CN213142212U - Portable nitric oxide generating device - Google Patents
Portable nitric oxide generating device Download PDFInfo
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- CN213142212U CN213142212U CN202021150411.6U CN202021150411U CN213142212U CN 213142212 U CN213142212 U CN 213142212U CN 202021150411 U CN202021150411 U CN 202021150411U CN 213142212 U CN213142212 U CN 213142212U
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Abstract
The utility model provides a portable nitric oxide generating device, which comprises a nitric oxide generating module and a gas mixing module which are connected in sequence; the nitric oxide generation module comprises an electrolytic cell and a gas-liquid separation device which are connected in a circulating manner; the gas mixing module comprises a gas mixing device connected with the gas-liquid separation device, the gas mixing device is externally connected with an air source, and NO discharged by the gas-liquid separation device enters the gas mixing device and then is mixed with air introduced from the air source to obtain therapeutic gas. The utility model discloses an electrolysis of electrolytic cell produces NO, can realize the gaseous instant emergence of NO according to the user demand, compares with the NO steel bottle that prior art adopted, and equipment area is littleer, and the operation is more nimble, and the integrated level is higher, carries more conveniently, uses safelyr.
Description
Technical Field
The utility model belongs to the technical field of medical instrument, a portable nitric oxide generating device is related to.
Background
Nitric oxide is an endogenous, small molecule substance with important physiological functions. The main functions include: increase vasodilation, prevent platelet adhesion, promote wound healing and angiogenesis, and can be released by macrophages and nasal epithelial cells as an effective antimicrobial agent. Direct inhalation nitric oxide therapy is approved by the U.S. food and drug administration as a therapeutic means for treating neonatal persistent pulmonary hypertension, and has been shown to improve body oxygenation and reduce the risk of high-risk extracorporal cardiopulmonary support therapy. Nitric oxide inhalation therapy not only dilates the pulmonary blood vessels and reduces pulmonary vascular resistance, but also is helpful in the treatment of other diseases including pneumonia, stroke, acute respiratory distress syndrome, and the like. Recent studies have reported that nitric oxide acts as an inhaled antibacterial agent in the treatment of cystic fibrosis, tuberculosis and as an anti-inflammatory agent to modulate the immune response and improve the survival of malaria patients. Nitric oxide inhalation therapy has also been shown to provide neuroprotection and reduce brain damage. Another potential reuse clinical application area of gaseous nitric oxide scanning gas in oxygenators used in extracorporeal circuits for cardiopulmonary bypass surgery, as well as cardiotomy air, can cause severe systemic inflammation in some patients, associated with inflammation and various organ failures, the severity of which is related to the length of the surgery time. The anti-inflammatory properties of nitric oxide may also be beneficial in reducing the occurrence of complications of these diseases.
CN110101946A discloses a portable nitric oxide therapeutic instrument, which comprises a housin, the casing internal fixation has NO control assembly, detection module, power supply module and control module, control module and power supply module electric connection, be provided with the handle on the casing, NO control assembly includes mass flow controller, detection module includes the air pump, detect sensor and three way solenoid valve, three way solenoid valve outlet pipeline divide into and detects the gas circuit and sets for the gas circuit, it links breather pump and detection sensor to detect the gas circuit, set for gas circuit and atmosphere intercommunication, detect the sensor, mass flow controller and three way solenoid valve all with control module electric connection, power supply module includes rechargeable battery group.
CN208193356U discloses a nitric oxide therapeutic apparatus, comprising: breathing machine, gaseous monitoring devices, gas mixing device and sampling device, breathing machine and gas monitoring devices all are connected with gas mixing device, and sampling device passes through the L type and connects and set up the sampling port on gas mixing device output and be connected, and wherein the confession human breathing's that the breathing machine produced mixes gas and the NO gas that gas monitoring devices produced form the treatment gas in mixing device, and gas monitoring devices is sent into with the treatment gas of gathering to sampling device.
CN110872714A discloses a portable nitric oxide maker, which comprises an air pump, a nitric oxide generator, a reduction module, wherein the nitric oxide generator is further connected with a nitric oxide concentration regulator and a numerical display; the nitric oxide generator is a closed container and is provided with electrolyte and electrodes, wherein the electrodes comprise an electrode cathode and an electrode anode, and the electrode anode and the electrode cathode are connected with a power supply; the closed container is provided with an air inlet pipe and an air outlet pipe, one end of the air inlet pipe is connected with an air pump, and the other end of the air inlet pipe extends into the electrolyte and is close to the cathode of the electrode; one end of the air outlet pipe is connected with the reduction module, and the other end of the air outlet pipe is positioned above the electrolyte.
SUMMERY OF THE UTILITY MODEL
Not enough to prior art exists, the utility model aims to provide a portable nitric oxide generating device, the utility model discloses an electrolysis cell electrolysis produces NO, can realize the gaseous instant emergence of NO according to the user demand, compares with the NO steel bottle that prior art adopted, and equipment area is littleer, and the operation is more nimble, and the integrated level is higher, and it is more convenient to carry, uses safelyr. The utility model discloses a set up gas-liquid separation device and separate NO gas from electrolyte, realized the gaseous high-efficient separation of NO, the NO purity of production is higher, accessory substance NO2The content of (A) is low.
