CN210022022U

CN210022022U - Mixing device with controllable liquid adding amount

Info

Publication number: CN210022022U
Application number: CN201920815620.9U
Authority: CN
Inventors: 罗前东; 肖启辉
Original assignee: Chengdu Psv New Biotechnology Co Ltd
Current assignee: Chengdu Pukang Weixin Biotechnology Co.,Ltd.
Priority date: 2019-05-31
Filing date: 2019-05-31
Publication date: 2020-02-07
Anticipated expiration: 2029-05-31

Abstract

The utility model discloses a controllable mixing arrangement of liquid feeding volume, including liquid bottle an, liquid bottle b and mixing bottle, liquid bottle an's bottom pass through pipeline an with mixing bottle's top is connected, be equipped with two-position two-way solenoid valve a, governing valve an and check valve an on the pipeline a in proper order, liquid bottle b's bottom pass through pipeline b with mixing bottle's top is connected, be equipped with two-position two-way solenoid valve b, governing valve b and check valve b on the pipeline b in proper order, the central screw hole of having seted up of mixing bottle, be equipped with the controller on the mixing bottle, be equipped with water level sensing in the mixing bottle, two-position two-way solenoid valve a, two-position two-way solenoid valve b, level sensor and motor an all with controller electric connection. The flow rate of the speed regulating valve a and the flow rate of the speed regulating valve b can be set on the controller, so that medicines with different proportions react in the mixing bottle, and a better chemical reaction effect is achieved.

Description

Mixing device with controllable liquid adding amount

Technical Field

The utility model relates to a controllable field of liquid feeding volume specifically is a controllable mixing arrangement of liquid feeding volume.

Background

Polyethylene glycol (PEG), also known as polyethylene oxide (PEO), is an amphiphilic polyether that is soluble in water and most organic solvents. PEG and its derivatives are one of the few polymers that are useful in biopharmaceutical products certified by the FDA in the united states. Polyethylene glycol (PEG) modification of proteins or polypeptides, i.e., pegylation, involves the chemical coupling of activated PEG to a protein or polypeptide molecule by covalent bonds.

Polypeptides, proteins and other bioactive molecules often have the defects of short half-life, easy immunogenicity or antigenicity generation, easy enzymolysis and the like in the medicinal process, and the PEG drug can overcome the defects. At this moment, the polyethylene glycol (PEG) and other medicines are required to be mixed in a certain proportion for chemical reaction, and the prior art simultaneously adopts manual proportioning, so that the time and labor are wasted, the accuracy is not high, and a device for quantitatively mixing various medicines is lacked.

SUMMERY OF THE UTILITY MODEL

An object of the utility model is to overcome prior art not enough, provide a controllable mixing arrangement of liquid feeding volume, including liquid bottle an, liquid bottle b and mixing bottle, be equipped with governing valve an and governing valve b on the pipeline an that liquid bottle an and mixing bottle are connected and the pipeline b that liquid bottle b and mixing bottle are connected respectively, can pass through the settlement of controller according to the proportion that needs to adjust corresponding governing valve, make the inflow of multiple medicine a proportion in the mixing bottle, still be equipped with belt cleaning device and agitating unit, agitating unit can stir multiple medicine, makes it intensive mixing, thereby reaches better chemical reaction effect, and belt cleaning device can wash liquid bottle an, liquid bottle b and mixing bottle when changing the medicine and mixing, avoids the mixed medicine of last time to produce the influence to this time mixed medicine.

The purpose of the utility model is realized through the following technical scheme: the utility model provides a controllable mixing arrangement of liquid feeding volume, includes liquid bottle an, liquid bottle b and mixing flask, liquid bottle an's bottom pass through pipeline an with the top of mixing flask is connected, be equipped with two-position two-way solenoid valve an, governing valve an and check valve an on the pipeline a in proper order, liquid bottle b's bottom pass through pipeline b with the top of mixing flask is connected, be equipped with two-position two-way solenoid valve b, governing valve b and check valve b on the pipeline b in proper order, threaded hole has been seted up at the center of mixing flask, be equipped with the controller on the mixing flask, be equipped with water level sensing in the mixing flask, two-position two-way solenoid valve a, two-position two-way solenoid valve b, level sensor and motor a all with controller electric connection. The flow rate of the speed regulating valve a and the flow rate of the speed regulating valve b can be set on the controller, so that medicines with different proportions can be obtained to react in the mixing bottle.

