CN213967173U - Platelet-rich plasma extraction device - Google Patents
Platelet-rich plasma extraction device Download PDFInfo
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- CN213967173U CN213967173U CN202022482899.9U CN202022482899U CN213967173U CN 213967173 U CN213967173 U CN 213967173U CN 202022482899 U CN202022482899 U CN 202022482899U CN 213967173 U CN213967173 U CN 213967173U
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Abstract
The utility model relates to a platelet-rich plasma extraction device, which comprises a first cylinder, a second cylinder and a third cylinder which are connected in sequence; the first barrel is provided with a blood injection hole and an air inlet, and the blood injection hole is detachably provided with a first plugging piece; a first sampling port is formed in the second cylinder body, and a second plugging piece is detachably arranged on the first sampling port; the second cylinder body is telescopic, so that the volume of an inner cavity of the second cylinder body is adjustable; one end of the third cylinder body, which is far away from the second cylinder body, is connected with an adjusting cover in a sealing way, and the adjusting cover can generate relative displacement with the third cylinder body so as to adjust the volume of an inner cavity of the third cylinder body; a first control valve is arranged at the joint of the first barrel and the second barrel, and a second control valve is arranged at the joint of the second barrel and the third barrel. The platelet-rich plasma extraction device provided by the disclosure does not need to transfer plasma, is convenient to operate, fundamentally reduces the possibility of plasma pollution, and is safe to use and convenient to operate.
Description
Technical Field
The utility model relates to a plasma collection system technical field especially relates to a rich platelet plasma extraction element.
Background
Platelet-rich plasma (PRP) is platelet-rich plasma obtained by extracting certain venous blood, and performing in vitro centrifugation and separation.
The main components of PRP are platelets, leukocytes and fibrin. After being activated, the blood platelet can release various bioactive factors, thereby promoting the regeneration and repair of soft and hard tissues. Thus, PRP is increasingly used in clinical applications including orthopedics, ophthalmology, orthopedics, and the like.
In the prior art, most of the PRP preparation methods are secondary centrifugation methods, that is, after blood is extracted, red blood cells, plasma and platelets are separated into layers by first centrifugation, then the plasma and platelet layers are transferred to a new container for second centrifugation, and the platelets are enriched at the bottom after the second centrifugation, so that platelet-rich plasma PRP and poor platelet plasma are obtained. Because the method needs two times of centrifugation work, the operation is complicated, especially the plasma and platelet layers need to be transferred to a new container after the first centrifugation, and bacterial pollution is possibly caused in the transferring process of the second centrifugation, thereby causing safety threat to patients.
SUMMERY OF THE UTILITY MODEL
To solve the above technical problem or at least partially solve the above technical problem, the present disclosure provides a platelet rich plasma extraction device.
The present disclosure provides a platelet rich plasma extraction device, which comprises a first cylinder, a second cylinder and a third cylinder, which are connected in sequence; the first barrel is provided with a blood injection hole and an air inlet, and the blood injection hole is detachably provided with a first plugging piece; a first sampling port is formed in the second cylinder, and a second plugging piece is detachably arranged on the first sampling port; the second cylinder body is telescopic, so that the volume of an inner cavity of the second cylinder body is adjustable; one end of the third cylinder body, which is far away from the second cylinder body, is connected with an adjusting cover in a sealing manner, and the adjusting cover can generate relative displacement with the third cylinder body so as to adjust the volume of an inner cavity of the third cylinder body; the connection part of the first cylinder and the second cylinder is provided with a first control valve for controlling the first cylinder to be communicated with or separated from the second cylinder, and the connection part of the second cylinder and the third cylinder is provided with a second control valve for controlling the second cylinder to be communicated with or separated from the third cylinder.
Optionally, the second cylinder is an axially telescopic flexible cylinder.
Optionally, the second cylinder includes a first sub-cylinder and a second sub-cylinder nested with each other, and the first sub-cylinder is movable relative to the second sub-cylinder in an axial direction of the second sub-cylinder.
Optionally, the inner wall of the first sub-cylinder is provided with a first internal thread, and the outer wall of the second sub-cylinder is provided with a first external thread which is used for being connected with the first internal thread in a matching manner.
Optionally, the adjusting cover is arranged at one end, far away from the second barrel, of the third barrel, a second internal thread is arranged on the inner wall of the adjusting cover, and a second external thread used for being connected with the second internal thread in a matched mode is arranged on the outer wall of the third barrel.
Optionally, a second sampling port is further formed in the first cylinder, and a third plugging piece is detachably arranged on the second sampling port.
Optionally, a third sampling port is further formed in the third cylinder, and a fourth plugging piece is detachably arranged on the third sampling port.