To achieve the purpose, the utility model adopts the following technical proposal:
in a first aspect, the present invention provides a portable nitric oxide generating apparatus, which comprises a nitric oxide generating module and a gas mixing module connected in sequence.
The nitric oxide generation module comprises an electrolytic cell and a gas-liquid separation device which are connected in a circulating manner.
The gas mixing module comprises a gas mixing device connected with the gas-liquid separation device, the gas mixing device is externally connected with an air source, and NO discharged by the gas-liquid separation device enters the gas mixing device and then is mixed with air introduced from the air source to obtain therapeutic gas.
The utility model discloses an electrolysis of electrolytic cell produces NO, can realize the gaseous instant emergence of NO according to the user demand, compares with the NO steel bottle that prior art adopted, and equipment area is littleer, and the operation is more nimble, and the integrated level is higher, carries more conveniently, uses safelyr. The utility model discloses a set up gas-liquid separation device and separate NO gas from electrolyte, realized the gaseous high-efficient separation of NO, the NO purity of production is higher, accessory substance NO2The content of (A) is low.
As an optimal technical scheme of the utility model, gas-liquid separation device include the casing and set up in its inside membrane module along the casing axial, shells inner wall and membrane module outer wall between form the gaseous holding chamber of annular column structure, the NO gas that the electrolytic bath produced together gets into the membrane module along with electrolyte, the NO gas in the in-process electrolyte that flows through the membrane module passes the membrane hole and gets into gaseous holding chamber, the electrolyte that the filtering has been NO gas flows back to the electrolytic bath in.
And a liquid pump is arranged on a connecting pipeline between the liquid outlet of the membrane module and the liquid return port of the electrolytic cell, and the electrolyte with NO gas filtered out flows back to the electrolytic cell through the liquid pump.
The gas mixing device is characterized in that the outer wall of the shell is provided with a gas inlet and a gas outlet which are communicated with the gas containing cavity, the gas inlet is externally connected with a carrier gas source, the carrier gas source conveys carrier gas into the gas containing cavity for driving NO gas to be discharged out of the gas containing cavity, the gas outlet is divided into two paths, and one path is connected with an NO gas inlet of the gas mixing device.
In the invention, the concentration of NO generated by the electrolytic cell is high, and the NO can not be completely utilized and inhaled by a patient, and only part of NO can be extracted and utilized by the device; therefore, the invention is provided with two pipelines at the air outlet, part of the NO/carrier gas mixed gas is led out, and the other part of the NO/carrier gas mixed gas is optionally discharged into the atmosphere or recycled.
As an optimized technical scheme of the utility model, the carrier gas source be first air pump, first air pump carry the air as the gaseous exhaust carrier gas of drive NO to gaseous holding intracavity.
As an optimized technical solution of the present invention, the nitric oxide generating apparatus further includes a gas concentration control module, and the gas concentration control module is used for detecting the NO concentration in the mixed gas and controlling the NO gas flow rate in a feedback manner.
The gas concentration control module comprises a gas concentration sensing device and a flow control device connected with the gas concentration sensing device in a feedback mode, the flow control device is arranged on a connecting pipeline between the gas-liquid separation device and the gas mixing device, the gas concentration sensing device is connected to a sampling port of the gas mixing device in an access mode, and the gas concentration sensing device is used for detecting the concentration of NO in the sampled gas.
And a sampling pump is arranged on a connecting pipeline between the gas concentration sensing device and the sampling port of the gas mixing device.
And a second air pump is arranged on a connecting pipeline between the gas-liquid separation device and the flow control device.
The therapeutic gas outlet of the gas mixing device is connected with a patient inhalation device.
As a preferred technical proposal of the utility model, the patient inhalation device is an oral-nasal mask.
As an optimized technical scheme of the utility model, the electrolytic cell be the airtight container that inside splendid attire had electrolyte, electrolyte in insert the electrode that two intervals set up, two electrodes are the anodal positive electrode of external power supply and the negative pole electrode of external power supply negative pole respectively.
As a preferred technical scheme of the utility model, the electrode include an at least electrode slice.
The number of the electrode plates forming the anode electrode is the same as or different from that of the electrode plates forming the cathode electrode.
The electrode plate is of a net structure.
The electrode plate is made of gold, platinum, carbon or stainless steel.
The electrode sheet material constituting the anode electrode is the same as or different from the electrode sheet material constituting the cathode electrode.
In a preferred embodiment of the present invention, the electrode includes at least two electrode sheets stacked closely, for example, 2, 3, 4, 5, 6, 7, 8, 9 or 10 electrode sheets, but the number is not limited to the above-mentioned values, and other values not listed in the above-mentioned range of values are also applicable.
As an optimized technical scheme of the utility model, nitric oxide generating device still include the shell, gas-liquid separation device, gas mixing module and gas concentration control module integrated arrangement inside the shell, the electrolytic cell can dismantle to set up in the shell outside.
The shell is provided with a groove for fixing the electrolytic cell, and the electrolytic cell is connected with a gas-liquid separation device positioned in the shell through an external liquid hose.
