CN216172323U - Ticagrelor raw material medicine synthesis reaction kettle - Google Patents
Ticagrelor raw material medicine synthesis reaction kettle Download PDFInfo
- Publication number
- CN216172323U CN216172323U CN202122625312.XU CN202122625312U CN216172323U CN 216172323 U CN216172323 U CN 216172323U CN 202122625312 U CN202122625312 U CN 202122625312U CN 216172323 U CN216172323 U CN 216172323U
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- China
- Prior art keywords
- reaction kettle
- feeding
- ticagrelor
- raw material
- synthesis reaction
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- 239000002994 raw material Substances 0.000 title claims abstract description 39
- OEKWJQXRCDYSHL-FNOIDJSQSA-N ticagrelor Chemical compound C1([C@@H]2C[C@H]2NC=2N=C(N=C3N([C@H]4[C@@H]([C@H](O)[C@@H](OCCO)C4)O)N=NC3=2)SCCC)=CC=C(F)C(F)=C1 OEKWJQXRCDYSHL-FNOIDJSQSA-N 0.000 title claims abstract description 27
- 229960002528 ticagrelor Drugs 0.000 title claims abstract description 27
- 239000003814 drug Substances 0.000 title claims abstract description 15
- 238000003786 synthesis reaction Methods 0.000 title claims abstract description 15
- 239000000463 material Substances 0.000 claims abstract description 25
- 238000006243 chemical reaction Methods 0.000 claims abstract description 18
- 239000011550 stock solution Substances 0.000 claims abstract description 17
- 238000003756 stirring Methods 0.000 claims abstract description 13
- 238000005303 weighing Methods 0.000 claims abstract description 8
- 229940079593 drug Drugs 0.000 claims description 6
- 238000004519 manufacturing process Methods 0.000 abstract description 5
- 238000001914 filtration Methods 0.000 abstract 1
- 239000007788 liquid Substances 0.000 description 3
- 235000017166 Bambusa arundinacea Nutrition 0.000 description 2
- 235000017491 Bambusa tulda Nutrition 0.000 description 2
- 241001330002 Bambuseae Species 0.000 description 2
- 235000015334 Phyllostachys viridis Nutrition 0.000 description 2
- 239000011425 bamboo Substances 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 230000004075 alteration Effects 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- 239000011344 liquid material Substances 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
Images
Landscapes
- Mixers Of The Rotary Stirring Type (AREA)
- Manufacture And Refinement Of Metals (AREA)
Abstract
The utility model provides a ticagrelor raw material medicine synthesis reaction kettle which comprises a reaction kettle, wherein an upper cover is fixedly arranged on the reaction kettle, feeding cylinders are fixedly arranged on two sides of the upper cover, a material distributing pipe is arranged at the top of each feeding cylinder, a filter screen is arranged at the bottom of each feeding cylinder, and a rotating stirring paddle is arranged in the reaction kettle. The raw materials and the stock solution of ticagrelor are respectively introduced into the two feeding cylinders through automatic control of the weighing and metering device, are uniformly distributed on the filtering sieve through the material distributing pipe, are then put into the reaction kettle, and are driven by the motor to rotate the stirring paddle so that the raw materials and the stock solution of ticagrelor are fully mixed and stirred, the uniform mixing of the materials is ensured, and the mixing production efficiency of ticagrelor is greatly improved.
Description
Technical Field
The utility model relates to the field of ticagrelor production, and particularly relates to a ticagrelor raw material medicine synthesis reaction kettle.
Background
When the ticagrelor raw material and the auxiliary material are mixed at present, in order to ensure that the raw material and the auxiliary material are uniformly mixed, the existing reaction kettle is single, the liquid raw material and the solid raw material are firstly separately configured, and the solid raw material and the liquid material are then sent into the reaction kettle and then mixed, so that the production efficiency is low, the materials are easily mixed unevenly in the generation process, and the mixing efficiency of the materials is influenced to a certain extent.
SUMMERY OF THE UTILITY MODEL
The utility model mainly aims to provide a ticagrelor raw material medicine synthesis reaction kettle, and solves the problems of low production efficiency and uneven mixing of ticagrelor raw materials and stock solution.
In order to solve the technical problems, the technical scheme adopted by the utility model is as follows: the material separating device comprises a reaction kettle, wherein an upper cover is fixedly arranged on the reaction kettle, feeding cylinders are fixedly arranged on two sides of the upper cover, a material separating pipe is arranged at the top of each feeding cylinder, a filter screen is arranged at the bottom of each feeding cylinder, and a rotating stirring paddle blade is arranged in the reaction kettle.
