CN208888247U - Test tube for the acquisition of blood excretion body - Google Patents
Test tube for the acquisition of blood excretion body Download PDFInfo
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- CN208888247U CN208888247U CN201821358760.XU CN201821358760U CN208888247U CN 208888247 U CN208888247 U CN 208888247U CN 201821358760 U CN201821358760 U CN 201821358760U CN 208888247 U CN208888247 U CN 208888247U
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- 238000012360 testing method Methods 0.000 title claims abstract description 108
- 230000029142 excretion Effects 0.000 title claims abstract description 62
- 210000004369 blood Anatomy 0.000 title claims abstract description 27
- 239000008280 blood Substances 0.000 title claims abstract description 27
- 238000001179 sorption measurement Methods 0.000 claims abstract description 55
- 239000000463 material Substances 0.000 claims abstract description 19
- 238000010276 construction Methods 0.000 claims abstract description 14
- 210000000601 blood cell Anatomy 0.000 claims abstract description 11
- 210000000813 small intestine Anatomy 0.000 claims abstract description 6
- 210000004027 cell Anatomy 0.000 claims description 6
- 239000011148 porous material Substances 0.000 claims description 4
- 210000004185 liver Anatomy 0.000 claims description 2
- 229920002521 macromolecule Polymers 0.000 claims 1
- 229920000669 heparin Polymers 0.000 abstract description 32
- 229960002897 heparin Drugs 0.000 abstract description 32
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 abstract description 28
- 241000973497 Siphonognathus argyrophanes Species 0.000 abstract description 13
- 238000000034 method Methods 0.000 abstract description 9
- 238000005199 ultracentrifugation Methods 0.000 description 8
- 102000039446 nucleic acids Human genes 0.000 description 7
- 108020004707 nucleic acids Proteins 0.000 description 7
- 150000007523 nucleic acids Chemical class 0.000 description 7
- 239000000284 extract Substances 0.000 description 6
- 108090000623 proteins and genes Proteins 0.000 description 6
- 102000004169 proteins and genes Human genes 0.000 description 6
- 239000000126 substance Substances 0.000 description 6
- 238000010586 diagram Methods 0.000 description 5
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
- 239000003153 chemical reaction reagent Substances 0.000 description 4
- 239000000243 solution Substances 0.000 description 4
- 239000004698 Polyethylene Substances 0.000 description 3
- 238000004458 analytical method Methods 0.000 description 3
- 238000005336 cracking Methods 0.000 description 3
- 238000001514 detection method Methods 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 239000002245 particle Substances 0.000 description 3
- 239000008363 phosphate buffer Substances 0.000 description 3
- 238000000159 protein binding assay Methods 0.000 description 3
- 238000000926 separation method Methods 0.000 description 3
- 210000002966 serum Anatomy 0.000 description 3
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 2
- 239000004743 Polypropylene Substances 0.000 description 2
- 238000010802 RNA extraction kit Methods 0.000 description 2
- 239000011324 bead Substances 0.000 description 2
- 238000013461 design Methods 0.000 description 2
- 238000010494 dissociation reaction Methods 0.000 description 2
- 230000005593 dissociations Effects 0.000 description 2
- 239000012894 fetal calf serum Substances 0.000 description 2
- 239000008187 granular material Substances 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- -1 polypropylene Polymers 0.000 description 2
- 229920001155 polypropylene Polymers 0.000 description 2
- 229920002635 polyurethane Polymers 0.000 description 2
- 239000004814 polyurethane Substances 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 208000037273 Pathologic Processes Diseases 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 150000001336 alkenes Chemical class 0.000 description 1
- 238000000149 argon plasma sintering Methods 0.000 description 1
- 230000008827 biological function Effects 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 210000001175 cerebrospinal fluid Anatomy 0.000 description 1
- 238000005660 chlorination reaction Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 230000035992 intercellular communication Effects 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- VIKNJXKGJWUCNN-XGXHKTLJSA-N norethisterone Chemical compound O=C1CC[C@@H]2[C@H]3CC[C@](C)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 VIKNJXKGJWUCNN-XGXHKTLJSA-N 0.000 description 1
- 230000009054 pathological process Effects 0.000 description 1
- 230000035479 physiological effects, processes and functions Effects 0.000 description 1
- 238000011020 pilot scale process Methods 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000004062 sedimentation Methods 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 238000001262 western blot Methods 0.000 description 1
Landscapes
- Investigating Or Analysing Biological Materials (AREA)
Abstract
The utility model relates to molecular biology and clinical testing techniques fields, specifically a kind of haemocyte without being centrifuged in removal sample, it is structurally reasonable, test tube for the acquisition of blood excretion body easily to operate, equipped with test tube main body, it is characterized in that inboard wall of test tube has the adsorption structure for increasing 10 times or more using specific surface area made of heparin modified high molecular material, adsorption structure is arranged in test tube lower part, the adsorption structure is porous structure or tooth array or Fractal array adsorption structure or class small intestine wall construction, it is additionally provided with the groove structure convenient for accelerating the discharge of blood blood cell, the top that adsorption structure is set of the groove structure, two or more the grooves around inboard wall of test tube setting are equipped in groove structure, groove extends to test tube mouth by the top of adsorption structure along test tube central axes, facilitate with acquisition timely, it is structurally reasonable, The significant advantage such as easy to operate.