As an optimized technical scheme of the utility model, the shell on imbed human-computer interaction interface.
The human-computer interaction section comprises a display screen and a control panel which are matched and suitable, and the display screen is electrically connected with the gas concentration sensing device and used for realizing real-time data transmission and interaction; the control panel is electrically connected with the flow control device and used for manually operating the flow control device.
It should be noted that, in the actual operation process of the nitric oxide generating device provided by the present invention, only an operator needs to adjust the NO concentration knob to a certain value gear, and control of the NO concentration in the therapeutic gas is realized through an internal program, so that the NO concentration reaches the NO concentration of the set value gear, and how to realize regulation and control of the NO concentration inside the nitric oxide generating device is not specifically limited and has special requirements, and optionally, the purpose of regulating the NO concentration in the produced therapeutic gas is achieved in the mixing stage by adjusting the mixing ratio between the NO/carrier gas mixture and the air (mainly realized by matching the gas concentration sensing device and the flow control device); or the NO generation rate is increased or reduced from the NO generation source by adjusting the current so as to achieve the purpose of regulating the NO concentration in the produced therapeutic gas; or the two ways are adopted simultaneously, so long as the NO concentration of the gear with the output NO concentration being the set value can be finally achieved.
The utility model provides a nitric oxide generating device's application method specifically includes following step:
(1) applying a current of 200-300 mA to an anode electrode and a cathode electrode in an electrolytic cell, wherein the anode electrode and the cathode electrode are composed of at least one electrode plate with a net structure, the number of the electrode plates for forming the anode electrode and the number of the electrode plates for forming the cathode electrode can be the same or different, the electrode plates are made of a material selected from gold, platinum, carbon or stainless steel, and the material of the electrode plate for forming the anode electrode can be the same or different from the material of the electrode plates for forming the cathode electrode;
the electrolyte comprises a buffer solution, nitrite and a copper-based catalyst, the concentration of the buffer solution is 0.01-3 mol/L, the buffer solution comprises a 4-hydroxyethyl piperazine ethanethiosulfonic acid buffer solution, a 3-morpholine propanesulfonic acid buffer solution, a phosphate buffer solution or an organic buffer solution, the concentration of the nitrite is 0.01-5 mol/L, the concentration of the copper-based catalyst is 1-7 mmol/L, and the copper-based catalyst is selected from one or a combination of at least two of tris (2-pyridylmethyl) amine copper (II), 1, 4, 7-triazacyclononane copper (II), 1, 4, 7-trimethyl-1, 4, 7-triazacyclononane copper (II), tris (2-aminoethyl) amine copper (II), tris (2-dimethylaminoethyl) amine copper (II) or bis (2-aminomethyl pyridine) -propionic acid copper (II) (ii) a
NO gas generated by electrolysis enters a gas-liquid separation device along with electrolyte, the electrolyte containing the NO gas is separated by a membrane component to obtain NO gas, and the NO gas enters a gas containing cavity for temporary storage;
the first air pump 6 is used for introducing 0.5-1.5L/min of air into the air accommodating cavity; the NO gas temporarily stored in the gas containing cavity is driven by air to be discharged out of the gas-liquid separation device, the mixed gas formed by the NO and the carrier gas is discharged out of the gas-liquid separation device at a speed of 0.5-1.5L/min, part of the mixed gas enters the gas mixing device through the flow control device, and the flow of the part of the mixed gas entering the gas mixing device accounts for 0.1-80% of the total flow of the mixed gas discharged by the gas-liquid separation device;
(2) introducing 1-10L/min of air into the gas mixing device by an air source, mixing the air with part of mixed gas entering the gas mixing device in the step (1) to obtain therapeutic gas, sampling the therapeutic gas by a sampling pump, and then sending the therapeutic gas into a gas concentration sensing device, wherein the gas concentration sensing device detects the NO concentration in the sampled gas, a control panel is provided with an NO concentration knob, 8 gears including 5ppm, 10ppm, 15ppm, 20ppm, 25ppm, 30ppm, 35ppm and 40 are arranged on the knob in a circle, an operator determines the concentration of the NO gas to be output by rotating the knob, and after the operator determines a certain adjusting gear, the concentration of the NO in the output therapeutic gas is the NO concentration corresponding to the gear after multiple sampling detection and logic control;
the specific logic control process comprises the following steps: when the measured value of the NO concentration in the sampled gas detected by the gas concentration sensing device is higher than the NO concentration set gear determined by an operator, sending a feedback signal to the flow control device to reduce the production flow of the first mixed gas; and when the measured value of the NO concentration in the sampled gas detected by the gas concentration sensing device is lower than the NO concentration set gear determined by an operator, sending a feedback signal to the flow control device to increase the flow rate of the first mixed gas.
The system refers to an equipment system, or a production equipment.
Compared with the prior art, the beneficial effects of the utility model are that:
(1) the utility model discloses an electrolysis of electrolytic cell produces NO, can realize the gaseous instant emergence of NO according to the user demand, compares with the NO steel bottle that prior art adopted, and equipment area is littleer, and the operation is more nimble, and the integrated level is higher, carries more conveniently, uses safelyr.
