CN211412029U - Condensation reaction kettle for producing 4-hydroxyethyl piperazine ethanesulfonic acid - Google Patents
Condensation reaction kettle for producing 4-hydroxyethyl piperazine ethanesulfonic acid Download PDFInfo
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- CN211412029U CN211412029U CN201921569566.0U CN201921569566U CN211412029U CN 211412029 U CN211412029 U CN 211412029U CN 201921569566 U CN201921569566 U CN 201921569566U CN 211412029 U CN211412029 U CN 211412029U
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- Prior art keywords
- kettle
- cauldron
- condensation reaction
- ethanesulfonic acid
- producing
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- 238000006482 condensation reaction Methods 0.000 title claims abstract description 21
- DBLXOVFQHHSKRC-UHFFFAOYSA-N ethanesulfonic acid;2-piperazin-1-ylethanol Chemical compound CCS(O)(=O)=O.OCCN1CCNCC1 DBLXOVFQHHSKRC-UHFFFAOYSA-N 0.000 title claims abstract description 18
- 238000010438 heat treatment Methods 0.000 claims abstract description 15
- 239000007788 liquid Substances 0.000 claims abstract description 15
- 239000007787 solid Substances 0.000 claims abstract description 11
- 238000007789 sealing Methods 0.000 claims description 18
- 238000003756 stirring Methods 0.000 claims description 17
- 238000007599 discharging Methods 0.000 claims description 3
- 230000009471 action Effects 0.000 abstract description 12
- 238000002156 mixing Methods 0.000 abstract description 7
- 230000008878 coupling Effects 0.000 abstract description 6
- 238000010168 coupling process Methods 0.000 abstract description 6
- 238000005859 coupling reaction Methods 0.000 abstract description 6
- 238000004519 manufacturing process Methods 0.000 abstract description 3
- 230000008901 benefit Effects 0.000 abstract description 2
- 238000012824 chemical production Methods 0.000 abstract description 2
- 238000006243 chemical reaction Methods 0.000 description 15
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 8
- 239000000872 buffer Substances 0.000 description 6
- 230000000694 effects Effects 0.000 description 6
- 238000004321 preservation Methods 0.000 description 6
- 239000002994 raw material Substances 0.000 description 6
- 238000011084 recovery Methods 0.000 description 3
- 238000009007 Diagnostic Kit Methods 0.000 description 2
- 239000012295 chemical reaction liquid Substances 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 239000001963 growth medium Substances 0.000 description 2
- SUMDYPCJJOFFON-UHFFFAOYSA-N isethionic acid Chemical compound OCCS(O)(=O)=O SUMDYPCJJOFFON-UHFFFAOYSA-N 0.000 description 2
- WFCSWCVEJLETKA-UHFFFAOYSA-N 2-piperazin-1-ylethanol Chemical compound OCCN1CCNCC1 WFCSWCVEJLETKA-UHFFFAOYSA-N 0.000 description 1
- 238000007400 DNA extraction Methods 0.000 description 1
- 102000003960 Ligases Human genes 0.000 description 1
- 108090000364 Ligases Proteins 0.000 description 1
- 206010067482 No adverse event Diseases 0.000 description 1
- 238000010802 RNA extraction kit Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000006177 biological buffer Substances 0.000 description 1
- 238000009396 hybridization Methods 0.000 description 1
- GPRLSGONYQIRFK-UHFFFAOYSA-N hydron Chemical group [H+] GPRLSGONYQIRFK-UHFFFAOYSA-N 0.000 description 1
- 238000009413 insulation Methods 0.000 description 1
- 238000002372 labelling Methods 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 239000011535 reaction buffer Substances 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
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Abstract
The utility model relates to a chemical production technical field, specificly disclose a condensation reaction cauldron of production 4-hydroxyethyl piperazine ethanesulfonic acid, including outer cauldron and interior cauldron, interior cauldron has been placed to the inside of outer cauldron, the outside of interior cauldron is at the inside heating resistor that is provided with of outer cauldron, the top fixed mounting of outer cauldron has a plurality of hydraulic stems, the top fixed connection of hydraulic stem is in the lower surface radial position of top cap, the intermediate position of top cap rotates and is provided with the (mixing) shaft, the top coaxial coupling of (mixing) shaft has from the driving wheel, fixed mounting has the motor on the top cap, the output shaft coaxial coupling of motor has the action wheel, the action wheel is connected through the belt from the driving wheel, be provided with a plurality of spiral leaves on the (mixing) shaft, the intercommunication has solid feed inlet and liquid feed inlet on the. The utility model discloses the advantage: simple structure, convenient operation, it is convenient to wash, maintain, and the security is high, the facilitate promotion is implemented.
