CN211542505U - Tablet press for valaciclovir hydrochloride tablets - Google Patents
Tablet press for valaciclovir hydrochloride tablets Download PDFInfo
- Publication number
- CN211542505U CN211542505U CN202020035856.3U CN202020035856U CN211542505U CN 211542505 U CN211542505 U CN 211542505U CN 202020035856 U CN202020035856 U CN 202020035856U CN 211542505 U CN211542505 U CN 211542505U
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- CN
- China
- Prior art keywords
- preforming
- blanking
- blanking plate
- hole
- tablet press
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- ZCDDBUOENGJMLV-QRPNPIFTSA-N Valacyclovir hydrochloride Chemical compound Cl.N1C(N)=NC(=O)C2=C1N(COCCOC(=O)[C@@H](N)C(C)C)C=N2 ZCDDBUOENGJMLV-QRPNPIFTSA-N 0.000 title claims abstract description 19
- 229940064636 valacyclovir hydrochloride Drugs 0.000 claims description 10
- 238000007790 scraping Methods 0.000 claims description 7
- 238000003825 pressing Methods 0.000 claims description 6
- 238000004519 manufacturing process Methods 0.000 abstract description 6
- 230000006978 adaptation Effects 0.000 abstract description 3
- 239000007932 molded tablet Substances 0.000 abstract 1
- 239000003826 tablet Substances 0.000 abstract 1
- 239000000463 material Substances 0.000 description 9
- 239000000843 powder Substances 0.000 description 7
- 229960004150 aciclovir Drugs 0.000 description 4
- MKUXAQIIEYXACX-UHFFFAOYSA-N aciclovir Chemical compound N1C(N)=NC(=O)C2=C1N(COCCO)C=N2 MKUXAQIIEYXACX-UHFFFAOYSA-N 0.000 description 4
- 238000009475 tablet pressing Methods 0.000 description 3
- 108020004414 DNA Proteins 0.000 description 2
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 description 2
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
- 238000003786 synthesis reaction Methods 0.000 description 2
- 102000053602 DNA Human genes 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- 229920000168 Microcrystalline cellulose Polymers 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- RXUWDKBZZLIASQ-UHFFFAOYSA-N Puerarin Natural products OCC1OC(Oc2c(O)cc(O)c3C(=O)C(=COc23)c4ccc(O)cc4)C(O)C(O)C1O RXUWDKBZZLIASQ-UHFFFAOYSA-N 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- HDOVUKNUBWVHOX-QMMMGPOBSA-N Valacyclovir Chemical compound N1C(N)=NC(=O)C2=C1N(COCCOC(=O)[C@@H](N)C(C)C)C=N2 HDOVUKNUBWVHOX-QMMMGPOBSA-N 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 230000000840 anti-viral effect Effects 0.000 description 1
- 239000004203 carnauba wax Substances 0.000 description 1
- 235000013869 carnauba wax Nutrition 0.000 description 1
- 229940082483 carnauba wax Drugs 0.000 description 1
- 229940075614 colloidal silicon dioxide Drugs 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 229960000913 crospovidone Drugs 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 1
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 1
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 1
- 229960003943 hypromellose Drugs 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- KHLVKKOJDHCJMG-QDBORUFSSA-L indigo carmine Chemical compound [Na+].[Na+].N/1C2=CC=C(S([O-])(=O)=O)C=C2C(=O)C\1=C1/NC2=CC=C(S(=O)(=O)[O-])C=C2C1=O KHLVKKOJDHCJMG-QDBORUFSSA-L 0.000 description 1
- 239000004179 indigotine Substances 0.000 description 1
- 235000012738 indigotine Nutrition 0.000 description 1
- 235000019359 magnesium stearate Nutrition 0.000 description 1
- 229940057948 magnesium stearate Drugs 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 229940016286 microcrystalline cellulose Drugs 0.000 description 1
- 235000019813 microcrystalline cellulose Nutrition 0.000 description 1
- 239000008108 microcrystalline cellulose Substances 0.000 description 1
