CN214174403U - Single-channel rotary nano enzyme immunoassay analyzer - Google Patents

Abstract

The utility model relates to the field of immunoassay, and discloses a single-channel rotary nano enzyme immunoassay analyzer, which comprises an analyzer shell, wherein a sample inlet is arranged on the analyzer shell, a detection mechanism, a liquid adding mechanism and a liquid absorbing mechanism are arranged in the analyzer shell, a rotary detection disc is rotationally connected in the analyzer shell, a plurality of radially arranged detection through grooves are arranged on the rotary detection disc, a deflectable bottom plate is arranged in each detection through groove, the bottom plate and the detection through grooves form a placing groove for placing a reagent card, and the placing groove can be right opposite to the sample inlet; and a limiting component for supporting the bottom plate is arranged below the rotary detection plate. The utility model discloses in, because set up the rotation type in the analysis appearance shell and detected the dish, and the rotation type has a plurality of standing groove on detecting the dish, consequently, can once only place a plurality of reagent cards on the rotation type detects the dish, detect the reagent card on the rotation type detects the dish in turn, and can break away from the standing groove automatically after the reagent card accomplishes the detection, improve detection efficiency.

Description

Single-channel rotary nano enzyme immunoassay analyzer

Technical Field

The utility model relates to an immunoassay field, concretely relates to single channel rotation type nanometer enzyme immunoassay appearance.

Background

The nano enzyme immunoassay analyzer is a medical detection device developed based on enzyme-linked immunosorbent assay technology, and is one of common devices for medical detection tests. At present, a nano enzyme immunoassay analyzer is usually single-channel sample injection, when the nano enzyme immunoassay analyzer is used, a reagent card with a sample is inserted into a sample injection port of the nano enzyme immunoassay analyzer, a developing solution is added into the reagent card through a liquid adding mechanism, redundant developing solution in the reagent card is sucked away through a liquid suction mechanism, then the reagent card is taken out after a detection head is used for detecting the developing degree of the reagent card, and then the next reagent card with the sample is inserted for detection, so that the operation is complex, and the detection efficiency is low.

SUMMERY OF THE UTILITY MODEL

The utility model discloses it is anticipated that a single channel rotation type nanometer enzyme immunoassay appearance is provided to there is the problem that detection efficiency is low when solving among the prior art single channel nanometer enzyme immunoassay appearance and using.

In order to achieve the above purpose, the utility model adopts the following technical scheme: single channel rotation type nanometer enzyme immunoassay appearance, including the analysis appearance shell, be equipped with the introduction port on the analysis appearance shell, be equipped with detection mechanism, liquid feeding mechanism and imbibition mechanism in the analysis appearance shell, the rotation is connected with the rotation type and is detected the dish in the analysis appearance shell, and detection mechanism, liquid feeding mechanism and imbibition mechanism all locate the top that the rotation type detected the dish, are equipped with the logical groove of detection of a plurality of radial settings on the rotation type detected the dish, detect the bottom plate that leads to the inslot and be equipped with the deflectable, and the bottom plate leads to the groove with the detection and forms the standing groove that is used for placing the reagent card, and the standing groove can just right with the introduction port.

The principle and the advantages of the scheme are as follows: in this scheme, have a plurality of standing grooves on the rotation type detection dish of rotation connection in the analysis appearance shell, during the use, rotate the rotation type detection dish for one of them standing groove is just right with the introduction port, so that in pushing reagent card into the standing groove, continue to rotate the rotation type detection dish, make next standing groove just right with the introduction port, repeat above-mentioned operation and can place a plurality of reagent cards respectively in the standing groove that corresponds. In addition, in the rotating process of the rotary detection disc, after the rotation can be stopped, the liquid adding mechanism adds the color developing liquid to the reagent card, the liquid absorbing mechanism sucks away the redundant color developing liquid, and then the detection mechanism detects the color developing liquid. Therefore, compared with the single-channel nano immunoassay analyzer in the prior art, the single-channel nano immunoassay analyzer has the advantage of continuous operation, and improves the detection efficiency. Moreover, the bottom plate can rotate, so that after the reagent card is detected, the bottom plate rotates and inclines, the reagent card in the placing groove automatically breaks away from the placing groove, a user is prevented from manually taking out the reagent card, and the detection efficiency is further improved.

