Full-automatic antibody detection equipment for coronavirus
Technical Field
The utility model relates to an antibody detection equipment field, specific full-automatic antibody detection equipment for coronavirus that says so.
Background
The detection of specific antibodies is aimed at assisting clinical diagnosis, and is also an index for observing curative effect and prognosis in some diseases, observation of vaccination effect, and detection of specific antibodies, especially gold-labeled method (also called immunogold-labeling technique), has special and important significance in epidemiological investigation of infectious diseases. In immune response, cellular immunity and humoral immunity are two closely related and mutually-regulated physiological processes, and a plurality of detection methods are available for the two immune reactions, but in clinical examination work, a plurality of antibody detection methods are available so far, besides traditional precipitation reaction, agglutination test and complement combination test, labeled immunoassay (such as enzyme-linked immunoassay, radioimmunoassay, fluorescent immunoassay, luminescent immunoassay and the like) becomes a main immunoassay technology, and the immunogold labeled technology is widely applied to the detection of virus antibodies because the detection method is most convenient and rapid and the result is fastest.
In the rapid detection process of some highly pathogenic virus antibodies, such as the detection of new coronavirus, most of the prior methods adopt manual blood sampling and centrifugation, and then a certain amount of serum is absorbed and dripped on a detection plate for detection and interpretation. However, under the condition of normalized defense, hospitals need to detect blood samples of hundreds of persons every day, and the deviation of the test result is easily caused by manual operation and manual judgment. Meanwhile, the detection efficiency is seriously influenced by pure manual operation, the workload of medical staff is greatly increased, and great potential biological safety risks exist. Therefore, the utility model relates to a full-automatic antibody detection equipment for coronavirus to improve detection efficiency, protect medical staff's safety.
SUMMERY OF THE UTILITY MODEL
To the problem among the prior art, the utility model provides a full-automatic antibody detection equipment for coronavirus.
The utility model provides a technical scheme that its technical problem adopted is: a full-automatic antibody detection device for coronavirus comprises a base, a protective sleeve, a transverse moving structure, a lifting structure, an extraction structure, a longitudinal moving structure, a fixing structure and a detection structure, wherein the protective sleeve for protection is installed at the top end of the base for supporting and fixing, and the transverse moving structure for transverse movement is installed inside the protective sleeve; the lifting structure for lifting is arranged at one end of the transverse moving structure, and the extraction structure for extracting the blood in the extraction pipe is arranged at the bottom end of the lifting structure; the protecting sleeve is internally provided with the longitudinal moving structure for longitudinally moving, the top end of the longitudinal moving structure is provided with the fixing structure for fixing the blood vessel frame, and one end of the longitudinal moving structure is provided with the detection structure for fixing the detection box.
Specifically, the lateral shifting structure includes a first lead screw, a first motor, a fixing block and a guide pillar, the first lead screw is rotatably connected to the inside of the protective sleeve, one end of the protective sleeve is fixed to the first motor, the first motor is fixedly connected to the first lead screw, the fixing block is in threaded connection with the outside of the first lead screw, the guide pillar is fixed to the inside of the protective sleeve, and the guide pillar penetrates through the fixing block and is in sliding connection with the fixing block.
Specifically, elevation structure is including installation piece, cylinder, ejector pin, fixed plate and slide bar, the installation piece is fixed in the one end of fixed block the top of installation piece is fixed the cylinder the bottom mounting of cylinder the ejector pin deviates from the one end of cylinder is fixed the fixed plate is close to the one end of ejector pin is fixed two in the vertical relation the slide bar, and two the slide bar runs through the installation piece and with installation piece sliding connection.
Specifically, the extraction structure includes a placing plate, a placing groove, a fixed pipe, a blood pumping pipe, an air pipe, a rotating sleeve, a ball and a first spring, wherein the placing plate is fixed at the bottom end of the fixed plate, the placing plate is provided with the placing groove with three sections in a trapezoid structure, the inside of the placing groove is connected with the fixed pipe with a section in a trapezoid structure and a hollow inside, the bottom end of the fixed pipe is in a linear relation and is fixed with a plurality of blood pumping pipes, one end of the fixed pipe is fixed with the air pipe, the inside of the placing plate is connected with the rotating sleeve, the rotating sleeve and the inside of the placing plate are connected with the ball in a rotating way, and the rotating sleeve and the placing plate are clamped and fixed with the first spring.