- MRWXACSTFXYYMV-FDDDBJFASA-N nebularine Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C2=NC=NC=C2N=C1 MRWXACSTFXYYMV-FDDDBJFASA-N 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 description 1
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
- 229940068968 polysorbate 80 Drugs 0.000 description 1
- 229920000053 polysorbate 80 Polymers 0.000 description 1
- 235000013809 polyvinylpolypyrrolidone Nutrition 0.000 description 1
- 229920000523 polyvinylpolypyrrolidone Polymers 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 229940069328 povidone Drugs 0.000 description 1
- 229940002612 prodrug Drugs 0.000 description 1
- 239000000651 prodrug Substances 0.000 description 1
- HKEAFJYKMMKDOR-VPRICQMDSA-N puerarin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1C1=C(O)C=CC(C2=O)=C1OC=C2C1=CC=C(O)C=C1 HKEAFJYKMMKDOR-VPRICQMDSA-N 0.000 description 1
- 239000002212 purine nucleoside Substances 0.000 description 1
- 238000007493 shaping process Methods 0.000 description 1
- 239000004408 titanium dioxide Substances 0.000 description 1
- 229960005196 titanium dioxide Drugs 0.000 description 1
- 235000010215 titanium dioxide Nutrition 0.000 description 1
- 229940108442 valtrex Drugs 0.000 description 1
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- Medicinal Preparation (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
Abstract
The utility model provides a tablet press for valaciclovir hydrochloride piece, comprises a workbench, the working rack lower extreme is equipped with a supporting bench, be equipped with driving motor on the supporting bench, driving motor's output and pivot are connected, be equipped with the preforming revolving stage in the pivot, be equipped with a plurality of preforming holes on the preforming revolving stage, preforming revolving stage downside is equipped with blanking plate, be equipped with the through-hole that supplies the pivot to pass on the blanking plate, blanking plate passes through the support frame and is connected with a supporting bench, be equipped with the blanking hole on the blanking plate, blanking hole and baffle box intercommunication, the working rack top is equipped with vertical telescopic machanism, vertical telescopic machanism lower extreme is equipped with the pressure disk, the pressure disk bottom is equipped with the pressure head with preforming hole adaptation, the hopper is connected through the link to the working rack inboard, the. The equipment enables the molded tablet to be easily unloaded, and improves the production efficiency.
Description
Technical Field
The utility model belongs to valaciclovir hydrochloride tablet production facility field, in particular to a tablet press for valaciclovir hydrochloride tablet.
Background
Valacyclovir Hydrochloride (Valacyclovir Hydrochloride) is a prodrug of acyclovir, is rapidly absorbed after being taken orally and is rapidly converted into acyclovir in vivo, the antiviral effect of the Valacyclovir Hydrochloride is exerted by the acyclovir, and the acyclovir is open-chain purine nucleoside, can inhibit the synthesis of virus deoxyribonucleic acid, and has little effect on the synthesis of host cell DNA.
Valacyclovir hydrochloride tablets are marketed in China, and the original research enterprise is the Puerarin Schke, the trade name of the Valtrex and the Chinese trade name of the Vidersi. The American specification discloses that the auxiliary materials of the product are as follows: carnauba wax, colloidal silicon dioxide, crospovidone, FD & C Blue No.2 Lake, hypromellose, magnesium stearate, microcrystalline cellulose, polyethylene glycol, polysorbate 80, povidone, and titanium dioxide.