Optionally, the inner diameter of the second cylinder at one end close to the first cylinder is gradually reduced along the direction close to the first cylinder; and/or the inner diameter of one end of the first cylinder body close to the second cylinder body is gradually reduced along the direction close to the second cylinder body, and the inner diameter of the third cylinder body close to the second cylinder body is gradually reduced.
Optionally, the first cylinder and one end of the second cylinder are detachably connected, and the other end of the second cylinder and the third cylinder are detachably connected.
Optionally, one end of the first cylinder and one end of the second cylinder are detachably connected through a first two-way joint, and the first control valve is arranged on the first two-way joint; the other end of the second cylinder body is detachably connected with the third cylinder body through a second two-way joint, and the second control valve is arranged on the second two-way joint.
Compared with the prior art, the technical scheme provided by the embodiment of the disclosure has the following advantages: through setting up first barrel, second barrel and the third barrel that connects gradually, the junction of first barrel and second barrel is provided with and is used for controlling first barrel and second barrel intercommunication or the first control flap that separates, and the junction of second barrel and third barrel is provided with and is used for controlling second barrel and third barrel intercommunication or the second control flap that separates, has seted up the blood filling hole on the first barrel. When the platelet rich plasma extraction device is used, blood is injected into the first cylinder through the blood injection hole, the first control valve and the second control valve are opened, and the platelet rich plasma extraction device provided by the disclosure is placed in a centrifuge for centrifugation; after centrifugation, the blood is divided into three layers, namely a plasma layer, a tunica albuginea layer and a red blood cell layer in sequence along the vertical direction from the first cylinder to the third cylinder. One end of the third cylinder body, which is far away from the second cylinder body, is connected with an adjusting cover in a sealing way, and the adjusting cover can generate relative displacement with the third cylinder body so as to adjust the volume of an inner cavity of the third cylinder body; the second cylinder body can stretch and retract, so that the volume of the inner cavity of the second cylinder body can be adjusted. Through the relative position of adjustment adjusting cover for the third barrel, make the three-layer blood after the centrifugation shift up on the whole, when the erythrocyte layer is held in the third barrel completely, close the second control valve, make the second barrel flexible after that, so that the leucocyte layer is held in the second barrel completely, close first control valve, at this moment, plasma layer, leucocyte layer and erythrocyte layer are located different barrels respectively, namely the plasma layer is located first barrel, the leucocyte layer is located the second barrel, the erythrocyte layer is located the third barrel, thereby separate rich platelet plasma from blood. The second cylinder is provided with a first sampling port, and when the blood platelet-rich plasma extraction device is used, platelet-rich plasma can be extracted through the first sampling port. In addition, detachably is provided with the second shutoff piece on the first sample connection, can be with first sample connection shutoff through the second shutoff piece, can prevent the pollution among the centrifugal process. Based on this, utilize the platelet rich plasma extraction element that this disclosure provided in the in-process of drawing platelet rich plasma, only need once centrifugation can accomplish the separation of plasma, platelet rich plasma and erythrocyte, need not to shift plasma, convenient operation has fundamentally reduced the contaminated possibility of plasma, safe in utilization, convenient operation.
Drawings
The accompanying drawings, which are incorporated in and constitute a part of this specification, illustrate embodiments consistent with the present disclosure and together with the description, serve to explain the principles of the disclosure.
In order to more clearly illustrate the embodiments or technical solutions in the prior art of the present disclosure, the drawings used in the description of the embodiments or prior art will be briefly described below, and it is obvious for those skilled in the art that other drawings can be obtained according to the drawings without inventive exercise.
Fig. 1 is a schematic structural diagram of a platelet rich plasma extraction device according to an embodiment of the disclosure;
fig. 2 is a partial schematic view of a second cylinder of the platelet rich plasma extraction device according to an embodiment of the disclosure;
fig. 3 is a schematic cross-sectional view of another embodiment of a second cylinder of the platelet rich plasma extraction device according to an embodiment of the disclosure;
FIG. 4 is an exploded view of FIG. 3;
fig. 5 is a schematic cross-sectional view of another embodiment of a second cylinder of the platelet rich plasma extraction device according to an embodiment of the disclosure;
FIG. 6 is an enlarged view of a portion A of FIG. 5;
fig. 7 is an exploded view of fig. 5.
Wherein, 10-a first cylinder; 11-a blood injection hole; 12-an air inlet; 13-a second sample port; 20-a second cylinder; 21-a first sub-cylinder; 22-a second sub-cylinder; 23-a first sampling port; 24-a flexible cylinder; 30-a third cylinder; 31-adjusting the cover; 32-a third sample port; 41-a first control valve; 42-second control valve.