Preferably, as an improvement, the bottom plate articulates in detecting logical inslot, spacing subassembly includes push rod motor and limiting plate, and push rod motor fixed mounting is in the bottom surface of rotation type detection dish, limiting plate and push rod motor's output fixed connection, and the upper surface of limiting plate is laminated with the bottom surface of rotation type detection dish mutually.

In the scheme, initially, a limiting plate in the limiting assembly is attached to the bottom surface of the rotary detection disc, and the bottom plate is in a horizontal state in the detection through groove, so that a user can push a reagent card to be detected into the placing groove; and after the reagent card detects and finishes, the push rod motor starts, drives the limiting plate and removes to the direction of keeping away from the rotation type and detecting the dish, and the bottom plate loses the support and deflects under the action of gravity, and the reagent card in the standing groove breaks away from the standing groove automatically, realizes the automatic play card of reagent card, avoids the manual reagent card that takes out of user, reduces user's operation, further improves detection efficiency.

Preferably, as an improvement, the two opposite side walls of the detection through groove are fixedly connected with wedge-shaped guide blocks for guiding the reagent card.

In this scheme, utilize wedge guide block direction reagent card to the user can accurately insert the reagent card in the standing groove of rotation type detection dish.

Preferably, as an improvement, liquid feeding mechanism includes the liquid feeding needle, and imbibition mechanism includes the imbibition needle, be equipped with the drive unit one that is used for driving liquid feeding needle and imbibition needle to go up and down in the analysis appearance shell, drive unit one includes motor one, ball screw pair and guide bar, and motor one is used for driving ball screw pair's lead screw and rotates, ball screw pair's nut fixedly connected with grip block, and the through-hole that supplies the guide bar to pass is seted up to the grip block, and liquid feeding needle and imbibition needle all are fixed in on the grip block.

In the scheme, the motor in the first driving unit drives the lead screw of the ball screw pair to rotate, and the nut of the ball screw pair drives the clamping block to move in the vertical direction, so that the liquid adding needle and the liquid sucking needle are lifted, the liquid adding needle can add color developing liquid to the reagent card, and meanwhile, the liquid sucking needle can suck away redundant color developing liquid in the reagent card.

Preferably, as an improvement, the bottom end of the liquid suction needle is lower than the bottom end of the liquid adding needle.

In the scheme, the bottom end of the liquid suction needle is limited to be lower than the bottom end of the liquid adding needle, so that when the bottom end of the liquid suction needle extends into a liquid suction port of the reagent card, the bottom end of the liquid adding needle can be suspended above a color development window of the reagent card, and the liquid adding needle is prevented from being immersed in color development liquid in the reagent card.

Preferably, as an improvement, be equipped with in the analysis appearance shell and be used for driving the rotation type to detect a second drive unit of dish pivoted, second drive unit includes motor two and drive belt, the coaxial fixedly connected with drive shaft of the second output end of motor, the coaxial fixedly connected with driven shaft of rotation type detection dish, through the transmission of drive belt between drive shaft and the driven shaft.

In this scheme, the second motor in the drive unit two drives the drive shaft and rotates, because through the transmission of drive belt between drive shaft and the driven shaft, consequently, the driven shaft can drive the rotation type and detect the dish and rotate to the rotation of rotation type detection dish is realized.

Preferably, as an improvement, a collection box with an open top is arranged in the analyzer housing, and the collection box is located below the rotary detection disc.

In this scheme, the collecting box can collect the reagent card that slides in the standing groove from rotation type detection dish to subsequent user unifies the processing.

Preferably, as an improvement, the side wall of the analyzer shell is provided with a window, the window is opposite to the collecting box, and a door body for closing the window is arranged at the window.

In this scheme, the user can open the door body, takes out the collecting box through the window to empty the reagent card in the collecting box into appointed reagent card recycling bin.

