CN210816569U - Isolator online detection sterilization system for high-activity substance production - Google Patents
Isolator online detection sterilization system for high-activity substance production Download PDFInfo
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- CN210816569U CN210816569U CN201921375008.0U CN201921375008U CN210816569U CN 210816569 U CN210816569 U CN 210816569U CN 201921375008 U CN201921375008 U CN 201921375008U CN 210816569 U CN210816569 U CN 210816569U
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- Prior art keywords
- pipeline
- particle
- isolator
- sampling
- way valve
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- 230000001954 sterilising effect Effects 0.000 title claims abstract description 34
- 238000004659 sterilization and disinfection Methods 0.000 title claims abstract description 34
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 21
- 230000000694 effects Effects 0.000 title claims description 16
- 239000000126 substance Substances 0.000 title claims description 15
- 238000001514 detection method Methods 0.000 title claims description 12
- 239000002245 particle Substances 0.000 claims abstract description 87
- 238000005070 sampling Methods 0.000 claims abstract description 83
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 28
- 241000894006 Bacteria Species 0.000 claims description 32
- 239000013543 active substance Substances 0.000 claims description 7
- 238000004891 communication Methods 0.000 claims description 3
- 238000001914 filtration Methods 0.000 claims description 3
- 238000000034 method Methods 0.000 abstract description 6
- 239000011149 active material Substances 0.000 abstract description 2
- 239000003814 drug Substances 0.000 description 2
- 238000012423 maintenance Methods 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000007905 drug manufacturing Methods 0.000 description 1
- 238000003912 environmental pollution Methods 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
Images
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- Sampling And Sample Adjustment (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Apparatus For Disinfection Or Sterilisation (AREA)
Abstract
The utility model provides an isolator on-line measuring sterilization system for high active material production, including isolator cavity, particle sampling device and circulating line intercommunication, particle sampling device includes particle sampling pipeline, particle sampling head, three-way valve and particle counter, the particle sampling head is located in the isolator cavity; the three-way valve is arranged on the particle sampling pipeline, the water inlet end of the three-way valve is communicated with the particle sampling head, one water outlet end of the three-way valve is communicated with a water discharge pipeline, and the other water outlet end of the three-way valve is communicated with the particle counter. The utility model provides an isolator on-line measuring sterilization system can in time clear away the particle on the pipeline inner wall to avoid operation in-process particle false alarm, improve production efficiency.
Description
Technical Field
The utility model relates to a food, drug manufacturing field, more specifically relates to an isolator on-line measuring sterilization system for production of high active substance.
Background
In the manufacturing and production process of food and medicine, the production is usually required to be carried out under clean and sterile environment, that is, most isolator devices are used, however, in the prior art, the isolator devices mainly have the following problems in the use process:
(1) particles are easy to accumulate on the inner walls of the planktonic bacteria and the particle sampling pipeline, and particle false alarm is easy to cause during operation;
(2) in the application process, if the pump stops running in an emergency, the pipeline airflow flows backwards into the isolator cavity, so that the internal environment of the cavity is easily polluted;
(3) when the device is applied to isolation of high-activity medicine production, active substances are easily accumulated inside the pipeline, and personnel infection is easily caused when parts are replaced.
Accordingly, there is a need for improvements in isolator systems of the prior art.
SUMMERY OF THE UTILITY MODEL
In view of the above, the utility model provides an isolator on-line detection sterilization system for high active material production, the utility model provides an isolator on-line detection sterilization system can in time clear away the particle on the pipeline inner wall to avoid the particle false alarm in the operation process; meanwhile, the risk of pollution to the internal environment of the isolator cavity in the operation process of the equipment can be reduced.
In order to achieve the above purpose, the technical scheme of the utility model is as follows:
an isolator online detection sterilization system for high-activity substance production comprises an isolator cavity, a particle sampling device and a circulating pipeline, wherein the particle sampling device is communicated with the circulating pipeline and comprises a particle sampling pipeline, a particle sampling head, a three-way valve and a particle counter, and the particle sampling head is arranged in the isolator cavity; the three-way valve is arranged on the particle sampling pipeline, the water inlet end of the three-way valve is communicated with the particle sampling head, one water outlet end of the three-way valve is communicated with a water discharge pipeline, and the other water outlet end of the three-way valve is communicated with the particle counter.
