CN213680635U

CN213680635U - Biochip hybridization box device for medicine screening

Info

Publication number: CN213680635U
Application number: CN202022369039.4U
Authority: CN
Inventors: 那日松; 张立新; 王毅; 刘佳; 赵熹
Original assignee: Jiangsu Renming Biotechnology Co ltd
Current assignee: Jiangsu Renming Biotechnology Co ltd
Priority date: 2020-10-22
Filing date: 2020-10-22
Publication date: 2021-07-13
Anticipated expiration: 2030-10-22

Abstract

The utility model provides a biochip hybridization box device for medicine screening, which relates to the technical field of biochip hybridization and aims to solve the problems of the prior biochip hybridization box that in the hybridization process of biochips, because biochips need to be placed in the hybridization box to complete mutual hybridization, if the biochips are taken by hands to perform mutual hybridization, when the biochips are touched by hands, the bacteria on the hands can infect the biochips, so that the hybridization liquid on the biochips can change outside the control range, thus easily causing the hybridization failure between the biochips, wasting time and causing economic loss, comprising a box body; a rectangular fixing frame is fixedly installed in the middle of the top plane of the box body. The utility model discloses in push away the inside absorbent biochip of taking out a section of thick bamboo and bear on the seat, need not touch the biochip with the hand in the operation process, can also accomplish under encapsulated situation, also avoided the bacterial impurity in the air to react with biochip emergence simultaneously.

Description

Biochip hybridization box device for medicine screening

Technical Field

The utility model relates to a biochip hybridization technical field, more specifically says, in particular to a biochip hybridization box-packed putting for medicine screening.

Background

Biochips, also called protein chips or gene chips, originate from crystallization combining DNA hybridization probe technology with semiconductor industry technology. The technology is that a large number of probe molecules are fixed on a support and then hybridized with DNA with fluorescent labels or other sample molecules (such as proteins, factors or small molecules), and the quantity and sequence information of the sample molecules are obtained by detecting the hybridization signal intensity of each probe molecule.

The existing biochip hybridization box device is mostly as a biochip hybridization device in patent application CN201821246455.1, including the hybridization furnace, be equipped with the furnace gate on the lateral wall of hybridization furnace, be equipped with the rack in the hybridization furnace, the rack includes two risers, two risers set up relatively, the interval is equipped with a plurality of plywoods between two risers, the plywoods are the rectangular board that the level was placed, the line at the center of upper and lower adjacent plywoods is the straight line of an slope and the line at the center of upper and lower adjacent plywoods is 30-60 with the contained angle between the horizontal plane, the hybridization box has been placed to the upper surface of plywoods, the bottom of hybridization furnace is equipped with the humidification dish that provides the hybridization environment of constant. Biochip hybridization device through the rack that sets up the echelonment, conveniently get and put hybridization box, simple structure, convenient operation.

According to the conventional biochip hybridization box, in the hybridization process of the biochips, since the biochips need to be placed in the hybridization box to complete the hybridization, if the biochips are taken by hands to perform the hybridization, the bacteria on the hands can infect the biochips when the hands touch the biochips, so that the hybridization liquid on the biochips can change outside the control range, the hybridization between the biochips fails, time is wasted, and economic loss is also caused.

In view of the above, the present invention provides a biochip hybridization cassette device for screening medicine by improving the existing structure and defects, so as to achieve the purpose of higher practical value.

SUMMERY OF THE UTILITY MODEL

In order to solve the technical problem, the utility model provides a biochip hybridization box-packed putting for medicine screening, with solving current biochip hybridization box, biochip carries out the in-process of hybridizing, because need put biochip and accomplish hybridization each other in hybridization box, if hybridize each other with taking biochip with the hand, when hand touching biochip, the bacterial infection biochip of probably handling the portion, consequently, the change outside the hybrid liquid on the biochip can produce control range, easily lead to the hybridization failure between the biochip, not only waste time has still caused economic loss's problem.

