
The external device of the person being monitored may be a wearable device (e.g., a wrist band, a watch, a necklace) or a non-wearable device (e.g., a smartphone add-on, a bedside device), which may be used or controlled by the person being monitored.
The above description is only for the preferred embodiment of the present invention, and although the present invention has been disclosed in the preferred embodiments, it is not intended to limit the present invention. The invention is not limited to the embodiments described herein, but is capable of other embodiments according to the invention, and may be used in various other applications, including, but not limited to, industrial, or industrial. Therefore, any simple modification, equivalent change and modification made to the above embodiments according to the technical substance of the present invention all fall within the protection scope of the technical solution of the present invention.

Claims (6)

1. A flexible digital cardiovascular stent, comprising:
a cardiovascular stent comprised of a metal wire;
a flexible digital system comprising a flexible substrate, a microelectronic device, and an encapsulation layer;
the microelectronic device is disposed on the flexible substrate;
the encapsulation layer covers the microelectronic device;
the packaging layer is formed by stacking a plurality of layers of flexible films and has deformation capacity;
the flexible digital system is arranged on the metal wire of the cardiovascular stent.
2. The carrier in accordance with claim 1, wherein said microelectronic device comprises a sensor, an integrated circuit, an antenna, and a supercapacitor;
the sensor comprises at least one of a ph sensor, a temperature sensor, a pressure sensor or a flow sensor for sensing blood physiological data;
the integrated circuit is used for acquiring, storing and modulating physiological data and converting a wireless power supply line signal into electric energy;
the antenna is used for sending physiological data and receiving wireless power supply signals;
the super capacitor is configured to store electrical energy.
3. The cradle of claim 2, wherein the integrated circuit comprises an acquisition module, a controller, an RF data transmitter, a memory, an encryption circuit, an RF rectifier, and a power supply circuit.
4. A stent according to claim 3, wherein the flexible digital system is provided on a single wire of a cardiovascular stent.
5. The stent of claim 3, wherein the flexible digital system is disposed over a plurality of wires of a cardiovascular stent.
6. The cradle of claim 5, wherein the integrated circuit, antenna and supercapacitor are disposed in a flexible digital system at an area where a plurality of wires meet, and wherein the at least one sensor is disposed in a flexible digital system at an area where a single wire is attached.
CN202220318585.1U 2022-02-17 2022-02-17 Flexible digital cardiovascular stent Active CN217366207U (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202220318585.1U CN217366207U (en) 2022-02-17 2022-02-17 Flexible digital cardiovascular stent

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN202220318585.1U CN217366207U (en) 2022-02-17 2022-02-17 Flexible digital cardiovascular stent

Publications (1)

Publication Number Publication Date
CN217366207U true CN217366207U (en) 2022-09-06

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