CN214830303U

CN214830303U - Air inlet and exhaust sterile structure of pharmaceutical and biological equipment

Info

Publication number: CN214830303U
Application number: CN202120367927.4U
Authority: CN
Inventors: 丁学君
Original assignee: Fresenius Kabi SSPC Pharmaceutical Co Ltd
Current assignee: Fresenius Kabi SSPC Pharmaceutical Co Ltd
Priority date: 2021-02-07
Filing date: 2021-02-07
Publication date: 2021-11-23
Anticipated expiration: 2031-02-07

Abstract

The utility model relates to an advance of pharmacy and biological equipment, the aseptic structure of exhaust, install pressure sensor and intake pipe at pharmacy pressure vessel's top, install admission valve and gas filtration degerming ware in the intake pipe, the admission valve sets up the rear at gas filtration degerming ware, be connected with the blast pipe in the intake pipe at admission valve rear, install discharge valve on the blast pipe, check valve and exhaust fan, discharge valve, admission valve and pressure sensor all link to each other with programmable logic controller, the check valve sets up the rear at discharge valve, the exhaust fan sets up the rear at the check valve, be connected with the condenser pipe on the blast pipe between exhaust fan and check valve, and the condenser pipe is vertical downward setting. The utility model discloses simple structure, job stabilization are reliable, the utility model discloses avoid being polluted by the liquid medicine in the gas filtration degerming ware use, improved the life of filter. Avoiding the cross contamination of the product caused by the contaminated filter.

Description

Air inlet and exhaust sterile structure of pharmaceutical and biological equipment

Technical Field

The utility model belongs to the technical field of pharmacy and biological equipment, concretely relates to pharmacy and biological equipment advance, exhaust aseptic structure.

Background

The technology of controlling microorganisms by equipment is widely used in the pharmaceutical field and is mainly used for preparation and storage of injection products, culture, purification, storage and the like of biological products. In this process step it must be ensured that the product is protected from external microorganisms under the protection of sterile gas.

At present, the pharmacy and biological industry generally adopt the aseptic respirator mechanism of admitting air and exhausting, and external microorganism can be effectively stopped to this structure, but the biggest problem is that the filter in the respirator is polluted by the liquid medicine in the equipment easily, can't carry out the washing of filter, forms cross contamination and does not accord with the requirement of GMP. And the polluted filter is easy to age after long-time work, which causes the service life of the filter to be shortened.

Disclosure of Invention

The utility model aims at overcoming the not enough of existence among the prior art, provide one kind can satisfy equipment aseptic admit air and aseptic exhaust action, do not cause the pollution, more accord with the requirement of GMP and can prolong filter life's advance, the aseptic structure of exhausting with exhaust equipment to relevant admit air.

According to the technical scheme provided by the utility model, the air inlet and exhaust sterile structure of the pharmaceutical and biological equipment comprises a pressure container, a pressure sensor, an air inlet pipe, an air inlet valve, an air filtering sterilizer, an exhaust pipe, an exhaust valve, a one-way valve, an exhaust fan, a condensation pipe and a programmable logic controller;

install pressure sensor and intake pipe at pharmaceutical pressure vessel's top, install admission valve and gas filtration degerming ware in the intake pipe, the admission valve sets up the rear at gas filtration degerming ware, be connected with the blast pipe in the intake pipe at admission valve rear, install discharge valve on the blast pipe, check valve and exhaust fan, discharge valve, admission valve and pressure sensor all link to each other with programmable logic controller, the check valve sets up the rear at discharge valve, the exhaust fan sets up the rear at the check valve, be connected with the condenser pipe on the blast pipe between exhaust fan and check valve, and the condenser pipe is vertical setting downwards.

Preferably, the exhaust pipe between the exhaust fan and the one-way valve is bent downwards, and the lowest part of the bent section is connected with the condensation pipe.

Preferably, the inner diameter of the condensation pipe is smaller than the inner diameter of the exhaust pipe. More preferably, the ratio of the inner diameter of the exhaust pipe to the inner diameter of the condensation pipe is (2-4): 1.

Preferably, the inner diameter of the intake pipe in front of the intake valve is smaller than the inner diameter of the intake pipe behind the intake valve. More preferably, the ratio of the inner diameter of the intake pipe behind the intake valve to the inner diameter of the intake pipe in front of the intake valve is (2-3): 1.

