CN217285866U - Novel buccal saliva sampling test paper and kit - Google Patents

Abstract

The utility model discloses a novel oral saliva sampling test paper, comprising: a first water-insoluble protective layer, a water-absorbing layer and a second water-insoluble protective layer which are connected in sequence; the first water-insoluble protective layer and the The second water-insoluble protective layer is porous. The oral saliva sampling test paper kit provided by the utility model solves the problem of strong discomfort caused by excessive stimulation of the oral cavity to the subject, and further solves the problem of increased cross-infection caused by saliva splashing.

Description

A new type of oral saliva sampling test paper and kit

technical field

The utility model relates to the field of oral saliva sampling, in particular to oral saliva sampling test paper.

Background technique

In recent years, with the development of medical technology, secretion sampling and testing has become an effective way to detect diseases. As a non-invasive diagnostic test, saliva has received more and more attention in the field of clinical medicine. As a substance secreted all the time in the human body, saliva always reflects the health of the human body. Saliva sampling is also easily accepted by subjects because it is non-invasive. The components in saliva are similar to blood. For subjects with blood coagulation disorders, saliva sampling is the best choice. At present, the commonly used saliva sampling method is that subjects spit a certain amount of saliva into a specific sampling tube or touch the inner wall of the oral cavity through a long cotton swab (test paper) to suck saliva from the oral cavity. It is not easy for the subjects to spit out enough saliva. During the sampling process, the contamination of saliva splashing is prone to occur. The saliva adheres to the outer wall of the sampling tube, resulting in cross-infection of the samples. Danger of infection. In addition, it is difficult to absorb saliva through long cotton swabs or test strips. During the sampling process, the cotton swabs or test strips rub against the mouth, causing the subjects to feel strong discomfort, often accompanied by vomiting, and the amount of saliva sampled is often insufficient. Detection, multiple sampling will repeatedly stimulate the mouth to vomit. Therefore, there is an urgent need for a saliva sampling test paper to minimize the cross-infection problem caused by the saliva splash and the strong discomfort caused by excessive stimulation of the oral cavity.

Utility model content

The utility model provides a novel oral saliva sampling test paper, which solves the problem of strong discomfort caused by excessive stimulation of the oral cavity to a subject, and further solves the problem of increased cross-infection caused by saliva splashing.

A first aspect, a novel oral saliva sampling test paper, comprising: a first water-insoluble protective layer, a water-absorbing layer, and a second water-insoluble protective layer connected in sequence;

The first water-insoluble protective layer and the second water-insoluble protective layer are porous.

The first water-insoluble layer protective layer and the second water-insoluble layer protective layer can protect the water-absorbing layer from being damaged by oral sucking after absorbing saliva. Sampling strips swell as they absorb saliva.

Further, the first water-insoluble protective layer and the second water-insoluble protective layer are porous, which is easy to make the test paper quickly absorb saliva, and the rough surface formed by the porous shape can stimulate the oral cavity to spontaneously appear sucking action, and promote the secretion of saliva in large quantities, Shorten the sampling time.

The first water-insoluble protective layer and the second water-soluble protective layer have edible substance layers outside.

The edible substance layer includes an outer fructose layer and an inner citric acid layer.

The edible substance layer is a multi-layered edible substance that is conducive to gland secretion, the outer layer is a fructose layer, which is beneficial to improve the discomfort caused by the initial test strip and reduce the resistance of younger users, and the middle inner layer is a citric acid layer. , Through citric acid can promote the speed of oral glands to generate secretions, increase the concentration of secretions. In the process of taking the test paper in the mouth, the sweet and sour substances enter the mouth, stimulate the salivary glands to secrete more saliva, and increase the amount of saliva in the mouth. At the same time, the sweet and sour taste of the sampling test paper can distract the attention of the children and improve the children's experience. The success rate of the subject's saliva sampling.

Preferably, for patients with xerostomia or users with glandular secretion dysfunction, an appropriate amount of adrenal M receptor agonist can also be added to the inner layer as required to promote the secretion of salivary glands in a short time.

