CN211318187U

CN211318187U - Optical detection system and blood coagulation analyzer

Info

Publication number: CN211318187U
Application number: CN201922139821.4U
Authority: CN
Inventors: 周祥
Original assignee: Shenzhen Dymind Biotechnology Co Ltd
Current assignee: Shenzhen Dymind Biotechnology Co Ltd
Priority date: 2019-11-29
Filing date: 2019-11-29
Publication date: 2020-08-21
Anticipated expiration: 2029-11-29

Abstract

The utility model provides an optical detection system and a blood coagulation analyzer comprising the same, which comprises an LED light source, an optical transmitter, an analyzer and a plurality of optical receivers; the wavelength range of emergent light of the LED light source is 640nm to 680nm, the light emitting angle range is-8 degrees to 8 degrees, the light transmitter comprises a first optical fiber and a plurality of second optical fibers optically coupled to the first optical fiber, the plurality of second optical fibers are arranged in one-to-one correspondence with a plurality of reaction stations for placing reaction containers, the plurality of reaction stations are arranged in one-to-one correspondence with a plurality of light receivers, and each light receiver is electrically connected with the analyzer; the emergent light of the LED light source is transmitted to each second optical fiber through the first optical fiber and then is irradiated to each corresponding light receiver through each corresponding reaction container. The LED light source with small angle and narrow band is adopted, the optical filter required by the traditional halogen lamp is omitted, and compared with the halogen lamp, the LED light source has the advantages of low cost and long service life, and the cost is effectively reduced.

Description

Optical detection system and blood coagulation analyzer

Technical Field

The utility model belongs to the technical field of medical instrument, more specifically say, relate to an optical detection system and blood coagulation analyzer.

Background

Magnetic bead method and optical method are two methods currently used in the market for analyzing blood coagulation samples, and among them, optical method has recently been favored by various manufacturers due to its excellent cost advantage and wide application range.

The optical method is a method of irradiating a reaction solution with light of a certain wavelength, and calculating and analyzing specific properties of a substance to be analyzed in the reaction solution by detecting and recording changes in scattered light or transmitted light caused during the precipitation of fibrin in the reaction solution.

The existing coagulation analyzer mostly obtains monochromatic incident light irradiated on reaction liquid by combining a halogen lamp with an optical filter, but the halogen lamp has short service life, so that the frequency of replacing a light source of the halogen lamp is high, and the cost of consumables brought by the optical filter is required to be borne, so that the cost of an optical detection and system coagulation analyzer is indirectly raised.

SUMMERY OF THE UTILITY MODEL

An object of the utility model is to provide an optical detection system to solve among the present coagulometer short-lived, the with high costs technical problem of optical detection system's light source.

In order to achieve the above object, the utility model adopts the following technical scheme:

an optical detection system is provided, which comprises an LED light source, a light transmitter, an analyzer and a plurality of light receivers;

the wavelength range of emergent light of the LED light source is 640nm to 680nm, and the range of the light-emitting angle of the emergent light of the LED light source is-8 degrees to 8 degrees;

the optical transmitter comprises a first optical fiber and a plurality of second optical fibers optically coupled to the first optical fiber, the plurality of second optical fibers are arranged in one-to-one correspondence with a plurality of reaction stations for placing reaction containers, the plurality of reaction stations are arranged in one-to-one correspondence with a plurality of optical receivers, and each optical receiver is electrically connected with the analyzer;

the emergent light of the LED light source is transmitted to each second optical fiber through the first optical fiber, then penetrates through each corresponding reaction container respectively, and irradiates each corresponding light receiver.

Further, the central wavelength of emergent light of the LED light source is 660 nm.

Further, the range of the light-emitting angle of the emergent light of the LED light source is-5 degrees to 5 degrees

Furthermore, the optical detection system further comprises an optical filter for filtering out external environment light and infrared light, wherein the optical filter is arranged between each reaction station and each light receiver.

Furthermore, the optical detection system further comprises a plurality of first lens groups for converging light, the first lens groups are arranged in a one-to-one correspondence manner with the plurality of second optical fibers, and emergent light of each second optical fiber is irradiated to the reaction container after passing through the first lens group corresponding to the emergent light of the second optical fiber.