Preferably, the circulating pipeline comprises a sampling circulating pipeline and a sterilization circulating pipeline, and the sterilization circulating pipeline is communicated with the isolator cavity; one end of the sampling circulating pipeline is connected with the particle counter, and the other end of the sampling circulating pipeline is connected with the sterilization circulating pipeline.
Preferably, a BIBO high-efficiency filtering unit is arranged on the sterilization circulating pipeline.
Preferably, a vacuum pump is installed on the sampling circulation pipeline, and a first filter is further installed on the sampling circulation pipeline between the vacuum pump and the particle counter.
Preferably, the system also comprises a planktonic bacteria collector arranged in the cavity of the isolator and a planktonic bacteria collecting pipeline connected with the planktonic bacteria collector; the other end of the planktonic bacteria collection pipeline is communicated with the sampling circulation pipeline, and a second filter is installed on the planktonic bacteria collection pipeline.
Preferably, a flow controller is installed on the planktonic bacteria collection pipeline, and the second filter is located between the flow controller and the planktonic bacteria collector.
Preferably, the communication position of the planktonic bacteria collection pipeline and the sampling circulation pipeline is located between the vacuum pump and the first filter.
The beneficial effects of the utility model reside in that:
(1) a three-way valve is arranged on a particle sampling pipeline connecting a particle sampling head and a particle counter, and is used for connecting the particle sampling pipeline to a drainage pipeline when the particle sampling pipeline is cleaned, so that particles adhered to the inner wall of the particle sampling pipeline are cleaned, and the possibility of particle false alarm caused by the adhesion of the particles to the inner wall of the particle sampling pipeline in the production process is reduced;
(2) a first filter is arranged between the particle counter and the vacuum pump, and a second filter is arranged between the planktonic bacteria collector and the flow controller and used for isolating high-activity substances, so that the high-activity substances in the vacuum pump can be prevented, and the risk that maintenance personnel contact the high-activity substances during maintenance of the vacuum pump is reduced;
(3) the sampling circulation pipeline is connected into the sterilization circulation pipeline, when the isolator is biologically purified, the particle sampling pipeline, the planktonic bacteria sampling pipeline and the sampling circulation pipeline are biologically purified together with the isolator, so that the risk of polluting the internal environment of the isolator due to the fact that gas in the particle sampling pipeline and the planktonic bacteria sampling pipeline flows backwards into the cavity of the isolator is reduced when emergency occurs.
Drawings
Fig. 1 is a schematic structural diagram of the present invention.
1, an isolator cavity; 2. a planktonic bacteria collector; 3. a particle sampling head; 4. a particle sampling line; 5. a three-way valve; 6. a drain line; 7. a particle counter; 8. a first filter; 9. a sampling circulation pipeline; 10. a vacuum pump; 11. a planktonic bacteria sampling pipeline; 12. a flow controller; 13. a second filter; 14. a sterilization circulation pipeline; 15. BIBO high efficiency filter unit.
Detailed Description
In order to make the above objects, features and advantages of the present invention more comprehensible, embodiments of the present invention are described in detail below with reference to the accompanying drawings. In the following description, numerous specific details are set forth in order to provide a thorough understanding of the present invention. The present invention can be embodied in many different forms other than those specifically described herein, and it will be apparent to those skilled in the art that similar modifications can be made without departing from the spirit and scope of the invention, and it is therefore not to be limited to the specific embodiments disclosed below.
In the description of the present invention, it should be noted that the terms "center", "upper", "lower", "left", "right", "vertical", "horizontal", "inner", "outer", and the like indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings, and are only for convenience of description and simplification of description, but do not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and thus, should not be construed as limiting the present invention. Furthermore, the terms "first," "second," and "third" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance.
Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. The terminology used in the description of the invention herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention.
