CN212091716U - Intermediate product deep layer filtration system - Google Patents
Intermediate product deep layer filtration system Download PDFInfo
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- CN212091716U CN212091716U CN202020082732.0U CN202020082732U CN212091716U CN 212091716 U CN212091716 U CN 212091716U CN 202020082732 U CN202020082732 U CN 202020082732U CN 212091716 U CN212091716 U CN 212091716U
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- 238000001914 filtration Methods 0.000 title claims abstract description 63
- 239000013067 intermediate product Substances 0.000 title claims abstract description 30
- 239000012528 membrane Substances 0.000 claims abstract description 105
- 238000011118 depth filtration Methods 0.000 claims abstract description 99
- 239000007788 liquid Substances 0.000 claims abstract description 63
- 239000000706 filtrate Substances 0.000 claims description 18
- 230000008859 change Effects 0.000 claims description 8
- 239000004677 Nylon Substances 0.000 claims description 4
- 239000002033 PVDF binder Substances 0.000 claims description 4
- 239000004743 Polypropylene Substances 0.000 claims description 4
- 238000011049 filling Methods 0.000 claims description 4
- 239000012535 impurity Substances 0.000 claims description 4
- 229920001778 nylon Polymers 0.000 claims description 4
- 239000002245 particle Substances 0.000 claims description 4
- 229920000515 polycarbonate Polymers 0.000 claims description 4
- 239000004417 polycarbonate Substances 0.000 claims description 4
- 229920000379 polypropylene carbonate Polymers 0.000 claims description 4
- 229920001296 polysiloxane Polymers 0.000 claims description 4
- 229920002981 polyvinylidene fluoride Polymers 0.000 claims description 4
- 239000011148 porous material Substances 0.000 claims description 4
- 238000001179 sorption measurement Methods 0.000 claims description 4
- 230000000694 effects Effects 0.000 claims description 3
- 238000007599 discharging Methods 0.000 claims description 2
- 230000010354 integration Effects 0.000 abstract description 3
- 239000000523 sample Substances 0.000 description 24
- 238000011068 loading method Methods 0.000 description 9
- 238000000034 method Methods 0.000 description 6
- 230000008569 process Effects 0.000 description 6
- 239000007853 buffer solution Substances 0.000 description 4
- 239000000872 buffer Substances 0.000 description 3
- 230000004048 modification Effects 0.000 description 3
- 238000012986 modification Methods 0.000 description 3
- 230000002093 peripheral effect Effects 0.000 description 3
- 238000011067 equilibration Methods 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 238000011020 pilot scale process Methods 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 238000005070 sampling Methods 0.000 description 2
- 230000007704 transition Effects 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 239000003513 alkali Substances 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 238000005260 corrosion Methods 0.000 description 1
- 230000007797 corrosion Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000011010 flushing procedure Methods 0.000 description 1
- 230000004907 flux Effects 0.000 description 1
- 238000002386 leaching Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000005374 membrane filtration Methods 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000002203 pretreatment Methods 0.000 description 1
- 238000011165 process development Methods 0.000 description 1
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- 239000012488 sample solution Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
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Abstract
An intermediate product deep filtration system can realize automatic integration of intermediate product deep filtration. The intermediate product depth filtration system includes a depth filtration membrane package and an external device having one or more post locations, each post location having a pair of post location ports, the external device being coupled to the depth filtration membrane package and capable of automatically controlling the depth filtration membrane package. The deep filtration membrane package is provided with a liquid inlet and a filtering outlet, a first connecting pipe, a first male connector and a first manual tightening connector are arranged on the liquid inlet side of the deep filtration membrane package, and a second connecting pipe, a second male connector and a second manual tightening connector are arranged on the filtering side of the deep filtration membrane package. The liquid inlet of the deep filtration membrane package is connected with one of the paired column ports of the external device through a first connecting pipe, a first male connector and a first manual connector, and the liquid outlet of the deep filtration membrane package is connected with the other of the paired column ports of the external device through a second connecting pipe, a second male connector and a second manual connector.