Furthermore, the optical transmitter further includes a plurality of second lens sets for aligning light, the plurality of second lens sets are disposed in one-to-one correspondence with the plurality of second optical fibers, and the emergent light of each second optical fiber irradiates the corresponding reaction container after passing through the corresponding second lens set.

Further, the optical receiver comprises a photodiode for receiving an optical signal, and the photodiode is electrically connected with the analyzer.

Further, the scattered light transmitted through the reaction vessel is incident on the light receiver corresponding thereto.

Further, the included angle between the light collected by each light receiver and the light incident on the corresponding reaction container is 70-110 °.

The utility model also provides a blood coagulation analyzer, include as above optical detection system, blood coagulation analyzer still includes the machine main part, the LED light source through first mounting bracket install in the machine main part.

The embodiment of the invention has the following beneficial effects:

the utility model provides an optical detection system, the wavelength range of the emergent light of the LED light source of adoption is 640nm to 680nm, optics angle range is-8 to 8, therefore have the monochromatic light attribute of low-angle (optics angle range is-8 to 8 degrees), narrowband (wavelength range is 640nm to 680nm), saved the required light filter of traditional halogen lamp, and compare the halogen lamp and have low cost, longe-lived advantage, effectively reduced the cost on the basis of reaching the inspection requirement; moreover, the second optical fiber is arranged, so that one LED light source can support the simultaneous inspection of the reaction liquid in a plurality of reaction containers, and the light source cost and the space resource are further saved. The utility model provides a blood coagulation analyzer has adopted above-mentioned optical detection system, therefore possesses the whole beneficial effect that this optical detection system possesses, and here is no longer repeated.

Drawings

In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the drawings required for the embodiments or the prior art descriptions will be briefly introduced below, and it is obvious that the drawings in the following description are only some embodiments of the present invention, and it is obvious for those skilled in the art to obtain other drawings without inventive labor.

Fig. 1 is a schematic structural diagram of an optical detection system according to an embodiment of the present invention;

fig. 2 is a schematic structural diagram of an optical detection system according to another embodiment of the present invention;

fig. 3 is a schematic structural diagram of a second mounting frame according to an embodiment of the present invention.

Wherein, in the figures, the respective reference numerals:

10. an optical detection system;

100. an LED light source;

200. an optical transmitter; 210. a first optical fiber; 220. a second optical fiber;

300. a controller;

400. an optical filter;

500. an optical receiver;

600. an analyzer; 610. a photoelectric signal conversion circuit; 620. a calculation module;

700. a first lens group;

800. a second lens group;

900. a second mounting bracket; 910. a slot position;

20. a reaction vessel.

Detailed Description

In order to make the technical problem, technical solution and advantageous effects to be solved by the present invention more clearly understood, the following description is given in conjunction with the accompanying drawings and embodiments to illustrate the present invention in further detail. It should be understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention.

It will be understood that when an element is referred to as being "secured to" or "disposed on" another element, it can be directly on the other element or be indirectly on the other element. When an element is referred to as being "connected to" another element, it can be directly connected to the other element or be indirectly connected to the other element.

It will be understood that the terms "length," "width," "upper," "lower," "front," "rear," "left," "right," "vertical," "horizontal," "top," "bottom," "inner," "outer," and the like are used in an orientation or positional relationship indicated in the drawings for convenience in describing the invention and to simplify the description, and are not intended to indicate or imply that the referenced device or element must have a particular orientation, be constructed and operated in a particular orientation, and are therefore not to be considered limiting of the invention.

Furthermore, the terms "first", "second" and "first" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include one or more of that feature. In the description of the present invention, "a plurality" means two or more unless specifically limited otherwise.

Referring to fig. 1 to 3, the present invention provides an optical detection system 10 and a blood coagulation analyzer, wherein the blood coagulation analyzer includes the optical detection system 10 and a main body (not shown), and is mainly used for measuring Prothrombin Time (PT), activated partial prothrombin time (APTT), Fibrinogen (FIB), hemozyme time (TT), extrinsic factor, intrinsic factor, and the like.

