CN210473107U - Ribavirin pure water crystallization device - Google Patents
Ribavirin pure water crystallization device Download PDFInfo
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- CN210473107U CN210473107U CN201920810353.6U CN201920810353U CN210473107U CN 210473107 U CN210473107 U CN 210473107U CN 201920810353 U CN201920810353 U CN 201920810353U CN 210473107 U CN210473107 U CN 210473107U
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Abstract
The utility model discloses a ribavirin pure water crystallization device, including the outer jar of body and the inner tank body, the inside of the outer jar of body is provided with the inner tank body, be formed with the accuse temperature chamber between the outer jar of body and the inner tank body, the top fixedly connected with of the inner tank body connects the casing, the inside of connecting the casing is provided with servo motor, servo motor's output fixedly connected with puddler, puddler and inner tank body swing joint, the puddler is located the inside fixed surface of the inner tank body and is connected with stirring fan blade, the outer surface of the inner tank body is located one side fixedly connected with inlet pipe of connecting the casing. This ribavirin pure water crystallization device through servo motor, puddler and stirring vane's design, has realized the stirring of internal jar of internal solution to accelerated the dissolution rate of solute, promoted work efficiency, moreover, the material of the internal jar of body, puddler and stirring vane is glass-lined, and its corrosion resistance has prolonged its life because the stainless steel.
Description
Technical Field
The utility model relates to a crystallization device technical field specifically is a ribavirin pure water crystallization device.
Background
Ribavirin is a novel nucleoside broad-spectrum antiviral drug, the production capacity in China is increased year by year, the market competition is increasingly severe, in order to improve the product competitiveness and take the domestic and international markets, the quality of the product is particularly important to be improved, the solubility data of ribavirin in ethanol aqueous solution under various concentrations is measured by adopting a static method, the experimental result shows that the solubility of ribavirin in the ethanol aqueous solution is increased along with the temperature rise, the drawing analysis shows that the width of a ribavirin metastable zone is increased along with the temperature rise in an ethanol aqueous solution system, the width of the ribavirin metastable zone is increased along with the increase of the concentration of the ethanol aqueous solution, meanwhile, the ratio of the metastable zone of a low temperature zone is much narrower, therefore, in order to obtain better supersaturation to control the product quality, the temperature reduction process of ribavirin crystallization is mainly controlled in a stable zone with larger width, i.e., a high temperature zone, and a high concentration ethanol aqueous solution is used as a recrystallization solvent.
The influence of the concentration of a recrystallization solvent, the cooling trend and the cooling rate in the ribavirin crystallization process, the surface roughness of a crystallization container, seed crystal addition and other factors on the ribavirin crystal form is analyzed, so that the better crystallization operation condition is determined, the influence of the operation conditions such as the stirring strength, the cooling rate, the reaction liquid concentration and the like in the crystallization process on the particle size distribution of ribavirin is researched by adopting a uniform design method, the influence of impurities and the solvent on the ribavirin crystallization is discussed, and the ribavirin pure water crystallization device is provided.
SUMMERY OF THE UTILITY MODEL
The utility model provides a not enough to prior art, the utility model provides a ribavirin pure water crystallization device has solved the problem of proposing in the above-mentioned background art.
The above technical purpose of the present invention can be achieved by the following technical solutions: the utility model provides a ribavirin pure water crystallization device, includes the outer jar of body and the internal tank body, the inside of the outer jar of body is provided with the internal tank body, be formed with the accuse temperature chamber between the outer jar of body and the internal tank body, the top fixedly connected with of the internal tank body connects the casing, the inside of connecting the casing is provided with servo motor, servo motor's output fixedly connected with puddler, puddler and internal tank body swing joint, the puddler is located the internal external fixedly connected with stirring fan blade of internal tank, the external surface of the internal tank is located one side fixedly connected with inlet pipe of connecting the casing, the bottom fixedly connected with discharging pipe of the internal tank body.
As a further preferable technical proposal of the utility model; the inner tank body is made of glass lining.
As a further preferable technical proposal of the utility model; the material of puddler and stirring fan blade is glass-lined.
As a further preferable technical proposal of the utility model; one side of discharging pipe is provided with the control valve, discharging pipe and the outer jar of the body one side fixedly connected with steam admission pipe of the outer jar of the body, the outer fixed surface of steam admission pipe is connected with the refrigerant water admission pipe, just the opposite side fixedly connected with discharge pipe of the outer jar of the body, fixed connection, just the one end fixedly connected with flange of discharging pipe.
As a further preferable technical proposal of the utility model; one side fixedly connected with steam admission pipe of the outer jar of body, the outer fixed surface of steam admission pipe is connected with refrigerant water admission pipe, just the opposite side fixedly connected with discharge pipe of the outer jar of body.
As a further preferable technical proposal of the utility model; one side of the steam inlet pipe is provided with a first flow control valve, one side of the refrigerant water inlet pipe is provided with a second flow control valve, and the refrigerant water inlet pipe is positioned between the first flow control valve and the outer tank body.