Further, liquid bottle a and liquid bottle b's top is equipped with inlet a and inlet b respectively, be equipped with valve a and valve b on inlet a and the inlet b respectively, the bottom of mixing bottle is equipped with the liquid outlet, be equipped with valve c on the liquid outlet. Different kinds of drugs can be added through the liquid inlet a and the liquid inlet b to be mixed in a certain proportion.

Further, still include titration outfit, titration outfit includes pipeline c, flowmeter, governing valve c and burette, the both ends of pipeline c are connected with liquid outlet and burette respectively, be equipped with flowmeter and governing valve c on the pipeline c, the flowmeter with controller electric connection, the flowmeter is used for receiving the signal of controller carries out flow rate control to governing valve c. The titration apparatus can flow the mixed drug out of the dropper at a certain flow rate.

Further, still be equipped with the two shunt tubes that lead to, two shunt tubes that lead to the shunt tubes respectively with liquid bottle a and liquid bottle b top intercommunication, the mainstream pipeline and the outside water source intercommunication of two shunt tubes, one side of mainstream pipeline is equipped with the high-pressure pump. The cleaning of the liquid bottle a and the liquid bottle b is realized.

Further, the mixing device comprises a cleaning device and a stirring device, and both the cleaning device and the stirring device can be independently installed in the mixing bottle.

Furthermore, the cleaning device comprises a motor, a cylindrical cap, a driving shaft, a driven shaft, a conical hairbrush and an elastic piece, one end of the driving shaft is connected with an output shaft of the motor, the other end of the driving shaft is connected with the elastic piece, the driven shaft is connected below the elastic piece, the cylindrical cap is rotatably arranged on the driving shaft, threads are arranged on the outer surface of the cylindrical cap, the threads on the cylindrical cap are matched with the threaded hole, and the conical hairbrush is arranged at one end, far away from the elastic piece, of the driven shaft. When other medicines need to be mixed, the cleaning device is arranged in the mixing bottle through the cylindrical cap, so that the cleaning device can clean the mixing bottle.

Further, the diameter of the large-diameter end of the tapered hairbrush is smaller than that of the threaded hole. The cleaning device can be arranged in the mixing bottle to clean the mixing bottle.

Furthermore, the stirring device comprises a motor a, a cylindrical cap a, a support rod and a spiral blade, one end of the support rod is connected with an output shaft of the motor a, one end of the support rod, which is close to the motor a, is rotatably sleeved with the cylindrical cap a, the outer surface of the cylindrical cap a is provided with threads, the threads on the cylindrical cap a are matched with the threaded hole, the spiral blade is arranged on the support rod, and the spiral blade is positioned below the cylindrical cap a. When carrying out the medicine and mixing, through cylinder cap a installs agitating unit in the mixing flask, realizes the stirring to mixing medicine in the mixing flask, reaches better chemical reaction effect.

The utility model has the advantages that:

a mixing device with controllable liquid adding amount comprises a liquid bottle a, a liquid bottle b and a mixing bottle, wherein a pipeline a for connecting the liquid bottle a with the mixing bottle and a pipeline b for connecting the liquid bottle b with the mixing bottle are respectively provided with a speed regulating valve a and a speed regulating valve b, and the corresponding speed regulating valves can be regulated according to the required medicine proportion through setting of a controller, so that a plurality of medicines can flow into the mixing bottle in a certain proportion;

still be equipped with agitating unit, can stir the mixed medicine, make it intensive mixing to reach better chemical reaction effect.

Still be equipped with belt cleaning device, can wash liquid bottle a, liquid bottle b and mixing bottle, carry out the mixture and the preparation of other medicines, make the controllable mixing arrangement of liquid feeding volume can carry out multiple medicine and mix, avoided the influence of the residue of mixing the medicine this time of last time to this mixed medicine, increased the utility model discloses an application range.