The utility model discloses a purpose and efficiency of biochip hybridization box device for medicine screening is reached by following specific technological means:

a biochip hybridization box device for medicine screening comprises a box body; a rectangular fixing frame is fixedly installed in the middle of the top plane of the box body; the box body comprises a sliding chute, the middle part of the upper end of the box body penetrates through the sliding chute, and the left end and the right end of the sliding chute are semicircular;

eight rectangular upright posts which are vertically upward and symmetrical to each other front and back are fixedly arranged on the bottom plane in the box body; four upright posts form a group from left to right; the middle parts of the upper end and the lower end of the fixed frame penetrate through a rectangular moving plate from left to right; a cylindrical drawing tube penetrates through the middle part of the moving plate from top to bottom; the lower end of the pumping cylinder penetrates through the box body; the top of each group of the upright posts is fixedly provided with a rectangular bearing box; the middle part of the top plane of the bearing box is provided with a downward-concave rectangular groove.

Furthermore, the fixed frame comprises a push-pull groove, fixed blocks, pin shafts and a rotating rod, the middle parts of the left side and the right side of the fixed frame penetrate through the rectangular push-pull groove, the front end of the top of the fixed frame is fixedly provided with the two rectangular fixed blocks which are symmetrical front and back, the front end of the top of the fixed frame is fixedly provided with the two cylindrical pin shafts which are symmetrical front and back, the middle parts of the pin shafts are provided with the rotating rods which rotate in parallel, and the head of the rotating rod is semicircular.

Furthermore, the movable plate comprises a fixed hole, a cylindrical fixed hole penetrates through the middle of the movable plate from top to bottom, and a sliding groove is formed right below the fixed hole.

Further, the drawing cylinder comprises a push-pull rod, a fixing ring and a handle, the inner side wall of the drawing cylinder is tightly attached to the cylindrical push-pull rod, the fixing ring is fixedly installed at the upper end of the outer side wall of the drawing cylinder, rectangular blocks are fixedly installed at the front end and the rear end of the fixing ring, and the handle is fixedly installed in the middle of the top of the push-pull rod.

Furthermore, the bearing box comprises bearing seats and leak holes, a cylindrical bearing seat is fixedly arranged in the middle of a groove at the top of the bearing box, the four bearing seats are arranged on the same horizontal straight line, a buckling cylindrical drawing tube is arranged right above the bearing seats, and two circular leak holes which penetrate through up and down are formed in the front end and the rear end of the groove at the top of the bearing box.

Compared with the prior art, the utility model discloses following beneficial effect has:

the box body is transparent, the semi-circle at the two ends of the sliding groove and one side of the bearing seat right below are on the same straight line up and down, the middle part of the top plane of the bearing box is provided with a concave rectangular groove, the front end of the top of the fixed frame is fixedly provided with two front and back symmetrical rectangular fixed blocks, the front end of the top of the fixed frame is fixedly provided with two front and back symmetrical cylindrical pin shafts, the middle part of each pin shaft is provided with a rotating rod which rotates in parallel, the head part of each rotating rod is semi-circle, the front and back of the four rotating rods are in parallel, the drawing tube can move left and right, when a biochip on which bearing seat needs to be adsorbed, the corresponding rotating rod above the bearing seat is rotated in advance, the left side of each rotating rod is tightly attached to the fixed blocks, at the moment, the drawing tube moves to the semi-circle position of each rotating rod to be clamped, then moves, four bearing seats are arranged on the same horizontal straight line, a buckled cylindrical pumping cylinder is arranged right above the bearing seats, the inner side wall of each fixing hole is tightly attached to the outer side wall of the pumping cylinder, the pumping cylinder moves along with the moving plate when moving left and right, the inner side wall of the pumping cylinder is tightly attached to a cylindrical push-pull rod, a fixing ring is fixedly installed at the upper end of the outer side wall of the pumping cylinder, rectangular blocks are fixedly installed at the front end and the rear end of the fixing ring, a handle is fixedly installed in the middle of the top of the push-pull rod, the pumping cylinder and the bearing seats are buckled up and down and are tightly attached without gaps, the handle is held to suck biochips on the bearing seats, the pumping cylinder is slightly moved upwards, then the biochips adsorbed by the pumping cylinder are moved left and right above the bearing seats needing hybridization, the pumping cylinder and the bearing seats are attached to form gaps again, the biochips adsorbed in the pumping cylinder are pushed, can be finished in a sealed state, and simultaneously avoids the reaction between bacterial impurities in the air and the biochip.

