CN216145318U - Device for displaying membrane protein model and membrane protein model display system - Google Patents
Device for displaying membrane protein model and membrane protein model display system Download PDFInfo
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- CN216145318U CN216145318U CN202121520150.7U CN202121520150U CN216145318U CN 216145318 U CN216145318 U CN 216145318U CN 202121520150 U CN202121520150 U CN 202121520150U CN 216145318 U CN216145318 U CN 216145318U
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Abstract
The utility model discloses a device for displaying a membrane protein model and a membrane protein model displaying system, belonging to the field of membrane protein displaying, wherein the device comprises a frame body and two supporting sheet layers fixed on the frame body, wherein the two supporting sheet layers are parallel and oppositely arranged, and the supporting sheet layers are respectively provided with a limiting through hole so that the membrane protein model is limited when passing through the limiting through hole; the system comprises the device and a membrane protein model arranged in the device in a penetrating way. The utility model has skillful structure and reasonable design, so that the two support sheet layers can divide the display space into three parts, thereby simulating the real cell environment that the phospholipid bilayer divides the cell into an intracellular region, a transmembrane region and an extracellular region, and enabling the membrane protein model inserted in the two support sheet layers to display more professional information.
Description
Technical Field
The utility model relates to the field of membrane protein model display, in particular to a device for displaying a membrane protein model and a membrane protein model display system.
Background
The membrane proteins comprise tetraspanin Claudin18.2, Claudin6 and heptasern GPCRs, and the Major Histocompatibility Complex (MHC) and the like are important targets in the field of antibody drug development. Based on the importance of the protein, the recombinant preparation, the structural modification, the display of important epitopes and the like of membrane proteins all need the support of computer node construction model and structural analysis.
In the prior art, the display of membrane protein is mainly realized through a membrane protein model, after the membrane protein structure is modeled, a 3D model is output and printed out through Stl file format, and related structural domains, important epitopes and the like on the model are colored through spraying or hand drawing.
However, in the prior art, the membrane protein model is simply fixed and then displayed, which results in that professional information loaded by the membrane protein structural model cannot be well displayed and conveyed in the biological engineering structural design.
SUMMERY OF THE UTILITY MODEL
The utility model aims to provide a device for displaying a membrane protein model and a membrane protein model displaying system, aiming at the problem that professional information loaded by the membrane protein model cannot be transmitted during displaying in the prior art.
In order to achieve the purpose, the technical scheme of the utility model is as follows:
in one aspect, the utility model provides a device for displaying a membrane protein model, which comprises a frame body and two support sheet layers fixed on the frame body, wherein the two support sheet layers are arranged in parallel and oppositely, and the support sheet layers are provided with limiting through holes so that the membrane protein model is limited when passing through the limiting through holes.
Preferably, the support lamella is network structure, network structure includes annular skeleton and is latticed connection a plurality of net rope in the annular skeleton, spacing perforation does network among the network structure.
In another preferred embodiment, the support sheet layer is a plate-shaped structure, and the limiting through hole is formed in the plate-shaped structure.
Preferably, the limiting perforations on the two support sheet layers are staggered.
Preferably, the limiting through holes are elliptical holes or strip-shaped holes.
Preferably, the two support plies are of different colors.
The rack body is fixed on the rack body, and the top cover is positioned above the two support sheet layers; the top cover is also provided with a pulling piece for pulling the membrane protein model positioned below when displaying.
Preferably, the drawing piece is a metal wire, and the top cover is provided with a fixing hole for fixing the metal wire.
Preferably, the top cover is transparent.
In another aspect, the present invention also provides a membrane protein model display system, comprising a membrane protein model and the device as described above; wherein the membrane protein model passes through both of the support sheets.
By adopting the technical scheme, due to the arrangement of the two support sheet layers which are vertically distributed in a stacked manner, the two support sheet layers can divide the display space into three parts, so that the simulated phospholipid bilayer divides the cell into a cell real environment of an intracellular region, a transmembrane region and an extracellular region, and a membrane protein model which is inserted into the two support sheet layers can display more professional information.
Drawings
FIG. 1 is a schematic structural diagram according to a first embodiment of the present invention;
FIG. 2 is a schematic structural diagram according to a second embodiment of the present invention;
FIG. 3 is a schematic view of two upper limiting perforations of the support sheet layer according to the second embodiment of the present invention;
fig. 4 is a schematic structural diagram of a third embodiment of the present invention.