Description
Technical field:
The utility model relates to molecular biology and clinical testing techniques fields, specifically a kind of without being centrifuged removal
Haemocyte in sample, test tube that is structurally reasonable, being acquired easily to operate for blood excretion body.
Background technique:
Excretion body is the vesicles that diameter is 30-150nm, is selectively packed and is discharged by living cells.In the body of human body
In liquid, such as blood, urine and cerebrospinal fluid, rich content.Contain different types of lipid, nucleic acid and albumen in excretion body
Deng these substances can be transported to specific target cell, to play corresponding biological function.Therefore, excretion body is thin
Huge effect is played in Intercellular communication and physiology and pathologic process.
Currently, there are mainly three types of the most common extracting methods of serum excretion body, one is ultracentrifugation method, the second is,
Immunomagnetic beads method, the third is RNA isolation kit, the relevant serum excretion provided such as the Thermo company in the U.S. and SBI company
The reagent preparation of body.But three has clearly disadvantageous place, and ultracentrifugation method, excretion body obtained is with high purity, still
Low yield, time-consuming, complicated for operation, and expensive equipment is not suitable for hospital's detection practice, and repeated centrifugation operation is it is also possible to capsule
Bubble damages, to reduce its quality；Immunomagnetic beads method, be capable of specificity captures corresponding excretion body, but this
Technology antibody higher cost, only a small number of Zoomlions company is grasped, such as SBI company, the U.S., is caused with high costs；Sedimentation
The yield that RNA isolation kit extracts excretion body is high, but its purity is too low, while obtaining excretion body, can also obtain many serum
The protein of middle high abundance.In addition, existing excretion body isolation technics uses Western blot usually after infecting a period of time
It verifies, is unable to real-time monitoring.
Summary of the invention:
The utility model is directed to shortcoming and defect existing in the prior art, proposes a kind of without centrifugal treating, structure
Rationally, the test tube acquired easily to operate for blood excretion body.
The utility model can be achieved by the following measures:
A kind of test tube for the acquisition of blood excretion body, is equipped with test tube main body, it is characterised in that inboard wall of test tube, which has, to be used
Specific surface area made of heparin modified high molecular material increases 10 times or more of adsorption structure, and adsorption structure is arranged under test tube
Portion.
Adsorption structure described in the utility model is porous structure or tooth array or Fractal array adsorption structure or class small intestine
Wall construction.
The groove structure convenient for accelerating the discharge of blood blood cell is additionally provided in the utility model test tube, the groove structure is set
It sets and is equipped with two or more the grooves around inboard wall of test tube setting in the top of adsorption structure, groove structure, groove is along test tube axis
Line extends to test tube mouth by the top of adsorption structure.
The 6-16 V-groove that groove structure described in the utility model is uniformly arranged around inboard wall of test tube, adjacent groove it
Between boss surface be convexly curved, convenient for accelerate blood or blood cell discharge.
Test tube main body described in the utility model is integrally formed using heparin modified high molecular material, or using by heparin modified
Embedded type structure made of high molecular material is embedded in common test tube, and the heparin modified high molecular material is heparin modified poly- second
Alkene or heparin modified polypropylene or heparin modified PVC or heparin modified polyurethane or heparin modified PVA material.
There is smooth bottom surface in the utility model test tube, be discharged convenient for blood.
The utility model is equipped with annular outer platform in order to hold and handle, in test tube mouth outer wall, and is equipped on test tube mouth
Pipe close.
Class small intestine wall construction in adsorption structure described in the utility model refers to that inboard wall of test tube increases equipped with specific surface area
10 times or more of policae circulane, pleat are fold.