(2) The utility model discloses a set up gas-liquid separation device and separate NO gas from electrolyte, realized the gaseous high-efficient separation of NO, the NO purity of production is higher, accessory substance NO2The content of (A) is low.
(3) The NO gas concentration is feedback controlled by the sensing device, is not influenced by the change of environmental factors such as temperature, pressure and the like in the system, and has the advantages of rapid response, convenient control, safety and reliability.
Drawings
Fig. 1 is a schematic structural diagram of a nitric oxide generator according to an embodiment of the present invention;
fig. 2 is a design diagram of an appearance of a nitric oxide generator according to an embodiment of the present invention;
wherein, 1-an electrolytic cell; 2-an anode electrode; 3-a cathode electrode; 4-a gas-liquid separation device; 5-liquid pump; 6-a first air pump; 7-a second air pump; 8-a flow control device; 9-a source of air; 10-a gas mixing device; 11-a sampling pump; 12-a gas concentration sensing device; 13-oronasal mask; 14-human-computer interaction interface.
Detailed Description
It is to be understood that in the description of the present invention, the terms "central," "longitudinal," "lateral," "upper," "lower," "front," "rear," "left," "right," "vertical," "horizontal," "top," "bottom," "inner," "outer," and the like are used in the orientation or positional relationship indicated in the drawings for the purpose of convenience and simplicity of description, and are not intended to indicate or imply that the referenced device or element must have a particular orientation, be constructed and operated in a particular orientation, and are not to be construed as limiting the present invention. Furthermore, the terms "first", "second", etc. are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defined as "first," "second," etc. may explicitly or implicitly include one or more of that feature. In the description of the present invention, "a plurality" means two or more unless otherwise specified.
It should be noted that, unless explicitly stated or limited otherwise, the terms "disposed," "connected" and "connected" in the description of the present invention are to be construed broadly, and may for example be fixedly connected, detachably connected or integrally connected; can be mechanically or electrically connected; they may be connected directly or indirectly through intervening media, or they may be interconnected between two elements. The specific meaning of the above terms in the present invention can be understood by those of ordinary skill in the art through specific situations.
The technical solution of the present invention is further explained by the following embodiments with reference to the accompanying drawings.
In one embodiment, the present invention provides a portable nitric oxide generating apparatus, which comprises a nitric oxide generating module and a gas mixing module connected in sequence, as shown in fig. 1.
The nitric oxide generating module comprises an electrolytic cell 1 and a gas-liquid separation device 4 which are connected in a circulating manner. The electrolytic cell 1 is a closed container filled with electrolyte, two electrodes arranged at intervals are inserted into the electrolyte, and the two electrodes are respectively an anode electrode 2 of an external power supply anode and a cathode electrode 3 of an external power supply cathode. The gas-liquid separation device 4 comprises a shell and a membrane assembly arranged in the shell along the axial direction, a gas containing cavity with an annular columnar structure is formed between the inner wall of the shell and the outer wall of the membrane assembly, NO gas generated by the electrolytic cell 1 enters the membrane assembly along with electrolyte, the NO gas in the electrolyte passes through membrane holes to enter the gas containing cavity in the process of flowing through the membrane assembly, and the electrolyte with the NO gas filtered out flows back to the electrolytic cell 1. A liquid pump 5 is arranged on a connecting pipeline between the liquid outlet of the membrane component and the liquid return port of the electrolytic cell 1, and the electrolyte with NO gas filtered is returned to the electrolytic cell 1 through the liquid pump 5. The outer wall of the shell is provided with an air inlet and an air outlet which are communicated with the gas containing cavity, the air inlet is externally connected with a carrier gas source, the carrier gas source conveys carrier gas to the gas containing cavity for driving NO gas to be discharged out of the gas containing cavity, the air outlet is divided into two paths, one path is connected into the atmosphere, and the other path is connected with an NO gas inlet of the gas mixing device 10. Specifically, the carrier gas source is a first air pump 6, and the first air pump 6 delivers air into the gas accommodating cavity as carrier gas for driving the discharge of NO gas.
The gas mixing module comprises a gas mixing device 10 connected with the gas-liquid separation device 4, the gas mixing device 10 is externally connected with an air source 9, and NO discharged by the gas-liquid separation device 4 enters the gas mixing device 10 and then is mixed with air introduced from the air source 9 to obtain therapeutic gas.
The nitric oxide generating device also comprises a gas concentration control module, and the gas concentration control module is used for detecting the concentration of NO in the mixed gas and controlling the extraction flow of NO gas in a feedback mode. The gas concentration control module comprises a gas concentration sensing device 12 and a flow control device 8 connected with the gas concentration sensing device 12 in a feedback mode, the flow control device 8 is arranged on a connecting pipeline between the gas-liquid separation device 4 and the gas mixing device 10, and a second air pump 7 is arranged on the connecting pipeline between the gas-liquid separation device 4 and the flow control device 8. The gas concentration sensing device 12 is connected to a sampling port of the gas mixing device 10, the gas concentration sensing device 12 is used for detecting the concentration of NO in the sampled gas, and a sampling pump 11 is arranged on a connecting pipeline between the gas concentration sensing device 12 and the sampling port of the gas mixing device 10. The therapeutic gas outlet of the gas mixing device 10 is connected to a patient inhalation device, in particular optionally an oronasal mask 13.
