CN215128536U - Monitoring devices for rat intraventricular pressure monitoring experiments - Google Patents
Monitoring devices for rat intraventricular pressure monitoring experiments Download PDFInfo
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- CN215128536U CN215128536U CN202121068352.2U CN202121068352U CN215128536U CN 215128536 U CN215128536 U CN 215128536U CN 202121068352 U CN202121068352 U CN 202121068352U CN 215128536 U CN215128536 U CN 215128536U
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Abstract
本实用新型公开了一种大鼠心室内压监测实验用监测装置，包括多道生理信号采集处理系统、压力换能器、压力信号采集数据线、三通阀门管、注射器和插管装置，压力换能器的信号输出端通过压力信号采集数据线与多道生理信号采集处理系统的信号输入端连接，压力换能器的一端与三通阀门管的第一端连接，注射器的接嘴管与三通阀门管的第二端连接，三通阀门管的第三端通过管道连接液体存储容器，插管装置与压力换能器的第二端连接。本实用新型可监测动物血压、心室内压、采集血液、以及经动静脉插管给药等，并且插管装置的设计更容易进行实验，此外，本实用新型设计的压力换能器能够对血压的检测数据更精准，更进一步使得监测血压的准确性。
The utility model discloses a monitoring device for a rat intraventricular pressure monitoring experiment, which comprises a multi-channel physiological signal acquisition and processing system, a pressure transducer, a pressure signal acquisition data line, a three-way valve tube, a syringe and an intubation device. The signal output end of the transducer is connected with the signal input end of the multi-channel physiological signal collection and processing system through the pressure signal collection data line, one end of the pressure transducer is connected with the first end of the three-way valve tube, and the nozzle tube of the syringe is connected with the first end of the three-way valve tube. The second end of the three-way valve tube is connected, the third end of the three-way valve tube is connected to the liquid storage container through a pipeline, and the intubation device is connected to the second end of the pressure transducer. The utility model can monitor animal blood pressure, intraventricular pressure, collect blood, and administer drugs through arterial and venous intubation, etc., and the design of the intubation device is easier to carry out experiments. The detection data is more accurate, which further improves the accuracy of monitoring blood pressure.
Description
Technical Field
The utility model relates to a medical treatment experimental apparatus especially relates to a monitoring devices for monitoring experiments is pressed to rat ventricle.
Background
The carotid intubation rat model is a common experimental animal operation model in the fields of life science, medical research and drug research and development, is suitable for operations of multiple administration, blood sampling and the like, and is particularly suitable for pharmacokinetic and toxicological dynamics research. Because the instrument and accessory have certain application scope, can't satisfy the carotid intubate of the used animal rat of this experiment, and pressure transducer detects pressure data inaccuracy scheduling problem, consequently, has the space of improving.
Disclosure of Invention
The utility model aims at providing a monitoring devices for rat intraventricular pressure monitoring experiments.
In order to achieve the purpose, the utility model is implemented according to the following technical scheme:
the utility model discloses a multichannel physiological signal gathers processing system, pressure transducer, pressure signal data acquisition line, tee bend valve pipe, syringe and intubation device, pressure transducer's signal output part passes through pressure signal data acquisition line with multichannel physiological signal gathers processing system's signal input part and connects, pressure transducer's one end with the first end of tee bend valve pipe is connected, the nozzle pipe of syringe with the second end of tee bend valve pipe is connected, the third end of tee bend valve pipe passes through pipe connection liquid storage container, intubation device with pressure transducer's second end is connected.
Furthermore, the intubation device is composed of an external intubation section, a through connection pipe head, a subcutaneous intubation section, a conical pipe head and a blood vessel interpolation intubation section, wherein one end of the external intubation section is connected with the second end of the pressure transducer, the other end of the external intubation section is connected with one end of the subcutaneous intubation section through the through connection pipe head, and the other end of the subcutaneous intubation section is connected with one end of the blood vessel interpolation intubation section through the conical pipe head.
Preferably, the diameter of the blood vessel interpolation pipe section is a three-way valve pipe connecting end, the length of the blood vessel interpolation pipe section is greater than that of the pressure signal acquisition data line, and the end of the blood vessel interpolation pipe section is of an inclined plane structure.
Further, the pressure transducer comprises an upper transducer shell, an insertion pipe connecting end, a three-way valve pipe connecting end, a lower transducer shell, an arc-shaped elastic electrode plate, a flat hard electrode plate, an annular electric conductor and an insulating fixed pressing plate, wherein the insertion pipe connecting end and the three-way valve pipe connecting end are arranged on the upper transducer shell, the insertion pipe connecting end and the three-way valve pipe connecting end are communicated and connected with the upper transducer shell, the lower end of the upper transducer shell is detachably connected with the lower transducer shell, a through hole is formed in the lower end of the lower transducer shell, the upper end of the arc-shaped elastic electrode plate covers the through hole of the lower transducer shell, the lower end face edge of the arc-shaped elastic electrode plate of the annular electric conductor is positioned at the middle part below the arc-shaped elastic electrode plate, the annular conductor and the flat hard electrode plate are tightly pressed through the insulating fixed pressing plate, the edge of the insulating fixed pressing plate is detachably and fixedly connected with the lower shell of the transducer, and the pressure signal acquisition data line is electrically connected with the flat hard electrode plate and the annular conductor.