Also include the third water-insoluble protective layer and the fourth water-insoluble protective layer outside the first water-insoluble protective layer and the second water-insoluble protective layer, respectively, and the third water-insoluble protective layer and the fourth water-insoluble protective layer. The outer surface of the water-insoluble protective layer is provided with bumps, wherein the third water-insoluble protective layer and the fourth water-insoluble protective layer are porous, and are respectively connected with the first water-insoluble protective layer and the second water-insoluble protective layer. corresponding holes. A third water-insoluble protective layer and a fourth water-insoluble protective layer are arranged to form a double-layer protection for the water-absorbing layer, so as to avoid damage to the sampling test paper due to the sucking action. The function of the bumps is to better stimulate the subjects to suck and produce a large amount of saliva and reduce the sampling time.

The sampling test paper is in the shape of a biconvex disk as a whole. The shape of the sampling test paper is that the thickness in the middle is greater than the thickness of the edge, that is, a biconvex disc shape with smooth edges, which reduces the adhesion of the test paper and saliva, so that when the sampling test paper is spit out from the mouth, it is easy to spit out the test paper, and it is not easy to stick to saliva and reduce saliva. Splash to avoid contamination and cross contamination.

In the second aspect, a novel oral saliva sampling test paper kit includes tweezers, a tweezers head, and the above-mentioned novel oral saliva sampling test paper; the tweezers head is sleeved on the tip of the tweezers.

Flanges are arranged on the periphery of the two tips of the tweezers, and the clipping and anastomotic surfaces of the tips are flat and are provided with anti-skid patterns, so that the sleeve head is not easy to fall off from the tweezers and the clipping is stable during use.

The tweezers cover is funnel-shaped, and the inner wall near the opening has rough stripes, which are in agreement with the flanges provided on the periphery of the two tips of the tweezers, so that the tweezers cannot easily fall off the tweezers.

The novel oral saliva sampling test paper kit further includes a head holder, which is used to be separated and placed on the tweezers head.

The tweezers are used together with the tweezers head, wherein the tweezers head is a one-time-use item, and the corresponding tweezer head model can be matched according to the size of the tweezers. When in use, place the sterilized tweezers on the tweezers, and the user does not need to touch the tweezers, and directly install the tweezers with the tweezers.

The sleeve head frame includes a box body, a double-layer tweezers head placement layer inside the box body, and the box body is arranged in a flip structure.

The head holder includes an external box body, and the box body is set as a flip structure, so that the tweezers head placed in the box can be protected from the contamination of pathogenic microorganisms in the external environment; the inside of the box body is double-layered, which can accommodate multiple tweezers at one time, and the tweezers head Neat and upright compartments are placed in the storage layer for easy access to the tweezers.

The novel oral saliva sampling test paper kit further comprises a sample bag, the sample bag contains a buffer solution, the sample bag is provided with a solution scale mark, and the opening of the sample bag is a plastic-sealed structure.

The subject can spit the test paper that absorbs enough saliva into the sample bag. The sample bag contains sterilized buffer, which can maintain the normal physiological activity of the cells in the saliva and facilitate the later detection of saliva. The sample bag adopts a self-closing mechanism, which can be sealed by pressing to avoid sample volatilization and cross infection between samples.

Further, the tweezers cover and the sample bag are disposable items, which are discarded after use, and the tweezers are sterilized with alcohol and reused.

A novel oral saliva sampling test paper and kit provided by the utility model has the following advantages:

1. The sampling test paper is made of composite multi-layer material, and the surface layer protects the inner layer, which effectively solves the problem that the general test paper is damaged under the action of external force after absorbing saliva.

2. The test strip does not come with an external catheter, which is small in size and can be completely contained in the oral cavity, and does not have cotton wool like cotton swabs, which can reduce the user's discomfort.

3. The surface of the test strip is porous, which stimulates the natural sucking action of the subjects to secrete a large amount of saliva, reduces the sampling time, and is conducive to promotion.

4. The tweezers are equipped with a disposable tweezers head, which can directly grasp the test paper and place it in the subject's mouth, and discard the disposable head to improve the sampling efficiency.