Detailed Description
In order that the above objects, features and advantages of the present disclosure may be more clearly understood, aspects of the present disclosure will be further described below. It should be noted that the embodiments and features of the embodiments of the present disclosure may be combined with each other without conflict.
In the following description, numerous specific details are set forth in order to provide a thorough understanding of the present disclosure, but the present disclosure may be practiced in other ways than those described herein; it is to be understood that the embodiments disclosed in the specification are only a few embodiments of the present disclosure, and not all embodiments.
Referring to fig. 1 to 7, the present disclosure provides a platelet rich plasma extraction device including a first cylinder 10, a second cylinder 20, and a third cylinder 30 connected in sequence; the first cylinder 10 is provided with a blood injection hole 11 and an air inlet 12, and the blood injection hole 11 is detachably provided with a first plugging piece; a first sampling port 23 is formed in the second cylinder 20, and a second plugging piece is detachably arranged on the first sampling port 23; the second cylinder body 20 can stretch and retract, so that the volume of the inner cavity of the second cylinder body 20 can be adjusted; one end of the third cylinder 30, which is far away from the second cylinder 20, is hermetically connected with an adjusting cover 31, and the adjusting cover 31 can be displaced relative to the third cylinder 30 to adjust the volume of the inner cavity of the third cylinder 30; a first control valve 41 for controlling the communication or separation of the first cylinder 10 and the second cylinder 20 is arranged at the joint of the first cylinder 10 and the second cylinder 20, and a second control valve 42 for controlling the communication or separation of the second cylinder 20 and the third cylinder 30 is arranged at the joint of the second cylinder 20 and the third cylinder 30.
Through above-mentioned technical scheme, this platelet rich plasma extraction element that openly provides only need once centrifugation just can separate and extract required PRP, and whole process need not the transfer of plasma, and the blood overall process is kept apart with external world completely to can realize the aseptic technique of overall process. The PRP separation method adopts a traditional centrifugation method and comprises the following specific steps:
1) the first control valve 41 and the second control valve 42 are opened, the collected blood with anticoagulant is injected into the first cylinder 10 through the blood injection hole 11, then the platelet-rich plasma extraction device provided by the present disclosure is placed in a centrifuge for centrifugation, after the centrifugation, the blood is divided into three layers, and the three layers are sequentially divided into a plasma layer, a tunica albuginea layer and a red blood cell layer along the vertical direction from the first cylinder 10 to the third cylinder 30.
2) The adjusting cover 31 is moved toward the direction close to the second cylinder 20 (i.e. the adjusting cover is moved upward), so that the red blood cell layer is moved upward as a whole, when the upper interface of the red blood cells moves to be flush with the port of the second cylinder 20 close to the third cylinder 30, the adjusting cover 31 is stopped moving, and the second control valve 42 is closed, at this time, the red blood cell layer is accommodated in the third cylinder 30 as a whole, and the white blood cell layer enters the second cylinder 20.
3) After the white film layer enters the second cylinder body 20, because the volume of the white film layer is lower, at this moment, there may be a plasma layer in the second cylinder body 20, at this moment, the second cylinder body 20 is telescopically adjusted, so that the inner cavity volume of the second cylinder body 20 is matched with the volume of the white film layer, that is, when the upper interface of the white film layer moves to be flush with the port of the second cylinder body 20 close to the first cylinder body 10, the telescopic adjustment of the second cylinder body 20 is stopped, and the first control valve 41 is closed, at this moment, the white film layer is integrally accommodated in the second cylinder body 20, and the plasma layer is integrally accommodated in the first cylinder body 10.
4) The second stopper on the first sampling port 23 is opened, the liquid taking end of the syringe extends into the second cylinder 20 through the first sampling port 23, and the white membrane substance in the second cylinder 20 is carefully extracted out.
In this embodiment, the volume of the second cylinder 20 is adjusted by stretching and contracting, so that the volume of the second cylinder is adapted to the volume of the tunica albuginea layer, the second cylinder 20 can be respectively separated from the third cylinder 30 and the first cylinder 10 by the second control valve 42 and the first control valve 41, so that the tunica albuginea layer is completely accommodated in the second cylinder 20, so that the platelet enrichment degree is higher, the maximum enrichment can be about 60 times, the operation is very convenient, in the operation process, the platelet loss is less, the difference in time of different personnel operation is not too large, and the consistency of the PRP quality can be ensured.