The optical inspection system 10 provided by the present invention will now be described. Referring to fig. 1 to 2, the optical detection system 10 includes an LED light source 100, a light transmitter 200, a controller 300, a filter 400, a light receiver 500, and an analyzer 600.

The LED light source 100 is stably mounted on the main body through a first mounting frame (not shown), the wavelength range of the emergent light of the LED light source 100 is 640nm to 680nm, and the light emitting angle range is-8 ° to 8 °, that is, the light emitting angle is within ± 8 °; the controller 300 is electrically connected to the LED light source 100, and is configured to control the on/off of the LED light source 100 and adjust the light intensity of the light emitted from the LED light source 100; the optical transmitter 200 includes a first optical fiber 210 and a plurality of second optical fibers 220, an input end of the first optical fiber 210 is mounted on the first mounting rack and can receive the emergent light of the LED light source 100, an output end of the first optical fiber 210 is optically coupled to each of the second optical fibers 220 and can distribute the emergent light energy of the LED light source 100 to each of the second optical fibers 220 according to a required proportion, that is, the light energy distributed to each of the second optical fibers 220 may be the same or different, and is not limited uniquely herein, and here, the distribution of the light energy can be realized by arranging a light distribution structure or a light uniformization structure; a plurality of reaction stations are arranged in the main body, a plurality of light receivers 500 are also arranged, the reaction stations can be used for placing the reaction containers 20, the reaction stations are arranged in one-to-one correspondence with the second optical fibers 220 and in one-to-one correspondence with the light receivers 500, namely, the reaction containers 20 are arranged in one-to-one correspondence with the second optical fibers 220 and in one-to-one correspondence with the light receivers 500, reaction liquid to be detected is arranged in each reaction container 20, and emergent light of each second optical fiber 220 irradiates the corresponding light receiver 500 after passing through the corresponding reaction container 20; each optical receiver 500 is electrically connected to the analyzer 600, and the analyzer 600 converts the intensity of the light energy and the time for acquiring the light, which are acquired by the optical receiver 500, into an electrical signal, which is then used as the analysis data to acquire the blood coagulation analysis result.

The utility model provides an optical detection system 10, the wavelength range of the emergent light of the LED light source 100 that adopts is 640nm to 680nm, and luminous angle scope is-8 to 8 degrees, thus has the monochromatic light attribute of low-angle, narrowband, has saved the required light filter of traditional halogen lamp, and compares the halogen lamp and have low cost, longe-lived advantage, effectively reduced the cost on the basis of reaching the inspection requirement; moreover, by arranging the second optical fiber 220, one LED light source 100 can support the simultaneous inspection of the reaction liquid in a plurality of reaction containers 20, thereby further saving the light source cost and the space resource.

In an embodiment, referring to fig. 1 to fig. 2, the wavelength of the emergent light of the LED light source 100 is preferably 660nm, and the light emitting angle is preferably in a range of-5 ° to 5 °, that is, the light emitting angle is within ± 5 °, and in other embodiments of the present invention, the wavelength of the emergent light of the LED light source 100 may also be 645nm, 650nm, 655nm, 670nm, 675nm, or the like, which is not limited herein.

It is understood that when the light energy distributed to each of the second optical fibers 220 is the same, a plurality of sets of control experiments with the same optical parameters can be performed simultaneously; when the light energy distributed to each second optical fiber 220 is different, different analysis experiments can be performed on different reaction liquids; thereby improving the experimental analysis efficiency on the whole and widening the application occasions of the blood coagulation analyzer.

The number of second fibers 220 is N, satisfying the relationship: n.gtoreq.4, more preferably 4 to 20.

In one embodiment, referring to fig. 1-2, the number of the second optical fibers 220 is 4. Of course, in other embodiments of the present invention, the number of the second optical fibers 220 may also be increased or decreased as required, for example, 18, 16, 13, 11, 8, 6, etc., which are not limited herein. It should be noted that the drawings in the specification are only a part of the structure of the optical detection system, and do not indicate that the optical detection system 10 only includes 4 second optical fibers 220.