In the figure, 1-frame body, 11-rod body, 12-base, 2-support sheet layer, 21-annular skeleton, 22-net rope, 3-limiting perforation, 4-membrane protein model, 5-top cover and 6-pulling piece.
Detailed Description
The following further describes embodiments of the present invention with reference to the drawings. It should be noted that the description of the embodiments is provided to help understanding of the present invention, but the present invention is not limited thereto. In addition, the technical features involved in the embodiments of the present invention described below may be combined with each other as long as they do not conflict with each other.
It should be noted that in the description of the present invention, the terms "upper", "lower", "left", "right", "front", "rear", and the like indicate orientations or positional relationships based on structures shown in the drawings, and are only used for convenience in describing the present invention, but do not indicate or imply that the referred device or element must have a specific orientation, be constructed in a specific orientation, and be operated, and thus, should not be construed as limiting the present invention.
In the technical scheme, the terms "first" and "second" are only used for referring to the same or similar structures or corresponding structures with similar functions, and are not used for ranking the importance of the structures, or comparing the sizes or other meanings.
In addition, unless expressly stated or limited otherwise, the terms "mounted" and "connected" are to be construed broadly, e.g., the connection may be a fixed connection, a removable connection, or an integral connection; can be mechanically or electrically connected; the two structures can be directly connected or indirectly connected through an intermediate medium, and the two structures can be communicated with each other. To those skilled in the art, the specific meanings of the above terms in the present invention can be understood in light of the present general concepts, in connection with the specific context of the scheme.
Example one
A device for displaying a membrane protein model is shown in figure 1 and comprises a frame body 1 and two support sheet layers 2 fixed on the frame body 1, wherein the two support sheet layers 2 are arranged in parallel and oppositely, and meanwhile, limiting through holes 3 are formed in the support sheet layers 2, so that a membrane protein model 4 is limited when passing through the limiting through holes 3 in the two support sheet layers 2.
In this embodiment, the frame body 1 includes a plurality of rod bodies 11 that are parallel to each other and are arranged vertically when using, and a plurality of rod bodies 11 enclose into the shape with support slice layer 2 looks adaptation to it is fixed with support slice layer 2 to be convenient for. Usually, the frame body 1 further includes a base 12, in this embodiment, the base 12 is configured to be a ring-shaped structure, and the lower ends of the rod bodies 11 are all fixed on the base 12, for example, a mounting hole is formed on the ring-shaped structure of the base 12, and the lower end of the rod body 11 is inserted into the mounting hole. Of course, in another embodiment, the base 12 may also be a plate-shaped structure with mounting holes.
In this embodiment, the supporting sheet layer 2 is configured to be a mesh structure, the mesh structure 2 includes an annular frame 21 and a plurality of mesh ropes 22 connected in the annular frame 21 in a mesh shape, and correspondingly, the limiting through holes 3 are meshes in the mesh structure. Wherein, the annular framework 21 is provided with a through hole matched with the rod body 11 for installation, so that the support sheet layer 2 is fixed on the rod body 11.
It will be appreciated that the two support sheets 2 are arranged one above the other and at a distance from each other so as to divide the space into three parts, thereby simulating the cellular real environment in which the phospholipid bilayer divides the cell into three parts, an intracellular region, a transmembrane region and an extracellular region, so that the membrane protein model interspersed between the two support sheets can exhibit more professional information.
In addition, the two support sheet layers 2 are configured to be different in color for the purpose of distinction, for example, specifically, the color of the net string 22 in the two support sheet layers 2 is configured to be different in color.
In this embodiment, the base 12 in the configuration frame body 1 and the annular framework 21 in the support sheet layer 2 are coaxially arranged in a circular structure; in another embodiment, the structures may be rectangular.
During the use, with the device according to the complete back of foretell structure installation, wear to establish the membrane protein model that needs the show again in two support lamella 2, utilize latticed structure to make the membrane protein model by spacing fixed, can demonstrate to can simulate cell environment, make the membrane protein model can show more professional information.
Example two
The difference from the first embodiment is that: in this embodiment, as shown in fig. 2, the supporting sheet layer 2 is configured to be a plate-shaped structure, and correspondingly, the limiting through hole 3 is a hole formed on the plate-shaped structure.
It will be appreciated that there is at least one of the restraining perforations 3 in the support sheet 2 and that the restraining perforations 3 in the two support sheets 2 are typically arranged in pairs.