To sum up, the utility model discloses following beneficial effect has:
1. this ribavirin pure water crystallization device, through servo motor, puddler and stirring fan's design, realized the stirring of the internal jar of internal solution of body to accelerated the dissolution rate of solute, promoted work efficiency, and, the material of the internal jar body, puddler and stirring fan is glass-lined, and glass-lined is burnt through the high temperature of 900 ℃ or so, makes corrosion resistant glass material sticiss in the metal surface and make, and it has good corrosion resistance, and the surface is smooth, wear-resisting, and has certain heat stability, especially its corrosion resistance because the stainless steel, has prolonged its life.
2. This ribavirin pure water crystallization device, through being connected equipment such as steam admission pipe and steam engine, import steam to the outer jar of body and the inner tank body between accuse temperature intracavity, heat the solution of the inner tank body inside, utilize the solubility of ribavirin in the ethanol along with the temperature rise and grow, make the solution in the inner tank body reach the saturation under the state of heating, then let in refrigerant water through the refrigerant water admission pipe to accuse temperature intracavity, make the solution that the inner tank body is in the saturated condition cool down, thereby precipitate the crystal.
Drawings
FIG. 1 is a schematic view of the cross-sectional structure of the present invention;
fig. 2 is a schematic view of the structure of the present invention.
In the figure: 1. an outer tank body; 2. an inner tank body; 3. a temperature control cavity; 4. connecting the shell; 5. a servo motor; 6. a stirring rod; 7. a stirring fan blade; 8. a feed pipe; 9. a discharge pipe; 10. a control valve; 11. a connecting flange; 12. a steam inlet pipe; 13. refrigerant water inlet pipe; 14. a discharge pipe; 15. a first flow control valve; 16. a second flow control valve.
Detailed Description
The technical solutions in the embodiments of the present invention will be described clearly and completely with reference to the accompanying drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only some embodiments of the present invention, not all embodiments.
Referring to fig. 1 to 2, the present invention provides a technical solution: a ribavirin pure water crystallization device comprises an outer tank body 1 and an inner tank body 2, wherein one side of the outer tank body 1 is fixedly connected with a steam inlet pipe 12, the outer surface of the steam inlet pipe 12 is fixedly connected with a refrigerant water inlet pipe 13, the other side of the outer tank body 1 is fixedly connected with a discharge pipe 14, one side of the steam inlet pipe 12 is provided with a first flow control valve 15, one side of the refrigerant water inlet pipe 13 is provided with a second flow control valve 16, the refrigerant water inlet pipe 13 is positioned between the first flow control valve 15 and the outer tank body 1, the inner tank body 2 is arranged inside the outer tank body 1, the inner tank body 2 is made of glass lining, a temperature control cavity 3 is formed between the outer tank body 1 and the inner tank body 2, the top end of the inner tank body 2 is fixedly connected with a connecting shell 4, a servo motor 5 is arranged inside the connecting shell 4, the output end of the servo motor 5 is fixedly connected with a stirring rod 6, and the stirring, the outer surface of the stirring rod 6 positioned inside the inner tank body 2 is fixedly connected with stirring fan blades 7, the stirring rod 6 and the stirring fan blades 7 are made of glass lining, one side of the outer surface of the inner tank body 2 positioned on the connecting shell 4 is fixedly connected with a feeding pipe 8, the bottom of the inner tank body 2 is fixedly connected with a discharging pipe 9, one side of the discharging pipe 9 is provided with a control valve 10, the discharging pipe 9 is fixedly connected with the outer tank body 1, and one end of the discharging pipe 9 is fixedly connected with a connecting flange 11;
further, the solvent in the inner tank body 2 is an ethanol water solution, and the solubility of the ethanol water solution is 90%;
furthermore, a universal stepless speed regulating frequency converter can be connected with the servo motor 5 and used for controlling the stirring speed, wherein the stirring speed is 64rpm before crystallization, and the stirring speed is 10rpm after crystallization;
furthermore, a temperature sensor can be arranged in the inner tank body 2, the temperature sensor can be a temperature sensor with the model number of BD-DS18B20-02, the temperature sensor seals a DS18B20 element in a stainless tube round tube, leads out a lead, is subjected to waterproof treatment, can adapt to severe working occasions such as humidity, water immersion, corrosion, collision, friction and the like, displays the temperature of the solution in the inner tank body 2 in real time, and controls the speed of steam and refrigerant water entering the temperature control cavity 3 through the first flow control valve 15 and the second control valve 16, so that the temperature in the inner tank body 2 is controlled;
furthermore, it can be connected to an external filter device via a connecting flange 11 at one end of the tapping pipe 9.
The electrical components presented in the document are all electrically connected with an external master controller and 220V mains, and the master controller can be a conventional known device controlled by a computer or the like.