Description
Technical Field
The utility model relates to the technical field of chemical production, in particular to a condensation reaction kettle for producing 4-hydroxyethyl piperazine ethanesulfonic acid.
Background
4-hydroxyethyl piperazine ethanesulfonic acid is a biological buffer, a reaction buffer, a prehybridization buffer and a hybridization buffer for separating and analyzing RNA nuclear components, is used for 3' -terminal labeling of RNA and T4RNA ligase, and is used in biochemical diagnostic kits, DNA/RNA extraction kits and PCR diagnostic kits. Has no toxic effect on cells. It is a hydrogen ion buffer that can control a constant pH range for a long period of time. The buffer capacity can be achieved by using the culture medium with the final concentration of 10-50mmol/L and the content of 20mmol/LHEPES in the culture medium. The 4-hydroxyethyl piperazine ethanesulfonic acid is generated by condensation reaction of N-hydroxyethyl piperazine and 2-hydroxyethyl sulfonic acid or salt thereof. The reaction needs a condensation reaction kettle.
Chinese patent (publication No. CN 206463947U, publication No. 2017.09.05) discloses a condensation reaction kettle, which comprises a kettle body, an electric stirring component, a heating component, a flow guide component and an ethanol recovery device; the flow guide part comprises two flow guide plates arranged on the inner wall of the kettle body and a group of horizontal and upward flow guide fins arranged on each flow guide plate; the two guide plates are symmetrically arranged relative to the axis of the kettle body; the ethanol recovery device comprises a cooler connected with an ethanol recovery outlet through a pipeline, a closed receiving cylinder connected with the cooler through a pipeline, a buffer tank connected with the closed receiving cylinder through a pipeline and a vacuum pump connected with the buffer tank through a pipeline; the closed receiving cylinder is provided with a discharging pipe. The condensation reaction kettle can improve the reaction efficiency and the reaction yield and can also timely recover the ethanol distilled in the condensation reaction process. However, the reaction kettle is inconvenient to clean after use, easy to cause pollution and inconvenient to popularize and implement.
SUMMERY OF THE UTILITY MODEL
An object of the utility model is to provide a condensation reaction cauldron of production 4-hydroxyethyl piperazine ethanesulfonic acid to solve the problem that proposes among the above-mentioned background art.
In order to achieve the above object, the utility model provides a following technical scheme:
the utility model provides a production 4-hydroxyethyl piperazine ethanesulfonic acid's condensation reaction cauldron, includes outer cauldron and interior cauldron, and the interior cauldron has been placed to the inside of outer cauldron, and the outside of interior cauldron is provided with heating resistor in outer cauldron is inside, and heating resistor can heat the interior cauldron. A temperature sensor is arranged in the outer kettle. The temperature sensor can sense the internal temperature of the inner kettle and is electrically connected with the heating resistor.