In this embodiment, the limiting perforations 3 arranged in pairs on the two support sheet layers 2 are staggered with respect to one another, i.e. the two limiting perforations 3 overlap only partially or not at all in the vertical direction, as shown in fig. 3.
In addition, in order to facilitate the membrane protein model to better penetrate through, in this embodiment, the limiting perforation 3 is an elliptical hole or a strip-shaped hole.
Also, for the sake of easy observation, the plate-like structure provided with the support sheet layer 2 is made of a transparent material, such as a transparent plastic plate. Which may be provided with different colours to facilitate rapid and convenient differentiation of the two support sheet layers 2 when displayed.
EXAMPLE III
It differs from any of the above embodiments in that: in this embodiment, as shown in fig. 4, the folding frame further includes a top cover 5, the top cover 5 is fixed on the frame body 1, and the top cover 5 is located above the two support sheet layers 2; in addition, a pulling piece 6 is also installed on the top cover 5 to pull the membrane protein model 4 positioned below when the membrane protein model 4 is displayed.
In this embodiment, the top cover 5 is preferably configured as a plate-shaped structure, which is fixed on the top end of the frame body 1 (specifically, the rod body 11) through a mounting hole or by means of adhesion, and, in order not to affect the display, the top cover 5 is configured to be made of a transparent material, such as transparent plastic.
In this embodiment, the pulling member 6 is preferably a metal wire, such as an iron wire or a copper wire, and the top cover 5 is provided with a fixing hole for fixing the upper end of the metal wire, while the lower end of the metal wire is connected to the membrane protein model 4 to be pulled.
Example four
A membrane protein model display system, comprising a membrane protein model 4 and the device provided in any of the above embodiments; wherein the membrane protein model 4 passes through two support sheets 2 in the device.
The embodiments of the present invention have been described in detail with reference to the accompanying drawings, but the present invention is not limited to the described embodiments. It will be apparent to those skilled in the art that various changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the utility model, and the scope of protection is still within the scope of the utility model.
Claims (10)
1. A device for the display of a membrane protein model, characterized in that: including the support body and fixing two support lamella on the support body, wherein, two support the parallel and relative setting of lamella, just all be provided with spacing perforation on the support lamella so that membrane protein model is followed by spacing when passing in the spacing perforation.
2. The apparatus of claim 1, wherein: the support lamella is network structure, network structure includes annular skeleton and is latticed connection and is in a plurality of net rope in the annular skeleton, spacing perforation does net among the network structure.
3. The apparatus of claim 1, wherein: the support sheet layer is of a plate-shaped structure, and the limiting through holes are formed in the plate-shaped structure.
4. The apparatus of claim 3, wherein: the limiting perforations on the two support sheet layers are staggered.
5. The apparatus of claim 4, wherein: the limiting through holes are elliptical holes or strip-shaped holes.
6. The apparatus of claim 1, wherein: the two support sheets are different in color.
7. The apparatus of any one of claims 1-6, wherein: the rack body is characterized by further comprising a top cover, wherein the top cover is fixed on the rack body and is positioned above the two support sheet layers; the top cover is also provided with a pulling piece for pulling the membrane protein model positioned below when displaying.
8. The apparatus of claim 7, wherein: the drawing piece is a metal wire, and a fixing hole for fixing the metal wire is formed in the top cover.
9. The apparatus of claim 7, wherein: the top cover is transparent.
10. A membrane protein model display system, comprising: comprising a membrane protein model and a device according to any one of claims 1 to 9; wherein the membrane protein model passes through both of the support sheets.
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| Application Number | Priority Date | Filing Date | Title |
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| CN202121520150.7U CN216145318U (en) | 2021-07-05 | 2021-07-05 | Device for displaying membrane protein model and membrane protein model display system |
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| Application Number | Priority Date | Filing Date | Title |
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| CN202121520150.7U CN216145318U (en) | 2021-07-05 | 2021-07-05 | Device for displaying membrane protein model and membrane protein model display system |
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| CN216145318U true CN216145318U (en) | 2022-03-29 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN117003876A (en) * | 2023-08-31 | 2023-11-07 | 恺佧生物科技(上海)有限公司 | Anti-CXCR4 membrane protein antibody and preparation method and application thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN117003876A (en) * | 2023-08-31 | 2023-11-07 | 恺佧生物科技(上海)有限公司 | Anti-CXCR4 membrane protein antibody and preparation method and application thereof |
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