Specifically, the longitudinal movement structure includes guide rail, slider, movable plate, second lead screw, nut cover and second motor, the guide rail is equipped with two, two the guide rail is parallel relation and all is fixed in the inside bottom of lag, two the equal sliding connection in outside of guide rail has the slider deviates from the one end of guide rail is fixed the movable plate the bottom fixed connection nut cover of movable plate the inside of lag rotates to be connected with the second lead screw the inside of lag is fixed the second motor, just the second motor with second lead screw fixed connection, the second lead screw runs through nut cover and with nut cover threaded connection.
Specifically, fixed knot constructs including fixed slot, splint, connecting block, second spring and rubber pad, the fixed slot is equipped with threely, and is three the fixed slot is parallel relationship of each other and locates the inside of movable plate the inside sliding connection of movable plate has the connecting block with the centre gripping is fixed between the movable plate the second spring the connecting block deviates from the one end of second spring is fixed splint, just the cross-section of splint is the trapezium structure splint deviate from the one end of connecting block is fixed the rubber pad.
Specifically, the detection structure comprises three grooves, a detection plate and limiting grooves, the three grooves are arranged in the movable plate in a mutually parallel relationship, the detection plate is arranged in each of the three grooves, and the plurality of limiting grooves which are linearly distributed are arranged in the detection plate.
The utility model has the advantages that:
(1) the utility model relates to a full-automatic antibody detection equipment for coronavirus, through the setting of lateral shifting structure, can move the blood of extraction to the detection area and detect, through the use of elevation structure, can make the extraction tube automatically stretch into the inside of blood vessel, through the setting of extraction structure, can automatically accomplish quantitative blood extraction, thereby can accomplish extraction, lift and translation motion, thereby can realize automation, reach the effect of increasing detection efficiency, namely when needing to extract the blood in the arranged blood vessel, the first motor works, because the first motor is fixedly connected with the first lead screw, and because the fixed block screwed on the outside of the first lead screw still is connected with the guide pillar in a sliding way, through the limiting effect of the guide pillar, when the first motor works, the first lead screw rotates and can drive the fixed block to carry out translation motion, through the translational motion of the fixed block, the automatic detection of the extracted blood drops in the detection area can be realized, thereby realizing automation and labor saving, when the fixed block moves to a specific position, the cylinder starts to work, because the ejector rod fixedly connected with the cylinder is fixed with the fixed plate, and because the fixed plate is limited through two slide rods, namely, the cylinder acts, the fixed plate can be driven to lift, thereby realizing the automatic extension of the extraction device into the blood vessel, thereby realizing the lifting automation and achieving the effect of time and labor saving, because the placing plate is fixed at the bottom end of the fixed plate, the fixed tube is detachably connected in the placing plate, because the blood extraction tube is fixed at the bottom end of the fixed tube, after the blood extraction tube is inserted into the blood vessel, a small amount of blood in the blood vessel can be extracted through the suction effect of an external trachea, because the blood extraction tube is provided with a plurality of blood extraction tubes, thereby can increase the quantity of disposable extraction, reach the effect that increases detection efficiency, and the standing groove also is equipped with a plurality ofly, thereby can further increase the number of disposable extraction, can also increase or less fixed pipe's number as appropriate according to in service behavior's difference, convenient and practical, and there is the commentaries on classics cover at the inside sliding connection who places the board, still rotate between the commentaries on classics cover and place the board and be connected with the ball, use through the cooperation of ball and first spring, can enough make things convenient for the inserting of fixed pipe can also play spacing fixed effect to fixed pipe.