5. The sample bag adopts a self-closing mechanism, which can be sealed by pressing to avoid sample volatilization and cross infection between samples.

Description of drawings

In order to more clearly illustrate the embodiments of the present utility model or the technical solutions in the prior art, the following briefly introduces the accompanying drawings that need to be used in the description of the embodiments or the prior art. Obviously, the accompanying drawings in the following description These are just some embodiments of the present invention, and for those of ordinary skill in the art, other drawings can also be obtained from these drawings without creative effort. Fig. 1 is the exploded view and structure diagram of the novel oral saliva sampling test paper provided by the embodiment of the present invention;

2 is a schematic diagram of the tweezers provided with the tweezers head provided by the embodiment of the present utility model;

3 is a schematic structural diagram of a tweezers head provided by an embodiment of the present invention;

4 is a schematic diagram of a sample bag provided by an embodiment of the present invention;

5 is a schematic structural diagram of a hood frame provided by an embodiment of the present invention;

In the picture: 1-first water-insoluble protective layer, 2-water-absorbing layer, 3-second water-insoluble protective layer, 4-hole, 5-tweezers head, 6-flip cover, 7-tweezers head placement layer, 8- Box, 9- tweezers, 10- edible substance layer, 11- third water-insoluble protective layer, 12- fourth water-insoluble protective layer.

Detailed ways

In order to make the objectives, technical solutions and advantages of the present invention more clear, the technical solutions of the present invention will be described in detail below. Obviously, the described embodiments are only a part of the embodiments of the present invention, but not all of the embodiments. Based on the embodiments of the present invention, all other implementations obtained by those of ordinary skill in the art without creative work fall within the scope of protection of the present invention.

It should be noted that, in the description of the present invention, the terms "first", "second", etc. are only used for description purposes, and should not be construed as indicating or implying relative importance or order. Furthermore, in the description of the present invention, unless otherwise specified, the meaning of "plurality" means at least two, and the meaning of "multilayer" means at least two layers.

Example 1

As shown in Figure 1, this case provides a new type of oral saliva sampling test paper, including:

The first water-insoluble protective layer 1, the water-absorbing layer 2, and the second water-insoluble protective layer 3 are connected in sequence; the first water-insoluble protective layer 1 and the second water-insoluble protective layer 3 are porous.

The first water-insoluble protective layer 1 and the second water-insoluble protective layer 3 can protect the water-absorbing layer 2 from being damaged by oral sucking after absorbing saliva. Sampling strips swell as they absorb saliva. The first water-insoluble protective layer 1 and the second water-insoluble protective layer 3 are porous. Among them, the porous shape is easy for the test strip to quickly absorb saliva, and the setting of the rough surface formed by the porous shape can stimulate the oral cavity to spontaneously suck, promote the secretion of saliva, and shorten the sampling time.

The first water-insoluble protective layer 1 and the second water-soluble protective layer 3 have an edible substance layer 10 outside. The edible substance layer 10 includes an outer fructose layer and an inner citric acid layer. The edible substance layer 10 is a multi-layered edible substance that is conducive to glandular secretion, the outer layer is a fructose layer, which is beneficial to improve the discomfort caused by the initial test paper and reduce the resistance of younger users, and the middle inner layer is citric acid. Layer, through the citric acid can promote the speed of secretion of oral glands, increase the concentration of secretions. In the process of taking the test paper in the mouth, the sweet and sour substances enter the mouth, stimulate the salivary glands to secrete more saliva, and increase the amount of saliva in the mouth. At the same time, the sweet and sour taste of the sampling test paper can distract the attention of the children and improve the children's experience. The success rate of the subject's saliva sampling. For patients with xerostomia or users with gland secretion dysfunction, an appropriate amount of adrenal M receptor agonist can be added to the inner layer as needed to promote the secretion of salivary glands in a short time.

The pores 4 on the first water-insoluble protective layer 1 and the second water-insoluble protective layer 3 are evenly distributed.