Description
Technical Field
The utility model relates to a filtration equipment technical field, more specifically relates to an intermediate product depth filtration system.
Background
In the prior art, the intermediate product deep filtration device mainly uses pressure as a driving force to remove particles and related impurities in the sample liquid through the surface adsorption and interception functions of a pore channel bent inside and a filling medium inside, so that the effect of clarifying the sample liquid is achieved. Wherein, in the process of pilot scale intermediate product deep filtration, the intermediate product deep filtration device comprises a sample loading container, a pump, a pressure detector, a deep filter, a collection container, a pipeline, an electronic balance and the like, and the components are connected in sequence. During the operation, the pump provides the inlet flow rate, the pressure detector detects the pressure, the pipeline for the inlet is connected with the sample loading container and the inlet of the deep filter, the pipeline for the outlet of the deep filter is connected with the collecting container, and the collecting container is arranged on the electronic balance. The inlet flow rate is controlled by adjusting the pump speed of the pump, the pressure change and the filtering amount are recorded by reading the readings of the pressure detector and the electronic balance, and the whole filtering process is subjected to occasional manual sampling for detecting the quality of the filtered product to monitor the whole experimental process.
Traditional pilot scale depth filtration needs tedious preparation work, and needs the whole control of manpower, calculates different inlet flow rates to pressure and volume change and the untimely sample of real-time recording consume time and manpower.
In order to save labor cost and improve efficiency, a technical problem to be solved by those skilled in the art is how to develop a novel intermediate product depth filtration system to overcome the above problems.
SUMMERY OF THE UTILITY MODEL
The utility model aims to solve the technical problem, its aim at provides a neotype intermediate product deep filtration system, can realize intermediate product deep filtration's automatic integration.
In order to achieve the above object, the utility model provides an intermediate product deep filtration system, characterized by includes: the deep filtration membrane package removes particles and impurities in the sample liquid through the surface adsorption and interception functions of the bent pore channels and the filling medium inside the deep filtration membrane package; and an external device having one or more column positions, each column position having a pair of column position ports, the external device being connected to the deep filtration membrane pack and being capable of automatically controlling the deep filtration membrane pack, the deep filtration membrane pack being provided with a liquid inlet through which a liquid to be filtered enters and a filtering-out port through which the filtered liquid is discharged, a first connection pipe being a liquid inlet side connection pipe, a first male connector being a liquid inlet side male connector, and a first hand-tightened connector being a liquid inlet side hand-tightened connector being provided on a liquid inlet side of the deep filtration membrane pack, and a second connection pipe being a filtering-out side connection pipe, a second male connector being a filtering-out side male connector, and a second hand-tightened connector being a filtering-out side hand-tightened connector being provided on a filtering-out side of the deep filtration membrane pack through the first connection pipe, a liquid inlet of the filtration membrane pack passing through the first connection pipe, a liquid, The first male connector and the first manual fastener are connected to one of the pair of pillar interfaces of the external device, that is, a first pillar interface, and the filtration port of the depth filter membrane module is connected to the other of the pair of pillar interfaces of the external device, that is, a second pillar interface, through the second connection pipe, the second male connector, and the second manual fastener.
Through constituting as above, because in the utility model discloses an in the intermediate product depth filtration system, external equipment with the depth filtration membrane package links, and can be right the depth filtration membrane package carries out automatic control, consequently, compares in the past, can realize intermediate product depth filtration's automatic integration, practices thrift human cost and raises the efficiency.
It is also preferred that the depth filtration membrane package is further provided with a vent for use in purging air bubbles from the depth filtration membrane package during rinsing.
With the above configuration, the air vent is provided, so that air bubbles in the depth filter membrane can be removed during rinsing, and the filtration efficiency in the middle product depth filter membrane can be improved.