The cone cell teeth that tooth array in adsorption structure described in the utility model is spaced by altitude range for 0.5-2 millimeters,
It is formed by the strip groove structural arrangement that distance range is 1-3 millimeters deep, wherein ditch piston ring land is equipped with extra projection or groove
To increase surface area；Wherein tooth array is formed by sawtooth unit repeated arrangement, and the sawtooth unit is successively arranged from top to bottom
The different V-type tooth of 3-6 length, the length of 3-6 V-type tooth are gradually reduced from top to bottom.
Pore diameter range is 0.05-0.5mm, hole depth range in porous structure in adsorption structure described in the utility model
For 0.05-0.1mm, aperture shape be circular hole or slotted eye or square hole or elongate holes or tri-angle-holed or pentagon hole or
Hexagonal hole.
When the utility model is used, taking above-mentioned test tube, blood to be processed is added in test tube, additional amount is 5-10 milli
It rises；Test tube is shaken, comes into full contact with sample in test tube with the adsorption structure on inboard wall of test tube；Examination intraluminal fluid of toppling over that treated
Body, the excretion somatocyst bubble substance in sample is attached on the adsorption structure on inboard wall of test tube at this time；It is careful with phosphate buffer
Tube wall is cleaned multiple times；Appropriate excretion body cracking is added to test tube again and RNA extracts reagent trizol, or heparin hydrolase is added
Or 8 mol/L sodium chloride solution dissociation excretion body carry out analysis of protein；It is settled by nucleic acid and obtains nucleic acid substances, Huo Zhetong
Cross antibody binding assay protein ingredient and content.
The utility model there is acquisition to facilitate timely compared with the prior art and design, structurally reasonable, easy to operate etc. aobvious
The advantages of work.
Detailed description of the invention:
Attached drawing 1 is the structural schematic diagram of the utility model.
Attached drawing 2 is the sectional view of groove structure in Fig. 1.
Attached drawing 3 is the schematic diagram of adsorption structure in the utility model, and wherein attached drawing 3-1 is the signal of the first adsorption structure
Figure, attached drawing 3-2 is second of adsorption structure schematic diagram, and attached drawing 3-3 is the third adsorption structure schematic diagram.
Attached drawing 4 is a kind of embodiment structure schematic diagram of tooth array in the utility model.
Attached drawing 5 is to separate excretion body excretion body grain size distribution obtained using conventional centrifugal method in embodiment 3.
Attached drawing 6 is in embodiment 3 using cuvette construction excretion body grain size distribution obtained in embodiment 1.
Attached drawing 7 is in embodiment 3 using cuvette construction excretion body grain size distribution obtained in embodiment 2.
Attached drawing 8 is to separate excretion body excretion bulk concentration FITC-SS bis- obtained using conventional centrifugal method in embodiment 3
Tie up scatter plot.
Attached drawing 9 is in embodiment 3 using cuvette construction separation excretion body excretion bulk concentration obtained in embodiment 1
FITC-SS two dimension scatter plot.
Attached drawing 10 is in embodiment 3 using cuvette construction separation excretion body excretion bulk concentration obtained in embodiment 2
FITC-SS two dimension scatter plot.
Appended drawing reference: test tube main body 1, adsorption structure 2, bottom surface 3, groove structure 4, annular outer platform 5, groove 6.
Specific embodiment:
The utility model is further described with reference to the accompanying drawings and examples.
As shown in the picture, the utility model proposes a kind of test tube for the acquisition of blood excretion body, it is equipped with test tube main body,
It is characterized in that inboard wall of test tube has the absorption for increasing 10 times or more using specific surface area made of heparin modified high molecular material
Structure, the adsorption structure are porous structure or tooth array or FRACTAL ADSORPTION structure or class small intestine wall construction, are had in test tube
Smooth bottom surface 3, adsorption structure 2 are arranged in test tube lower part, are additionally provided with as shown in Fig. 2, in test tube convenient for accelerating blood blood cell
The groove structure 4 of discharge, the top that adsorption structure 2 is arranged in of the groove structure 4 are equipped with two or more in groove structure 4
Around the groove 6 of inboard wall of test tube setting, groove 6 extends to test tube mouth by the top of adsorption structure along test tube central axes.
6 or 8 V-grooves 6 that groove structure 4 described in the utility model is preferably uniformly arranged around inboard wall of test tube are adjacent
Boss surface between groove 6 is convexly curved, convenient for accelerating blood or blood cell discharge.