Preferably, an electrode plate sealing ring is arranged between the arc-shaped elastic electrode plate and the lower shell of the transducer.
The utility model has the advantages that:
the utility model relates to a monitoring devices for rat intraventricular pressure monitoring experiments compares with prior art, the utility model discloses can monitor animal blood pressure, intraventricular pressure, gather blood and through the arteriovenous intubate class of dosing to intubate device's design is tested more easily, in addition, the utility model relates to a pressure transducer can be more accurate to the detection data of blood pressure, and further makes the accuracy of monitoring blood pressure, has the value of popularization and application.
Drawings
Fig. 1 is a schematic structural diagram of the present invention;
fig. 2 is a schematic diagram of the pressure transducer structure of the present invention.
Detailed Description
The invention will be further described with reference to the drawings and specific embodiments, illustrative embodiments and description of which are provided herein to explain the invention, but not as a limitation thereof.
As shown in fig. 1: the utility model discloses a multichannel physiological signal gathers processing system 1, pressure transducer 2, pressure signal data line 3, three-way valve door pipe 4, syringe 5 and intubation device, pressure transducer 2's signal output part passes through pressure signal data line 3 with multichannel physiological signal gathers processing system 1's signal input part connects, pressure transducer 2's one end with three-way valve door pipe 4's first end is connected, syringe 5's nozzle pipe with three-way valve door pipe 4's second end is connected, three-way valve door pipe 4's third end passes through pipe connection liquid storage container, intubation device with pressure transducer 2's second end is connected.
Further, the intubation device is composed of an external intubation section 6, a through connector 7, a subcutaneous intubation section 8, a tapered connector 9 and a blood vessel interpolation intubation section 10, wherein one end of the external intubation section 6 is connected with the second end of the pressure transducer 2, the other end of the external intubation section 6 is connected with one end of the subcutaneous intubation section 8 through the through connector 7, and the other end of the subcutaneous intubation section 8 is connected with one end of the blood vessel interpolation intubation section 10 through the tapered connector 9.
Preferably, the diameter of the blood vessel interpolation pipe section 10 is 1 three-way valve pipe connection end 23, the length of the blood vessel interpolation pipe section 10 is greater than 10, the pressure signal acquisition data line 3 three-way valve pipe connection end 23, and the end of the blood vessel interpolation pipe section 10 is of an inclined plane structure.
As shown in fig. 2: the pressure transducer 2 is composed of an upper transducer shell 21, an insertion pipe connecting end 22, a three-way valve pipe connecting end 23, a lower transducer shell 24, an arc-shaped elastic electrode plate 25, a flat hard electrode plate 26, an annular conductor 27 and an insulating fixed pressing plate 29, wherein the insertion pipe connecting end 22 and the three-way valve pipe connecting end 23 are arranged on the upper transducer shell 21, the insertion pipe connecting end 22 and the three-way valve pipe connecting end 23 are communicated and connected with the upper transducer shell 21, the lower end of the upper transducer shell 21 is detachably connected with the lower transducer shell 24, a through hole is formed in the lower end of the lower transducer shell 24, the upper end of the arc-shaped elastic electrode plate 25 covers the through hole of the lower transducer shell 24, the annular conductor 27 is positioned at the lower end face edge of the arc-shaped elastic electrode plate 25, the flat hard electrode plate 26 is positioned in the middle of the lower part of the arc-shaped elastic electrode plate 25, the annular conductor 27 and the flat hard electrode plate 26 are tightly pressed through the insulating fixed pressing plate 29, the edge of the insulating fixed pressing plate 29 is detachably and fixedly connected with the lower shell 24 of the transducer, and the pressure signal acquisition data line 3 is electrically connected with the flat hard electrode plate 26 and the annular conductor 27.
Preferably, an electrode plate sealing ring 28 is arranged between the arc-shaped elastic electrode plate 25 and the transducer lower shell 24.
The working principle of the utility model is as follows:
during intubation experiments, the intravascular insertion tube section 10 is inserted into a blood vessel, the subcutaneous insertion tube section 8 is positioned in subcutaneous tissue, the extracorporeal insertion tube section 6 is positioned outside the body, blood pressure is transmitted into the upper transducer shell 21 of the pressure transducer 2 through the extracorporeal insertion tube section 6 and the insertion tube connecting end 22, because the arc-shaped elastic electrode plate 25 is of an arc-shaped structure and is soft, the arc-shaped elastic electrode plate 25 is pressed and deformed, therefore, according to different pressures, the contact surfaces of the arc-shaped elastic electrode plate 25 and the flat hard electrode plate 26 are different, and the contact surfaces of the arc-shaped elastic electrode plate 25 and the flat hard electrode plate 26 are different, so that the electrification rates are different, the multi-channel physiological signal acquisition and processing system 1 is connected with the flat hard electrode plate 26 and the arc elastic electrode plate 25 through the pressure signal acquisition data line 3, therefore, the multi-channel physiological signal acquisition and processing system 1 converts the conductivity between the arc-shaped elastic electrode plate 25 and the flat rigid electrode plate 26 into a pressure signal.