Preferably, the first connection pipe is connected to the liquid inlet of the depth filtration membrane module at one end thereof by the adapter change of the connector and connected to the first manual tightening connector at the other end thereof by the adapter change of the first male connector, on the liquid inlet side of the depth filtration membrane module.
Preferably, on the filtration side of the depth filter membrane module, one end of the second connection pipe is connected to the filtration port of the depth filter membrane module by switching the joint of the connector, and the other end of the second connection pipe is connected to the second hand-held joint by switching the joint of the second male joint.
With the above-described structure, the connection between the connection pipe and the liquid inlet/outlet of the depth filter membrane package and the hand-tightening joint is realized by the joint conversion of the connection head, so that the degree of generalization of the parts can be improved.
Preferably, the first male adaptor, the first manual-tightening adaptor, the second male adaptor and the second manual-tightening adaptor are 1/16 luer adaptors, and are made of PVDF, nylon, polypropylene or polycarbonate.
Through the structure, the luer connector is convenient to connect, so that the connectors connected with the deep filtration membrane package are all luer connectors, the connection with the deep filtration membrane package can be more convenient, the labor cost can be further saved, and the efficiency can be improved. In addition, the joint made of PVDF, nylon, polypropylene or polycarbonate has good alkali resistance and corrosion resistance and long service life.
Further, it is preferable that the first connection pipe and the second connection pipe are 16# silicone tubes.
By the structure, the silicone tube is easy to match with the joint, and the cable ties are used for fixing at the pipeline interface in actual operation, so that the connection operation can be easy.
Further, preferably, the external device is AKTA chromatograph.
Preferably, the external device is provided with a pump valve connected to the liquid pump, a column valve having the pair of column ports of the one or more column positions, and a collection valve connected to a collection container.
With the above configuration, since the external device (AKTA chromatograph) has the pump valve connected to the liquid pump, a reproducible stable flow rate can be provided by the liquid pump. In addition, the external device (AKTA chromatograph) has a collection valve that allows the collection of sample fluids at different times or volumes.
The following means are mentioned for the connection of the inlet and outlet ports of the depth filtration membrane module to the plurality of column sites of the external device:
the liquid inlet and the filtering-out port of one depth filtration membrane package are respectively connected with the first column port and the second column port of the paired column ports of the more than one column;
a plurality of depth filtration membranes are connected to one or more pairs of column ports of the one or more column ports;
a plurality of depth filtration membranes are connected in series to at least one pair of column ports of the pair of column ports or the plurality of pairs of column ports;
at least one pair of column ports of the pair of column ports or the plurality of pairs of column ports is connected with N deep filtration membranes in parallel.
On the liquid inlet side of the N depth filtration membranes, the first connecting pipe is an (N +1) through pipe, a first pipe port of the (N +1) through pipe is connected with the first column interface (A) in the paired column interfaces, and other pipe ports of the (N +1) through pipe are connected with the liquid inlet of each of the N depth filtration membranes.
At the filtrate outlets of the N depth filtration membranes, the second connection tube is another (N +1) through tube, a first tube port of the other (N +1) through tube being joined to the second one of the pair of column-level interfaces, the other port of the other (N +1) through tube being joined to the filtrate outlet of each of the N depth filtration membranes.
With the above configuration, the connection mode between the depth filtration membrane module and the external device can be flexibly selected as required, and a desired filtration effect can be achieved.
Drawings
Fig. 1 is a schematic perspective view of the peripheral structure of a depth filtration membrane package in an intermediate depth filtration system according to the present invention.
Fig. 2 is an exploded perspective view of the perimeter structure of a depth filtration membrane package in the intermediate depth filtration system shown in fig. 1.
Fig. 3 is a schematic diagram of the connection of the liquid inlet and the liquid outlet of the depth filtration membrane package in the intermediate product depth filtration system of the present invention to an external device.
Fig. 4 is an explanatory view of an operation process when the intermediate depth filtration system of the present invention is used for a depth filtration operation.
