CN210572335U

CN210572335U - High-sensitivity specific protein analyzer

Info

Publication number: CN210572335U
Application number: CN201921172880.5U
Authority: CN
Inventors: 田树伟; 鲁翌; 刘介; 王骏勤
Original assignee: Wuhan Thalys Biological Technology Co ltd
Current assignee: Wuhan Thalys Biological Technology Co ltd
Priority date: 2019-07-24
Filing date: 2019-07-24
Publication date: 2020-05-19
Anticipated expiration: 2029-07-24

Abstract

The utility model relates to a high-sensitivity specific protein analyzer, which comprises a shell and a power supply, wherein a detection mechanism is arranged on the shell, a detection cell is arranged on the detection mechanism, the detection mechanism is an optical detection mechanism, and comprises a light source which is arranged at the front side of the detection cell and provides incident light, and a light chopper, a light condenser and a detector which are sequentially and fixedly arranged along the detection cell; the specific protein analyzer further comprises a touch display screen and a control chip, wherein the touch display screen is fixedly arranged on the front face of the shell and used for inputting instructions and displaying detection results, and the control chip is electrically connected with the detector and the touch display screen and used for controlling all electronic elements of the specific protein analyzer. The utility model discloses a scattering is than turbid mode detection, not only detects that the precision is high, the reaction is sensitive, detection speed is fast, and the linear range who detects moreover is wide.

Description

High-sensitivity specific protein analyzer

Technical Field

The utility model relates to the field of biotechnology, concretely relates to high sensitive specific protein analyzer.

Background

The basic principle of the analyzer is that after the antigen in the sample reacts with latex reagent (antibody), the antigen is crosslinked to form larger particles, incident light meets the particles and deflects to form scattering at a certain angle, the change of the intensity of the scattered light is in direct proportion to the reaction rate, and the reaction rate is in positive correlation with the content of the antigen to be detected in the sample within a certain concentration range (namely a linear range). Therefore, the content of the substance to be detected in the sample can be calculated by continuously monitoring the change of the scattered light intensity of the reaction system.

The immunoturbidimetry is to detect the soluble antigen-antibody complex by a transmission turbidimeter or a scattering turbidimeter; the turbidity formed in the liquid phase thus determines the antigen content. The technology was first reported by Richie in 1967, gradually improved in the 70 s of the 20 th century, and initially used for clinical routine examination in the initial 80 s, but the technology has not been widely used clinically until the automated detection system (ICS) introduced by Beckman, USA, is accepted by numerous laboratories.

Transmittance turbidimetry and scattering turbidimetry are two common methods of immune turbidimetry, and the reaction principle is the same, except that the detected optical signal is different from the detector of the instrument. Both have advantages and disadvantages: the transmittance ratio is simple and convenient to operate, is suitable for a common automatic biochemical analyzer and a common spectrophotometer, and can be developed in almost all laboratories. The defects are that the sensitivity and the precision are not ideal enough, the required antiserum amount is large, and the detection period is long. The advantages of scattering turbidimetry are high sensitivity, high precision and rapid detection. The method has the disadvantages that a special analysis instrument is needed, and the intensity of scattered light is much weaker than that of transmitted light, so that the light intensity is not easy to detect when a substance to be detected with extremely low concentration is detected, and the linear range of detection is narrow.

SUMMERY OF THE UTILITY MODEL

The utility model discloses to the technical problem who exists among the prior art, provide a specific protein analyzer of high sensitivity, adopt the scattering to detect than turbid mode, not only detect that the precision is high, the reaction is sensitive, detection speed is fast, the linear range who detects moreover is wide.

The utility model provides an above-mentioned technical problem's technical scheme as follows: a high-sensitivity specific protein analyzer comprises a shell and a power supply, wherein a detection mechanism is arranged on the shell, a detection cell is arranged on the detection mechanism, the detection mechanism is an optical detection mechanism and comprises a light source, a light chopper, a light condenser and a detector, the light source is arranged on the front side of the detection cell and used for providing incident light, and the light chopper, the light condenser and the detector are fixedly arranged backwards along the detection cell in sequence; the specific protein analyzer further comprises a touch display screen and a control chip, wherein the touch display screen is fixedly arranged on the front face of the shell and used for inputting instructions and displaying detection results, and the control chip is electrically connected with the detector and the touch display screen and used for controlling all electronic elements of the specific protein analyzer.

On the basis of the technical scheme, the utility model discloses can also do following improvement.

Further, the casing openly still fixed mounting have the printer, the printer is connected with the control chip electricity.

Further, a card reader is fixedly mounted on the front face of the shell and electrically connected with the control chip.

Furthermore, a switch for controlling the on-off of the power supply is fixedly installed on the back surface of the shell.

Further, the condenser is a condenser, and the size of the condenser covers the whole detection light path.

Further, the detector is arranged at the focal point of the condenser.

Further, the light source is an LED light source.

The utility model has the advantages that: the utility model discloses the spotlight ware has been set up on detection mechanism's light path for on assembling the scattered light and projecting the detector, set up behind the spotlight ware, the scattered light obtains assembling, and the luminous intensity has strengthened a lot than current instrument, has effectively improved the degree of catching of detector to the scattered light, has greatly promoted the sensitivity of detector, the low concentration substance that awaits measuring that can't detect out to current instrument, the utility model discloses also can accurately provide the detection.

Drawings

Fig. 1 is a schematic structural diagram of an embodiment of the present invention;

FIG. 2 is a schematic rear view of the structure of FIG. 1;

fig. 3 is a schematic diagram of an internal circuit structure of an embodiment of the present invention;

fig. 4 is a schematic view of an optical path structure of a detection mechanism according to an embodiment of the present invention;

in the drawings, the components represented by the respective reference numerals are listed below:

1. the device comprises a shell, 2, a detection mechanism, 2a, a light chopper, 2b, a condenser, 2c, a detector, 2d, a light source, 3, a detection pool, 4, a touch display screen, 5, a printer, 6, a card reader, 7, a switch, 8, a power supply, 9 and a control chip.