In an embodiment, referring to fig. 1 to 2, the optical detection system 10 further includes an optical filter 400 for filtering stray light in an external environment space and also filtering various infrared lights on other components of the blood coagulation analyzer, specifically, the optical filter 400 is disposed between each reaction station and each optical receiver 500, that is, the optical filter 400 is additionally disposed between the optical receiver 500 and the reaction container 20, so as to effectively reduce interference caused by the ambient light and the infrared lights, reduce analysis noise, and improve detection accuracy; it should be noted that various types of infrared light on other components in the blood coagulation analyzer cannot be filtered by a general light shield, but once the infrared light enters the light receiver 500 by mistake, a large detection error is caused, so that the detection effect can be further optimized and the accuracy can be improved by arranging the optical filter 400 between each reaction station and each light receiver 500. Preferably, a plurality of filters 400 are provided, and the plurality of filters 400 are provided in one-to-one correspondence with the plurality of light receivers 500.

In an embodiment, the light source detection system 10 further includes an attenuation sheet disposed on a side of each optical filter 400 close to the optical receiver 500, and in this embodiment, for convenience of processing and assembly, the attenuation sheet is configured to be a strip shape, so that each optical receiver 500 and each optical filter 400 can be separated together, thereby appropriately weakening the light energy and preventing the light energy received by the optical receiver 500 from being too strong to reach saturation and further affecting the detection result. Of course, in other embodiments of the present invention, the attenuation sheet may also be a circular sheet or an oval sheet, which is not limited herein only based on the actual layout and installation requirements.

In an embodiment, referring to fig. 3, the optical detection system 10 further includes a second mounting frame 900, the second mounting frame 900 is detachably connected to the main body, the second mounting frame 900 is provided with a plurality of slots 910, the plurality of slots 910 are distributed in an annular array, and the plurality of second optical fibers 220 are installed in the plurality of slots 910 in a one-to-one correspondence manner; therefore, the positions of the second optical fibers 220 can be fixed, and the second optical fibers 220 are guided to different directions, so that the corresponding reaction stations 300 and the corresponding light receivers 500 can be conveniently arranged, and the optical detection system 10 and the blood coagulation analyzer are more compact in structure and smaller in occupied space.

In an embodiment, referring to fig. 2, the light transmitter 200 further includes a first lens set 700 for converging light, and the light output from the second optical fiber 220 passes through the first lens set 700 and then irradiates on the reaction container 20 on the reaction station, so as to reduce the light divergence degree, concentrate and easily collect light energy, thereby improving the detection precision. Preferably, in this embodiment, the first lens group 700 includes one or more condenser lenses, and the specific number and arrangement position thereof are not limited.

In an embodiment, referring to fig. 2, the light transmitter 200 further includes a second lens set 800 for collimating light, and light emitted from the first lens set 700 passes through the second lens set 800 and then irradiates the reaction container 20, so as to improve the straightness of light, further concentrate light energy, optimize the light collection precision and the calculation progress, and thus improve the detection precision of the optical detection system 10. Preferably, in this embodiment, the second lens group 800 includes one or more collimating lenses, and the specific number and arrangement position thereof are not limited.

In other embodiments, one of the first lens group 700 and the second lens group 800 may be selected, or the first lens group and the second lens group may be omitted, which is not limited herein.

In an embodiment, the LED light sources 100 may be provided in plural, the wavelengths of the light emitted from each LED light source 100 are different from each other, the plural LED light sources 100 are mounted on a rotating rack, the rotating rack is driven to rotate by a driver, so as to drive each LED light source 100 to switch positions, the light emitted from any LED light source 100 can be coupled to the input end of the first optical fiber 210, the controller 300 is electrically connected to the driver and each LED light source 100, the controller 300 controls the driver to operate, and controls the specific LED light source 100 to emit light at a specific time, that is, the controller 300 switches the position and on/off of each LED light source 100 as required, so as to continuously change the wavelength of the light entering the first optical fiber 210, thereby obtaining diversified and omnidirectional experimental data; in addition, compared with the conventional method of switching the wavelength of light by switching the optical filter, the method has the advantages of improving the efficiency and the cost.