In the preferred scheme, the upper cover middle part is equipped with the motor fixed slot, and the both sides of upper cover are equipped with the fixed slot, and feeding cylinder tip passes through the bolt fastening on the fixed slot.
In the preferred scheme, a motor is fixedly arranged on the motor fixing groove, and an output shaft of the motor is fixedly connected with the stirring paddle.
In the preferred scheme, the feeding cylinders are semicircular arcs, and the two feeding cylinders are spliced to form a circular ring.
In the preferred scheme, the feeding cylinder on one side is communicated with the stock solution feeding pipe, the feeding cylinder on the other side is communicated with the raw material feeding pipe, the material distributing pipe is a four-way pipe, and the raw material and the stock solution are uniformly distributed and introduced into the filter sieve through the material distributing pipe.
In the preferred scheme, the end part of the material distributing pipe is respectively communicated with the upper part, the middle part and the lower part of the feeding cylinder.
In the preferred scheme, a flowmeter is arranged on the stock solution feeding pipe, and the mass of the stock solution fed is controlled by the flowmeter.
In the preferred scheme, raw materials inlet pipe tip is equipped with weighing device, and through the raw materials quality of weighing device control feeding, the raw materials is carried to the feed cylinder in through pneumatic conveying mechanism.
The utility model provides a ticagrelor raw material medicine synthesis reaction kettle, wherein a raw material and a stock solution of ticagrelor are automatically controlled by a weighing and metering device and respectively introduced into two feeding cylinders, are uniformly distributed on a filter sieve through a material distribution pipe and then are put into the reaction kettle, and then a stirring paddle is driven by a motor to rotate, so that the raw material and the stock solution of ticagrelor are fully mixed and stirred, the uniform mixing of the materials is ensured, and the mixing production efficiency of ticagrelor is greatly improved.
Drawings
The utility model is further illustrated by the following examples in conjunction with the accompanying drawings:
FIG. 1 is an elevational view of the overall construction of the present invention;
FIG. 2 is a front cross-sectional view of the overall structure of the present invention;
FIG. 3 is an exploded view of the feed cylinder of the present invention in connection with the upper cover;
FIG. 4 is a top view of the feed cylinder and upper cover of the present invention in connection;
FIG. 5 is a cross-sectional view of the utility model A-A;
FIG. 6 is a cross-sectional view of the utility model B-B;
in the figure: a reaction kettle 1; a discharge port 101; an upper cover 2; a fixing groove 201; a motor fixing groove 202; a feed cylinder 3; a material distributing pipe 301; a filter screen 302; a motor 4; a stock solution feeding pipe 5; a flow meter 6; a raw material feed pipe 7; the stirring blade 8.
Detailed Description
Example 1
As shown in fig. 1-6, a ticagrelor raw material drug synthesis reaction kettle comprises a reaction kettle 1, wherein an upper cover 2 is fixedly arranged on the reaction kettle 1, feeding cylinders 3 are fixedly arranged on two sides of the upper cover 2, a material distributing pipe 301 is arranged at the top of each feeding cylinder 3, a filter screen 302 is arranged at the bottom of each feeding cylinder 3, and a rotating stirring paddle blade 8 is arranged in the reaction kettle 1. From this structure, ticagrelor's raw materials and stoste let in two feed cylinder 3 respectively in, through dividing material pipe 301 with material dispersion even let in filter sieve 302, then let in reation kettle 1 in, stir intensive mixing to raw materials and stoste through stirring paddle 8, then discharge through the discharge gate 101 of reation kettle 1 bottom.
In the preferred scheme, upper cover 2 middle part is equipped with motor fixed slot 202, and the both sides of upper cover 2 are equipped with fixed slot 201, and feed cylinder 3 tip passes through the bolt fastening on fixed slot 201. From this structure, two feeding section of thick bamboo 3 cover 2 surfaces, and the installation of feeding section of thick bamboo 3 is dismantled simple and conveniently.
In the preferred scheme, a motor 4 is fixedly arranged on the motor fixing groove 202, and an output shaft of the motor 4 is fixedly connected with the stirring paddle blade 8. With the structure, the motor 4 is arranged in the motor fixing groove 202, and the motor 4 drives the stirring blade 8 to rotate.
In the preferred scheme, the feeding cylinders 3 are semicircular arcs, and the two feeding cylinders 3 are spliced to form a circular ring. From this structure, two feed cylinder 3 distribute in reation kettle 1's both sides, respectively from the even raw materials and the stoste of letting in ticagrelor to reation kettle 1 of two directions.