In this embodiment, by providing the first barrel 10, the second barrel 20 and the third barrel 30 which are connected in sequence, a first control valve 41 for controlling the first barrel 10 to be communicated with or separated from the second barrel 20 is disposed at a joint of the first barrel 10 and the second barrel 20, a second control valve 42 for controlling the second barrel 20 to be communicated with or separated from the third barrel 30 is disposed at a joint of the second barrel 20 and the third barrel 30, and the first barrel 10 is provided with the blood injection hole 11. When in specific use, blood is injected into the first cylinder 10 through the blood injection hole 11, the first control valve 41 and the second control valve 42 are opened, and the platelet-rich plasma extraction device provided by the disclosure is placed in a centrifuge for centrifugation; after the centrifugation, the blood was divided into three layers, namely, a plasma layer, a tunica albuginea layer and a red blood cell layer in this order in the vertical direction from the first tube 10 to the third tube 30. One end of the third cylinder 30, which is far away from the second cylinder 20, is hermetically connected with an adjusting cover 31, and the adjusting cover 31 can be displaced relative to the third cylinder 30 to adjust the volume of the inner cavity of the third cylinder 30; the second cylinder 20 can be extended and retracted, so that the volume of the inner cavity of the second cylinder 20 can be adjusted. The relative position of the adjusting cover 31 with respect to the third cylinder 30 is adjusted to move the centrifuged three layers of blood upward as a whole, when the red blood cell layer is completely accommodated in the third cylinder 30, the second control valve 42 is closed, then the second cylinder 20 is made to extend and retract, so that the white blood cell layer is completely accommodated in the second cylinder 20, and the first control valve 41 is closed, at this time, the plasma layer, the white blood cell layer and the red blood cell layer are respectively located in different cylinders, that is, the plasma layer is located in the first cylinder 10, the white blood cell layer is located in the second cylinder 20, and the red blood cell layer is located in the third cylinder 30, so that the platelet-rich plasma is separated from the blood. The second cylinder 20 is provided with a first sampling port 23, and when in use, the platelet-rich plasma can be extracted through the first sampling port 23. In addition, detachably is provided with the second shutoff piece on the first sample connection 23, can be with first sample connection 23 shutoff through the second shutoff piece, can prevent the pollution in the centrifugal process. Based on this, utilize the platelet rich plasma extraction element that this disclosure provided in the in-process of drawing platelet rich plasma, only need once centrifugation can accomplish the separation of plasma, platelet rich plasma and erythrocyte, need not to shift plasma, convenient operation has fundamentally reduced the contaminated possibility of plasma, safe in utilization, convenient operation.
In particular, the first cylinder 10, the second cylinder 20, the third cylinder 30 and the adjusting cover 31 have high strength to ensure that the first cylinder 10, the second cylinder 20, the third cylinder 30 and the adjusting cover 31 are not damaged during centrifugation. The first cylinder 10, the second cylinder 20 and the third cylinder 30 can all be made of transparent materials, so that the condition of internal blood can be seen, and a user can clearly observe the liquid level change in the first cylinder 10, the second cylinder 20 and the third cylinder 30, and the adjustment is facilitated.
In this embodiment, the air inlet 12 is provided with a ventilation dustproof and antibacterial filter membrane, which can ensure that the air pressure in the platelet-rich plasma extraction device provided by the present disclosure is the same as the external air pressure, and can also filter the pollution particles such as bacteria in the air.
Wherein, first shutoff piece uses when injecting blood back centrifugation, can seal blood filling hole 11, can effectively prevent the pollution in the centrifugation process. In an actual product, the first blocking member may be formed as a cap that is placed on the blood-injecting hole 11 to perform sealing, and in addition, the first blocking member may be formed as a stopper or plug that is fitted into the blood-injecting hole 11 to perform sealing by being inserted into the blood-injecting hole 11.
In addition, the second plugging member can be covered on the first sampling port 23 for sealing as the first plugging member is arranged, and can also be inserted into the first sampling port 23 for sealing.
As an alternative embodiment, referring to fig. 2, in order to facilitate adjustment of the lumen volume of the second barrel 20, the second barrel 20 is an axially telescoping flexible barrel 24. The flexible cylinder 24 is made of an elastic transparent material, for example, silica gel with high transparency can be selected, and the flexible cylinder has flexible deformation and expansion and is convenient for observing the blood condition in the flexible cylinder 24 and the actual moving position of blood. In addition, the flexible cylinder 24 can stay at any deformation position along the axial direction of the second cylinder 20 to maintain the deformation state, so that the inner cavity volume of the second cylinder is stable after being adjusted.
In addition, at least part of the second cylinder 20 along the axial direction is the flexible cylinder 24, that is, the second cylinder 20 can be formed into the flexible cylinder 24, the sealing effect is good, the inner cavity of the second cylinder 20 has a wide adjustment range, and the applicability is strong. Of course, the second cylinder 20 may have a part of the cylinder in the axial direction as the flexible cylinder 24, in this case, the flexible cylinder 24 and the second cylinder 20 may be integrally formed, or may be connected together by a sealant or the like along the axial direction of the second cylinder 20, so that the flexible cylinder 24 and the second cylinder 20 form an axially telescopic cylinder.