Preferably, as an improvement, the bottom plate is provided with a plurality of balls.

In this scheme, the frictional force between the reducible reagent card of ball on the bottom plate and the bottom plate, the person of facilitating the use pushes the reagent card standing groove, also is convenient for reagent card roll-off standing groove.

Preferably, as an improvement, a pull-down baffle is installed at the sample inlet.

In this scheme, when not using the analysis appearance, shelter from the introduction port by the baffle, avoid impurity such as external dust to get into the inside of analysis appearance shell.

Drawings

Fig. 1 is a schematic structural diagram of a single-channel rotary nanoenzyme immunoassay analyzer according to an embodiment of the present invention;

FIG. 2 is a longitudinal cross-sectional view of FIG. 1;

FIG. 3 is an enlarged view of A in FIG. 2;

FIG. 4 is a top view of the guide bar and clamping block of FIG. 2;

FIG. 5 is an enlarged schematic view of B in FIG. 2;

FIG. 6 is a top view of the rotary test tray of FIG. 2;

FIG. 7 is an enlarged view of C in FIG. 6;

figure 8 is a longitudinal cross-sectional view of the stop assembly.

Detailed Description

The following is further detailed by way of specific embodiments:

reference numerals in the drawings of the specification include: the analyzer comprises an analyzer shell 1, a baffle 2, a door body 3, a detection head 4, a liquid adding needle 5, a liquid sucking needle 6, a first motor 7, a guide rod 8, a lead screw 9, a nut 10, a clamping block 11, a fixing part 110, a deformation part 120, an L-shaped groove 12, a screw 13, a rotary detection disc 14, a wedge-shaped guide block 15, a bottom plate 16, a rotary roller 17, a placing groove 18, a ball 19, a push rod motor 20, a limiting plate 21, a second motor 22, a transmission belt 23, a driving shaft 24, a driven shaft 25 and a collecting box 26.

This embodiment is substantially as shown in fig. 1: the single-channel rotary nano enzyme immunoassay analyzer comprises an analyzer shell 1, wherein a sample inlet and a window are arranged on the analyzer shell 1, a pull-down baffle 2 is installed at the sample inlet, and specifically, the baffle 2 is vertically connected to the side wall of the analyzer shell 1 in a sliding manner through a T-shaped groove; a door body 3 for closing the window is installed at the window, and specifically, the door body 3 is hinged to the side wall of the analyzer housing 1 through a hinge.

Be equipped with detection mechanism, liquid feeding mechanism and imbibition mechanism in the analysis appearance shell 1, it is shown in combination with fig. 2, detection mechanism includes that fixed mounting detects head 4 in analysis appearance shell 1 is inside, in this embodiment, detects head 4 and is the structure of shooing among the prior art, and its principle and connected mode, user mode are prior art, and this embodiment is not optimized to the structure of shooing. The liquid adding mechanism comprises a liquid adding needle 5, the liquid suction mechanism comprises a liquid suction needle 6, and as shown in a combined figure 3, the bottom end of the liquid suction needle 6 is lower than the bottom end of the liquid adding needle 5.

The analyzer comprises an analyzer shell 1, wherein a first driving unit used for driving a liquid feeding needle 5 and a liquid sucking needle 6 to ascend and descend is arranged in the analyzer shell 1, the first driving unit comprises a first motor 7, a ball screw pair and a guide rod 8, the first motor 7 is used for driving a lead screw 9 of the ball screw pair to rotate, the first motor 7 is fixedly installed on the inner side top wall of the analyzer shell 1 through screws, specifically, the output end of the first motor 7 drives the lead screw 9 of the ball screw pair to rotate through a driving belt, and the top end of the lead screw 9 of the ball screw pair is rotatably connected to the inner side top wall of the analyzer shell 1 through a bearing. The nut 10 welding of ball screw is vice has grip block 11, and grip block 11 sets up the through-hole that supplies guide bar 8 to pass, and the top of guide bar 8 welds on the inboard roof of analysis appearance shell 1. Add on liquid needle 5 and imbibition needle 6 all are fixed in grip block 11, specifically, it is shown in combination figure 4, set up the mounting hole of two vertical settings on the grip block 11, two mounting holes supply imbibition needle 6 and add liquid needle 5 to insert respectively, set up the L type groove 12 with the mounting hole intercommunication on the grip block 11, L type groove 12 divide into fixed part 110 and deformation portion 120 with grip block 11, threaded blind hole has still been seted up on the grip block 11, threaded blind hole threaded connection has screw 13, threaded blind hole runs through deformation portion 120 and extends to fixed part 110. In this embodiment, when the screw 13 is tightened, the deformation portion 120 is bent toward the fixing portion 110 by an acting force, so that the gap of the L-shaped groove 12 is reduced, the liquid suction needle 6 and the liquid feeding needle 5 in the mounting hole are clamped, and the liquid suction needle 6 and the liquid feeding needle 5 are clamped and fixed.