Referring to fig. 1, an isolator online detection sterilization system for high-activity substance production comprises an isolator cavity 1, a particle sampling device and a circulation pipeline, wherein the particle sampling device is communicated with the circulation pipeline and comprises a particle sampling pipeline 4, a particle sampling head 3, a three-way valve 5 and a particle counter 7, and the particle sampling head 3 is arranged in the isolator cavity; the three-way valve 5 is arranged on the particle sampling pipeline 4, the water inlet end of the three-way valve is communicated with the particle sampling head 3, one water outlet end of the three-way valve 5 is communicated with a water drainage pipeline 6, and the other water outlet end of the three-way valve is communicated with the particle counter 7.
In this embodiment, a three-way valve 5 is disposed on a particle sampling pipeline 4 connecting a particle sampling head 3 and a particle counter 7, a water inlet end of the three-way valve is communicated with the particle sampling head 3, one water outlet end of the three-way valve is connected with a water discharge pipeline 6, the other water outlet end is communicated with the particle counter 7, when the particle sampling pipeline 4 needs to be cleaned, water is introduced from the particle sampling head 3, specifically, water can be poured into the particle sampling pipeline 4 through the particle sampling head 3 by a beaker or other container, and the like, the water outlet end of the three-way valve communicated with the particle counter 7 is closed, the water outlet end of the three-way valve communicated with the water discharge pipeline 6 is opened, so that the particle sampling pipeline 4 is communicated with the water discharge pipeline 6 when the particle sampling pipeline 4 is cleaned, that water after the particle sampling pipeline 4 is cleaned is discharged through the water discharge pipeline 6, and particles adhered to, the probability of particle false alarm caused by particles adhered to the inner wall of the particle pipeline in the production process is reduced, and meanwhile, the influence on the particle counter 7 when the particle sampling pipeline 4 is cleaned is avoided.
With continued reference to fig. 1, the circulation line comprises a sampling circulation line 9 and a sterilization circulation line 14, the sterilization circulation line 14 is communicated with the isolator cavity 1; one end of the sampling circulating pipeline 9 is connected with the particle counter 7, and the other end is connected with the sterilization circulating pipeline 14.
Specifically, in the present embodiment, the sampling circulation pipeline 9 is communicated with the sterilization circulation pipeline 14, so that when the interior of the isolator cavity 1 is biologically purified, the particle sampling pipeline 4, the sampling circulation pipeline 9 and other pipelines can be biologically purified together, thereby reducing the risk of polluting the environment inside the isolator due to the gas in the particle sampling pipeline 4 flowing back into the isolator cavity 1 in an emergency; in addition, the BIBO high-efficiency filtering unit 15 is arranged on the sterilization circulating pipeline 14, so that the sterilization gas can be prevented from being directly discharged into the air when being discharged after circulating sterilization, and the environmental pollution is reduced.
With continued reference to fig. 1, a vacuum pump 10 is installed on the sampling circulation pipeline 9, and a first filter 8 is also installed on the sampling circulation pipeline 9 between the vacuum pump 10 and the particle counter 7; the vacuum pump is used for isolating high-activity substances, the high-activity substances in the vacuum pump 10 can be prevented, and the risk that the maintainers contact the high-activity substances when the vacuum pump 10 is overhauled is reduced.
With continuing reference to fig. 1, the isolator on-line detection sterilization system further includes a planktonic bacteria collector 2 installed in the isolator cavity 1 and a planktonic bacteria collection pipeline 11 connected to the planktonic bacteria collector 2; the other end of the planktonic bacteria collection pipeline 11 is communicated with the sampling circulation pipeline 9, and a second filter 13 is installed on the planktonic bacteria collection pipeline 11; the device is also used for isolating the high-activity substances and avoiding the access of maintainers to the high-activity substances.
A flow controller 12 is installed on the planktonic bacteria sampling pipeline 11, and the second filter 13 is located between the flow controller 12 and the planktonic bacteria collector 2; thereby ensuring the stability of the sample collected by the planktonic bacteria collector 2, and simultaneously, the second filter 13 is arranged at the front end of the flow controller 12, so that the high-activity substances in the flow controller 12 can be prevented.