(symbol description)
100 intermediate depth filtration system;
200 deep filtration membrane package;
210 liquid inlet;
220 filtering outlet;
230 an exhaust port;
300 an external device;
310 a pump valve;
a 320-column position valve;
330 a collection valve;
400a first connecting tube;
400a1 one end of a first connecting tube;
400a2 the other end of the first connecting tube;
400b a second connecting tube;
400b1 one end of a second connecting tube;
400b2 the other end of the second connecting tube;
500a first male connector;
500b a second male connector;
600a first manual gripping tab;
600b a second hand-grip tab;
700a connecting head;
700b a connector;
a, a first column interface;
and B, second column interface.
Detailed Description
In order to more clearly explain the technical solution of the present invention, the following detailed description of the embodiments of the present invention is provided with reference to the accompanying drawings.
Fig. 1 is a schematic perspective view of the peripheral structure of a depth filtration membrane package 200 in an intermediate depth filtration system 100 according to the present invention, fig. 2 is an exploded perspective view of the peripheral structure of the depth filtration membrane package 200 in the intermediate depth filtration system 100 shown in fig. 1, and fig. 3 is a schematic view of the connection of an inlet 210 and a filtrate outlet 220 of the depth filtration membrane package 200 in the intermediate depth filtration system 100 according to the present invention to an external device 300.
As shown in fig. 1 to 3, the intermediate product depth filtration system 100 of the present invention mainly includes: the deep filtration membrane package 200 removes particles and related impurities in the sample liquid through the surface adsorption and interception functions of the curved pore channels and the internal filling medium inside the deep filtration membrane package 200 so as to realize the function of clarifying the sample liquid; and an external device 300, wherein the external device 300 is connected with the depth filtration membrane module 200, and automatically controls the depth filtration membrane module 200 by setting key parameters such as pressure and flow rate.
The depth filter membrane package 200 is provided with a liquid inlet 210 for the liquid to be filtered, a filtrate outlet 220 for discharging the filtered liquid, and a gas outlet 230 for removing bubbles from the depth filter membrane package 200 during rinsing.
On the inlet side of the depth filtration membrane module 200, a first connection pipe 400a as an inlet side connection pipe, a first male connector 500a as an inlet side male connector, and a first hand-fastening connector 600a as an inlet side hand-fastening connector are provided.
The first connector 400a has one end 400a1 connected to the inlet 210 of the depth filter membrane package 200, for example, by a connector transition of the connector 700a, and another end 400a2 connected to the first manual connector 600a by a connector transition of the first male connector 500 a.
On the filtrate side of the depth filtration membrane module 200, a second connection tube 400b as a filtrate side connection tube, a second male connector 500b as a filtrate side male connector, and a second hand connector 600b as a filtrate side hand connector are provided.
One end 400b1 of the second connection tube 400b is connected to the filtrate outlet 220 of the depth filter membrane module 200 by, for example, switching the connector of the connector 700b, and the other end 400b2 is connected to the second hand connector 600b by switching the connector of the second male connector 500 b.
The utility model discloses in, first public joint 500a first manual tight joint 600a second public joint 500b with second manual tight joint 600b is 1/16 luer joint, and its material is PVDF, nylon, polypropylene or polycarbonate, first connecting pipe 400a and second connecting pipe 400b are 16# silicone tube to pipeline kneck all is fixed with the ribbon during actual operation.
In the present invention, the external device 300 is, for example, an AKTA chromatograph.
More specifically, as shown in fig. 3, a pump valve 310, a column position valve 320, and a collection valve 330 are provided on the external device 300.
The pump valve 310 is connected to a liquid pump (not shown) for pumping buffer solution or sample solution, and the liquid pump can prevent the neutralized sample from blocking the mixing tank.
The column level valve 320 has at least one pair of column level ports (e.g., a pair of column level ports A, B), and one of the pair of column level ports A, B (e.g., a first column level port a) is connected to the inlet port 210 of the depth filter membrane package 200 via a first manual adapter 600a, a first male adapter 500a, a first connecting tube 400a, and a connector 700a provided at the inlet side, and the other of the pair of column level ports A, B (e.g., a second column level port B) is connected to the filtrate port 220 of the depth filter membrane package 200 via a second manual adapter 600B, a second male adapter 500B, a second connecting tube 400B, and a connector 700B provided at the filtrate side.