But the common tabletting equipment is not easy to unload. For example, CN204914690U discloses a tabletting device for processing donkey-hide gelatin tabletting candies, which comprises a tabletting machine base, wherein a tabletting turntable is arranged on the machine base, a feeder, a strickling device and a pressing device are sequentially arranged on the upper portion of the turntable along the rotation direction of the materials, a plurality of tabletting grooves are circumferentially distributed on the tabletting turntable, the feeder comprises a support and a hopper which is arranged on the support through an elastic gasket, a discharge port of the hopper is positioned on the upper portion of the tabletting groove of the tabletting turntable, a vibrating motor is fixedly arranged on the hopper, the strickling device is an elastic sheet fixedly arranged on the tabletting machine base at one end, and the bottom edge of the elastic sheet is tightly attached to the upper surface of the tabletting turntable. The hopper driven by the vibration motor can smoothly discharge materials under the vibration effect, and the elastic sheet sweeps the materials in the pressing sheet groove of the rotary table along with the rotation of the rotary table and then is pressed by the pressing device, so that the quality of products is ensured. After the tablet press completes tablet pressing, the tablet pressing is not easy to take out of the tablet pressing groove, and the production efficiency is reduced.
Disclosure of Invention
The utility model aims to solve the technical problem that a tablet press for valaciclovir hydrochloride tablet is provided, the preforming after the shaping is unloaded easily, improves production efficiency.
In order to solve the technical problem, the utility model discloses the technical scheme who adopts is: the utility model provides a tablet press for valaciclovir hydrochloride piece, which comprises a workbench, the workstation lower extreme is equipped with a supporting bench, be equipped with driving motor on the supporting bench, driving motor's output is connected with the pivot, be equipped with the preforming revolving stage in the pivot, be equipped with a plurality of preforming holes on the preforming revolving stage, preforming revolving stage downside is equipped with blanking plate, be equipped with the through-hole that supplies the pivot to pass on the blanking plate, blanking plate passes through the support frame and is connected with a supporting bench, be equipped with the blanking hole on the blanking plate, blanking hole and baffle box intercommunication, the workstation top is equipped with vertical telescopic machanism, vertical telescopic machanism lower extreme is equipped with the pressure disk, the pressure disk bottom is equipped with the pressure head with preforming hole adaptation, the workstation inboard is connected the hopper through the link.
In the preferred scheme, the support frame includes the bracing piece, is equipped with the through-hole that supplies the bracing piece to pass through on the brace table, is equipped with the spring between flitch and the brace table.
In a preferred scheme, the vertical telescopic mechanism is an air cylinder.
In the preferred scheme, the inner side of the working frame is provided with an annular guide rail, and the bottom of the tabletting turntable is provided with a sliding block matched with the annular guide rail.
In the preferred scheme, the upper side of the tabletting rotary table is provided with a scraping plate, and the scraping plate is connected with the working frame.
The utility model provides a pair of a tablet press for valaciclovir hydrochloride piece rotates through the order of preforming revolving stage, realizes reinforced to each preforming hole, and the preforming hole of reinforced completion rotates to the pressure head below, realizes the preforming, and the preforming hole after the preforming rotates to blanking hole position and with blanking hole coincidence, accomplishes the blanking, and the order rotates, realizes the continuous progression and the blanking of preforming. The device is unloaded conveniently, improves the production efficiency of preforming.
Drawings
The invention will be further explained with reference to the following figures and examples:
fig. 1 is a schematic view of the overall structure of the present invention;
FIG. 2 is a cross-sectional view taken along plane A-A of FIG. 1;
in the figure: the automatic material scraping device comprises a working frame 1, a supporting table 2, a driving motor 3, a rotating shaft 4, a tabletting rotary table 5, a blanking plate 6, a supporting frame 7, a material guide chute 8, a vertical telescopic mechanism 9, a pressure plate 10, a pressure head 11, a connecting frame 12, a hopper 13, a valve 14, an annular guide rail 15, a sliding block 16, a scraping plate 17, a tabletting hole 501, a blanking hole 601, a supporting rod 701, a spring 702 and a discharge hole 1301.