The nitric oxide generating device further comprises a shell, the gas-liquid separation device 4, the gas mixing module and the gas concentration control module are integrally arranged inside the shell, and the electrolytic cell 1 is detachably arranged outside the shell. The shell is provided with a groove (shown in figure 2) for fixing the electrolytic cell 1, and the electrolytic cell 1 is connected with a gas-liquid separation device 4 positioned in the shell through an external liquid hose. A human-computer interaction interface 14 (shown in fig. 2) is embedded in the shell, the human-computer interaction section comprises a display screen and a control panel which are matched and suitable, and the display screen is electrically connected with the gas concentration sensing device 12 and used for realizing real-time data transmission and interaction; the control panel is electrically connected to the flow control device 8 and is used for manually operating the flow control device 8.
Example 1
The utility model provides an above-mentioned nitric oxide generating device's application method, application method include following step:
(1) applying a current of 200mA to an anode electrode 2 and a cathode electrode 3 in an electrolytic cell 1, wherein the anode electrode 2 and the cathode electrode 3 are both composed of a piece of net-shaped electrode slice, and the anode electrode 2 and the cathode electrode 3 are made of the same electrode slice material and are both gold;
the electrolyte generates NO gas in the electrolytic process, the adopted electrolyte comprises a buffer solution, nitrite and a copper-based catalyst, the concentration of the buffer solution is 0.01mol/L of 4-hydroxyethyl piperazine ethanethiosulfonic acid buffer solution, the concentration of the nitrite is 0.01mol/L, the concentration of the copper-based catalyst is 1mmol/L, and the copper-based catalyst is tris (2-pyridylmethyl) amine copper (II);
NO gas generated by electrolysis enters a gas-liquid separation device 4 along with electrolyte, the electrolyte containing the NO gas is separated by a membrane component to obtain NO gas, and the NO gas enters a gas accommodating cavity for temporary storage;
the first air pump 6 feeds 0.5L/min of air into the air accommodating cavity; the NO gas temporarily stored in the gas containing cavity is driven by air to be discharged out of the gas-liquid separating device 4, the mixed gas formed by NO and carrier gas is discharged out of the gas-liquid separating device at the speed of 0.5L/min, part of the mixed gas enters the gas mixing device 10 through the flow control device 8, and the flow of the part of the mixed gas entering the gas mixing device accounts for 0.1% of the total flow of the mixed gas discharged by the gas-liquid separating device;
(2) the air source 9 introduces 1L/min of air into the gas mixing device 10, the air is mixed with part of mixed gas entering the gas mixing device in the step (1) to obtain treatment gas, the treatment gas is sampled by the sampling pump 11 and then sent to the gas concentration sensing device 12, the gas concentration sensing device 12 detects the NO concentration in the sampled gas, a control panel is provided with an NO concentration knob, 8 gears including 5ppm, 10ppm, 15ppm, 20ppm, 25ppm, 30ppm, 35ppm and 40ppm are arranged on the knob in a circle, an operator determines the concentration of the NO gas to be output by rotating the knob, and after the operator determines a certain adjusting gear, the concentration of the NO in the output treatment gas is the NO concentration corresponding to the gear after multiple sampling detection and logic control;
the specific logic control process comprises the following steps: when the measured value of the NO concentration in the sampled gas detected by the gas concentration sensing device 12 is higher than the NO concentration set gear determined by the operator, a feedback signal is sent to the flow control device 8 to reduce the flow rate of the first mixed gas; when the measured value of the NO concentration in the sampled gas detected by the gas concentration sensing device 12 is lower than the NO concentration set gear determined by the operator, a feedback signal is sent to the flow control device 8 to increase the flow rate of the first mixed gas.
