CN215783597U - Tablet medicine grinds and collection device in pharmacokinetic experiment - Google Patents
Tablet medicine grinds and collection device in pharmacokinetic experiment Download PDFInfo
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- CN215783597U CN215783597U CN202121358140.8U CN202121358140U CN215783597U CN 215783597 U CN215783597 U CN 215783597U CN 202121358140 U CN202121358140 U CN 202121358140U CN 215783597 U CN215783597 U CN 215783597U
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- 239000003814 drug Substances 0.000 title claims abstract description 46
- 238000002474 experimental method Methods 0.000 title claims abstract description 20
- 238000012216 screening Methods 0.000 claims abstract description 23
- 230000005540 biological transmission Effects 0.000 claims description 2
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 229940127557 pharmaceutical product Drugs 0.000 claims 1
- 239000000843 powder Substances 0.000 abstract description 21
- 229940079593 drug Drugs 0.000 abstract description 14
- 239000002245 particle Substances 0.000 description 6
- 239000011449 brick Substances 0.000 description 5
- 230000005611 electricity Effects 0.000 description 4
- 239000004744 fabric Substances 0.000 description 3
- 238000000034 method Methods 0.000 description 2
- 230000001360 synchronised effect Effects 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000029142 excretion Effects 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
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Abstract
The utility model discloses a device for grinding and collecting tablet medicines in pharmacokinetic experiments, which comprises a workbench and a grinding unit, wherein the workbench is provided with a grinding unit; the upper surface of the working plate table is symmetrically provided with conical chutes, the bottom surface of the working plate table is provided with a screening and collecting unit, the upper surface of the screening and collecting unit is provided with supporting plates at equal angles, the upper ends of the four supporting plates are fixedly connected with the lower end of the outer arc surface of the grinding cylinder, and a discharge port at the lower end of the grinding cylinder is communicated with a feed port at the upper end of the screening and collecting unit; the grinding unit is arranged on the outer arc surface of the grinding cylinder, the middle of the upper end of the grinding unit is in sliding connection with the inner arc surface of the grinding cylinder, and the lower end of the grinding unit is located inside the grinding cylinder. This tablet medicine grinds and collection device in pharmacokinetic experiment improves the grinding efficiency of medicine, guarantees the grinding quality of medicine, makes the collection of powder more complete, reduces the inside powder of equipment and remains.
Description
Technical Field
The utility model relates to the technical field of pharmacokinetic experiments, in particular to a device for grinding and collecting tablet medicines in pharmacokinetic experiments.
Background
Pharmacokinetics, i.e., pharmacokinetics, is a subject for quantitatively researching absorption, distribution, metabolism and excretion rules of drugs in organisms and explaining the rule of blood concentration changing along with time by applying mathematical principles and methods. With the development of pharmaceutical chemistry and the continuous improvement of human health level, the requirements on the pharmacokinetic properties of drugs are higher and higher, and the pharmacokinetic properties of drugs need to be obtained through multiple experiments.
For tablet medicines, the tablet medicines need to be ground into powder during pharmacokinetic experiments, so that the pharmacokinetic properties of the tablets can be accurately and efficiently known through the experiments. Therefore, a device for grinding and collecting tablet medicines in pharmacokinetic experiments is provided.
SUMMERY OF THE UTILITY MODEL
The utility model aims to overcome the defects in the prior art, provides a device for grinding and collecting tablets in a pharmacokinetic experiment, improves the grinding efficiency of the medicines, ensures the grinding quality of the medicines, enables the collection of medicinal powder to be more complete, reduces the medicinal powder residue in equipment and can effectively solve the problems in the background art.