The sampling test paper is in the shape of a biconvex disk as a whole. The shape of the sampling test paper is that the thickness in the middle is greater than the thickness of the edge, that is, a biconvex disc shape with smooth edges, which reduces the adhesion of the test paper and saliva, so that when the sampling test paper is spit out from the mouth, it is easy to spit out the test paper, and it is not easy to stick to saliva and reduce saliva. Splash to avoid contamination and cross contamination.

When in use, the sampling test paper is placed between the upper jaw and the tongue surface of the subject, and the mouth is closed naturally. The rough surface formed by the mouthfeel and porous morphology enhances the subject's autonomous sucking action, and a large amount of saliva is secreted in the oral cavity, which enters through the pores on the first water-insoluble protective layer 1 and the second water-insoluble protective layer 3 of the sampling test paper. To the water-absorbing layer 2, the subject can judge whether the collection is complete according to the degree of swelling of the test paper.

Example 2

Embodiment 2 provides a new type of oral saliva sampling test paper, which is different from Embodiment 1 in that the sampling test paper further includes a test strip located on the outside of the first water-insoluble protective layer 1 and the second water-insoluble protective layer 3 respectively. The third water-insoluble protective layer 11 and the fourth water-insoluble protective layer 12, and the outer surfaces of the third water-insoluble protective layer 11 and the fourth water-insoluble protective layer 12 are provided with bumps, wherein the third water-insoluble protective layer The layer 11 and the fourth water-insoluble protective layer 12 are porous and correspond to the pores 4 on the first water-insoluble protective layer 1 and the second water-insoluble protective layer 3, respectively. A third water-insoluble protective layer and a fourth water-insoluble protective layer are arranged to form a double-layer protection for the water-absorbing layer, so as to avoid damage to the sampling test paper due to the sucking action. The function of the bumps is to better stimulate the subjects to suck and produce a large amount of saliva and reduce the sampling time. The edible substance layer 10 is located outside the third water-insoluble protective layer 11 and the fourth water-insoluble protective layer 12 .

Example 3

In clinical examinations, saliva is often used to detect the content of various substances in the body, such as cortisol.

As shown in Figure 1-5, this case provides a new type of oral saliva sampling test strip assembly, including:

The tweezers 9 , the tweezers sleeve 5 , and the above-mentioned novel oral saliva sampling test paper; the tweezers sleeve 5 is sleeved on the tip of the tweezers 9 .

Flanges are arranged on the periphery of the two tips of the tweezers 9, and the clipping and anastomotic surfaces of the tips are flat and are provided with anti-skid patterns, so that the sleeve head is not easy to fall off the tweezers and the clipping is stable during use.

The tweezers head 5 is in the shape of a long and thin funnel, and the inner wall near the opening has rough stripes, which are in line with the flanges provided on the periphery of the two tips of the tweezers 9, so that the tweezers head 5 is not easy to fall off the tweezers 9.

A new type of oral saliva sampling test paper kit further includes a head holder, which is used to be separated and placed on the tweezers head 5 .

The tweezers 9 are used together with the tweezers head 5 , wherein the tweezers head 5 is a one-time use item, and a corresponding model of the tweezers head 5 can be matched according to the size of the tweezers 9 . When in use, the sterilized tweezers head 5 is placed on the head holder, and the user does not need to touch the head, and directly installs the head 5 by holding the tweezers 9 .

The head holder includes an outer case 8 and a double-layer tweezers head placement layer 7 inside the case, and the case 8 is configured as a flip 6 structure.

The head holder includes an external box 8, and the box 8 is configured as a flip 6 structure, which can protect the tweezers 5 placed in the box from contamination by pathogenic microorganisms in the external environment; the inside of the box 8 is double-layered and can accommodate multiple tweezers at a time. The tweezers 5 and the tweezers 5 are neatly and vertically placed in the placement layer, so that the tweezers 5 can be easily taken and placed.

A novel oral saliva sampling test paper kit further includes a sample bag, wherein the sample bag contains buffer solution, the sample bag is provided with a solution scale mark, and the opening of the sample bag is a plastic sealing structure.