As another alternative embodiment, referring to fig. 3 to 7, in order to adjust the cavity volume of the second cylinder 20, the second cylinder 20 includes a first sub-cylinder 21 and a second sub-cylinder 22 nested with each other, and the first sub-cylinder 21 is movable relative to the second sub-cylinder 22 in the axial direction of the second sub-cylinder 22 so that the cavity volume of the second cylinder 20 matches the volume of the tunica albuginea layer to be stored.
The first sub-cylinder 21 and the second sub-cylinder 22 are both opened at the joint, so that the first sub-cylinder 21 and the second sub-cylinder 22 are nested with each other to form a communicated inner cavity, thereby facilitating the storage of the white film layer.
Referring to fig. 3 and 4, an end of the first sub-cylinder 21 adjacent to the second sub-cylinder 22 is circumferentially provided with a receiving groove, and an end of the second sub-cylinder 22 adjacent to the first sub-cylinder 21 is formed as an adjustment area, which is adapted to the receiving groove. When the first sub-cylinder 21 moves relative to the second sub-cylinder 22 in the axial direction of the second sub-cylinder 22, the accommodating groove is always coated outside the adjusting area, so that the first sub-cylinder 21 and the second sub-cylinder 22 are communicated to form a closed inner cavity. Wherein a sealing member, such as a packing ring, is provided at the junction of the regulation region and the receiving groove to prevent the white membrane stored in the second cylinder 20 from leaking outside.
In the present embodiment, the second cylinder 20 is provided with the first sampling port 23, and particularly, the first sampling port 23 is provided on the first sub-cylinder 21 or the second sub-cylinder 22, and referring to fig. 3 and 4, the first sampling port 23 may be provided on an outer wall of the first sub-cylinder 21 or the second sub-cylinder 22. The first sampling port 23 is of a cylindrical structure, and one end of the cylindrical structure, which is far away from the second cylinder 20, does not exceed the plane where the side wall with the largest aperture in the first cylinder 10 and the third cylinder 30 is located, so that the first sampling port 23 is prevented from being broken or damaged due to collision; the cylinder is internally provided with a hollow passage which extends to the inner cavity of the first sub-cylinder body 21 or the second sub-cylinder body 22, the liquid taking end of the syringe extends into the second cylinder body 20 through the first sampling port 23, and the white membrane layer substances in the second cylinder body 20 are carefully and completely extracted. Of course, the sampling end of the syringe may be used to extract the buffy coat layer at a port of the first sampling port 23 remote from the second barrel 20, and the platelet or other substance is extracted from the hollow channel through the sampling end of the syringe.
Referring to fig. 5 and 7, an end of the first sub-cylinder 21 adjacent to the second sub-cylinder 22 is circumferentially provided with a receiving groove, and an end of the second sub-cylinder 22 adjacent to the first sub-cylinder 21 is formed as an adjustment area, which is adapted to the receiving groove. When the first sub-cylinder 21 moves relative to the second sub-cylinder 22 in the axial direction of the second sub-cylinder 22, the accommodating groove is always coated outside the adjusting area, so that the first sub-cylinder 21 and the second sub-cylinder 22 are communicated to form a closed inner cavity. When the accommodation zone cladding is in the holding tank, the inner wall of first sub-barrel 21 and the inner wall parallel and level of second sub-barrel 22, the outer wall of first sub-barrel 21 and the outer wall parallel and level of second sub-barrel 22, the aesthetic property is good, and is sealed effectual. The thickness of one end of the adjusting area far away from the wrapping area becomes larger to form a stop portion, so that when the first sub-cylinder 21 moves relative to the second sub-cylinder 22, the first sub-cylinder 21 can be prevented from being separated from the second sub-cylinder 22. In addition, a sealing member, such as a packing ring, is provided at the junction of the regulation region and the receiving groove to prevent the white membrane stored in the second cylinder 20 from leaking outside.
In this embodiment, the second cylinder 20 is provided with a first sampling port 23, and particularly, the first sampling port 23 is provided on the first sub-cylinder 21 or the second sub-cylinder 22, as shown in fig. 5 and fig. 6, along the wall thickness direction of the second cylinder, the first sampling port 23 may be directly provided on the side wall of the first sub-cylinder 21 or directly provided on the side wall of the second sub-cylinder 22, the first sampling port 23 is a cylindrical structure, a hollow passage is provided inside the cylinder, the hollow passage extends to the inner cavity of the first sub-cylinder 21 or the second sub-cylinder 22, the liquid taking end of the syringe extends into the second cylinder 20 through the first sampling port 23, and the white membranous substance in the second cylinder 20 is carefully extracted.