(2) The utility model relates to a full-automatic antibody detection equipment for coronavirus, through the setting of the longitudinal movement structure, can realize the automatic inspection and discharging work of blood sample and detection device, thereby can realize the automatic inspection and discharging work, reach the effect of increasing the detection efficiency, and through the setting of the fixed structure, can carry out the automatic clamping work to the blood vessel frame, thereby can avoid the blood vessel frame from deviating or toppling over in the blood drawing process, and can place the detection piece in order in cooperation with the setting of the detection structure, can automatically drip the drawn blood into the detection piece placed in order to carry out the antibody detection in cooperation with the setting of the drawing structure, is convenient and fast, can judge a plurality of detection structures simultaneously, does not need manual work to drip one by one for reading, thereby can greatly improve the detection efficiency, when the antibody detection of a blood sample needs to be carried out, only the blood vessel frame which is placed and uncapped needs to be placed inside the fixed groove inside the movable plate, the connecting blocks are connected with the two ends of the fixed groove and the inside of the movable plate in a sliding manner, the second spring is clamped and fixed between the connecting blocks and the movable plate, the clamping plates in the trapezoidal structures are fixed with the connecting blocks, when the blood vessel frame is placed inside the fixed groove, the blood vessel frame can automatically extrude the clamping plates, when the blood vessel frame is placed stably, the blood vessel frame can be clamped and fixed under the elastic force of the second spring, the phenomenon that the blood vessel frame slides when the blood sample is drawn is avoided, then the detection sheet for detecting the antibody is sequentially placed inside the limiting groove on the detection plate, after the blood vessel frame is placed completely, the second motor works, the second lead screw is fixed with the second motor, and the second lead screw is in threaded connection with the nut sleeve fixed at the bottom end of the movable plate, and the movable plate is also connected with the protective sleeve in a sliding manner through the sliding block and the guide rail, so that the movable plate can be driven to move to a specific position when the second motor works, when blood is drawn by the blood drawing tube and the drawn blood is dripped on the detection sheet on the detection plate, the detection work of the antibody can be carried out, the whole process is completely automated, and the detection efficiency can be greatly improved.
Drawings
The present invention will be further explained with reference to the drawings and examples.
FIG. 1 is a schematic structural diagram of the overall structure of a preferred embodiment of the fully automatic antibody detection apparatus for coronavirus according to the present invention;
FIG. 2 is an enlarged view of portion A of FIG. 1;
FIG. 3 is an enlarged view of the portion B shown in FIG. 1;
FIG. 4 is a schematic diagram of the extraction structure shown in FIG. 1;
FIG. 5 is an enlarged view of the portion C shown in FIG. 4;
FIG. 6 is a schematic view showing a coupling structure of the moving plate and the detection plate shown in FIG. 1;
fig. 7 is an enlarged view of the portion D shown in fig. 6.
In the figure: 1. the device comprises a base, 2, a protective sleeve, 3, a transverse moving structure, 31, a first screw rod, 32, a first motor, 33, a fixed block, 34, a guide post, 4, a lifting structure, 41, an installation block, 42, a cylinder, 43, a push rod, 44, a fixed plate, 45, a slide rod, 5, an extraction structure, 51, a placing plate, 52, a placing groove, 53, a fixed pipe, 54, an extraction pipe, 55, an air pipe, 56, a rotating sleeve, 57, a ball, 58, a first spring, 6, a longitudinal moving structure, 61, a guide rail, 62, a sliding block, 63, a moving plate, 64, a second screw rod, 65, a nut sleeve, 66, a second motor, 7, a fixed structure, 71, a fixed groove, 72, a clamping plate, 73, a connecting block, 74, a second spring, 75, a rubber pad, 8, a detection structure, 81, a groove, 82, a detection plate, 83 and a limiting groove.
Detailed Description
In order to make the technical means, creation features, achievement purposes and functions of the present invention easy to understand and understand, the present invention is further described below with reference to the following embodiments.