Example (b):
1. laboratory animal
Adult SD rats, manufacturer: sbefu (beijing) biotechnology limited, grade: SPF stage
2. Experimental equipment
Animal surgery equipment: surgical scissors, ophthalmic scissors, artery clamp, ophthalmology tweezers, medical gauze piece, intubation device, rat fixed station the utility model discloses a pressure transducer 2, multichannel physiological signal acquisition processing system 1: model RM6240C (Chengdu Instrument factory), animal anesthesia machine: matrx VIP 3000 (American MIDMARK)
3. Drugs and reagents
Isoflurane (CAS number: 26675-46-7), Ron's reagent.
Heparin sodium injection (batch No. 51610110, 2 ml: 12500 units), Kyowa Tenbang Biochemical medicine GmbH.
Sodium chloride injection (batch No. 2014.8.15), Shandong Qi Du pharmaceutical Co., Ltd.
Preparation before experiment: the prepared pressure transducer 2 and the three-way valve pipe 4 are respectively connected with the multi-channel physiological signal acquisition and processing system 1, the injector 5 (the capacity is at least 20ml) with heparin and the tube inserting device, the injector 5 with the heparin is pushed to empty bubbles at each position in the three-way valve pipe 4, whether the three-way valve pipe 4 leaks gas or leaks liquid is checked, and then the three-way interface is turned to seal each position for later use.
The experimental steps are as follows:
1. anesthesia fixation
The weight range of the rat used in the experiment is 250-300g, and the rat is fixed on a rat fixing table in a supine position after anesthesia.
2. Experimental procedures
Firstly, cutting the skin of the neck of a rat, carrying out blunt separation on neck muscles and fascia, fully exposing a neck blood vessel, carefully separating connective tissues around the left carotid artery until the carotid artery is about 1-1.5 cm free, and taking the connective tissues as long as possible under the condition, clamping one side close to the head, namely the far end, by using an artery clamp to ensure that blood in the blood vessel is full, and then clamping the near end;
the left hand lifts the separated arterial blood vessel with the ophthalmological forceps, and the right hand carefully cuts an oblique incision with the ophthalmological forceps, which should be as small as possible (the incision should not cut the blood vessel). Then, the cut carotid oblique orifice is gently grasped by an ophthalmic forceps, the other hand carefully inserts the intravascular cannula 10 while slowly dropping a normal saline solution containing heparin (heparin 2mg/100ml normal saline solution) to prevent coagulation or bubble formation in the catheter, and the intravascular cannula 10 is inserted and then the proximal vascular clamp is released. At this time, the three-way valve tube 4 is rotated to seal the end of the syringe 5, so that the intubation device is communicated with the pressure transducer 2. The intubation device is inserted about 2cm, qualified arterial blood pressure waveforms are acquired by the physiological signal acquisition and processing system 1, namely, the measurement is stopped, and data are stored to be analyzed.
And then, slowly pushing the blood vessel interpolation pipe section 10 for about 3-5 cm until slight blocking feeling exists, and then slowly pushing the blood vessel interpolation pipe section 10 to a monitoring system ventricular pressure measurement area to acquire qualified ventricular pressure waveforms, namely stopping measurement and storing data for analysis. In order to ensure that the intubation device can be inserted and delivered smoothly, the sodium chloride injection is dripped into the incision of the blood vessel to keep moist in the operation process.
The foregoing shows and describes the general principles and features of the present invention, together with the advantages thereof. It will be understood by those skilled in the art that the present invention is not limited to the embodiments described above, which are given by way of illustration only, and that various changes and modifications may be made without departing from the spirit and scope of the invention as defined by the appended claims. The scope of the invention is defined by the appended claims and equivalents thereof.
Claims (5)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202121068352.2U CN215128536U (en) | 2021-05-12 | 2021-05-12 | Monitoring devices for rat intraventricular pressure monitoring experiments |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202121068352.2U CN215128536U (en) | 2021-05-12 | 2021-05-12 | Monitoring devices for rat intraventricular pressure monitoring experiments |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN215128536U true CN215128536U (en) | 2021-12-14 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202121068352.2U Expired - Fee Related CN215128536U (en) | 2021-05-12 | 2021-05-12 | Monitoring devices for rat intraventricular pressure monitoring experiments |
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| Country | Link |
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| CN (1) | CN215128536U (en) |
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2021
- 2021-05-12 CN CN202121068352.2U patent/CN215128536U/en not_active Expired - Fee Related
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| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20211214 |