Rotation connection has the rotation type to detect dish 14 in 1 rotations of analysis appearance shell, and detection mechanism, liquid feeding mechanism and imbibition mechanism all locate the rotation type and detect the top of dish 14, combine fig. 5 and fig. 6 to show, are equipped with the detection that a plurality of radial set up on the rotation type and lead to the groove, and in this embodiment, detect quantity and be six, and six detect lead to groove along circumference evenly distributed.

Detect logical both sides wall relative all the welding of groove and be used for leading the wedge guide block 15 of reagent card, it has bottom plate 16 to detect to lead to the inslot to articulate, specifically, it is shown in combination figure 7, the roller 17 is changeed in all the welding of bottom plate 16's both sides wall, detect to lead to the relative both sides wall of groove and all offer the mounting hole that supplies to change roller 17 and stretch into, bottom plate 16 and detection lead to the groove and form the standing groove 18 that is used for placing the reagent card, standing groove 18 can just right with the introduction port. The upper surface of the base plate 16 is provided with a plurality of balls 19 to reduce friction between the base plate 16 and the reagent card.

As shown in fig. 2, 5 and 8, a limiting component for supporting the bottom plate is arranged below the rotary detection disc, the limiting component includes a push rod motor 20 and a limiting plate 21, the push rod motor 20 is fixedly mounted on the bottom surface of the rotary detection disc 14 through screws, the limiting plate 21 is fixedly connected with the output end of the push rod motor 20 through bolts, and the upper surface of the limiting plate 21 is attached to the bottom surface of the rotary detection disc 14, so that the bottom plate 16 is in a horizontal state in the detection through groove.

As shown in fig. 2, a second driving unit for driving the rotary detection disc 14 to rotate is arranged in the analyzer housing 1, the second driving unit includes a second motor 22 and a transmission belt 23, the second motor 22 is fixedly mounted on the inner top wall of the analyzer housing 1 through screws, an output end of the second motor 22 is coaxially and fixedly connected with a driving shaft 24 through bolts, the rotary detection disc 14 is coaxially and fixedly connected with a driven shaft 25 through bolts, a top end of the driven shaft 25 is rotatably connected with the inner top wall of the analyzer housing 1 through a bearing, and the driving shaft 24 and the driven shaft 25 are transmitted through the transmission belt 23.

A collection box 26 with an open top is arranged in the analyzer shell 1, the collection box 26 is positioned below the rotary detection disc 14, and the collection box 26 is opposite to the window, so that a user can take out the collection box 26 through the window after opening the door body 3.

In this embodiment, the serial number of the placement groove 18 facing the sample inlet is one, and the serial numbers are performed in reverse time for six placement grooves 18 (as shown in fig. 6, the serial number of the placement groove 18 located at the lowermost position is one), so the liquid adding mechanism and the liquid suction mechanism are located directly above the placement groove 18 having the serial number of four, the detection head 4 is located directly above the placement groove 18 having the serial number of five, and the driving unit one, the driving unit two, and the detection mechanism have sufficient installation spaces and do not affect each other. In this embodiment, the first motor 7 and the second motor 22 are both servo motors.