As shown in fig. 1-7, the fully automatic antibody detection device for coronavirus of the present invention comprises a base 1, a protective cover 2, a lateral moving structure 3, a lifting structure 4, an extraction structure 5, a longitudinal moving structure 6, a fixing structure 7, and a detection structure 8, wherein the protective cover 2 for protecting is installed on the top end of the base 1 for supporting and fixing, and the lateral moving structure 3 for moving laterally is installed inside the protective cover 2; the lifting structure 4 for lifting is arranged at one end of the transverse moving structure 3, and the extraction structure 5 for extracting blood in the extraction pipe is arranged at the bottom end of the lifting structure 4; the longitudinal moving structure 6 for performing longitudinal movement is arranged in the protecting sleeve 2, the fixing structure 7 for performing fixing of the blood vessel rack is arranged at the top end of the longitudinal moving structure 6, and the detection structure 8 for fixing the detection box is arranged at one end of the longitudinal moving structure 6.
Specifically, the traverse structure 3 includes a first lead screw 31, a first motor 32, a fixing block 33 and a guide post 34, the first lead screw 31 is rotatably connected inside the protecting sleeve 2, the first motor 32 is fixed at one end of the protecting sleeve 2, the first motor 32 is fixedly connected with the first lead screw 31, the fixing block 33 is connected with the outer portion of the first lead screw 31 through a thread, the guide post 34 is fixed inside the protecting sleeve 2, the guide post 34 penetrates through the fixing block 33 and is slidably connected with the fixing block 33, when blood in the arranged blood vessel needs to be extracted, the first motor 21 works, because the first motor 21 is fixedly connected with the first lead screw 31, and because the fixing block 33 which is threadedly connected with the outer portion of the first lead screw 31 is also slidably connected with the guide post 34, through the limiting effect of the guide post 34, when the first motor 32 works, the first screw rod 31 rotates to drive the fixing block 33 to perform translational motion, and through the translational motion of the fixing block 33, the blood drops extracted can be automatically detected in a detection area, so that automation is realized, and trouble and labor are saved.
Specifically, the lifting structure 4 includes a mounting block 41, an air cylinder 42, a push rod 43, a fixing plate 44 and a slide rod 45, the mounting block 41 is fixed at one end of the fixing block 33, the air cylinder 42 is fixed at the top end of the mounting block 41, the push rod 43 is fixed at the bottom end of the air cylinder 42, the fixing plate 44 is fixed at one end of the push rod 43 away from the air cylinder 42, two slide rods 45 are fixed at one end of the fixing plate 44 close to the push rod 43 in a vertical relationship, and the two slide rods 45 penetrate through the mounting block 41 and are slidably connected with the mounting block 41, when the fixing block 33 moves to a specific position, the air cylinder 42 starts to operate, because the push rod 43 fixedly connected with the air cylinder 42 is fixed with the fixing plate 44, and because the fixing plate 44 is limited by the two slide rods 45, that is, when the air cylinder 42 operates, the fixing plate 44 can be driven to lift, so that the extraction device can automatically extend into the blood vessel, the lifting automation is realized, and the effects of time saving and labor saving are achieved.
Specifically, the extraction structure 5 includes a placement plate 51, a placement groove 52, a fixing tube 53, an extraction tube 54, an air tube 55, a rotating sleeve 56, a ball 57, and a first spring 58, the placement plate 51 is fixed to the bottom end of the fixing plate 44, the placement plate 51 is provided with the three placement grooves 52 each having a trapezoidal cross section, the fixing tube 53 having a trapezoidal cross section and a hollow interior is slidably connected to the interior of the placement groove 52, the extraction tubes 54 are fixed to the bottom end of the fixing tube 53 in a linear relationship, the air tube 55 is fixed to one end of the fixing tube 53, the rotating sleeve 56 is slidably connected to the interior of the placement plate 51, the ball 57 is rotatably connected to the interiors of the rotating sleeve 56 and the placement plate 51, the first spring 58 is sandwiched and fixed between the rotating sleeve 56 and the placement plate 51, and the placement plate 51 is fixed to the bottom end of the fixing plate 44, the fixing tube 53 is detachably connected to the inside of the placing plate 51, the blood drawing tube 54 is fixed at the bottom end of the fixing tube 53, after the blood drawing tube 54 is inserted into the blood vessel, a small amount of blood in the blood vessel can be drawn by the suction action of the external trachea, the blood drawing tube 54 is provided with a plurality of blood drawing tubes, so that the number of one-time drawing can be increased, the effect of increasing the detection efficiency is achieved, the placing groove 52 is also provided with a plurality of blood drawing tubes, so that the number of one-time drawing can be further increased, the number of the fixing tubes 53 can be increased or reduced as required according to different use conditions, the blood drawing tube is convenient and practical, the rotating sleeve 56 is slidably connected to the inside of the placing plate 51, the rolling ball 57 is rotatably connected between the rotating sleeve 56 and the placing plate 51, and the rolling ball 57 and the first spring 58 are matched for use, the insertion of the fixing tube 53 can be facilitated, and the fixing tube 53 can be limited and fixed.