Preferably, a cleaning pipe is further attached to the pharmaceutical pressure vessel, and a shower ball located in the pharmaceutical pressure vessel is attached to the cleaning pipe.

The utility model discloses simple structure, job stabilization are reliable, the utility model discloses can avoid the contaminated risk of filter, finally avoid the product to be polluted by the pollution of pollution filter, improve the life of filter.

Drawings

Fig. 1 is a schematic view of the overall structure of the present invention.

Detailed Description

The present invention will be further described with reference to the following specific embodiments.

An air inlet and exhaust sterile structure of pharmaceutical and biological equipment comprises a pharmaceutical pressure container 1, a pressure sensor 2, an air inlet pipe 3, an air inlet valve 4, a gas filtering sterilizer 5, an exhaust pipe 6, an exhaust valve 7, a one-way valve 8, an exhaust fan 9, a condensation pipe 10 and a programmable logic controller 11; of course, the pharmaceutical pressure container 1 of the present invention must be provided with a conventional material inlet and a material outlet.

Install pressure sensor 2 and intake pipe 3 at the top of medicine pressure vessel 1, install admission valve 4 and gas filtration degerming ware 5 in intake pipe 3, admission valve 4 sets up the rear at gas filtration degerming ware 5, be connected with blast pipe 6 in the intake pipe 3 at admission valve 4 rear, install discharge valve 7 on blast pipe 6, check valve 8 and exhaust fan 9, discharge valve 7, admission valve 4 and pressure sensor 2 all link to each other with programmable logic controller 11, check valve 8 sets up the rear at discharge valve 7, exhaust fan 9 sets up the rear at check valve 8, be connected with condenser pipe 10 on blast pipe 6 between exhaust fan 9 and check valve 8, and condenser pipe 10 is vertical downward setting.

The exhaust pipe 6 between the exhaust fan 9 and the one-way valve 8 is bent downwards, and the lowest part of the bent section is connected with the condensation pipe 10.

The inside diameter of the condensation duct 10 is smaller than the inside diameter of the exhaust duct 6. The ratio of the inner diameter of the exhaust pipe 6 to the inner diameter of the condensation pipe 10 is (2-4): 1. The proportional design aims at discharging gas and condensed water in the exhaust process through the one-way valve 8, the condensed water flows into the condensation pipe 10 due to self weight and finally flows into the floor drain of a clean area, and the gas upwards enters the exhaust fan 9 to be discharged. If the ratio of the inner diameter of the exhaust pipe 6 to the inner diameter of the condensation pipe 10 is less than 2, the condensed water is easy to enter the exhaust fan 9; if the ratio of the inner diameter of the exhaust pipe 6 to the inner diameter of the condensation duct 10 is larger than 4, it is easy to cause a large amount of exhaust gas to enter the clean zone.

The ratio of the inner diameter of the air inlet pipe 3 behind the air inlet valve 4 to the inner diameter of the air inlet pipe 3 in front of the air inlet valve 4 is (2-3): 1. This ratio is designed to avoid contamination of gas filter sterilization unit 5 by the gas in pharmaceutical pressure vessel 1 during intake. If the ratio of the inner diameter of the inlet pipe 3 behind the inlet valve 4 to the inner diameter of the inlet pipe 3 in front of the inlet valve 4 is less than 2:1, the gas in the pharmaceutical pressure vessel 1 is likely to flow into the gas filtering sterilizer 5 when the inlet valve 4 is closed.

A cleaning pipe 12 is further mounted on the pharmaceutical pressure vessel 1, and a spray ball 13 positioned in the pharmaceutical pressure vessel 1 is mounted on the cleaning pipe 12.

The utility model discloses a theory of operation is: the programmable logic controller 11 opens the air inlet valve 4 when the air inlet is needed according to the pressure judgment detected by the pressure sensor 2, the high-pressure air enters the pressure container 1 after the degerming and filtering of the air filtering and sterilizing device 5, and the programmable logic controller 11 closes the air inlet valve 4 when the pressure reaches the requirement, wherein the air inlet process is a sterile air inlet process.