The top fixed mounting of outer cauldron has a plurality of hydraulic stems, and the top fixed connection of hydraulic stem is in the lower surface radial position of top cap. Under the action of the hydraulic rod, the top cover is lifted, so that the sealing and the opening of the inner kettle are completed. The intermediate position of top cap rotates and is provided with the (mixing) shaft, and the top coaxial coupling of (mixing) shaft has from the driving wheel, and fixed mounting has the motor on the top cap from the side of driving wheel, and the output shaft coaxial coupling of motor has the action wheel, and the action wheel with connect through the belt from the driving wheel. Under the drive of the motor, the driving wheel drives the driven wheel to rotate, so that the stirring shaft rotates. The stirring shaft is provided with a plurality of spiral blades, the stirring shaft drives the spiral blades to rotate, so that stirring is completed, the spiral blades rotate to complete the internal reaction system inside the inner kettle to form internal circulation, the solid-liquid contact probability is increased, and the reaction efficiency is improved. The top cover is communicated with a solid feeding hole and a liquid feeding hole, solid raw materials enter the inner kettle through the solid feeding hole, and liquid raw materials enter the inner kettle through the liquid feeding hole. The bottoms of the inner kettle and the outer kettle are communicated with a discharge port, and the reaction liquid in the inner kettle can be discharged by opening the discharge port.
As a further aspect of the present invention: the bottom of outer cauldron is fixed to be provided with the landing leg, and the landing leg has supporting role to outer cauldron, makes placing of outer cauldron stable, firm.
As a further aspect of the present invention: the outside of heating resistor is provided with the heat preservation in outer cauldron inside, and the heat preservation has the heat preservation effect, has avoided the heat to run off.
As a further aspect of the present invention: the upper surface of top cap is provided with the dustcoat, and the dustcoat covers motor, action wheel and driven wheel inside, has avoided personnel to contact the action wheel and has followed the driving wheel, has guaranteed driven smooth and easy and the safety of device.
As a further aspect of the present invention: the top cover is also provided with an observation window through which the internal reaction condition of the inner kettle can be observed.
As a further aspect of the present invention: the seal groove has been seted up at the top of interior cauldron, and the lower fixed surface of top cap is provided with the sealing washer, and when the top cap descends, the sealing washer nestification is in the inside of seal groove to make top cap and interior cauldron sealed, it is sealed effectual.
Compared with the prior art, the beneficial effects of the utility model are that: under the effect of hydraulic stem, the top cap goes up and down to the sealed of cauldron is opened in accomplishing, makes things convenient for reation kettle's cleanness and maintenance, makes reation kettle wash convenient and fast. The helical blade rotates to complete the internal circulation of the reaction system in the inner kettle, so that the solid-liquid contact probability is increased, and the reaction efficiency is improved. When the top cover descends, the sealing ring is nested in the sealing groove, so that the top cover and the inner kettle are sealed, and the sealing effect is good. The utility model discloses the advantage: simple structure, convenient operation, it is convenient to wash, maintain, and the security is high, the facilitate promotion is implemented.
Drawings
FIG. 1 is a schematic perspective view of a condensation reaction kettle for producing 4-hydroxyethylpiperazine ethanesulfonic acid.
FIG. 2 is a schematic diagram of the internal structure of a condensation reaction kettle for producing 4-hydroxyethyl piperazine ethanesulfonic acid.
FIG. 3 is a schematic structural diagram of an inner kettle of a condensation reaction kettle for producing 4-hydroxyethyl piperazine ethanesulfonic acid.
In the figure, a supporting leg 1, an outer kettle 2, a hydraulic rod 3, a top cover 4, a motor 5, a driving wheel 6, a solid feeding hole 7, a driven wheel 8, an observation window 9, a liquid feeding hole 10, a discharging hole 11, a heat insulation layer 12, an inner kettle 13, a stirring shaft 14, an outer cover 15, a sealing ring 16, a spiral blade 17, a heating resistor 18 and a sealing groove 19.
Detailed Description
In order to clearly understand the technical features, objects and effects of the present invention, the present invention will now be described with reference to the accompanying drawings.