Specifically, the longitudinal moving structure 6 includes two guide rails 61, a sliding block 62, a moving plate 63, a second lead screw 64, a nut sleeve 65 and a second motor 66, the two guide rails 61 are fixed at the bottom end of the interior of the protecting cover 2 in parallel, the sliding block 62 is connected to the exterior of the two guide rails 61 in a sliding manner, the moving plate 63 is fixed at one end of the sliding block 62 away from the guide rails 61, the nut sleeve 65 is fixed at the bottom end of the moving plate 63, the second lead screw 64 is rotatably connected to the interior of the protecting cover 2, the second motor 66 is fixed to the interior of the protecting cover 2, the second motor 66 is fixedly connected to the second lead screw 64, the second lead screw 64 penetrates through the nut sleeve 65 and is in threaded connection with the nut sleeve 65, and after the vascular stent is placed, the second motor 66 works, since the second lead screw 66 is fixed to the second motor 66, the second lead screw 64 is in threaded connection with the nut sleeve 65 fixed to the bottom end of the moving plate 63, and the moving plate 63 is further in sliding connection with the protective sleeve 2 through the slider 62 and the guide rail 61, when the second motor 66 works, the moving plate 63 can be driven to move to a specific position.
Specifically, fixed knot constructs 7 and includes fixed slot 71, splint 72, connecting block 73, second spring 74 and rubber pad 75, fixed slot 71 is equipped with threely, and threely fixed slot 71 is parallel relation of each other and locates the inside of moving plate 63 the inside sliding connection of moving plate 63 has connecting block 73 with the centre gripping is fixed between the moving plate 63 second spring 74 connecting block 73 deviates from the one end of second spring 74 is fixed splint 72, just the cross-section of splint 72 is the trapezium structure splint 72 deviates from the one end of connecting block 73 is fixed rubber pad 75, when needing to carry out the antibody detection of blood sample, only need will put and remove the blood pipe support of cap and place in the inside of moving plate 63 fixed slot 71 inside can, because the both ends of fixed slot 71 the inside, The inside sliding connection of moving plate 63 has connecting block 73 with the centre gripping is fixed between the moving plate 63 second spring 74, and is the trapezium structure splint 72 with connecting block 73 is fixed, when putting into the blood vessel frame during the inside of fixed slot 71, the blood vessel frame will splint 72 is automatic extrudees, works as the blood vessel frame is placed stably the back, and this moment the blood vessel frame will be in carry out the centre gripping under the spring action of second spring 74 and fix, avoid the gliding condition to appear in the blood vessel frame when the extraction blood sample.
Specifically, the detection structure 8 includes three grooves 81, detection plates 82 and limiting grooves 83, the three grooves 81 are arranged inside the moving plate 63 in a parallel relationship, the detection plates 82 are arranged inside the three grooves 81, a plurality of limiting grooves 83 are arranged inside the detection plates 82 in a linear distribution, then detection plates for detecting antibodies are sequentially arranged inside the limiting grooves 83 on the detection plates 72, when the blood drawn by the blood drawing tube 54 drops the drawn blood on the detection plates 82, the detection work of the antibodies can be performed, the whole process is completely automated, and the detection efficiency can be greatly improved.