As an alternative embodiment, the first sub-cylinder 21 and the second sub-cylinder 22 are nested together, and the second sub-cylinder 22 can move relative to the first sub-cylinder 21 in the axial direction of the first sub-cylinder 21.
Further, a first internal thread is arranged on the inner wall of the first sub-cylinder 21, and a first external thread for matching connection with the first internal thread is arranged on the outer wall of the second sub-cylinder 22. The first internal thread and the first external thread are smooth in rotation, and great labor is not consumed. The first sub-cylinder 21 and the second sub-cylinder 22 are in threaded connection, so that the interface can be conveniently adjusted in a rotating mode, and the interface can be prevented from being disturbed due to vibration caused by sudden change of force when the interface is adjusted. During the specific use, multiplicable sealing washer between first internal thread and first external screw thread, perhaps directly make first internal thread and first external screw thread adopt the rubber material to guarantee the leakproofness that first sub-barrel 21 and second sub-barrel 22 are connected, do not have the leakage when guaranteeing the centrifugation.
In the present embodiment, referring to fig. 1, an adjusting cover 31 covers an end of the third cylinder 30 far from the second cylinder 20, a second internal thread is provided on an inner wall of the adjusting cover 31, and a second external thread for matching connection with the second internal thread is provided on an outer wall of the third cylinder 30. The adjusting cover 31 and the third cylinder 30 are connected together through the corresponding second internal threads and the second external threads, so that the rotation is smooth, the large strength or the stagnation feeling is avoided, the interface can be conveniently adjusted in a rotating manner, and the situation that the interface is disturbed due to the vibration caused by sudden change of force during adjustment can be prevented. During the specific use, can increase the sealing washer between adjusting cover 31 and the third barrel 30 or directly select for use adjusting cover 31 for the rubber adjusting cover to guarantee to adjust the leakproofness that cover 31 and third barrel 30 are connected, do not have the leakage when guaranteeing to centrifugate.
As another alternative, the adjusting cover 31 is disposed in the third cylinder 30, and the adjusting cover 31 can slide axially along the inner wall surface of the third cylinder 30. The adjusting cover 31 separates the inner cavity of the third cylinder 30 into a first cavity and a second cavity, the first cavity is located on one side of the adjusting cover 31 close to the second cylinder 20 and can be communicated with the second cylinder 20, the second cavity is located on one side of the adjusting cover 31 far away from the second cylinder 20, and the adjusting cover 31 can slide along the axial direction of the third cylinder 30 to adjust the volume of the first cavity and the second cavity and further adjust the volume of the inner cavity of the third cylinder 30.
During specific implementation, one end of the third cylinder 30, which is far away from the second cylinder 20, is provided with an adjusting structure connected with the adjusting cover 31, the adjusting structure comprises an adjusting rod and an adjusting cap, the adjusting cap is sleeved on the outer wall of the third cylinder 30, which is far away from the second cylinder 20, and the connecting rod is connected with the adjusting cover 31 and the adjusting cap respectively. The adjusting rod can drive the adjusting cover 31 to slide along the axial direction of the third cylinder 30, so as to adjust the position of the adjusting cover 31 in the axial direction in the third cylinder 30.
Further, be provided with the second internal thread on adjusting the cap, be provided with the second external thread that is used for with second internal thread accordant connection on the outer wall of third barrel 30, adjust cap and third barrel 30 threaded connection. When the position of the adjusting cover 31 in the third cylinder 30 needs to be adjusted, the adjusting cap can be screwed, so as to change the depth of the adjusting rod extending into the third cylinder 30, and further change the position of the adjusting cover 31 in the third cylinder 30 to change the volume of the inner cavity of the third cylinder.
In this embodiment, referring to fig. 1, a second sampling port 13 is further formed on the first barrel 10, and a third blocking piece is detachably disposed on the second sampling port 13. The second sampling port 13 can be arranged on the second sampling port 13 in a manner similar to the arrangement manner of the first sampling port 23, and similarly, the third plugging member can be arranged in a manner similar to the arrangement manner of the first plugging member, and can be inserted into the second sampling port 13 for sealing.
Further, referring to fig. 1, a third sampling port 32 is further formed in the third cylinder 30, and a fourth blocking piece is detachably disposed on the third sampling port 32. The third sampling port 32 is arranged like the first sampling port 23, and similarly, the fourth plugging member is arranged like the first plugging member, and can be covered on the third sampling port 32 for sealing, or inserted into the third sampling port 32 for sealing. In addition, the third sampling port 32 may also be formed as a blood injection hole, so that blood may be injected into the platelet rich plasma extraction device provided by the present disclosure through the third sampling port 32.