In order to achieve the purpose, the utility model provides the following technical scheme: a device for grinding and collecting tablet medicines in pharmacokinetic experiments comprises a workbench and a grinding unit;
the upper surface of the working plate table is symmetrically provided with conical chutes, the bottom surface of the working plate table is provided with a screening and collecting unit, the upper surface of the screening and collecting unit is provided with supporting plates at equal angles, the upper ends of the four supporting plates are fixedly connected with the lower end of the outer arc surface of the grinding cylinder, and a discharge port at the lower end of the grinding cylinder is communicated with a feed port at the upper end of the screening and collecting unit;
the grinding unit is arranged on the outer arc surface of the grinding cylinder, the middle of the upper end of the grinding unit is in sliding connection with the inner arc surface of the grinding cylinder, and the lower end of the grinding unit is located inside the grinding cylinder.
Furthermore, a control switch group is arranged on the front side face of the workbench, and the input end of the control switch group is electrically connected with an external power supply.
Furthermore, the screening and collecting unit comprises a collecting box, a screen and a collecting tank, wherein sliders symmetrically arranged on the bottom surface of the collecting box are respectively in sliding connection with the tapered chutes, chutes arranged at the upper end of the collecting box are in sliding connection with the frame of the screen, chutes arranged at the lower end of the collecting box are in sliding connection with the frame of the collecting tank, and screening after medicine grinding is realized.
Further, screening collection unit still includes circle axle, disc, first motor, driven pulley and drive pulley, first motor sets up in the bottom surface front end of work board platform, and the output shaft lower extreme of first motor is equipped with drive pulley, and the circle axle passes through bearing symmetry and rotates inside connecting the round hole that sets up in work board platform upper surface left and right sides symmetry, and the lower extreme of circle axle all is equipped with driven pulley, and driven pulley all passes through belt and drive pulley transmission, and the upper end of circle axle all is equipped with the disc, and two discs correspond the setting with the collecting box, and the output of the input electric connection control switch group of first motor provides the drive for the screening of powder.
Further, the grinding unit includes the second motor, the abrasive brick, the grinding ring, grind arch and plectane, the extrados of plectane and the intrados upper end sliding connection of grinding vessel, the upper surface middle part of plectane is equipped with the second motor, the output shaft of second motor passes through the through-hole rotation at bearing and plectane middle part and is connected and be equipped with the abrasive brick in end department, the extrados lower extreme of abrasive brick and the intrados lower extreme of grinding vessel all are equipped with evenly distributed's abrasive ring, the abrasive ring of extrados lower extreme of abrasive brick and the abrasive ring dislocation set of intrados lower extreme of grinding vessel, the toper cambered surface of abrasive brick lower extreme and the toper cambered surface of the inside lower extreme of grinding vessel all are equipped with evenly distributed's grinding arch, the input electricity connection control switch group's of second motor output, improve the grinding efficiency of medicine.
Further, the grinding unit still includes right angle backup pad and electric putter, electric putter sets up respectively in the mounting panel upper surface that grinding vessel outer arc symmetry set up, and electric putter's flexible end upper end all is equipped with the right angle backup pad, and the vertical plate body lower extreme of right angle backup pad all is connected with the last fixed surface of plectane, and electric putter's input electricity connection control switch group's output reduces the inside powder of equipment and remains.
Furthermore, a feeding funnel is arranged at a feeding port at the edge of the upper surface of the circular plate, so that the tablet medicines can conveniently enter the grinding cylinder.