When the inside of the pressure container 1 needs to be exhausted, the exhaust valve 7 is opened, gas in the pressure container 1 enters the one-way valve 8 through the exhaust valve 7, the one-way valve 8 is opened under the action of exhaust pressure, most of the gas is pumped to an outdoor unclean area through the exhaust pipe 6 and the exhaust fan 9, and a small part of the gas and liquid drops are downwards discharged into a floor drain of the clean area through the condensing pipe 10. The exhaust process is controlled by the one-way valve 7, so that the gas and liquid drops in the exhaust pipe 6 and the condensation pipe 10 are prevented from reversely polluting the pharmaceutical pressure container 1, and the asepsis is ensured during the exhaust.

After the exhaust, exhaust fan 9 is in the running state all the time, and under the negative pressure effect of exhaust fan 9, the clean air in clean district gets into blast pipe 6 through condenser pipe 10 and discharges to outdoor again, and in this process, blast pipe 6 and condenser pipe 10 obtain drying and purification, have avoided microorganism to breed.

Cleaning and disinfection, when pressure vessel 1 needs cleaning or sterilization, insert washing liquid or high temperature vapor and spout from spraying ball 13 through scavenge pipe 12, make partial shower water or vapor to intake pipe 3 at intake valve 4 rear end when discharge valve 7 opens, discharge valve 7, check valve 8, blast pipe 6 and condenser pipe 10 carry out synchronous cleaning or disinfection, cleaning and disinfection back exhaust fan 9 is in running state all the time, under the negative pressure effect of exhaust fan 9, the clean air in clean district gets into blast pipe 6 through condenser pipe 10 and discharges to outdoor again, in this process, blast pipe 6 and condenser pipe 10 obtain dry and purification, guarantee that discharging equipment is in clean state.

Claims

1. An air inlet and exhaust sterile structure of pharmaceutical and biological equipment is characterized in that: the device comprises a pressure container (1), a pressure sensor (2), an air inlet pipe (3), an air inlet valve (4), an air filtering sterilizer (5), an exhaust pipe (6), an exhaust valve (7), a one-way valve (8), an exhaust fan (9), a condensation pipe (10) and a programmable logic controller (11);

a pressure sensor (2) and an air inlet pipe (3) are arranged at the top of the pressure container (1), an air inlet valve (4) and an air filtering sterilizer (5) are arranged on the air inlet pipe (3), the air inlet valve (4) is arranged at the rear part of the air filtering sterilizer (5), an exhaust pipe (6) is connected on the air inlet pipe (3) behind the air inlet valve (4), an exhaust valve (7), a one-way valve (8) and an exhaust fan (9) are arranged on the exhaust pipe (6), the exhaust valve (7), the intake valve (4) and the pressure sensor (2) are all connected with a programmable logic controller (11), the one-way valve (8) is arranged behind the exhaust valve (7), the exhaust fan (9) is arranged behind the one-way valve (8), a condensing pipe (10) is connected on the exhaust pipe (6) between the exhaust fan (9) and the one-way valve (8), and the condensing pipe (10) is vertically arranged downwards.

2. The air intake and exhaust aseptic structure of pharmaceutical and biological equipment as claimed in claim 1, wherein: the exhaust pipe (6) between the exhaust fan (9) and the one-way valve (8) is bent downwards, and the lowest part of the bent section is connected with the condensation pipe (10).

3. The air intake and exhaust sterile structure of pharmaceutical and biological equipment according to claim 1 or 2, wherein: the inner diameter of the condensation pipe (10) is smaller than that of the exhaust pipe (6).

4. The air intake and exhaust aseptic structure of pharmaceutical and biological equipment as claimed in claim 3, wherein: the ratio of the inner diameter of the exhaust pipe (6) to the inner diameter of the condensation pipe (10) is (2-4): 1.

5. The air intake and exhaust aseptic structure of pharmaceutical and biological equipment as claimed in claim 1, wherein: the inner diameter of the air inlet pipe (3) in front of the air inlet valve (4) is smaller than the inner diameter of the air inlet pipe (3) behind the air inlet valve (4).

6. The air intake and exhaust aseptic structure of pharmaceutical and biological equipment as claimed in claim 5, wherein: the ratio of the inner diameter of the air inlet pipe (3) behind the air inlet valve (4) to the inner diameter of the air inlet pipe (3) in front of the air inlet valve (4) is (2-3): 1.

7. The air intake and exhaust aseptic structure of pharmaceutical and biological equipment as claimed in claim 1, wherein: the pressure container (1) is also provided with a cleaning pipe (12), and the cleaning pipe (12) is provided with a spraying ball (13) positioned in the pressure container (1).