Additional advantages, objects, and features of the invention will be set forth in part in the description which follows and in part will become apparent to those having ordinary skill in the art upon examination of the following or may be learned from practice of the invention.

Drawings

Fig. 1 is a schematic view of the front structure of the present invention.

Fig. 2 is a schematic view of the upper left front structure of the present invention.

Fig. 3 is a schematic structural view of the present invention with the box removed.

Fig. 4 is a schematic view of the disassembly structure of the present invention.

In the drawings, the corresponding relationship between the component names and the reference numbers is as follows:

1. a box body; 101. a chute; 2. a fixing frame; 201. a push-pull groove; 202. a fixed block; 203. a pin shaft; 204. a rotating rod; 3. a column; 4. moving the plate; 401. a fixing hole; 5. drawing the tube; 501. a push-pull rod; 502. a fixing ring; 503. a handle; 6. a carrying box; 601. a bearing seat; 602. and (4) a leak hole.

Detailed Description

The following describes embodiments of the present invention in further detail with reference to the accompanying drawings and examples. The following examples are intended to illustrate the invention, but are not intended to limit the scope of the invention.

In the description of the present invention, "a plurality" means two or more unless otherwise specified; the terms "upper", "lower", "left", "right", "inner", "outer", "front", "rear", "head", "tail", and the like indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings, and are merely for convenience of description and simplicity of description, and do not indicate or imply that the device or element being referred to must have a particular orientation, be constructed and operated in a particular orientation, and thus, should not be construed as limiting the present invention. Furthermore, the terms "first," "second," "third," and the like are used for descriptive purposes only and are not to be construed as indicating or implying relative importance.

In the description of the present invention, it is to be noted that, unless otherwise explicitly specified or limited, the terms "connected" and "connected" are to be interpreted broadly, and may be, for example, fixedly connected, detachably connected, or integrally connected; can be mechanically or electrically connected; may be directly connected or indirectly connected through an intermediate. The specific meaning of the above terms in the present invention can be understood in specific cases to those skilled in the art.

Example (b):

as shown in figures 1 to 4:

the utility model provides a biochip hybridization box device for medicine screening, which comprises a box body 1; a rectangular fixing frame 2 is fixedly arranged in the middle of the top plane of the box body 1; the box body 1 is transparent, the box body 1 comprises a sliding groove 101, the middle part of the upper end of the box body 1 penetrates through the sliding groove 101, the left end and the right end of the sliding groove 101 are semicircular, and the semicircular ends of the sliding groove 101 are aligned with the upper side and the lower side of one side of a bearing seat 601 right below;

eight rectangular upright posts 3 which are vertically upward and symmetrical to each other front and back are fixedly arranged on the bottom plane in the box body 1; four upright posts 3 are in a group from left to right; a rectangular moving plate 4 penetrates through the middle parts of the upper end and the lower end of the fixed frame 2 from left to right; the movable plate 4 comprises a fixed hole 401, the middle part of the movable plate 4 vertically penetrates through the cylindrical fixed hole 401, a chute 101 is arranged right below the fixed hole 401, the inner side wall of the fixed hole 401 is tightly attached to the outer side wall of the drawing cylinder 5, and the drawing cylinder 5 moves along with the movable plate 4 when the movable plate moves left and right;

a cylindrical drawing tube 5 penetrates through the middle part of the moving plate 4 from top to bottom; the lower end of the pumping cylinder 5 penetrates through the box body 1; the top of each group of upright posts 3 is fixedly provided with a rectangular bearing box 6; the middle part of the top plane of the bearing box 6 is provided with a downward rectangular groove.