Compared with the prior art, the utility model has the beneficial effects that:
1. the tablet medicine is put into the feeding hopper, the tablet medicine enters the grinding cylinder through the feeding hopper, then enters the gap between the inner arc surface of the grinding cylinder and the outer arc surface of the grinding block through the guide of the conical surface at the upper end of the grinding block, the second motor is operated through the regulation and control of the control switch group, the output shaft rotates to drive the grinding block to rotate, the grinding block drives the grinding ring of the outer arc surface thereof to rotate, the grinding ring uniformly arranged on the outer arc surface of the grinding block and the grinding ring uniformly arranged at the lower end of the inner arc surface of the grinding cylinder extrude the tablet medicine, the tablet medicine is crushed, the crushed medicine enters the gap between the conical inner wall surface at the lower end of the grinding cylinder and the conical surface at the lower end of the grinding block, the crushed medicine is ground through the grinding bulges uniformly distributed on the conical inner wall surface at the lower end of the grinding cylinder and the grinding bulges uniformly distributed on the conical surface at the lower end of the grinding block, and the grinding efficiency of the medicine is improved, after the medicine is ground, the electric push rod stretches and retracts to rotate by controlling the switch group to drive the right-angle supporting plate to move up and down, the right-angle supporting plate drives the circular plate to move up and down along the inner arc surface of the grinding cylinder, a grinding ring at the lower end of the outer arc surface of the grinding block is contacted with a grinding ring at the lower end of the inner arc surface of the grinding cylinder, the medicine adhered to the surface of the grinding ring is separated by the rotation of the grinding ring at the lower end of the outer arc surface of the grinding block, the screening and collecting unit drives the equipment to shake, so that the medicine powder is collected more completely, and the medicine powder residue in the equipment is reduced;
2. after the medicine is ground by the grinding unit, the medicine enters the upper end inside the collecting tank through a discharge port at the lower end of the grinding cylinder, the medicine powder is firstly contacted with the screen, the first motor is operated by controlling a switch group, an output shaft rotates to drive a driving belt pulley to rotate, the driving belt pulley drives two driven belt pulleys to rotate through a belt, the driven belt pulley drives a circular shaft to rotate, the circular shaft drives two circular discs to synchronously rotate eccentrically, when the point of the outer arc surface of the left circular disc, which is closest to the central axis of the left circular shaft, is contacted with the left side of the collecting tank, the point of the outer arc surface of the right circular disc, which is farthest from the central axis of the right circular shaft, is contacted with the right side surface of the collecting tank, the two circular discs can push the collecting tank to move leftwards and rightwards along two conical chutes along with the synchronous eccentric rotation of the two circular discs, thereby realizing the sliding of the screen, and the medicine powder with the required particle size enters the collecting tank through the screen, the powder that the particle diameter can not reach the demand is detained on the screen cloth, and the staff can pull out the screen cloth through the handle of screen cloth front surface, pours the powder that the particle diameter can not reach the demand into grinding vessel inside again and grinds, guarantees the grinding quality of medicine.
Drawings
FIG. 1 is a schematic perspective view of the present invention;
FIG. 2 is a schematic view of the internal cross-section structure of the present invention.
In the figure: 1. the automatic grinding machine comprises a working table, 2 control switch groups, 3 conical chutes, 4 screening and collecting units, 41 collecting boxes, 42 screens, 43 collecting tanks, 44 circular shafts, 45 circular discs, 46 first motors, 47 driven pulleys, 48 driving pulleys, 5 supporting plates, 6 grinding cylinders, 7 grinding units, 71 second motors, 72 right-angle supporting plates, 73 electric push rods, 74 grinding blocks, 75 grinding rings, 76 grinding protrusions, 77 circular discs and 8 feeding hoppers.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Referring to fig. 1-2, the apparatus for grinding and collecting tablet in pharmacokinetic experiments provided in this embodiment includes a worktable 1 and a grinding unit 7; the front side of the working board table 1 is provided with a control switch group 2, and the input end of the control switch group 2 is electrically connected with an external power supply.