Example 1
Referring to fig. 1-2, a condensation reaction kettle for producing 4-hydroxyethylpiperazine ethanesulfonic acid comprises an outer kettle 2 and an inner kettle 13, wherein a support leg 1 is fixedly arranged at the bottom of the outer kettle 2, and the support leg 1 has a supporting function on the outer kettle 2, so that the outer kettle 2 is stably and firmly placed. Inner kettle 13 has been placed to outer cauldron 2's inside, and inner kettle 13's the outside is provided with heating resistor 18 in outer cauldron 2 is inside, and heating resistor 18 can heat inner kettle 13. A temperature sensor is arranged in the outer kettle 2. The temperature sensor can sense the internal temperature of the inner kettle 13 and is electrically connected with the heating resistor 18. The outside of heating resistor 18 is provided with heat preservation 12 in outer cauldron 2 is inside, and heat preservation 12 has the heat preservation effect, has avoided the heat to run off.
The top fixed mounting of outer cauldron 2 has a plurality of hydraulic stem 3, and the top fixed connection of hydraulic stem 3 is in the lower surface radial position of top cap 4. Under the action of the hydraulic rod 3, the top cover 4 is lifted, thereby completing the sealing and the opening of the inner kettle 13. The intermediate position of top cap 4 rotates and is provided with (mixing) shaft 14, and the top coaxial coupling of (mixing) shaft 14 has from driving wheel 8, and fixed mounting has motor 5 from the side of driving wheel 8 on top cap 4, and motor 5's output shaft coaxial coupling has action wheel 6, and action wheel 6 is connected through the belt from driving wheel 8. Under the drive of the motor 5, the driving wheel 6 drives the driven wheel 8 to rotate, so that the stirring shaft 14 rotates. The stirring shaft 14 is provided with a plurality of spiral blades 17, the stirring shaft 14 drives the spiral blades 17 to rotate, so that stirring is completed, the spiral blades 17 rotate to complete internal circulation of an internal reaction system in the inner kettle 13, the solid-liquid contact probability is increased, and the reaction efficiency is improved. The upper surface of top cap 4 is provided with dustcoat 15, and dustcoat 15 covers motor 5, action wheel 6 and from driving wheel 8 inside, has avoided personnel to contact action wheel 6 and from driving wheel 8, has guaranteed driven smooth and easy and the safety of device. The top cover 4 is communicated with a solid feed inlet 7 and a liquid feed inlet 10, solid raw materials enter the inner kettle 13 through the solid feed inlet 7, and liquid raw materials enter the inner kettle 13 through the liquid feed inlet 10. The top cover 4 is also provided with an observation window 9, and the reaction condition in the inner kettle 13 can be observed through the observation window 9. The bottom parts of the inner kettle 13 and the outer kettle 2 are communicated with a discharge port 11, and the reaction liquid in the inner kettle 13 can be discharged by opening the discharge port 11.
The utility model discloses a theory of operation is: the solid raw material enters the inner kettle 13 through the solid feed inlet 7, and the liquid raw material enters the inner kettle 13 through the liquid feed inlet 10. The heating resistor 18 can heat the inner pot 13 by setting the heating temperature. Under the drive of the motor 5, the driving wheel 6 drives the driven wheel 8 to rotate, so that the stirring shaft 14 rotates. The stirring shaft 14 is provided with a plurality of spiral blades 17, the stirring shaft 14 drives the spiral blades 17 to rotate, so that stirring is completed, the spiral blades 17 rotate to complete internal circulation of an internal reaction system in the inner kettle 13, the solid-liquid contact probability is increased, and the reaction efficiency is improved. The reaction solution in the inner vessel 13 can be discharged by opening the discharge port 11. The hydraulic rod 3 is started, the top cover 4 is lifted, and the interior of the inner kettle 13 can be cleaned.