Detailed Description

The principles and features of the present invention are described below in conjunction with the following drawings, the examples given are only intended to illustrate the present invention and are not intended to limit the scope of the present invention.

As shown in fig. 1 and fig. 3, the utility model relates to a high-sensitivity specific protein analyzer, which comprises a casing 1 and a power supply 8, a detection mechanism 2 is arranged on the casing 1, and a detection pool 3 is arranged on the detection mechanism 2.

As shown in fig. 4, the detection mechanism 2 is an optical detection mechanism, and includes a light source 2d arranged at the front side of the detection cell 3 and providing incident light, and a light shutter 2a, a light condenser 2b, and a detector 2c fixedly arranged in this order rearward along the detection cell 3. The detection mechanism 2 is arranged inside the shell 1, and the light source 2d is arranged at the front end of the detection cell 3 and provides incident illumination.

The specific protein analyzer further comprises a touch display screen 4 and a control chip 9, wherein the touch display screen 4 is fixedly arranged on the front surface of the shell 1 and used for inputting instructions and displaying detection results. The control chip 9 is electrically connected with the detector 2c and the touch display screen 4 and is used for controlling each electronic element of the specific protein analyzer.

During detection, a detected sample is placed in the detection cell 3, the power supply 8 is started, an instruction is input on the touch display screen 4, incident light emitted by the light source 2d penetrates through the detection cell 3 and a substance to be detected, the transmitted light is shielded by the light shield 2a, and scattered light is scattered to the periphery. The scattered light is collected by the condenser 2b and projected onto the detector 2 c. According to the nephelometry, the detector 2c obtains light intensity data by monitoring the change of the scattered light intensity, the light intensity data is transmitted to the control chip 9, the control chip 9 calculates the content of the object to be measured in the corresponding sample, and the touch display screen 4 is controlled to display the final measurement result.

Preferably, the front surface of the housing 1 can also be fixedly provided with a printer 5, and the printer 5 is electrically connected with the control chip 9. The corresponding instruction can be input by using the touch display screen 4, and the detection result can be printed.

Preferably, a card reader 6 can be fixedly mounted on the front surface of the housing 1, and the card reader 6 is electrically connected with the control chip 9. When the card reader 6 is used by a user, the standard curve can be directly input by swiping a card, so that the method is accurate and convenient, a standard product is not required to be purchased, the reagent dosage is saved, the cost is saved, and the detection cost is reduced.

As shown in fig. 2, the present invention further provides an improved technical solution, in the improved technical solution, a switch 7 for controlling the on/off of the power supply can be further fixedly installed on the back of the casing 1.

As shown in fig. 4, the present invention further provides an improved technical solution, in the improved technical solution, the condenser 2b is a condenser lens, and the size thereof covers the whole detection light path.

Preferably, the detector 2c is arranged at the focal point of the condenser 2 b.

The layout configuration of the scheme considers that when some substances to be detected with extremely low concentration are detected, the light intensity is not easy to detect, so that most of scattered light needs to be converged to the detector 2c to obtain detection data, and the size of the condenser lens needs to cover the whole light path. In this way, the scattered light can be collected as much as possible. To further increase the sensitivity of the detection, the detector 2c may be placed at the focus of the condenser lens, which enables the detector 2c to receive a stronger intensity of the scattered light.

The utility model discloses still provide modified technical scheme, in modified technical scheme, light source 2d is the LED light source. The performance is more stable and the energy is saved.

The above description is only for the preferred embodiment of the present invention, and is not intended to limit the present invention, and any modifications, equivalent replacements, improvements, etc. made within the spirit and principle of the present invention should be included within the protection scope of the present invention.

Claims

1. The utility model provides a high sensitive specific protein analyzer, includes casing (1) and power (8), be provided with detection mechanism (2) on casing (1), be provided with detection pond (3) on detection mechanism (2), its characterized in that: the detection mechanism (2) is an optical detection mechanism and comprises a light source (2d) which is arranged at the front side of the detection cell (3) and provides incident light, and a light chopper (2a), a light condenser (2b) and a detector (2c) which are fixedly arranged backwards along the detection cell (3); the specific protein analyzer further comprises a touch display screen (4) and a control chip (9), wherein the touch display screen (4) is fixedly arranged on the front face of the shell (1) and used for inputting instructions and displaying detection results, and the control chip (9) is electrically connected with the detector (2c) and the touch display screen (4) and used for controlling all electronic elements of the specific protein analyzer.

2. The highly sensitive specific protein analyzer according to claim 1, wherein: casing (1) openly still fixed mounting have printer (5), printer (5) are connected with control chip (9) electricity.

3. The highly sensitive specific protein analyzer according to claim 1, wherein: the front surface of the shell (1) is also fixedly provided with a card reader (6), and the card reader (6) is electrically connected with the control chip (9).

4. The highly sensitive specific protein analyzer according to claim 1, wherein: and a switch (7) for controlling the on-off of the power supply is fixedly arranged on the back surface of the shell (1).

5. The highly sensitive specific protein analyzer according to claim 1, wherein: the condenser (2b) is a condenser, and the size of the condenser covers the whole detection light path.

6. The highly sensitive specific protein analyzer according to claim 1, wherein: the detector (2c) is arranged at the focal point of the condenser (2 b).

7. The highly sensitive specific protein analyzer according to any one of claims 1 to 6, wherein: the light source (2d) is an LED light source.