Detailed Description
As shown in fig. 1-2, a tablet press for valacyclovir hydrochloride tablets comprises a work frame 1, in this embodiment, the work frame 1 is a box structure, a support platform 2 is arranged at the lower end of the work frame 1, a driving motor 3 is arranged on the support platform 2, the driving motor 3 is a stepping motor, the output end of the driving motor 3 is connected with a rotating shaft 4, a tablet rotating platform 5 is arranged on the rotating shaft 4, a plurality of tablet holes 501 are arranged on the tablet rotating platform 5, in this embodiment, the number of the tablet holes 501 is four, a blanking plate 6 is arranged at the lower side of the tablet rotating platform 5, the blanking plate 6 is arranged close to the bottom of the tablet rotating platform 5, the blanking plate 6 is connected with the support platform 2 through a support frame 7, a blanking hole 601 is arranged on the blanking plate 6, the blanking hole 601 is aligned with one of the tablet holes 501, the blanking hole 601 is communicated with a material guide chute 8, a vertical telescopic, vertical telescopic machanism 9 is the cylinder, and the cylinder also can be replaced with electric putter etc. and the 9 lower extremes of vertical telescopic machanism is equipped with pressure disk 10, pressure disk 10 bottom be equipped with the pressure head 11 of preforming hole 501 adaptation, and 1 inboards in the work rest are through connecting bracket 12 connection hopper 13, and the bin outlet 1301 of hopper 13 sets up in the top of preforming hole 501, and bin outlet 1301 is equipped with valve 14, and solenoid valve can be chooseed for use to valve 14.
During the specific use, firstly add prepared valaciclovir hydrochloride powder in hopper 13, open valve 14, the material powder is discharged to preforming hole 501 from bin outlet 1301, close valve 14, start driving motor 3, make preforming revolving stage 5 anticlockwise rotate 90 degrees, preforming hole 501 filled with the powder rotates to vertical telescopic machanism 9 below, start vertical telescopic machanism 9 and carry out the preforming to the powder, after the preforming is accomplished, preforming revolving stage 5 continues to rotate 90 degrees and rotates, preforming hole 501 that the preforming was located rotates to blanking hole 601 coincidence, accomplish the blanking, the order rotates, realize the continuous advance and the blanking of preforming. The device is unloaded conveniently, improves the production efficiency of preforming.
Preferably, the supporting frame 7 includes a supporting rod 701, a through hole for the supporting rod 701 to pass through is formed in the supporting platform 2, a spring 702 is arranged between the blanking plate 6 and the supporting platform 2, and the spring 702 is sleeved on the supporting rod 701. Through setting up spring 702, guarantee blanking plate 6 and hug closely 5 bottoms settings of preforming revolving stage, when can effectively reducing preforming revolving stage 5 and rotate, the volume of leaking out of powder.
Preferably, the inner side of the working frame 1 is provided with an annular guide rail 15, and the bottom of the tabletting turntable 5 is provided with a slide block 16 matched with the annular guide rail 15.
Through the cooperation of annular guide 15 and slider 16, can improve the supporting role to preforming revolving stage 5, improve stability.
Preferably, 5 upsides of preforming revolving stage are equipped with scrapes flitch 17, scrape flitch 17 and are connected with work frame 1, scrape flitch 17 and set up between hopper 13 and vertical telescopic machanism 9, and after feeding into the preforming hole 501, preforming revolving stage 5 pivoted in-process scrapes flitch 17 and realizes scraping the material of powder, strikes off unnecessary powder, can guarantee that the specification of preforming is unified.