The collection valve 330 is connected to a collection container (not shown) and is opened during liquid collection for collecting the filtered buffer solution or sample liquid.
Only one depth filtration membrane module 200 with a feed port 210 and a filtrate port 220 coupled to a first column port a and a second column port B, respectively, of a pair of column ports A, B is illustrated, but it should be noted that the present invention is not limited thereto.
As a first variation of attachment, a plurality of depth filtration membranes 200 may be attached in series with one of at least one pair of column ports (e.g., pair of column ports A, B). In this case, the inlet port 210 of a first depth filtration membrane module 200 of the plurality of depth filtration membrane modules 200 is connected to the first column port a, the filtrate port 220 of the first depth filtration membrane module 200 is connected to the inlet port 210 of a second depth filtration membrane module 200, … …, for example, by a connecting tube or the like, and the filtrate port 220 of the last depth filtration membrane module 200 is connected to the second column port B.
As a second variant of the joining, a plurality of depth filtration membrane packages 200 may be joined in parallel to a plurality of pairs of column-level interfaces (e.g., pairs of first and second column-level interfaces a, B, pairs of third and fourth column-level interfaces) of the at least one pair of column-level interfaces. In this case, the liquid inlets 210 of N depth filtration membranes 200 of the plurality of depth filtration membranes 200 are connected by N +1 pipes and then connected to the first column port a, the filtration ports 220 thereof are also connected by N +1 pipes and then connected to the second column port B, and the liquid inlets 210 of the other N depth filtration membranes 200 of the plurality of depth filtration membranes 200 are connected by N +1 pipes and then connected to the third column port, and the filtration ports 220 thereof are connected by N +1 pipes and then connected to the fourth column port.
Next, referring to fig. 4, the operation process of the intermediate product depth filtration system 100 of the present invention for performing the depth filtration operation will be described. Fig. 4 is an explanatory view of an operation of the intermediate depth filtration system 100 according to the present invention in a depth filtration operation.
Before the operation of the intermediate product depth filtration system 100, the depth filtration membrane module 200 is first connected to an external device 300(AKTA chromatograph), and other necessary operational components, such as a liquid pump, collection vessel, air sensor, UV detector, pH and conductance detector, pressure detector, flow meter, etc., are installed as needed.
During operation, the external device 300(AKTA chromatograph) is programmed to automatically control the filtering operation by setting key parameters such as pressure and flow rate. Throughout the operation, pressure, flow rate were monitored in real time using an external device 300(AKTA chromatograph), and data were mapped.
The overall operation of the intermediate product depth filtration system 100 shown in fig. 4 (process run) includes rinsing, equilibrating, loading (collecting), rinsing, etc. In addition, during the program run, the air sensor, UV detector, pH and conductance detector, pressure detector, and flow meter need to be turned on. Specifically, the upper limit of the pre-column pressure is set to the upper limit of the pressure resistance of the deep-bed filtration membrane, and the differential pressure (Δ P) is set to the upper limit of the process development required pressure.
Rinsing with water
The depth filtration membrane package 200 requires first a pre-treatment, i.e., rinsing, prior to use. At this time, the inlet port 210 of the depth filtration membrane cartridge 200 was connected to an external device 300(AKTA chromatograph), while the vent port 230 was opened, and back pressure was intermittently applied at a low flow rate to remove air bubbles in the membrane. The flow rate of the pump (calculated from the inlet flux) is then set and the flush performed until the pressure and flush volume meet the requirements.