The specific implementation process is as follows: initially, the upper surface of the limiting plate 21 in the limiting assembly is attached to the bottom surface of the rotary detection disc 14, and at this time, the bottom surface of the bottom plate 16 is also attached to the upper surface of the limiting plate 21, so that the bottom plate 16 is in a horizontal state, and further the bottom plate 16 is stably formed with the detection through groove to form the placing groove 18, so that the reagent card can be horizontally and stably placed in the placing groove 18 after being pushed into the placing groove 18.

Then, the user pulls up the shutter 2 to expose the sample inlet, and at this time, one of the six placing grooves 18 faces the sample inlet, and the user pushes the reagent card into the placing groove 18. Subsequently, the second motor 22 is started, the second motor 22 drives the driving shaft 24 to rotate, the driving shaft 24 drives the driven shaft 25 to rotate through the transmission belt 23, the driven shaft 25 drives the rotary detection disc 14 to rotate counterclockwise, and the second motor 22 can control the angle of each rotation of the rotary detection disc 14. By repeating the above operation, six reagent cards can be pushed into the six placing grooves 18, respectively.

After a user pushes six reagent cards into six placing grooves 18 respectively, the second motor 22 continues to enable the rotary detection disc 14 to intermittently rotate, in the rotating process, when one placing groove 18 is aligned with the liquid adding needle 5 and the liquid suction needle 6, the second motor 22 stops working, the placing groove 18 is enabled to stay at the position for a period of time, the first motor 7 is started, the output end of the first motor 7 rotates positively, the lead screw 9 of the ball screw pair rotates positively under the driving of the driving belt, the nut 10 of the ball screw pair drives the clamping block 11 to move downwards until the bottom end of the liquid suction needle 6 extends into a liquid suction port of the reagent card, and the first motor 7 stops working. At this time, the liquid adding needle 5 is positioned right above the color development window of the reagent card, so that the liquid adding needle 5 can add the color development liquid to the color development window of the reagent card, after the color development liquid is added, the bottom end of the liquid suction needle 6 is overflowed by the color development liquid, the liquid suction needle 6 can suck the redundant color development liquid in the reagent card, and the influence of the color development liquid on the detection of the subsequent detection head 4 is avoided. After the liquid sucking needle 6 sucks redundant color developing liquid in the reagent card, the motor I7 is started, the output end of the motor I7 rotates reversely, then the screw 9 of the ball screw pair rotates reversely, the nut 10 of the ball screw pair drives the clamping block 11 to move upwards for resetting, so that the liquid adding needle 5 and the liquid sucking needle 6 move upwards for resetting, and the reagent card can move along with the rotary detection disc 14.

Thereafter, the second motor 22 is started, so that the rotary detection tray 14 continues to rotate counterclockwise, and the reagent card in the next placement groove 18 comes under the liquid adding needle 5 and the liquid suction needle 6, so as to add the color developing liquid. In the above process, the reagent card added with the developing solution comes under the detection head 4, and the detection head 4 photographs the card for detection. This is repeated until all six reagent cards are added with the developing solution and photographed for detection by the detection head 4.

Finally, six reagent cards all accomplish the detection, push rod motor 20 starts, push rod motor 20's output drives limiting plate 21 downstream, bottom plate 16 loses limiting plate 21's support, then, bottom plate 16 takes place to deflect under the action of gravity, the one end downward sloping of the rotation type detection dish 14 centre of a circle is kept away from to bottom plate 16 promptly, then, the reagent card in the standing groove 18 is automatic landing under the action of gravity, and drop in collecting box 26, realize the automatic play card of reagent card, avoid the manual card of getting of user, further improve detection efficiency.

When the number of the reagent cards in the collection box 26 is large, the user opens the door body 3 to expose the window, the collection box 26 is taken out through the window, and then the reagent cards in the collection box 26 are dumped into the designated reagent card recovery barrel.

In summary, in the present embodiment, the user can put six test agent cards into the six placing slots 18 of the rotary testing tray 14 at a time, so as to perform continuous testing, shorten the testing time, and improve the testing efficiency. Moreover, in this embodiment, the detected reagent card can automatically slide into the collection box 26, so that the user is prevented from manually taking out the reagent card, the detection efficiency is further improved, and the method is very suitable for detecting samples in batches.