Wherein: the upper surface of the working plate table 1 is symmetrically provided with conical chutes 3, the bottom surface of the working plate table 1 is provided with a screening and collecting unit 4, the upper surface of the screening and collecting unit 4 is provided with supporting plates 5 at equal angles, the upper ends of the four supporting plates 5 are fixedly connected with the lower end of the outer cambered surface of the grinding cylinder 6, and a discharge port at the lower end of the grinding cylinder 6 is communicated with a feed port at the upper end of the screening and collecting unit 4; the screening and collecting unit 4 comprises a collecting box 41, a screen 42 and a collecting tank 43, wherein the sliding blocks symmetrically arranged on the bottom surface of the collecting box 41 are respectively in sliding connection with the tapered sliding chutes 3, the sliding chute arranged at the upper end of the collecting box 41 is in sliding connection with the frame of the screen 42, and the sliding chute arranged at the lower end of the collecting box 41 is in sliding connection with the frame of the collecting tank 43; screening collection unit 4 still includes circle axle 44, disc 45, first motor 46, driven pulley 47 and drive pulley 48, first motor 46 sets up in the bottom surface front end of work board platform 1, first motor 46's output shaft lower extreme is equipped with drive pulley 48, circle axle 44 passes through bearing symmetry and rotates inside the round hole of connecting in the symmetrical setting of work board platform 1 upper surface left and right sides, the lower extreme of circle axle 41 all is equipped with driven pulley 47, driven pulley 47 all transmits through belt and drive pulley 48, the upper end of circle axle 44 all is equipped with disc 45, two discs 45 correspond the setting with collecting box 41, the output of control switch group 2 is connected to first motor 46's input electricity.
Wherein: the grinding unit 7 is arranged on the outer arc surface of the grinding cylinder 6, the middle part of the upper end of the grinding unit 7 is in sliding connection with the inner arc surface of the grinding cylinder 6, and the lower end of the grinding unit 7 is positioned in the grinding cylinder 6; the grinding unit 7 comprises a second motor 71, a grinding block 74, a grinding ring 75, a grinding bulge 76 and a circular plate 77, the outer arc surface of the circular plate 77 is slidably connected with the upper end of the inner arc surface of the grinding cylinder 6, the middle part of the upper surface of the circular plate 77 is provided with the second motor 71, the output shaft of the second motor 71 is rotatably connected with the through hole in the middle part of the circular plate 77 through a bearing, the grinding block 74 is arranged at the end head, the lower end of the outer arc surface of the grinding block 74 and the lower end of the inner arc surface of the grinding cylinder 6 are both provided with the grinding rings 75 which are uniformly distributed, the grinding ring 75 at the lower end of the outer arc surface of the grinding block 74 and the grinding ring 75 at the lower end of the inner arc surface of the grinding cylinder 6 are arranged in a staggered manner, the conical arc surface at the lower end of the grinding block 74 and the conical arc surface at the lower end of the inner lower end of the grinding cylinder 6 are both provided with the grinding bulge 76 which are uniformly distributed, and the input end of the second motor 71 is electrically connected with the output end of the control switch group 2; grinding unit 7 still includes right angle backup pad 72 and electric putter 73, and electric putter 73 sets up respectively in the mounting panel upper surface that grinding vessel 6 outer arc symmetry set up, and electric putter 73's flexible end upper end all is equipped with right angle backup pad 72, and the vertical plate body lower extreme of right angle backup pad 72 all is connected with the last fixed surface of plectane 77, and electric putter 73's input electricity connection control switch group 2's output, and the feed inlet department at plectane 77 upper surface edge is equipped with feed hopper 8.