The subject can spit the test paper that absorbs enough saliva into the sample bag. The sample bag contains sterilized buffer, which can maintain the normal physiological activity of the cells in the saliva and facilitate the later detection of saliva. The sample bag adopts a self-closing mechanism, which can be sealed by pressing to avoid sample volatilization and cross infection between samples.

The tweezers cover 5 and the sample bag are disposable and discarded after use, and the tweezers 9 are sterilized with alcohol and reused.

When in use, the user matches the tweezers 5 according to the model of the tweezers 9, holds the tweezers 9 and takes the neatly and upright tweezers 5 which are placed in the tweezers. The stripes fit with the flanges provided on the periphery of the two tips of the tweezers 9 , and the tweezers sleeve 5 is tightly fitted on the tweezers 9 . Hold the end of the tweezers 9 away from the tip to pick up the sampling test paper, open the subject's mouth, place the sampling test paper between the upper jaw and the tongue surface, close the mouth naturally, and sample the first water-insoluble protective layer 1 and the second water-soluble protective layer of the test paper. The sweet and sour taste of the edible substance layer outside 3 and the rough surface formed by the porous shape enhance the subject's autonomous sucking action, and a large amount of saliva is secreted in the oral cavity. The holes 4 on the water-soluble protective layer 3 enter into the water-absorbing layer 2 . Subjects can judge whether the collection is complete according to the degree of swelling of the test strip. After the collection, the subjects naturally lowered their heads and opened their mouths, opened the sample bag with both hands, spit the test paper into the sample bag containing the buffer, and then sealed the sample bag by pressing.

Although the embodiments of the present invention have been shown and described above, it should be understood that the above embodiments are exemplary and should not be construed as limitations of the present invention, and those of ordinary skill in the art are within the scope of the present invention Variations, modifications, substitutions and variations can be made to the above-described embodiments.

Claims (10)

1. A novel buccal saliva sampling test paper is characterized by comprising a first water-insoluble protective layer, a water absorption layer and a second water-insoluble protective layer which are sequentially connected;

the first water-insoluble protective layer and the second water-insoluble protective layer are porous.

2. The novel buccal saliva sampling test paper as claimed in claim 1, wherein the first water-insoluble protective layer and the second water-soluble protective layer are externally provided with edible substance layers.

3. The novel buccal saliva sampling test paper as claimed in claim 2, wherein the edible substance layer comprises an outer fructose layer and an inner citric acid layer.

4. The novel buccal saliva sampling test paper as claimed in any one of claims 1 to 3, further comprising a third water-insoluble protective layer and a fourth water-insoluble protective layer respectively positioned outside the first water-insoluble protective layer and the second water-insoluble protective layer, wherein the outer surfaces of the third water-insoluble protective layer and the fourth water-insoluble protective layer are provided with salient points, and the third water-insoluble protective layer and the fourth water-insoluble protective layer are porous and correspond to the holes on the first water-insoluble protective layer and the second water-insoluble protective layer respectively.

5. The novel buccal saliva sampling test paper as claimed in claim 1, wherein the sampling test paper is integrally in the shape of a biconvex disc.

6. A novel buccal saliva sampling test paper kit, which is characterized by comprising tweezers, a tweezers sleeve head, the novel buccal saliva sampling test paper as claimed in any one of claims 1 to 5; the forceps sleeve head is used for being sleeved on the tip end of the forceps.

7. The novel buccal saliva sampling test strip kit as claimed in claim 6, wherein the tweezers are provided with flanges on the peripheries of the two tips.

8. The novel buccal saliva sampling test paper kit of claim 6, wherein the forceps cuff is funnel-shaped.

9. The novel buccal saliva sampling test paper kit of claim 6, further comprising a headgear; the sleeve frame comprises a box body and a double-layer sleeve head placing layer inside the box body, and the box body is of a flip structure.

10. The novel buccal saliva sampling test paper kit as claimed in claim 6, further comprising a sample bag, wherein the sample bag contains a buffer solution, solution scale marks are arranged on the sample bag, and a plastic package structure is arranged at an opening of the sample bag.

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