When the utility model is used, when the antibody detection of blood samples is needed, only the placed and uncapped blood vessel frame is needed to be placed in the fixed groove 71 inside the movable plate 63, because the connecting block 73 is connected with the two ends of the fixed groove 71 and the inside of the movable plate 63 in a sliding way, the second spring 74 is clamped and fixed between the connecting block 73 and the movable plate 63, the clamping plate 72 in a ladder-shaped structure is fixed with the connecting block 73, when the blood vessel frame is placed in the fixed groove 71, the blood vessel frame can automatically extrude the clamping plate 72, when the blood vessel frame is placed stably, the blood vessel frame can be clamped and fixed under the elastic force of the second spring 74, the sliding condition of the blood vessel frame when blood samples are extracted is avoided, then the detection plate for detecting the antibody is placed in the limit groove 83 on the 72 according to the order, after the vascular stent is placed, the second motor 66 works, because the second lead screw 66 is fixed with the second motor 66, the second lead screw 64 is in threaded connection with the nut sleeve 65 fixed at the bottom end of the moving plate 63, and the moving plate 63 is also in sliding connection with the protective sleeve 2 through the slide block 62 and the guide rail 61, when the second motor 66 works, the moving plate 63 can be driven to move to a specific position, when blood in the arranged blood vessel needs to be extracted, the first motor 21 works, because the first motor 21 is fixedly connected with the first lead screw 31, and because the fixed block 33 in threaded connection with the outer part of the first lead screw 31 is also in sliding connection with the guide post 34, through the limiting function of the guide post 34, when the first motor 32 works, the first screw rod 31 can drive the fixed block 33 to perform translational motion, and the translational motion of the fixed block 33 can automatically detect the extracted blood drops in a detection area, so that the automation is realized, the trouble and the labor are saved, when the fixed block 33 moves to a specific position, the air cylinder 42 starts to work, the ejector rod 43 fixedly connected with the air cylinder 42 is fixed with the fixed plate 44, and the fixed plate 44 is limited by the two slide rods 45, namely, the fixed plate 44 can be driven to lift when the air cylinder 42 acts, so that the extraction device can automatically extend into the blood vessel, the lifting automation is realized, the time and the labor are saved, the placing plate 51 is fixed at the bottom end of the fixed plate 44, and the fixed tube 53 is detachably connected in the placing plate 51, because the blood drawing tube 54 is fixed at the bottom end of the fixed tube 53, after the blood drawing tube 54 is inserted into the blood vessel, a small amount of blood in the blood vessel can be drawn by the suction action of the external trachea, because the blood drawing tube 54 is provided with a plurality of blood drawing tubes, the number of the blood drawing tubes can be increased at one time, the effect of increasing the detection efficiency is achieved, the placing groove 52 is also provided with a plurality of blood drawing tubes, the number of the blood drawing tubes can be further increased at one time, the number of the fixed tubes 53 can be increased or decreased as required according to different use conditions, the convenience and the practicability are achieved, the rotating sleeve 56 is connected in the placing plate 51 in a sliding manner, the rolling balls 57 are also connected between the rotating sleeve 56 and the placing plate 51 in a rotating manner, and through the matching use of the rolling balls 57 and the first springs 58, the insertion of the fixed tube 53 can be facilitated, and the fixed tube 53 can also play a role of limiting and fixing, then, the detection sheet for detecting the antibody is sequentially placed in the limit groove 83 on the detection plate 72, when the blood drawn by the blood drawing tube 54 drops the drawn blood on the detection sheet on the detection plate 82, the detection work of the antibody can be carried out, the whole process is completely automated, and the detection efficiency can be greatly improved.
It is obvious to a person skilled in the art that the invention is not restricted to details of the above-described exemplary embodiments, but that it can be implemented in other specific forms without departing from the spirit or essential characteristics of the invention. The present embodiments are therefore to be considered in all respects as illustrative and not restrictive, the scope of the invention being indicated by the appended claims rather than by the foregoing description, and all changes which come within the meaning and range of equivalency of the claims are therefore intended to be embraced therein. Any reference sign in a claim should not be construed as limiting the claim concerned.
Furthermore, it should be understood that although the present description refers to embodiments, not every embodiment may contain only a single embodiment, and such description is for clarity only, and those skilled in the art should integrate the description, and the embodiments may be combined as appropriate to form other embodiments understood by those skilled in the art.