Example 2
Referring to fig. 3, on the basis of embodiment 1, a sealing groove 19 is formed at the top of the inner kettle 13, a sealing ring 16 is fixedly disposed on the lower surface of the top cover 4, and when the top cover 4 descends, the sealing ring 16 is nested inside the sealing groove 19, so that the top cover 4 and the inner kettle 13 are sealed, and the sealing effect is good.
The above-mentioned embodiments only represent the preferred embodiments of the present invention, and the description thereof is more specific and detailed, but not to be construed as limiting the scope of the present invention. It should be noted that, for those skilled in the art, without departing from the spirit of the present invention, several changes, modifications and substitutions can be made, which are all within the scope of the present invention. Therefore, the protection scope of the present invention should be subject to the appended claims.
Claims (6)
1. A condensation reaction kettle for producing 4-hydroxyethyl piperazine ethanesulfonic acid comprises an outer kettle (2) and an inner kettle (13), wherein the inner kettle (13) is placed inside the outer kettle (2), and a heating resistor (18) is arranged outside the inner kettle (13) and inside the outer kettle (2), and is characterized in that a plurality of hydraulic rods (3) are fixedly installed at the top of the outer kettle (2), the tops of the hydraulic rods (3) are fixedly connected to the radial position of the lower surface of a top cover (4), a stirring shaft (14) is rotatably arranged at the middle position of the top cover (4), and the top of the stirring shaft (14) is coaxially connected with a driven wheel (8);
the top cover (4) is fixedly provided with a motor (5), an output shaft of the motor (5) is coaxially connected with a driving wheel (6), the driving wheel (6) and a driven wheel (8) are connected through a belt, a plurality of spiral blades (17) are arranged on a stirring shaft (14), the top cover (4) is communicated with a solid feeding hole (7) and a liquid feeding hole (10), and the bottoms of the inner kettle (13) and the outer kettle (2) are communicated with a discharging hole (11).
2. The condensation reaction kettle for producing 4-hydroxyethyl piperazine ethanesulfonic acid according to claim 1, characterized in that the bottom of the outer kettle (2) is fixedly provided with legs (1).
3. The condensation reaction kettle for producing 4-hydroxyethyl piperazine ethanesulfonic acid according to claim 1, characterized in that the outside of the heating resistor (18) is provided with an insulating layer (12) inside the outer kettle (2).
4. The condensation reaction kettle for producing 4-hydroxyethyl piperazine ethanesulfonic acid according to claim 1, characterized in that the upper surface of the top cover (4) is provided with a cover (15), and the cover (15) covers the motor (5), the driving wheel (6) and the driven wheel (8) inside.
5. The condensation reaction kettle for producing 4-hydroxyethyl piperazine ethanesulfonic acid according to claim 1, characterized in that the top cover (4) is further provided with a viewing window (9).
6. The condensation reaction kettle for producing 4-hydroxyethyl piperazine ethanesulfonic acid according to any one of claims 1 to 5, characterized in that a sealing groove (19) is formed at the top of the inner kettle (13), and a sealing ring (16) is fixedly arranged on the lower surface of the top cover (4), and the sealing ring (16) is embedded in the sealing groove (19).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201921569566.0U CN211412029U (en) | 2019-09-19 | 2019-09-19 | Condensation reaction kettle for producing 4-hydroxyethyl piperazine ethanesulfonic acid |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201921569566.0U CN211412029U (en) | 2019-09-19 | 2019-09-19 | Condensation reaction kettle for producing 4-hydroxyethyl piperazine ethanesulfonic acid |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN211412029U true CN211412029U (en) | 2020-09-04 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201921569566.0U Active CN211412029U (en) | 2019-09-19 | 2019-09-19 | Condensation reaction kettle for producing 4-hydroxyethyl piperazine ethanesulfonic acid |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN211412029U (en) |
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2019
- 2019-09-19 CN CN201921569566.0U patent/CN211412029U/en active Active
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