Drawings

FIG. 1 is a schematic structural view of a mixing device with controllable liquid feeding amount of the present invention;

FIG. 2 is a schematic structural view of a titration apparatus of a mixing apparatus with controllable liquid-feeding amount of the present invention;

FIG. 3 is a schematic structural view of a cleaning device of a mixing device with controllable liquid feeding amount of the present invention;

FIG. 4 is a schematic structural view of a mixing device with controllable liquid feeding amount of the present invention;

in the figure, 1-liquid bottle a, 2-liquid bottle b, 3-mixing bottle, 4-valve a, 5-liquid inlet a, 6-valve b, 7-liquid inlet b, 8-two-way shunt pipe, 9-high pressure pump, 10-main flow pipeline, 11-two-position two-way electromagnetic valve a, 12-speed regulating valve a, 13-one-way valve a, 14-two-position two-way electromagnetic valve b, 15-speed regulating valve b, 16-one-way valve b, 17-motor a, 18-controller, 19-water level sensor, 20-support rod, 21-valve c, 22-liquid outlet, 23-flowmeter, 24-speed regulating valve c, 25-dropper, 26-motor, 27-driving shaft, 28-driven shaft, 29-conical brush and 30-elastic part, 31-cylindrical cap, 32-helical blade, 33-pipe b, 34-pipe a, 35-pipe c, 36-threaded hole, 37-cylindrical cap a.

Detailed Description

The technical solution of the present invention is described in further detail below with reference to the accompanying drawings, but the scope of the present invention is not limited to the following description.

As shown in fig. 1, a mixing device with controllable liquid adding amount comprises a liquid bottle a1, a liquid bottle b2 and a mixing bottle 3, wherein the bottom of the liquid bottle a1 is connected with the top of the mixing bottle 3 through a pipeline a34, a two-position two-way electromagnetic valve a11, a speed regulating valve a12 and a one-way valve a13 are sequentially arranged on the pipeline a34, the bottom of the liquid bottle b2 is connected with the top of the mixing bottle 3 through a pipeline b33, a two-position two-way electromagnetic valve b14, a speed regulating valve b15 and a one-way valve b16 are sequentially arranged on the pipeline b33, a threaded hole 36 is formed in the center of the mixing bottle 3, a controller 18 is arranged on the mixing bottle 3, a water level sensor 19 is arranged in the mixing bottle 3, and the two-position two-way electromagnetic valve a11, the two-position two-way electromagnetic valve b14, the water level sensor 19 and a motor. The utility model discloses more than two liquid bottles, the number that can mix the medicine according to actual need increases the quantity of suitable liquid bottle.

Polypeptide, protein and other bioactive molecules have the defects of short half-life period, easy immunogenicity or antigenicity generation, easy enzymolysis and the like in the medicinal process, and the PEGylated medicine has the advantages of longer half-life period of ①, lower maximum blood concentration of ②, smaller fluctuation of ③ blood concentration, less enzyme degradation of ④, less immunogenicity and antigenicity of ⑤, less toxicity of ⑥, better solubility of ⑦, reduced administration frequency of ⑧, improved compliance of patients and improved life quality, stronger passive targeting action of ⑩ liposome to tumors, and the PEGylation has the effect of 'diamond-point formation of gold' to the medicine, and a certain proportion of mixing is needed when the PEG is used for modifying the medicine.

As shown in fig. 2, the top of liquid bottle a1 and liquid bottle b2 is provided with liquid inlet a5 and liquid inlet b7 respectively, be provided with valve a4 and valve b6 on liquid inlet a5 and liquid inlet b7 respectively, the bottom of mixing bottle 3 is provided with liquid outlet 22, be provided with valve c21 on liquid outlet 22, still include titration outfit, titration outfit includes pipeline c35, flowmeter 23, governing valve c24 and burette 25, the both ends of pipeline c35 are connected with liquid outlet 22 and burette 25 respectively, be provided with flowmeter 23 and governing valve c24 on pipeline c35, flowmeter 23 with controller 18 electric connection, flowmeter 23 is used for receiving the signal of controller 18 carries out flow rate control to governing valve c 24. The burette 25 is used for detecting the quantitative outflow of the mixed medicine, detecting whether a preset effect is achieved or not, and enabling the mixed medicine to quantitatively flow out of the burette 25 after the preset effect is achieved. The operation process of the burette 25 is that the flow rate is set on the controller, then the valve c21 on the liquid outlet 22 is opened, the flow meter 23 controls the flow rate of the speed regulating valve c24 to make the medicine mixed in the mixing bottle 3 flow out according to the preset flow rate, and the valve c21 is closed to stop the flow of the mixed medicine.