The above description is only an example of the present invention, and the detailed technical solutions and/or characteristics known in the solutions are not described too much here. It should be noted that, for those skilled in the art, without departing from the technical solution of the present invention, several modifications and improvements can be made, which should also be regarded as the protection scope of the present invention, and these will not affect the effect of the implementation of the present invention and the practicability of the patent. The scope of the claims of the present application shall be determined by the contents of the claims, and the description of the embodiments and the like in the specification shall be used to explain the contents of the claims.

Claims (10)

1. Single channel rotation type nanometer enzyme immunoassay appearance, including the analysis appearance shell, be equipped with the introduction port on the analysis appearance shell, be equipped with detection mechanism, liquid feeding mechanism and imbibition mechanism in the analysis appearance shell, its characterized in that: a rotary detection disc is rotationally connected in the analyzer shell, the detection mechanism, the liquid feeding mechanism and the liquid suction mechanism are all arranged above the rotary detection disc, a plurality of radially arranged detection through grooves are arranged on the rotary detection disc, deflectable bottom plates are arranged in the detection through grooves, the bottom plates and the detection through grooves form a placing groove for placing a reagent card, and the placing groove can be right opposite to the sample inlet; and a limiting assembly used for supporting the bottom plate is arranged below the rotary detection plate.

2. The single-channel rotary nanoenzyme immunoassay analyzer of claim 1, wherein: the bottom plate articulates and leads to the inslot in the detection, spacing subassembly includes push rod motor and limiting plate, and push rod motor fixed mounting is in the bottom surface of rotation type detection dish, limiting plate and push rod motor's output fixed connection, and the upper surface of limiting plate is laminated with the bottom surface of rotation type detection dish mutually.

3. The single-channel rotary nanoenzyme immunoassay analyzer of claim 2, wherein: and two opposite side walls of the detection through groove are fixedly connected with wedge-shaped guide blocks for guiding the reagent card.

4. The single-channel rotary nanoenzyme immunoassay analyzer of claim 3, wherein: the liquid feeding mechanism comprises a liquid feeding needle, the liquid suction mechanism comprises a liquid suction needle, a first driving unit used for driving the liquid feeding needle and the liquid suction needle to ascend and descend is arranged in the shell of the analyzer, the first driving unit comprises a motor I, a ball screw pair and a guide rod, the motor I is used for driving a screw of the ball screw pair to rotate, a clamping block is fixedly connected to a nut of the ball screw pair, a through hole for the guide rod to penetrate through is formed in the clamping block, and the liquid feeding needle and the liquid suction needle are fixed on the clamping block.

5. The single-channel rotary nanoenzyme immunoassay analyzer of claim 4, wherein: the bottom end of the liquid suction needle is lower than the bottom end of the liquid adding needle.

6. The single-channel rotary nanoenzyme immunoassay analyzer of claim 5, wherein: the analyzer is characterized in that a second driving unit used for driving the rotary detection disc to rotate is arranged in the analyzer shell and comprises a second motor and a transmission belt, the output end of the second motor is fixedly connected with a driving shaft coaxially, the rotary detection disc is fixedly connected with a driven shaft coaxially, and the driving shaft and the driven shaft are driven through the transmission belt.

7. The single-channel rotary nanoenzyme immunoassay analyzer of claim 2 or 6, wherein: a collecting box with an opening at the top is arranged in the analyzer shell and is positioned below the rotary detection disc.

8. The single-channel rotary nanoenzyme immunoassay analyzer of claim 7, wherein: the side wall of the analyzer shell is provided with a window, the window is opposite to the collecting box, and a door body used for sealing the window is arranged at the window.

9. The single-channel rotary nanoenzyme immunoassay analyzer of claim 8, wherein: the bottom plate is provided with a plurality of balls.

10. The single-channel rotary nanoenzyme immunoassay analyzer of claim 9, wherein: and a pull-down baffle is arranged at the sample inlet.

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