In the present embodiment, referring to fig. 1, 3 and 5, in a direction approaching the first cylinder 10, an inner diameter of one end of the second cylinder 20 approaching the first cylinder 10 is gradually reduced, that is, one end of the second cylinder 20 approaching the first cylinder 10 is formed as a tapered section; through this structural design, when the upper interface of adjustment tunica albuginea, close on the junction of first barrel 10 and second barrel 20, the upper interface of tunica albuginea can slowly rise and with the port parallel and level that is close to first barrel 10 of second barrel 20, avoid tunica albuginea to enter into first barrel, improve and adjust the precision, save time. In addition, the two ends of the conical section of the second cylinder 20 are both formed into a rounded design, so that hemoglobin is not easily damaged in the centrifugal process, and the occurrence of hemolysis is avoided to a certain extent.
In a specific implementation, the inner diameter of the first cylinder 10 near one end of the second cylinder 20 is gradually reduced, and the inner diameter of the third cylinder 30 near the second cylinder 20 is gradually reduced along the direction near the second cylinder 20. By adopting the design, the white film layer with small volume ratio can be conveniently concentrated in the second cylinder 20. Particularly, the inner diameter of the third cylinder 30 close to the second cylinder 20 is gradually reduced, so that when the upper interface of the red blood cell layer is adjusted, the upper interface of the red blood cell layer is close to the joint of the third cylinder 30 and the second cylinder 20, and can slowly rise and be flush with the port of the third cylinder close to the second cylinder, thereby avoiding the interface disturbance phenomenon caused by down-regulating the red blood cell layer when the red blood cell layer enters the second cylinder 20, and improving the adjustment precision.
In this embodiment, one end of the first cylinder 10 and one end of the second cylinder 20 are detachably connected, and the other end of the second cylinder 20 and the third cylinder 30 are detachably connected, so that any one of the required cylinders can be detached without affecting the remaining cylinders.
Wherein, the junction of the first cylinder 10 and the second cylinder 20 is formed as a rounded corner, and the junction of the second cylinder 20 and the third cylinder 30 is also formed as a rounded corner. By such design, on the one hand, after the blood enters the first barrel 10 from the blood injection hole 11, the blood can more conveniently and smoothly enter the second barrel 20 and the third barrel 30 in sequence. On the other hand, in the centrifugation process, the rounding design of the connection part can prevent the hemoglobin from being damaged, thereby avoiding the occurrence of hemolysis.
Further, referring to fig. 1, one ends of the first and second cylinders 10 and 20 are detachably connected by a first double joint, and a first control valve 41 is provided on the first double joint; the other end of the second cylinder 20 and the third cylinder 30 are detachably connected by a second double-way joint, and a second control valve 42 is provided on the second double-way joint.
In this example, one end of the first cylinder 10 away from the blood injection hole 11 is open, both ends of the second cylinder 20 are open, and one end of the third cylinder 30 away from the adjusting cap 30 is open, wherein the open end of the first cylinder 10 away from the blood injection hole 11 and one end of the second cylinder 20 are detachably connected through a first two-way joint, and a first control valve 41 provided on the first two-way joint can be opened or closed to connect or separate the first cylinder 10 and the second cylinder 20; the open end of the third cylinder 30 away from the adjusting cover 30 and the other end of the second cylinder 20 are detachably connected by a second two-way joint, and a second control valve 42 provided on the second two-way joint can be opened or closed to connect or separate the third cylinder 30 and the second cylinder 20.
The first double-way joint and the second double-way joint can be luer double-way joints with control valves, and the first barrel 10, the second barrel 20 and the third barrel 30 are detachably connected through the luer double-way joints in sequence, so that one required barrel can be detached without affecting other barrels.
It is noted that, in this document, relational terms such as "first" and "second," and the like, may be used solely to distinguish one entity or action from another entity or action without necessarily requiring or implying any actual such relationship or order between such entities or actions. Also, the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or apparatus. Without further limitation, an element defined by the phrase "comprising an … …" does not exclude the presence of other identical elements in a process, method, article, or apparatus that comprises the element.
The foregoing are merely exemplary embodiments of the present disclosure, which enable those skilled in the art to understand or practice the present disclosure. Various modifications to these embodiments will be readily apparent to those skilled in the art, and the generic principles defined herein may be applied to other embodiments without departing from the spirit or scope of the disclosure. Thus, the present disclosure is not intended to be limited to the embodiments shown herein but is to be accorded the widest scope consistent with the principles and novel features disclosed herein.