Balancing
The submerged membrane filtration module 200 after flushing is subjected to parameter balancing of the use environment. Specifically, the flow rate of the liquid pump and the required buffer volume are set, the equilibration is performed using the sample pump, the pH and conductance of the filtrate port 220 of the depth filtration membrane package 200 are detected using the pH and conductance detector, and the completion of the parameter equilibration is judged based on the pH and conductance and the buffer volume.
Sample loading and collection
The flow rate and sample loading volume of the liquid pump are set, sample loading is performed using the sample pump, collection of flow-through samples can be performed according to the UV value, and collection of samples at sampling points can be performed using an automatic collector. Specifically, in the initial stage of the sample loading, the amount of the sample introduced is small, and most of the liquid flowing out from the filtering port 220 is a buffer liquid, and at this time, the UV value is low and the sample is not collected, and as the sample loading progresses, the amount of the sample introduced increases, and the content of the sample liquid in the liquid flowing out from the filtering port 220 increases, and when the UV value exceeds a predetermined value, the collection valve 330 is automatically opened, and the liquid flowing out from the filtering port 220 is collected in the collection container.
Leaching with water
The flow rate of the liquid pump and the rinsing volume were set and collection of flow-through samples was performed according to the UV value. Specifically, at the initial stage of loading and starting rinsing, the entering amount of the leacheate (buffer solution) is small, most of the liquid flowing out of the filtering port 220 is the sample liquid, the UV value is still high, the collection is continued, the amount of the entering leacheate (buffer solution) is increased along with the rinsing, the content of the sample liquid in the fluid flowing out of the filtering port 220 is reduced, and when the UV value is lower than a certain preset value, the collection valve 330 is automatically closed, and the collection is not performed any more.
Additional advantages and modifications will readily occur to those skilled in the art. Therefore, the invention in its broader aspects is not limited to the specific details and representative embodiments shown and described herein. Accordingly, modifications may be made without departing from the spirit or scope of the general inventive concept as defined by the appended claims and their equivalents.
For example, in the embodiment of the present invention, the example in which the external device 300 is an AKTA chromatograph has been described, but the present invention is not limited to this, and may be an automated system adapted to other types.
In addition, in the embodiment of the present invention, the example in which the one end 400a1 of the first connection pipe 400a is connected to the inlet 210 of the depth filtration membrane package 200 through the joint change of the connection head 700a and the one end 400b1 of the second connection pipe 400b is connected to the filtration outlet 220 of the depth filtration membrane package 200 through the joint change of the connection head 700b has been described, but the present invention is not limited thereto, and the one end 400a1 of the first connection pipe 400a may be directly connected to the inlet 210 of the depth filtration membrane package 200 and the one end 400b1 of the second connection pipe 400b may be directly connected to the filtration outlet 220 of the depth filtration membrane package 200.
In the above description, the connection of the depth filtration membrane module 200 and the external device 300 is exemplified by one example of connection and two modifications of connection, but those skilled in the art may select and use the above connection simultaneously as necessary.
Claims (12)
1. An intermediate product depth filtration system (100), comprising:
the deep filtration membrane package (200) removes particles and impurities in the sample liquid through the surface adsorption and interception effects of the bent pore channels inside the deep filtration membrane package (200) and the filling medium inside the deep filtration membrane package; and
an external device (300) having more than one column site, each column site having a pair of column site interfaces (A, B), said external device (300) being coupled to said depth filtration membrane module (200) and capable of automatically controlling said depth filtration membrane module (200),
the deep layer filtering film package (200) is provided with a liquid inlet (210) for the liquid to be filtered to enter and a filtering outlet (220) for discharging the filtered liquid,
on the liquid inlet side of the depth filtration membrane module (200), a first connection pipe (400a) as a liquid inlet side connection pipe, a first male connector (500a) as a liquid inlet side male connector, and a first hand-tightened connector (600a) as a liquid inlet side hand-tightened connector are provided, and
a second connection pipe (400b) as a filtration side connection pipe, a second male connector (500b) as a filtration side male connector, and a second hand-tight connector (600b) as a filtration side hand-tight connector are provided on the filtration side of the deep filtration membrane pack (200),
the liquid inlet (210) of the depth filtration membrane package (200) is connected to one of the pair of column-level ports (A, B), namely a first column-level port (A), of the external device (300) via the first connecting tube (400a), the first male connector (500a) and the first manual fastening connector (600a),
the filtrate outlet (220) of the depth filtration membrane module (200) is connected to the second column port (B), which is the other column port of the pair of column ports (A, B) of the external device (300), via the second connection tube (400B), the second male connector (500B), and the second hand-held connector (600B).