In the preferred scheme, the feeding cylinder 3 on one side is communicated with the stock solution feeding pipe 5, the feeding cylinder 3 on the other side is communicated with the raw material feeding pipe 7, the material separating pipe 301 is a four-way pipe, and the raw material and the stock solution are uniformly divided by the material separating pipe 301 and introduced into the filter sieve 302.
In a preferred scheme, the end part of the material distributing pipe 301 is respectively communicated with the upper part, the middle part and the lower part of the feeding cylinder 3. With this structure, the starting material and the stock solution of ticagrelor were introduced into reaction tank 1 from three positions, respectively.
In the preferred scheme, a flowmeter 6 is arranged on the raw liquid feeding pipe 5, and the quality of the fed raw liquid is controlled by the flowmeter 6.
In the preferred scheme, the end part of the raw material feeding pipe 7 is provided with a weighing device, the raw material quality of feeding is controlled by the weighing device, and the raw material is conveyed into the feeding cylinder 3 through the pneumatic conveying mechanism.
The above-described embodiments are merely preferred embodiments of the present invention, and should not be construed as limiting the present invention, and the scope of the present invention is defined by the claims, and equivalents including technical features described in the claims. I.e., equivalent alterations and modifications within the scope hereof, are also intended to be within the scope of the utility model.
Claims (8)
1. A ticagrelor raw material medicine synthesis reaction kettle is characterized in that: the device comprises a reaction kettle (1), wherein an upper cover (2) is fixedly arranged on the reaction kettle (1), feeding cylinders (3) are fixedly arranged on two sides of the upper cover (2), a material distributing pipe (301) is arranged at the top of each feeding cylinder (3), a filter screen (302) is arranged at the bottom of each feeding cylinder (3), and a rotating stirring paddle blade (8) is arranged in the reaction kettle (1).
2. The ticagrelor bulk drug synthesis reaction kettle according to claim 1, which is characterized in that: the middle part of the upper cover (2) is provided with a motor fixing groove (202), the two sides of the upper cover (2) are provided with fixing grooves (201), and the end part of the feeding cylinder (3) is fixed on the fixing grooves (201) through bolts.
3. The ticagrelor bulk drug synthesis reaction kettle as set forth in claim 2, wherein: the motor fixing groove (202) is fixedly provided with a motor (4), and an output shaft of the motor (4) is fixedly connected with the stirring paddle blade (8).
4. The ticagrelor bulk drug synthesis reaction kettle according to claim 1, which is characterized in that: the feeding cylinders (3) are semicircular arcs, and the two feeding cylinders (3) are spliced to form a circular ring.
5. The ticagrelor bulk drug synthesis reaction kettle according to claim 1, which is characterized in that: the feeding cylinder (3) on one side is communicated with the stock solution feeding pipe (5), the feeding cylinder (3) on the other side is communicated with the raw material feeding pipe (7), the material distributing pipe (301) is a four-way pipe, and the raw material and the stock solution are uniformly distributed through the material distributing pipe (301) and are introduced into the filter sieve (302).
6. The ticagrelor bulk drug synthesis reaction kettle according to claim 1, which is characterized in that: the end part of the material distributing pipe (301) is respectively communicated with the upper part, the middle part and the lower part of the feeding cylinder (3).
7. The ticagrelor raw material medicine synthesis reaction kettle as claimed in claim 5, is characterized in that: the stock solution feeding pipe (5) is provided with a flowmeter (6), and the mass of the fed stock solution is controlled by the flowmeter (6).
8. The ticagrelor raw material medicine synthesis reaction kettle as claimed in claim 5, is characterized in that: the end part of the raw material feeding pipe (7) is provided with a weighing device, the raw material quality of feeding is controlled by the weighing device, and the raw material is conveyed into the feeding cylinder (3) through the pneumatic conveying mechanism.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202122625312.XU CN216172323U (en) | 2021-10-29 | 2021-10-29 | Ticagrelor raw material medicine synthesis reaction kettle |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202122625312.XU CN216172323U (en) | 2021-10-29 | 2021-10-29 | Ticagrelor raw material medicine synthesis reaction kettle |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN216172323U true CN216172323U (en) | 2022-04-05 |
Family
ID=80894102
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202122625312.XU Active CN216172323U (en) | 2021-10-29 | 2021-10-29 | Ticagrelor raw material medicine synthesis reaction kettle |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN216172323U (en) |
-
2021
- 2021-10-29 CN CN202122625312.XU patent/CN216172323U/en active Active
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