As shown in fig. 3, a two-way shunt pipe 8 is further provided, the two shunt pipes of the two-way shunt pipe 8 are respectively communicated with the tops of the liquid bottle a1 and the liquid bottle b2, the main flow pipeline 10 of the two-way shunt pipe 8 is communicated with an external water source, one side of the main flow pipeline 10 is provided with a high-pressure pump 9, the cleaning device and the stirring device can be independently installed in the mixing bottle 3, the cleaning device comprises a motor 26, a cylindrical cap 31, a driving shaft 27, a driven shaft 28, a tapered hair brush 29 and an elastic element 30, one end of the driving shaft 27 is connected with an output shaft of the motor 26, the other end of the driving shaft is connected with the elastic element 30, the driven shaft 28 is connected below the elastic element 30, the cylindrical cap 31 is rotatably provided on the driving shaft 27, the outer surface of the cylindrical cap 31 is provided with threads, and the threads on the cylindrical cap 31 are matched, the end of the driven shaft 28 far away from the elastic element 30 is provided with the taper brush 29, and the diameter of the end with the large diameter of the taper brush 29 is smaller than that of the threaded hole 36. The cleaning device is used for cleaning the liquid bottle a1, the liquid bottle b2 and the mixing bottle 3, is used for mixing other medicines after cleaning, and avoids the influence of the last medicine on the medicine.

The working process of the cleaning device is as follows: insert belt cleaning device from screw hole 36 in mixing bottle 3, screw through cylinder cap 31, starter motor 26, motor 26 drives driving shaft 27 and rotates, driving shaft 27 makes driven shaft 28 rotate through elastic component 30, toper brush 29 on the driven shaft 28 rotates, elastic component 30 makes driven shaft 28 receive the effect of centripetal force when rotatory, make driven shaft 28 be circular motion in mixing bottle 3, belt cleaning device's washing scope has been increased, toper brush 29 sets up to the toper and makes the water in mixing bottle 3 form the swirl simultaneously, reach better cleaning performance.

As shown in fig. 4, the stirring device includes a motor a17, a cylindrical cap a37, a supporting rod 20, and a helical blade 32, wherein one end of the supporting rod 20 is connected with an output shaft of the motor a17, one end of the supporting rod 20 close to the motor a17 is rotatably sleeved with the cylindrical cap a37, the outer surface of the cylindrical cap a37 is provided with a thread, the thread on the cylindrical cap a37 is matched with the threaded hole 36, the helical blade 32 is arranged on the supporting rod 20, and the helical blade is located below the cylindrical cap a 37. The stirring device is used for stirring the medicines in the mixing bottle 3 to ensure that the medicines are mixed more fully and a better chemical reaction effect is achieved, and the specific operation process is that the stirring device is fixed in the mixing bottle 3 through a cylinder a37, a motor a17 is started, and a motor a17 drives a supporting rod 20 and a helical blade 32 to rotate, so that the effect of stirring the mixing bottle 3 is achieved.

The mixing device with the controllable liquid adding amount is provided with a cleaning device and a stirring device, the cleaning device is fixed in the mixing bottle 3 through a cylindrical cap 31, the stirring device is fixed in the mixing bottle 3 through a cylindrical cap a37, the stirring device is installed when medicines are mixed, and the cleaning device is installed when the stirring device is replaced during cleaning.

The foregoing is illustrative of the preferred embodiments of the present invention, and it is to be understood that the invention is not limited to the precise forms disclosed herein, and that various other combinations, modifications, and environments may be resorted to, falling within the scope of the invention as defined by the appended claims. But that modifications and variations may be effected by those skilled in the art without departing from the spirit and scope of the invention, which is to be limited only by the claims appended hereto.