In one embodiment, referring to fig. 1 to 2, each light receiver 500 collects the scattered light transmitted through the corresponding reaction container 20. Of course, in other embodiments of the present invention, the light receiver 500 can also receive the transmitted light transmitted through the reaction container 20, which is not limited herein.

In one embodiment, referring to fig. 1 to 2, the angle between the scattered light collected by each light receiver 500 and the light incident on the corresponding reaction container 20 is in a range of 70 ° to 110 °. The angle between the light collected by each light receiver 500 and the light incident on the corresponding reaction vessel 20 is referred to as a deviation angle, and in the present embodiment, the deviation angle is preferably 90 °.

In an embodiment, the optical receiver 500 includes a light receiving element and a third mounting frame, the light receiving element is mounted on the main body through the third mounting frame for receiving the light signal transmitted through the collimating mirror; preferably, in the present embodiment, the optical receiving element is a photodiode; of course, in other embodiments of the present invention, the light receiving element may also be other types of electronic elements capable of receiving light signals, and is not limited herein.

In an embodiment, referring to fig. 2, the analyzer 600 includes a photoelectric signal conversion circuit 610 and a calculation module 620, the photoelectric signal conversion circuit 610 is electrically connected to the photodiode and electrically connected to the calculation module 620, the photoelectric signal conversion circuit 610 can convert the optical signal received by the photodiode into an electrical signal, and then the detection result is calculated by a preset program in the calculation module 620.

In one embodiment, the reaction vessel 20 is a transparent glass member, or a transparent plastic member. Of course, in other embodiments of the present invention, the reaction vessel 20 may be other transparent material, which is not limited herein.

The utility model provides a blood coagulation analyzer has possessed above-mentioned optical detection system 10's whole beneficial effect because of having adopted above-mentioned optical detection system 10, and the here is no longer repeated.

The above description is only exemplary of the present invention and should not be taken as limiting the scope of the present invention, as any modifications, equivalents, improvements and the like made within the spirit and principles of the present invention are intended to be included within the scope of the present invention.

Claims

1. An optical inspection system, characterized by: the LED light source, the light transmitter, the analyzer and the light receivers are included;

2. The optical inspection system of claim 1 wherein: the wavelength of emergent light of the LED light source is 660 nm.

3. The optical inspection system of claim 1 wherein: the range of the light emitting angle of the emergent light of the LED light source is-5 degrees to 5 degrees.

4. The optical inspection system of claim 1 wherein: the optical detection system further comprises an optical filter for filtering out external environment light and infrared light, and the optical filter is arranged between each reaction station and each light receiver.

5. The optical inspection system of claim 1 wherein: the optical detection system further comprises a first lens group used for converging light, the first lens group is provided with a plurality of lenses, the first lens group is arranged in a one-to-one correspondence manner with the second optical fibers, and emergent light of the second optical fibers irradiates the reaction container corresponding to the emergent light after penetrating through the first lens group corresponding to the emergent light.

6. The optical inspection system of claim 1 wherein: the optical transmitter further comprises a plurality of second lens groups for aligning light, the plurality of second lens groups are arranged in one-to-one correspondence with the plurality of second optical fibers, and emergent light of each second optical fiber irradiates the corresponding reaction container after penetrating through the corresponding second lens group.

7. The optical inspection system of claim 1 wherein: the optical receiver comprises a photodiode for receiving an optical signal, and the photodiode is electrically connected with the analyzer.

8. The optical inspection system of claim 1 wherein: the scattered light transmitted through the reaction vessel is incident into the corresponding light receiver.

9. The optical inspection system of claim 8, wherein: the included angle between the scattered light collected by each light receiver and the light incident to the corresponding reaction container is 70-110 degrees.

10. Blood coagulation analysis appearance, its characterized in that: the optical detection system of any one of claims 1 to 9, wherein the coagulation analyzer further comprises a main body, and the LED light source is mounted on the main body through a first mounting bracket.