2. The intermediate product depth filtration system (100) of claim 1,
the depth filtration membrane package (200) is further provided with an air outlet (230) for use in removing air bubbles from the depth filtration membrane package (200) during rinsing.
3. The intermediate product depth filtration system (100) of claim 1,
on the liquid inlet side of the depth filtration membrane module (200), one end of the first connecting pipe (400a) is connected to the liquid inlet (210) of the depth filtration membrane module (200) by means of a connector switch of a connecting head, and the other end is connected to the first manual grip connector (600a) by means of a connector switch of the first male connector (500 a).
4. The intermediate product depth filtration system (100) of claim 1,
on the filtration side of the depth filter membrane module (200), one end of the second connection pipe (400b) is connected to the filtration outlet (220) of the depth filter membrane module (200) by the joint change of the connector, and the other end is connected to the second hand-held joint (600b) by the joint change of the second male joint (500 b).
5. The intermediate product depth filtration system (100) of claim 1,
the first male connector (500a), the first manual fastening connector (600a), the second male connector (500b) and the second manual fastening connector (600b) are 1/16 luer connectors, and are made of PVDF, nylon, polypropylene or polycarbonate.
6. The intermediate product depth filtration system (100) of claim 1,
the first connecting pipe (400a) and the second connecting pipe (400b) are 16# silicone tubes.
7. The intermediate product depth filtration system (100) of claim 1,
the external device (300) is an AKTA chromatograph.
8. The intermediate product depth filtration system (100) of claim 7,
a pump valve (310), a column position valve (320) and a collecting valve (330) are arranged on the external device (300), wherein,
the pump valve (310) is connected to a liquid pump,
the column position valve (320) having the pair of column position interfaces (A, B) of the one or more column positions,
the collection valve (330) is connected to a collection container.
9. The intermediate depth filtration system (100) of claim 8,
the inlet (210) and the outlet (220) of one of the depth filtration membrane packages (200) are in communication with the first column port (A) and the second column port (B) of the pair of column ports (A, B), respectively.
10. The intermediate depth filtration system (100) of claim 8,
a plurality of the depth filtration membranes (200) are attached to one or more pairs of the column ports.
11. The intermediate product depth filtration system (100) of claim 10,
a plurality of depth filtration membranes (200) are connected in series to at least one of the pair of column ports or the plurality of pairs of column ports.
12. The intermediate product depth filtration system (100) of claim 10,
n deep-layer filter membranes (200) are connected in parallel on at least one pair of column interfaces of one or more pairs of column interfaces,
on the feed side of the N depth filtration membranes (200), the first connection tube (400a) is an N +1 through tube, a first tube port of the N +1 through tube being joined to the first column port (A) of the pair of column ports (A, B), the other tube ports of the N +1 through tube being joined to the feed port (210) of each of the N depth filtration membranes (200),
at the filtrate outlets of the N depth filtration membranes (200), the second connection tube (400B) is another N + 1-tube, a first tube port of the other N + 1-tube being joined to the second column port (B) of the pair of column ports (A, B), the other port of the other N + 1-tube being joined to the filtrate outlet (220) of each of the N depth filtration membranes (200).
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|---|---|---|---|
| CN202020082732.0U CN212091716U (en) | 2020-01-15 | 2020-01-15 | Intermediate product deep layer filtration system |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202020082732.0U CN212091716U (en) | 2020-01-15 | 2020-01-15 | Intermediate product deep layer filtration system |
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