Example 2
The utility model provides an above-mentioned nitric oxide generating device's application method, application method include following step:
(1) applying 220mA current to an anode electrode 2 and a cathode electrode 3 in an electrolytic cell 1, wherein the anode electrode and the cathode electrode are both composed of two tightly stacked net-shaped electrode plates, and the anode electrode 2 and the cathode electrode 3 are made of the same electrode plate material and are both platinum;
the electrolyte generates NO gas in the electrolytic process; the electrolyte comprises a buffer solution, nitrite and a copper-based catalyst, wherein the concentration of the buffer solution is 1mol/L of 3-morpholine propanesulfonic acid buffer solution, the concentration of the nitrite is 1mol/L, the concentration of the copper-based catalyst is 3mmol/L, and the copper-based catalyst is 1, 4, 7-triazacyclononane copper (II);
NO gas generated by electrolysis enters a gas-liquid separation device 4 along with electrolyte, the electrolyte containing the NO gas is separated by a membrane component to obtain NO gas, and the NO gas enters a gas accommodating cavity for temporary storage;
the first air pump 6 feeds 0.7L/min of air into the air accommodating cavity; the NO gas temporarily stored in the gas containing cavity is driven by air to be discharged out of the gas-liquid separating device 4, the mixed gas formed by NO and carrier gas is discharged out of the gas-liquid separating device at the speed of 0.7L/min, part of the mixed gas enters the gas mixing device 10 through the flow control device 8, and the flow of the part of the mixed gas entering the gas mixing device accounts for 20% of the total flow of the mixed gas discharged by the gas-liquid separating device;
(2) 3L/min of air is introduced into a gas mixing device 10 by an air source 9, the air is mixed with part of mixed gas entering the gas mixing device in the step (1) to obtain treatment gas, the treatment gas is sampled by a sampling pump 11 and then is sent into a gas concentration sensing device 12, the gas concentration sensing device 12 detects the NO concentration in the sampled gas, a control panel is provided with an NO concentration knob, 8 gears of 5ppm, 10ppm, 15ppm, 20ppm, 25ppm, 30ppm, 35ppm and 40ppm are arranged on the knob in one circle, an operator determines the concentration of the NO gas to be output by rotating the knob, and after the operator determines a certain adjusting gear, the concentration of the NO in the output treatment gas is the NO concentration corresponding to the gear after multiple sampling detection and logic control;
the specific logic control process comprises the following steps: when the measured value of the NO concentration in the sampled gas detected by the gas concentration sensing device 12 is higher than the NO concentration set gear determined by the operator, a feedback signal is sent to the flow control device 8 to reduce the flow rate of the first mixed gas; when the measured value of the NO concentration in the sampled gas detected by the gas concentration sensing device 12 is lower than the NO concentration set gear determined by the operator, a feedback signal is sent to the flow control device 8 to increase the flow rate of the first mixed gas.
Example 3
The utility model provides an above-mentioned nitric oxide generating device's application method, application method include following step:
(1) applying 250mA current to an anode electrode 2 and a cathode electrode 3 in an electrolytic cell 1, wherein the anode electrode and the cathode electrode are both composed of four tightly stacked mesh-structured electrode plates, and the anode electrode 2 and the cathode electrode 3 are made of carbon materials and are made of the same material;
the electrolyte generates NO gas in the electrolytic process, and the adopted electrolyte comprises a buffer solution, nitrite and a copper-based catalyst, wherein the concentration of the buffer solution is 1.5mol/L phosphate buffer solution, the concentration of the nitrite is 3mol/L, the concentration of the copper-based catalyst is 4mmol/L, and the copper-based catalyst is 1, 4, 7-trimethyl-1, 4, 7-triazacyclononane copper (II);
NO gas generated by electrolysis enters a gas-liquid separation device 4 along with electrolyte, the electrolyte containing the NO gas is separated by a membrane component to obtain NO gas, and the NO gas enters a gas accommodating cavity for temporary storage;
the first air pump 6 feeds 1L/min of air into the air accommodating cavity; the NO gas temporarily stored in the gas containing cavity is driven by air to be discharged out of the gas-liquid separating device 4, the mixed gas formed by NO and carrier gas is discharged out of the gas-liquid separating device at the speed of 1L/min, part of the mixed gas enters the gas mixing device 10 through the flow control device 8, and the flow of the part of the mixed gas entering the gas mixing device accounts for 40% of the total flow of the mixed gas discharged by the gas-liquid separating device;
(2) the air source 9 introduces 5L/min of air into the gas mixing device 10, the air is mixed with part of mixed gas entering the gas mixing device in the step (1) to obtain treatment gas, the treatment gas is sampled by the sampling pump 11 and then sent to the gas concentration sensing device 12, the gas concentration sensing device 12 detects the NO concentration in the sampled gas, a control panel is provided with an NO concentration knob, 8 gears including 5ppm, 10ppm, 15ppm, 20ppm, 25ppm, 30ppm, 35ppm and 40ppm are arranged on the knob in a circle, an operator determines the concentration of the NO gas to be output by rotating the knob, and after the operator determines a certain adjusting gear, the concentration of the NO in the output treatment gas is the NO concentration corresponding to the gear after multiple sampling detection and logic control;
the specific logic control process comprises the following steps: when the measured value of the NO concentration in the sampled gas detected by the gas concentration sensing device 12 is higher than the NO concentration set gear determined by the operator, a feedback signal is sent to the flow control device 8 to reduce the flow rate of the first mixed gas; when the measured value of the NO concentration in the sampled gas detected by the gas concentration sensing device 12 is lower than the NO concentration set gear determined by the operator, a feedback signal is sent to the flow control device 8 to increase the flow rate of the first mixed gas.