The fixed frame 2 comprises a push-pull groove 201, a fixed block 202, a pin shaft 203 and a rotating rod 204, the rectangular push-pull groove 201 is penetrated through the middle parts of the left side and the right side of the fixed frame 2, the two rectangular fixed blocks 202 which are symmetrical front and back are fixedly installed at the front end of the top of the fixed frame 2, the two cylindrical pin shafts 203 which are symmetrical front and back are fixedly installed at the front end of the top of the fixed frame 2, the rotating rod 204 which rotates in parallel is installed at the middle part of the pin shaft 203, the head part of the rotating rod 204 is semicircular, the four rotating rods 204 are parallel front and back, the pumping cylinder 5 can move left and right, when a biochip on the bearing seat 601 needs to be adsorbed, the rotating rod 204 corresponding to the upper part of the bearing seat 601 rotates in advance, the fixed block 202 is attached to the left side of the rotating rod 204, at the moment, the.

Wherein, the pumping cylinder 5 comprises a push-pull rod 501, a fixing ring 502 and a handle 503, the inner side wall of the pumping cylinder 5 is tightly attached to the cylindrical push-pull rod 501, the upper end of the outer side wall of the pumping cylinder 5 is fixedly provided with the fixing ring 502, the front end and the rear end of the fixing ring 502 are fixedly provided with rectangular blocks, the middle part of the top of the push-pull rod 501 is fixedly provided with the handle 503, the pumping cylinder 5 and the bearing seat 601 are buckled up and down and tightly attached without a gap, the biochip on the bearing seat 601 is sucked by holding the handle 503 to suck upwards, the pumping cylinder 5 is slightly moved, then the biochip adsorbed by the suction tube 5 is moved to the upper side of the bearing seat 601 needing hybridization, the suction tube 5 and the bearing seat 601 are attached to leave a gap, the biochip adsorbed in the suction tube 5 is pushed to the bearing seat 601, the biochip can be touched by hands in the operation process, the operation can be finished in a sealed state, and the bacterial impurities in the air are also prevented from reacting with the biochip.

Wherein, bear box 6 including bearing seat 601 and small opening 602, bear a columniform bearing seat 601 of middle part fixed mounting of box 6 top groove, four bear seat 601 on same horizontal straight line, bear and have a cylindrical section of thick bamboo 5 of taking out of lock directly over the seat 601, bear the circular small opening 602 that two run through from top to bottom is seted up at the front and back both ends of box 6 top groove, the middle part of bearing the top of seat 601 has a recessed circular recess, bear seat 601 groove and put different biochip, set up small opening 602 and can let the better clearance of the inside of bearing box 6.

The specific use mode and function of the embodiment are as follows:

the box body 1 is transparent, the semicircle at the two ends of the sliding groove 101 is on the same straight line with the upper and lower parts of one side of the bearing seat 601 right below, the middle part of the top plane of the bearing box 6 is provided with a downward concave rectangular groove, the front end of the top part of the fixed frame 2 is fixedly provided with two front and rear mutually symmetrical rectangular fixed blocks 202, the front end of the top part of the fixed frame 2 is fixedly provided with two front and rear mutually symmetrical cylindrical pin shafts 203, the middle part of the pin shaft 203 is provided with a rotating rod 204 which rotates in parallel, the head part of the rotating rod 204 is semicircular, the four rotating rods 204 are in a parallel state, the drawing tube 5 can move left and right, when a biochip on the bearing seat 601 needs to be adsorbed, the corresponding rotating rod 204 above the bearing seat 601 is rotated in advance, the left side of the rotating rod 204 is tightly attached to the fixed block 202, at the moment, the drawing tube 5 moves to the semicircle of the rotating rod 204 to be blocked, the drawing tube 5 moves downwards, four bearing seats 601 are on the same horizontal straight line, a buckled cylindrical extraction tube 5 is arranged right above the bearing seats 601, the inner side wall of a fixed hole 401 is tightly attached to the outer side wall of the extraction tube 5, the extraction tube 5 moves along with the movable plate 4 when moving left and right, the inner side wall of the extraction tube 5 is tightly attached to a cylindrical push-pull rod 501, a fixed ring 502 is fixedly arranged at the upper end of the outer side wall of the extraction tube 5, rectangular blocks are fixedly arranged at the front end and the rear end of the fixed ring 502, a handle 503 is fixedly arranged in the middle of the top of the push-pull rod 501, the extraction tube 5 and the bearing seats 601 are buckled up and down and tightly attached without gaps, the handle 503 is held to suck the biological chips on the bearing seats 601, the extraction tube 5 is slightly moved upwards, then the biological chips adsorbed by the extraction tube 5 are moved to the upper side and the lower side of the bearing seats 601 to be hybridized, gaps are reserved between the extraction tube 5 and the bearing, the operation process can be completed in a sealed state without touching the biochip by hands, and bacterial impurities in the air are prevented from reacting with the biochip.