Claims

1. The mixing device with the controllable liquid adding amount is characterized by comprising a liquid bottle a (1), a liquid bottle b (2) and a mixing bottle (3), wherein the bottom of the liquid bottle a (1) is connected with the top of the mixing bottle (3) through a pipeline a (34), a two-position two-way electromagnetic valve a (11), a speed regulating valve a (12) and a one-way valve a (13) are sequentially arranged on the pipeline a (34), the bottom of the liquid bottle b (2) is connected with the top of the mixing bottle (3) through a pipeline b (33), a two-position two-way electromagnetic valve b (14), a speed regulating valve b (15) and a one-way valve b (16) are sequentially arranged on the pipeline b (33), a threaded hole (36) is formed in the center of the mixing bottle (3), a controller (18) is arranged on the mixing bottle (3), a water level sensor (19) is arranged in the mixing bottle (3), the two-position two-way electromagnetic valve a (11), the two-position two-way electromagnetic valve b (14), the water level sensor (19) and the motor a (17) are electrically connected with the controller (18).

2. The mixing device with controllable liquid adding amount according to claim 1, wherein the liquid bottle a (1) and the liquid bottle b (2) are respectively provided with a liquid inlet a (5) and a liquid inlet b (7) at the top, the liquid inlet a (5) and the liquid inlet b (7) are respectively provided with a valve a (4) and a valve b (6), the mixing bottle (3) is provided with a liquid outlet (22) at the bottom, and the liquid outlet (22) is provided with a valve c (21).

3. The mixing device with controllable liquid adding amount according to claim 2, further comprising a titration device, wherein the titration device comprises a pipeline c (35), a flow meter (23), a speed regulating valve c (24) and a dropper (25), two ends of the pipeline c (35) are respectively connected with the liquid outlet (22) and the dropper (25), the pipeline c (35) is provided with the flow meter (23) and the speed regulating valve c (24), the flow meter (23) is electrically connected with the controller (18), and the flow meter (23) is used for receiving a signal of the controller (18) to control the flow rate of the speed regulating valve c (24).

4. A mixing device with controllable liquid adding amount according to claim 1, characterized in that a two-way shunt pipe (8) is further provided, two shunt pipes of the two-way shunt pipe (8) are respectively communicated with the tops of the liquid bottle a (1) and the liquid bottle b (2), a main flow pipe (10) of the two-way shunt pipe (8) is communicated with an external water source, and a high-pressure pump (9) is arranged on one side of the main flow pipe (10).

5. A mixing device with controlled filling according to claim 1, further comprising a cleaning device and a stirring device, both of which are separately mountable in the mixing flask (3).

6. The mixing device with controllable liquid adding amount according to claim 5, characterized in that the cleaning device comprises a motor (26), a cylindrical cap (31), a driving shaft (27), a driven shaft (28), a conical brush (29) and an elastic member (30), one end of the driving shaft (27) is connected with an output shaft of the motor (26), the other end of the driving shaft is connected with the elastic member (30), the driven shaft (28) is connected below the elastic member (30), the cylindrical cap (31) is rotatably arranged on the driving shaft (27), the outer surface of the cylindrical cap (31) is provided with threads, the threads on the cylindrical cap (31) are matched with the threaded hole (36), and the conical brush (29) is arranged at one end of the driven shaft (28) far away from the elastic member (30).

7. A mixing device with controlled filling according to claim 6, wherein the end of the conical brush (29) with the larger diameter has a smaller diameter than the threaded hole (36).

8. The mixing device with the controllable adding amount according to claim 5, characterized in that the stirring device comprises a motor a (17), a cylindrical cap a (37), a supporting rod (20) and a helical blade (32), wherein one end of the supporting rod (20) is connected with an output shaft of the motor a (17), one end of the supporting rod (20) close to the motor a (17) is rotatably sleeved with the cylindrical cap a (37), the outer surface of the cylindrical cap a (37) is provided with threads, the threads on the cylindrical cap a (37) are matched with the threaded hole (36), the helical blade (32) is arranged on the supporting rod (20), and the helical blade is positioned below the cylindrical cap a (37).