Example 4
The utility model provides an above-mentioned nitric oxide generating device's application method, application method include following step:
(1) applying 270mA current to an anode electrode 2 and a cathode electrode 3 in an electrolytic cell 1, wherein the anode electrode and the cathode electrode are both composed of six tightly stacked net-shaped electrode plates, and the anode electrode 2 and the cathode electrode 3 are made of stainless steel materials and are made of the same material;
the electrolyte generates NO gas in the electrolytic process, the adopted electrolyte comprises a buffer solution, nitrite and a copper-based catalyst, the concentration of the buffer solution is 2mol/L of organic buffer solution, the concentration of the nitrite is 4mol/L, the concentration of the copper-based catalyst is 5mmol/L, and the copper-based catalyst is tris (2-aminoethyl) amine copper (II);
NO gas generated by electrolysis enters a gas-liquid separation device 4 along with electrolyte, the electrolyte containing the NO gas is separated by a membrane component to obtain NO gas, and the NO gas enters a gas accommodating cavity for temporary storage;
the first air pump 6 introduces 1.3L/min of air into the gas containing cavity, NO gas temporarily stored in the gas containing cavity is driven by the air to be discharged out of the gas-liquid separating device 4, mixed gas formed by NO and carrier gas is discharged out of the gas-liquid separating device at 1.3L/min, part of the mixed gas enters the gas mixing device 10 through the flow control device 8, and the flow of the part of the mixed gas entering the gas mixing device accounts for 60% of the total flow of the mixed gas discharged by the gas-liquid separating device;
(2) the air source 9 introduces 7L/min of air into the gas mixing device 10, the air is mixed with part of mixed gas entering the gas mixing device in the step (1) to obtain treatment gas, the treatment gas is sampled by the sampling pump 11 and then sent to the gas concentration sensing device 12, the gas concentration sensing device 12 detects the NO concentration in the sampled gas, a control panel is provided with an NO concentration knob, 8 gears including 5ppm, 10ppm, 15ppm, 20ppm, 25ppm, 30ppm, 35ppm and 40ppm are arranged on the knob in a circle, an operator determines the concentration of the NO gas to be output by rotating the knob, and after the operator determines a certain adjusting gear, the concentration of the NO in the output treatment gas is the NO concentration corresponding to the gear after multiple sampling detection and logic control;
the specific logic control process comprises the following steps: when the measured value of the NO concentration in the sampled gas detected by the gas concentration sensing device 12 is higher than the NO concentration set gear determined by the operator, a feedback signal is sent to the flow control device 8 to reduce the flow rate of the first mixed gas; when the measured value of the NO concentration in the sampled gas detected by the gas concentration sensing device 12 is lower than the NO concentration set gear determined by the operator, a feedback signal is sent to the flow control device 8 to increase the flow rate of the first mixed gas.
Example 5
The utility model provides an above-mentioned nitric oxide generating device's application method, application method include following step:
(1) applying 300mA current to an anode electrode 2 and a cathode electrode 3 in an electrolytic cell 1, wherein the anode electrode and the cathode electrode are both composed of eight tightly stacked mesh-structured electrode plates, and the anode electrode 2 and the cathode electrode 3 are made of carbon materials and are made of the same material;
the electrolyte generates NO gas in the electrolytic process, the adopted electrolyte comprises a buffer solution, nitrite and a copper-based catalyst, the concentration of the buffer solution is 3 mol/L4-hydroxyethyl piperazine ethanethiosulfonic acid buffer solution, the concentration of the nitrite is 5mol/L, the concentration of the copper-based catalyst is 7mmol/L, and the copper-based catalyst is tris (2-dimethylaminoethyl) amine copper (II);
NO gas generated by electrolysis enters a gas-liquid separation device 4 along with electrolyte, the electrolyte containing the NO gas is separated by a membrane component to obtain NO gas, and the NO gas enters a gas accommodating cavity for temporary storage;
the first air pump 6 pumps 1.5L/min of air into the air accommodating cavity; the NO gas temporarily stored in the gas containing cavity is driven by air to be discharged out of the gas-liquid separating device 4, the mixed gas formed by NO and carrier gas is discharged out of the gas-liquid separating device at the speed of 1.5L/min, part of the mixed gas enters the gas mixing device 10 through the flow control device 8, and the flow of the part of the mixed gas entering the gas mixing device accounts for 80% of the total flow of the mixed gas discharged by the gas-liquid separating device;
(2) the air source 9 introduces 10L/min of air into the gas mixing device 10, the air is mixed with part of mixed gas entering the gas mixing device in the step (1) to obtain treatment gas, the treatment gas is sampled by the sampling pump 11 and then sent to the gas concentration sensing device 12, the gas concentration sensing device 12 detects the NO concentration in the sampled gas, a control panel is provided with an NO concentration knob, 8 gears including 5ppm, 10ppm, 15ppm, 20ppm, 25ppm, 30ppm, 35ppm and 40ppm are arranged on the knob in a circle, an operator determines the concentration of the NO gas to be output by rotating the knob, and after the operator determines a certain adjusting gear, the concentration of the NO in the output treatment gas is the NO concentration corresponding to the gear after multiple sampling detection and logic control;
the specific logic control process comprises the following steps: when the measured value of the NO concentration in the sampled gas detected by the gas concentration sensing device 12 is higher than the NO concentration set gear determined by the operator, a feedback signal is sent to the flow control device 8 to reduce the flow rate of the first mixed gas; when the measured value of the NO concentration in the sampled gas detected by the gas concentration sensing device 12 is lower than the NO concentration set gear determined by the operator, a feedback signal is sent to the flow control device 8 to increase the flow rate of the first mixed gas.