Claims (5)
1. A tablet press for valacyclovir hydrochloride tablets, comprising: comprises a working frame (1), a supporting table (2) is arranged at the lower end of the working frame (1), a driving motor (3) is arranged on the supporting table (2), the output end of the driving motor (3) is connected with a rotating shaft (4), a tabletting rotary table (5) is arranged on the rotating shaft (4), a plurality of tabletting holes (501) are arranged on the tabletting rotary table (5), a blanking plate (6) is arranged at the lower side of the tabletting rotary table (5), through holes for the rotating shaft (4) to pass through are arranged on the blanking plate (6), the blanking plate (6) is connected with the supporting table (2) through a supporting frame (7), blanking holes (601) are arranged on the blanking plate (6), the blanking holes (601) are communicated with a guide chute (8), a vertical telescopic mechanism (9) is arranged at the top of the working frame (1), a pressing disc (10) is arranged at the lower end of the vertical telescopic mechanism (9), a pressing head (11, the inner side of the working frame (1) is connected with the hopper (13) through the connecting frame (12), the discharge opening (1301) of the hopper (13) is arranged above the pressing sheet hole (501), and the valve (14) is arranged at the discharge opening (1301).
2. A tablet press for valacyclovir hydrochloride tablets as claimed in claim 1, wherein: the support frame (7) comprises a support rod (701), a through hole for the support rod (701) to pass through is formed in the support platform (2), and a spring (702) is arranged between the blanking plate (6) and the support platform (2).
3. A tablet press for valacyclovir hydrochloride tablets as claimed in claim 1, wherein: the vertical telescopic mechanism (9) is a cylinder.
4. A tablet press for valacyclovir hydrochloride tablets as claimed in claim 1, wherein: an annular guide rail (15) is arranged on the inner side of the working frame (1), and a sliding block (16) matched with the annular guide rail (15) is arranged at the bottom of the tabletting rotary table (5).
5. A tablet press for valacyclovir hydrochloride tablets as claimed in claim 1, wherein: and a scraping plate (17) is arranged on the upper side of the tabletting rotary table (5), and the scraping plate (17) is connected with the working frame (1).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202020035856.3U CN211542505U (en) | 2020-01-08 | 2020-01-08 | Tablet press for valaciclovir hydrochloride tablets |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202020035856.3U CN211542505U (en) | 2020-01-08 | 2020-01-08 | Tablet press for valaciclovir hydrochloride tablets |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN211542505U true CN211542505U (en) | 2020-09-22 |
Family
ID=72490134
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202020035856.3U Active CN211542505U (en) | 2020-01-08 | 2020-01-08 | Tablet press for valaciclovir hydrochloride tablets |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN211542505U (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113478894A (en) * | 2021-08-12 | 2021-10-08 | 江苏江大源生态生物科技股份有限公司 | Tablet powder direct-pressing forming device and method |
| CN114279275A (en) * | 2021-11-30 | 2022-04-05 | 湖北航鹏化学动力科技有限责任公司 | Big powder column charge device of initiating explosive device |
| CN114604535A (en) * | 2022-03-18 | 2022-06-10 | 长江大学 | Leak protection material structure of pellet manufacture machine for animal feed processing |
| CN114939999A (en) * | 2022-05-16 | 2022-08-26 | 霍山县天下泽雨生物科技发展有限公司 | Tabletting device and method for dendrobium huoshanense production |
-
2020
- 2020-01-08 CN CN202020035856.3U patent/CN211542505U/en active Active
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113478894A (en) * | 2021-08-12 | 2021-10-08 | 江苏江大源生态生物科技股份有限公司 | Tablet powder direct-pressing forming device and method |
| CN114279275A (en) * | 2021-11-30 | 2022-04-05 | 湖北航鹏化学动力科技有限责任公司 | Big powder column charge device of initiating explosive device |
| CN114604535A (en) * | 2022-03-18 | 2022-06-10 | 长江大学 | Leak protection material structure of pellet manufacture machine for animal feed processing |
| CN114604535B (en) * | 2022-03-18 | 2023-11-21 | 长江大学 | Leak protection material structure of granulation machine for animal feed processing |
| CN114939999A (en) * | 2022-05-16 | 2022-08-26 | 霍山县天下泽雨生物科技发展有限公司 | Tabletting device and method for dendrobium huoshanense production |
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