The working principle of the utility model is as follows:
the tablet medicine is placed in the feeding hopper 8, enters the grinding cylinder 6 through the feeding hopper 8, and then enters the gap between the inner arc surface of the grinding cylinder 6 and the outer arc surface of the grinding block 74 under the guidance of the conical surface at the upper end of the grinding block 74;
through the regulation and control of the control switch group 2, the second motor 71 drives the grinding block 74 to rotate, the grinding block 74 drives the grinding ring 75 on the outer arc surface of the grinding block 74 to rotate, the grinding ring 75 uniformly arranged on the outer arc surface of the grinding block 74 and the grinding ring 75 uniformly arranged at the lower end of the inner arc surface of the grinding cylinder 6 extrude the tablet medicines, and the tablet medicines are crushed;
the crushed medicine enters a gap between the conical inner wall surface at the lower end of the grinding cylinder 6 and the conical surface at the lower end of the grinding block 74, and the crushed medicine is ground through the grinding bulges 76 uniformly distributed on the conical inner wall surface at the lower end of the grinding cylinder 6 and the grinding bulges 76 uniformly distributed on the conical surface at the lower end of the grinding block 74, so that the grinding efficiency of the medicine is improved;
after the medicine is ground into powder, the powder enters the upper end inside the collection box 41 through the discharge hole at the lower end of the grinding cylinder 6, the powder firstly contacts with the screen 42, the first motor 46 drives the driving belt pulley 48 to rotate through the regulation and control of the control switch group 2, the driving belt pulley 48 drives the two driven belt pulleys 47 to rotate through the belt, the driven belt pulley 47 drives the circular shaft 44 to rotate, the circular shaft 44 drives the two disks 45 to synchronously eccentrically rotate, when the point of the outer arc surface of the disk 45 at the left side, which is closest to the central axis of the circular shaft 44 at the left side, contacts with the left side of the collection box 41, the point of the outer arc surface of the disk 45 at the right side, which is farthest from the central axis of the circular shaft 44 at the right side, contacts with the right side surface of the collection box 41, and along with the synchronous eccentric rotation of the two disks 45, the two disks 45 can push the collection box 41 to move left and right along the two conical chutes 3, thereby realizing the sliding of the screen 42, and the powder with the required particle size enters the collection box 43 through the screen 42, the medicinal powder with the particle size not reaching the requirement is retained on the screen 42, the screen 42 is pulled out by a handle on the front surface of the screen 42, and the medicinal powder with the particle size not reaching the requirement is poured into the grinding cylinder 6 again for grinding again, so that the grinding quality of the medicine is ensured;
after the medicine grinds the completion, regulation and control through control switch group 2, electric putter 73 drives right angle backup pad 72 and reciprocates, right angle backup pad 72 drives plectane 77 and reciprocates along the intrados of grinding vessel 6, make grinding ring 75 of grinding piece 74 extrados lower extreme and the grinding ring 75 contact of grinding vessel 6 intrados lower extreme, rotation through grinding ring 75 of grinding piece 74 extrados lower extreme, the medicine that makes grinding ring 75 surface adhesion breaks away from, along with screening collection unit 4 drives equipment and rocks, make the collection of powder more complete, it remains to reduce the inside powder of equipment.
The above description is only an embodiment of the present invention, and not intended to limit the scope of the present invention, and all modifications of equivalent structures and equivalent processes, which are made by using the contents of the present specification and the accompanying drawings, or directly or indirectly applied to other related technical fields, are included in the scope of the present invention.
Claims (7)
1. A tablet medicine grinds and collection device in pharmacokinetic experiment which characterized in that: comprises a working plate table (1) and a grinding unit (7);
the upper surface of the working plate table (1) is symmetrically provided with conical chutes (3), the bottom surface of the working plate table is provided with a screening and collecting unit (4), the upper surface of the screening and collecting unit (4) is provided with supporting plates (5) at equal angles, the upper ends of the four supporting plates (5) are fixedly connected with the lower end of the outer arc surface of a grinding cylinder (6), and a discharge hole at the lower end of the grinding cylinder (6) is communicated with a feed hole at the upper end of the screening and collecting unit (4);
the grinding unit (7) is arranged on the outer arc surface of the grinding cylinder (6), the middle of the upper end of the grinding unit is connected with the inner arc surface of the grinding cylinder (6) in a sliding mode, and the lower end of the grinding unit (7) is located inside the grinding cylinder (6).
2. The apparatus for grinding and collecting a tablet in a pharmacokinetic experiment as claimed in claim 1, wherein: the front side of the workbench (1) is provided with a control switch group (2), and the input end of the control switch group (2) is electrically connected with an external power supply.
3. The apparatus for grinding and collecting a tablet in a pharmacokinetic experiment as claimed in claim 2, wherein: the screening and collecting unit (4) comprises a collecting box (41), a screen (42) and a collecting tank (43); the sliding blocks symmetrically arranged on the bottom surface of the collecting box (41) are respectively connected with the conical sliding chutes (3) in a sliding manner; the chute arranged at the upper end of the collecting box (41) is in sliding connection with the frame of the screen (42), and the chute arranged at the lower end of the collecting box is in sliding connection with the frame of the collecting tank (43).