The applicant states that the above description is only a specific embodiment of the present invention, but the protection scope of the present invention is not limited thereto, and those skilled in the art should understand that any changes or substitutions easily conceivable by those skilled in the art within the technical scope of the present invention are within the protection scope and the disclosure scope of the present invention.
Claims (10)
1. A portable nitric oxide generating device is characterized by comprising a nitric oxide generating module and a gas mixing module which are sequentially connected;
the nitric oxide generation module comprises an electrolytic cell and a gas-liquid separation device which are connected in a circulating manner;
the gas mixing module comprises a gas mixing device connected with the gas-liquid separation device, the gas mixing device is externally connected with an air source, and NO discharged by the gas-liquid separation device enters the gas mixing device and then is mixed with air introduced from the air source to obtain therapeutic gas.
2. The nitric oxide generating device according to claim 1, wherein the gas-liquid separating device comprises a housing and a membrane module axially arranged inside the housing, a gas accommodating cavity of an annular columnar structure is formed between an inner wall of the housing and an outer wall of the membrane module, NO gas generated by the electrolytic cell enters the membrane module along with the electrolyte, NO gas in the electrolyte passes through membrane holes to enter the gas accommodating cavity in the process of flowing through the membrane module, and the electrolyte with NO gas filtered flows back to the electrolytic cell;
a liquid pump is arranged on a connecting pipeline between a liquid outlet of the membrane module and a liquid return port of the electrolytic cell, and the electrolyte with NO gas filtered out is returned to the electrolytic cell through the liquid pump;
the gas mixing device is characterized in that the outer wall of the shell is provided with a gas inlet and a gas outlet which are communicated with the gas containing cavity, the gas inlet is externally connected with a carrier gas source, the carrier gas source conveys carrier gas into the gas containing cavity for driving NO gas to be discharged out of the gas containing cavity, the gas outlet is divided into two paths, and one path is connected with an NO gas inlet of the gas mixing device.
3. The nitric oxide generating device according to claim 2, wherein the carrier gas source is a first air pump, and the first air pump delivers air into the gas accommodating chamber as a carrier gas for driving the discharge of NO gas.
4. The nitric oxide generating device according to claim 3, further comprising a gas concentration control module, wherein the gas concentration control module is used for detecting the concentration of NO in the mixed gas and controlling the output flow of NO gas in a feedback manner;
the gas concentration control module comprises a gas concentration sensing device and a flow control device which is connected with the gas concentration sensing device in a feedback mode, the flow control device is arranged on a connecting pipeline between the gas-liquid separation device and the gas mixing device, the gas concentration sensing device is connected to a sampling port of the gas mixing device, and the gas concentration sensing device is used for detecting the concentration of NO in the sampled gas;
a sampling pump is arranged on a connecting pipeline between the gas concentration sensing device and the sampling port of the gas mixing device;
a second air pump is arranged on a connecting pipeline between the gas-liquid separation device and the flow control device;
the therapeutic gas outlet of the gas mixing device is connected with a patient inhalation device.
5. A nitric oxide generating device according to claim 4, wherein said patient inhaling means is an oronasal mask.
6. The nitric oxide generating device according to claim 5, wherein the electrolytic cell is a closed container with electrolyte, two electrodes are inserted into the electrolyte and are an anode electrode of an external power supply anode and a cathode electrode of an external power supply cathode.
7. A nitric oxide generator according to claim 6, wherein said electrodes comprise at least one electrode sheet;
the number of the electrode slices forming the anode electrode is the same as or different from that of the electrode slices forming the cathode electrode;
the electrode plate is of a net structure;
the electrode plate is made of gold, platinum, carbon or stainless steel;
the electrode sheet material constituting the anode electrode is the same as or different from the electrode sheet material constituting the cathode electrode.
8. A nitric oxide generator according to claim 7, wherein said electrodes comprise at least two closely stacked electrode sheets.
9. The nitric oxide generating device according to claim 8, further comprising a housing, wherein the gas-liquid separation device, the gas mixing module and the gas concentration control module are integrally arranged inside the housing, and the electrolytic cell is detachably arranged outside the housing;
the shell is provided with a groove for fixing the electrolytic cell, and the electrolytic cell is connected with a gas-liquid separation device positioned in the shell through an external liquid hose.
10. The nitric oxide generating device according to claim 9, wherein a human-machine interface is embedded in the housing;
the human-computer interaction interface comprises a display screen and a control panel which are matched and suitable, and the display screen is electrically connected with the gas concentration sensing device and used for realizing real-time data transmission and interaction; the control panel is electrically connected with the flow control device and used for manually operating the flow control device.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202021150411.6U CN213142212U (en) | 2020-06-19 | 2020-06-19 | Portable nitric oxide generating device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202021150411.6U CN213142212U (en) | 2020-06-19 | 2020-06-19 | Portable nitric oxide generating device |
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| Publication Number | Publication Date |
|---|---|
| CN213142212U true CN213142212U (en) | 2021-05-07 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202021150411.6U Active CN213142212U (en) | 2020-06-19 | 2020-06-19 | Portable nitric oxide generating device |
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| Country | Link |
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| CN (1) | CN213142212U (en) |
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