Claims (10)
1. The platelet-rich plasma extraction device is characterized by comprising a first cylinder (10), a second cylinder (20) and a third cylinder (30) which are sequentially connected;
a blood injection hole (11) and an air inlet (12) are formed in the first barrel (10), and a first blocking piece is detachably arranged on the blood injection hole (11);
a first sampling port (23) is formed in the second cylinder (20), and a second plugging piece is detachably arranged on the first sampling port (23); the second cylinder body (20) is telescopic, so that the volume of an inner cavity of the second cylinder body (20) is adjustable;
one end of the third cylinder body (30) far away from the second cylinder body (20) is connected with an adjusting cover (31) in a sealing mode, and the adjusting cover (31) can be displaced relative to the third cylinder body (30) to adjust the volume of the inner cavity of the third cylinder body (30);
the connection part of the first cylinder (10) and the second cylinder (20) is provided with a first control valve (41) for controlling the first cylinder (10) to be communicated with or separated from the second cylinder (20), and the connection part of the second cylinder (20) and the third cylinder (30) is provided with a second control valve (42) for controlling the second cylinder (20) to be communicated with or separated from the third cylinder (30).
2. The platelet rich plasma extraction device of claim 1, wherein the second cylinder (20) is an axially telescoping flexible cylinder (24).
3. The platelet-rich plasma extraction device according to claim 1, wherein the second cylinder (20) includes a first sub-cylinder (21) and a second sub-cylinder (22) nested with each other, the first sub-cylinder (21) being movable relative to the second sub-cylinder (22) in an axial direction along the second sub-cylinder (22).
4. The platelet-rich plasma extraction device according to claim 3, wherein the inner wall of the first sub-cylinder (21) is provided with a first internal thread, and the outer wall of the second sub-cylinder (22) is provided with a first external thread for matching connection with the first internal thread.
5. The platelet-rich plasma extraction device according to claim 1, wherein the adjusting cap (31) is disposed on an end of the third cylinder (30) far away from the second cylinder (20), a second internal thread is disposed on an inner wall of the adjusting cap (31), and a second external thread for matching connection with the second internal thread is disposed on an outer wall of the third cylinder (30).
6. The platelet-rich plasma extraction device according to any one of claims 1 to 5, wherein the first cylinder (10) further has a second sampling port (13), and the second sampling port (13) is detachably provided with a third blocking member.
7. The platelet-rich plasma extraction device according to any one of claims 1 to 5, wherein a third sampling port (32) is further opened on the third cylinder (30), and a fourth blocking piece is detachably arranged on the third sampling port (32).
8. The platelet-rich plasma extraction device according to any one of claims 1 to 5, wherein an inner diameter of an end of the second cylinder (20) near the first cylinder (10) is gradually reduced in a direction near the first cylinder (10);
and/or the inner diameter of one end of the first cylinder (10) close to the second cylinder (20) is gradually reduced, and the inner diameter of the third cylinder (30) close to the second cylinder (20) is gradually reduced.
9. The platelet-rich plasma extraction device according to claim 1, wherein the first cylinder (10) and one end of the second cylinder (20) are detachably connected, and the other end of the second cylinder (20) and the third cylinder (30) are detachably connected.
10. The platelet-rich plasma extraction device according to claim 9, wherein one end of the first cylinder (10) and one end of the second cylinder (20) are detachably connected by a first two-way joint, and the first control valve (41) is provided on the first two-way joint;
the other end of the second cylinder (20) is detachably connected with the third cylinder (30) through a second double-way joint, and the second control valve (42) is arranged on the second double-way joint.
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| CN202022482899.9U CN213967173U (en) | 2020-10-30 | 2020-10-30 | Platelet-rich plasma extraction device |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114146827A (en) * | 2021-11-26 | 2022-03-08 | 南京双威生物医学科技有限公司 | One-time centrifugal preparation method of platelet-rich plasma |
| CN115350509A (en) * | 2022-09-02 | 2022-11-18 | 杭州锐健马斯汀医疗器材有限公司 | Separating device |
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2020
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114146827A (en) * | 2021-11-26 | 2022-03-08 | 南京双威生物医学科技有限公司 | One-time centrifugal preparation method of platelet-rich plasma |
| CN114146827B (en) * | 2021-11-26 | 2024-01-23 | 南京双威生物医学科技有限公司 | One-time centrifugation preparation method of platelet-rich plasma |
| CN115350509A (en) * | 2022-09-02 | 2022-11-18 | 杭州锐健马斯汀医疗器材有限公司 | Separating device |
| CN115350509B (en) * | 2022-09-02 | 2023-11-24 | 杭州锐健马斯汀医疗器材有限公司 | separation device |
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