In conclusion, the ribavirin pure water crystallization device realizes the stirring of the solution in the inner tank body 2 through the design of the servo motor 5, the stirring rod 6 and the stirring fan blades 7, thereby accelerating the dissolution rate of solute and improving the working efficiency, moreover, the inner tank body 2, the stirring rod 6 and the stirring fan blades 7 are all made of glass lining, the glass lining is sintered at high temperature of about 900 ℃, so that corrosion-resistant glass materials are tightly adhered to the metal surface, the glass lining has good corrosion resistance, smooth and wear-resistant surface and certain thermal stability, particularly, the service life of the glass lining is prolonged due to stainless steel, the steam inlet pipe 12 is connected with equipment such as a steam engine, steam is input into the temperature control cavity 3 between the outer tank body 1 and the inner tank body 2, the solution in the inner tank body 2 is heated, the solubility of ribavirin in ethanol is increased along with the rise of temperature, the solution in the inner tank body 2 is saturated in the heating state, and then the refrigerant water is introduced into the temperature control cavity 3 through the refrigerant water inlet pipe 13, so that the solution in the saturated state in the inner tank body 2 is cooled, and crystals are separated out.
The above, only be the concrete implementation of the preferred embodiment of the present invention, but the protection scope of the present invention is not limited thereto, and any person skilled in the art is in the technical scope of the present invention, according to the technical solution of the present invention and the utility model, the concept of which is equivalent to replace or change, should be covered within the protection scope of the present invention.
Claims (6)
1. The utility model provides a ribavirin pure water crystallization device, includes outer jar of body (1) and inner tank body (2), its characterized in that: the inside of the outer tank body (1) is provided with the inner tank body (2), be formed with accuse temperature chamber (3) between the outer tank body (1) and the inner tank body (2), the top fixedly connected with of the inner tank body (2) connects casing (4), the inside of connecting casing (4) is provided with servo motor (5), the output end fixedly connected with puddler (6) of servo motor (5), puddler (6) and inner tank body (2) swing joint, puddler (6) are located the inside fixed surface of the inner tank body (2) and are connected with stirring fan blade (7), the outer surface of the inner tank body (2) is located one side fixedly connected with inlet pipe (8) of connecting casing (4), the bottom fixedly connected with discharging pipe (9) of the inner tank body (2).
2. The ribavirin pure water crystallization device according to claim 1, characterized in that: the inner tank body (2) is made of glass lining.
3. The ribavirin pure water crystallization device according to claim 1, characterized in that: the stirring rod (6) and the stirring fan blades (7) are made of glass lining.
4. The ribavirin pure water crystallization device according to claim 1, characterized in that: one side of discharging pipe (9) is provided with control valve (10), discharging pipe (9) and the outer jar of body (1) fixed connection, just the one end fixed connection of discharging pipe (9) has flange (11).
5. The ribavirin pure water crystallization device according to claim 1, characterized in that: one side fixedly connected with steam admission pipe (12) of outer jar body (1), the surface fixedly connected with refrigerant water admission pipe (13) of steam admission pipe (12), just opposite side fixedly connected with discharge pipe (14) of outer jar body (1).
6. The ribavirin pure water crystallization device according to claim 5, characterized in that: one side of the steam inlet pipe (12) is provided with a first flow control valve (15), one side of the refrigerant water inlet pipe (13) is provided with a second flow control valve (16), and the refrigerant water inlet pipe (13) is positioned between the first flow control valve (15) and the outer tank body (1).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201920810353.6U CN210473107U (en) | 2019-05-31 | 2019-05-31 | Ribavirin pure water crystallization device |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201920810353.6U CN210473107U (en) | 2019-05-31 | 2019-05-31 | Ribavirin pure water crystallization device |
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| Publication Number | Publication Date |
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| CN210473107U true CN210473107U (en) | 2020-05-08 |
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| CN201920810353.6U Active CN210473107U (en) | 2019-05-31 | 2019-05-31 | Ribavirin pure water crystallization device |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113996081A (en) * | 2021-11-08 | 2022-02-01 | 东台品青生物科技有限公司 | Crystalline glucose low temperature crystallization resumes uses intensification equipment |
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2019
- 2019-05-31 CN CN201920810353.6U patent/CN210473107U/en active Active
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113996081A (en) * | 2021-11-08 | 2022-02-01 | 东台品青生物科技有限公司 | Crystalline glucose low temperature crystallization resumes uses intensification equipment |
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Effective date of registration: 20220721 Address after: 313000 room 260, floor 2, building 1, No. 1800, Wangmushan Road, Huzhou City, Zhejiang Province Patentee after: Baishan Technology (Huzhou) Co.,Ltd. Address before: 313200 sanlitang, Qianyuan Town, Deqing County, Huzhou City, Zhejiang Province Patentee before: ZHEJIANG ZHEBEI PHARMACEUTICAL CO.,LTD. |