Further, in this embodiment, a communication point between the planktonic bacteria collection pipeline 11 and the sampling circulation pipeline 9 is located between the vacuum pump 10 and the first filter 8; so that the first filter 8 and the second filter 13 can process the particle sampling line 4 and the planktonic bacteria sampling line 11, respectively.
The technical features of the embodiments described above may be arbitrarily combined, and for the sake of brevity, all possible combinations of the technical features in the embodiments described above are not described, but should be considered as being within the scope of the present specification as long as there is no contradiction between the combinations of the technical features.
The above-mentioned embodiments only represent some embodiments of the present invention, and the description thereof is specific and detailed, but not to be construed as limiting the scope of the present invention. It should be noted that, for those skilled in the art, without departing from the spirit of the present invention, several variations and modifications can be made, which are within the scope of the present invention. Therefore, the protection scope of the present invention should be subject to the appended claims.
Claims (7)
1. The isolator online detection sterilization system for high-activity substance production is characterized by comprising an isolator cavity (1), a particle sampling device and a circulating pipeline, wherein the particle sampling device is communicated with the circulating pipeline and comprises a particle sampling pipeline (4), a particle sampling head (3), a three-way valve (5) and a particle counter (7), and the particle sampling head (3) is arranged in the isolator cavity; the three-way valve (5) is arranged on the particle sampling pipeline (4), the water inlet end of the three-way valve is communicated with the particle sampling head (3), a water outlet end of the three-way valve (5) is communicated with a water drainage pipeline (6), and the other water outlet end of the three-way valve is communicated with the particle counter (7).
2. The isolator online detection sterilization system for high active substance production according to claim 1, characterized in that the circulation line comprises a sampling circulation line (9) and a sterilization circulation line (14), the sterilization circulation line (14) being in communication with the isolator cavity (1); one end of the sampling circulating pipeline (9) is connected with the particle counter (7), and the other end of the sampling circulating pipeline is connected with the sterilization circulating pipeline (14).
3. The isolator online-detection sterilization system for high-active-substance production according to claim 2, characterized in that a BIBO high-efficiency filtration unit (15) is installed on the sterilization circulation line (14).
4. The isolator in-line testing sterilization system for high active substance production according to claim 2, characterized in that a vacuum pump (10) is installed on the sampling circulation line (9), and a first filter (8) is also installed on the sampling circulation line (9) between the vacuum pump (10) and the particle counter (7).
5. The isolator online detection sterilization system for the production of high-activity substances according to claim 4, characterized by further comprising a planktonic bacteria collector (2) installed in the isolator cavity (1) and a planktonic bacteria collection pipeline (11) connected with the planktonic bacteria collector (2); the other end of the planktonic bacteria collection pipeline (11) is communicated with the sampling circulation pipeline (9), and a second filter (13) is installed on the planktonic bacteria collection pipeline (11).
6. The isolator online detection sterilization system for high active substance production according to claim 5, wherein a flow controller (12) is installed on the planktonic bacteria collection pipeline (11), and the second filter (13) is located between the flow controller (12) and the planktonic bacteria collector (2).
7. Isolator in-line testing sterilization system for the production of highly active substances according to claim 5, characterized in that the connection of the planktonic bacteria collection line (11) with the sampling circulation line (9) is located between the vacuum pump (10) and the first filter (8).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201921375008.0U CN210816569U (en) | 2019-08-23 | 2019-08-23 | Isolator online detection sterilization system for high-activity substance production |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201921375008.0U CN210816569U (en) | 2019-08-23 | 2019-08-23 | Isolator online detection sterilization system for high-activity substance production |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN210816569U true CN210816569U (en) | 2020-06-23 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201921375008.0U Active CN210816569U (en) | 2019-08-23 | 2019-08-23 | Isolator online detection sterilization system for high-activity substance production |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN210816569U (en) |
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2019
- 2019-08-23 CN CN201921375008.0U patent/CN210816569U/en active Active
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