4. The apparatus for grinding and collecting a tablet in a pharmacokinetic experiment as claimed in claim 3, wherein: the screening and collecting unit (4) further comprises a circular shaft (44), a circular disc (45), a first motor (46), a driven belt pulley (47) and a driving belt pulley (48); the first motor (46) is arranged at the front end of the bottom surface of the workbench (1), and a driving belt pulley (48) is arranged at the lower end of an output shaft of the first motor (46); the round shaft (44) is symmetrically and rotatably connected into round holes symmetrically formed in the left side and the right side of the upper surface of the workbench (1) through bearings, the lower end of the round shaft (41) is provided with a driven belt pulley (47), and the driven belt pulleys (47) are all in transmission with a driving belt pulley (48) through belts; the upper end of the round shaft (44) is provided with a disc (45), and the two discs (45) are arranged corresponding to the collecting box (41); the input end of the first motor (46) is electrically connected with the output end of the control switch group (2).
5. The apparatus for grinding and collecting a tablet in a pharmacokinetic experiment as claimed in claim 2, wherein: the grinding unit (7) comprises a second motor (71), a grinding block (74), a grinding ring (75), a grinding bulge (76) and a circular plate (77); the outer arc surface of the circular plate (77) is in sliding connection with the upper end of the inner arc surface of the grinding cylinder (6), the middle part of the upper surface of the circular plate (77) is provided with a second motor (71), an output shaft of the second motor (71) is in rotating connection with a through hole in the middle part of the circular plate (77) through a bearing, a grinding block (74) is arranged at the end, the lower end of the outer arc surface of the grinding block (74) and the lower end of the inner arc surface of the grinding cylinder (6) are both provided with grinding rings (75) which are uniformly distributed, and the grinding rings (75) at the lower end of the outer arc surface of the grinding block (74) and the grinding rings (75) at the lower end of the inner arc surface of the grinding cylinder (6) are arranged in a staggered mode; the conical cambered surface of the lower end of the grinding block (74) and the conical cambered surface of the lower end in the grinding cylinder (6) are both provided with uniformly distributed grinding bulges (76), and the input end of the second motor (71) is electrically connected with the output end of the control switch group (2).
6. The apparatus for grinding and collecting a tablet in a pharmacokinetic experiment as claimed in claim 5, wherein: the grinding unit (7) further comprises a right-angle support plate (72) and an electric push rod (73); the electric push rods (73) are respectively arranged on the upper surfaces of the mounting plates symmetrically arranged on the outer arc surfaces of the grinding cylinders (6), the upper ends of the telescopic ends of the electric push rods (73) are respectively provided with a right-angle support plate (72), and the lower ends of the vertical plate bodies of the right-angle support plates (72) are fixedly connected with the upper surface of a circular plate (77); the input end of the electric push rod (73) is electrically connected with the output end of the control switch group (2).
7. The apparatus for grinding and collecting a pharmaceutical product for pharmacokinetic experiment as claimed in claim 5 or 6, wherein: and a feeding funnel (8) is arranged at a feeding port at the edge of the upper surface of the circular plate (77).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202121358140.8U CN215783597U (en) | 2021-06-18 | 2021-06-18 | Tablet medicine grinds and collection device in pharmacokinetic experiment |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202121358140.8U CN215783597U (en) | 2021-06-18 | 2021-06-18 | Tablet medicine grinds and collection device in pharmacokinetic experiment |
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| CN215783597U true CN215783597U (en) | 2022-02-11 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114602588A (en) * | 2022-02-22 | 2022-06-10 | 湖北鑫京北数码科技有限公司 | Coaxial high-speed grinding device and method for powdered ink processing |
-
2021
- 2021-06-18 CN CN202121358140.8U patent/CN215783597U/en active Active
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114602588A (en) * | 2022-02-22 | 2022-06-10 | 湖北鑫京北数码科技有限公司 | Coaxial high-speed grinding device and method for powdered ink processing |
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