The embodiments of the present invention have been presented for purposes of illustration and description, and are not intended to be exhaustive or limited to the invention in the form disclosed. Many modifications and variations will be apparent to those of ordinary skill in the art. The embodiment was chosen and described in order to best explain the principles of the invention and the practical application, and to enable others of ordinary skill in the art to understand the invention for various embodiments with various modifications as are suited to the particular use contemplated.

Claims

1. A biochip hybridization box device for medicine screening is characterized in that: comprises a box body (1); a rectangular fixing frame (2) is fixedly arranged in the middle of the top plane of the box body (1); the box body (1) comprises a sliding groove (101), the middle part of the upper end of the box body (1) penetrates through the sliding groove (101), and the left end and the right end of the sliding groove (101) are semicircular;

eight rectangular upright posts (3) which are vertically upward and symmetrical to each other front and back are fixedly arranged on the bottom plane in the box body (1); the four upright posts (3) form a group from left to right; the middle parts of the upper end and the lower end of the fixed frame (2) penetrate through a rectangular moving plate (4) from left to right; a cylindrical drawing tube (5) penetrates through the middle part of the moving plate (4) up and down; the lower end of the drawing cylinder (5) penetrates through the box body (1); the top of each group of upright posts (3) is fixedly provided with a rectangular bearing box (6); the middle part of the top plane of the bearing box (6) is provided with a downward-concave rectangular groove.

2. The biochip hybridization cassette apparatus for screening medicine according to claim 1, wherein: the fixing frame (2) comprises a push-pull groove (201), fixing blocks (202), pin shafts (203) and rotating rods (204), the middle parts of the left side and the right side of the fixing frame (2) penetrate through the push-pull groove (201) of a rectangle, the two front and back rectangular fixing blocks (202) which are symmetrical to each other are fixedly installed at the front end of the top of the fixing frame (2), two front and back cylindrical pin shafts (203) which are symmetrical to each other are fixedly installed at the front end of the top of the fixing frame (2), the rotating rods (204) which rotate in parallel are installed in the middle of the pin shafts (203), and the heads of the rotating rods.

3. The biochip hybridization cassette apparatus for screening medicine according to claim 1, wherein: the movable plate (4) comprises a fixed hole (401), the middle of the movable plate (4) penetrates through the cylindrical fixed hole (401) from top to bottom, and a sliding groove (101) is formed right below the fixed hole (401).

4. The biochip hybridization cassette apparatus for screening medicine according to claim 1, wherein: the drawing cylinder (5) comprises a push-pull rod (501), a fixing ring (502) and a handle (503), the inner side wall of the drawing cylinder (5) is tightly attached to the push-pull rod (501) in a cylindrical shape, the fixing ring (502) is fixedly installed at the upper end of the outer side wall of the drawing cylinder (5), rectangular blocks are fixedly installed at the front end and the rear end of the fixing ring (502), and the handle (503) is fixedly installed in the middle of the top of the push-pull rod (501).

5. The biochip hybridization cassette apparatus for screening medicine according to claim 1, wherein: bear box (6) including bearing seat (601) and small opening (602), bear a columniform bearing seat (601) of middle part fixed mounting of box (6) top recess, four bear seat (601) on same horizontal straight line, bear and have a cylindrical section of thick bamboo (5) of taking out of lock directly over seat (601), bear round small opening (602) that two run through from top to bottom is seted up at both ends around box (6) top recess.