Test tube main body 1 described in the utility model is integrally formed using heparin modified high molecular material, or is used and repaired by heparin
It adorns in the insertion common test tube of embedded type structure made of high molecular material, the heparin modified high molecular material is heparin modified poly-
Ethylene or heparin modified polypropylene or heparin modified PVC or heparin modified polyurethane.
The utility model is equipped with annular outer platform 5 in order to hold and handle, in test tube mouth outer wall, and is equipped on test tube mouth
Pipe close.
The cone cell teeth that tooth array in adsorption structure described in the utility model is spaced by altitude range for 0.5-2 millimeters,
It is formed by the strip groove structural arrangement that distance range is 1-3 millimeters deep, wherein ditch piston ring land is equipped with extra projection or groove
To increase surface area；Wherein tooth array is formed by sawtooth unit repeated arrangement, and the sawtooth unit is successively arranged from top to bottom
The different V-type tooth of 3-6 length, the length of preferably three V-type teeth are gradually reduced from top to bottom.
Pore diameter range is 0.05-0.5mm, hole depth range in porous structure in adsorption structure described in the utility model
For 0.05-0.5mm.
Embodiment 1:
A kind of test tube for the acquisition of blood excretion body is equipped with test tube main body 1, and inboard wall of test tube, which has, uses heparin modified height
Adsorption structure 2 made of molecular material, the adsorption structure are porous structure, have smooth bottom surface 3, adsorption structure in test tube
2 settings are additionally provided with the groove structure 4 convenient for accelerating the discharge of blood blood cell in test tube lower part, test tube, and the groove structure 4 is set
It sets and is equipped with two or more the grooves 6 around inboard wall of test tube setting in the top of adsorption structure 2, groove structure 4, groove 6 is along test tube
Central axes extend to test tube mouth by the top of adsorption structure；8 V-type ditches that the groove structure 4 is uniformly arranged around inboard wall of test tube
Slot 6, the boss surface between adjacent groove 6 are convexly curved, convenient for accelerating blood or blood cell discharge；The test tube main body
1 is integrally formed using heparin modified high molecular material, or embedding using the embedded type structure made of heparin modified high molecular material
Enter in common test tube, the heparin modified high molecular material is heparin modified PE or heparin modified PVC；In order to hold and handle,
It is equipped with annular outer platform 5 in test tube mouth outer wall, and is equipped with pipe close on test tube mouth；
As shown in Fig. 3, when adsorption structure is porous structure, pore diameter range 0.05-0.5mm, hole depth range are
Blood to be processed is added in test tube when in use by 0.05-0.5mm, and additional amount is 5-10 milliliters；Test tube is shaken, is made in test tube
Sample comes into full contact with the adsorption structure on inboard wall of test tube；Examination liquid in pipe of toppling over that treated, at this time the excretion body in sample
Vesica substance is attached on the adsorption structure on inboard wall of test tube；Tube wall is carefully cleaned multiple times with phosphate buffer；To in step 4
Appropriate excretion body cracking is added in test tube and RNA extracts reagent trizol, and heparin hydrolase or 8 mol/L chlorinations are either added
Sodium solution dissociates excretion body and carries out analysis of protein；It is settled by nucleic acid and obtains nucleic acid substances, or pass through antibody binding assay egg
Bai Chengfen and content.
Embodiment 2:
The utility model proposes a kind of test tubes for the acquisition of blood excretion body, are equipped with test tube main body 1, inboard wall of test tube tool
Have using adsorption structure 2 made of heparin modified high molecular material, the adsorption structure is tooth array, is had in test tube smooth
Bottom surface 3, adsorption structure 2 be arranged in test tube lower part, be additionally provided with as shown in Fig. 2, in test tube convenient for accelerate blood blood cell discharge
Groove structure 4, the top that adsorption structure 2 is arranged in of the groove structure 4 is equipped with two or more in groove structure 4 around examination
The groove 6 of inside pipe wall setting, groove 6 extend to test tube mouth by the top of adsorption structure along test tube central axes；The groove structure 4
It is preferred that the boss surface between 6 or 8 V-grooves 6 that inboard wall of test tube is uniformly arranged, adjacent groove 6 is in the arc of evagination
Shape, convenient for accelerating blood or blood cell discharge；The test tube main body 1 is integrally formed using heparin modified high molecular material, or is used
The embedded type structure made of heparin modified high molecular material is embedded in common test tube, and the heparin modified high molecular material is liver
Element modification PE or heparin modified PVC；In order to hold and handle, it is equipped with annular outer platform 5 in test tube mouth outer wall, and on test tube mouth
Equipped with pipe close.
The cone cell teeth that tooth array in adsorption structure described in the utility model is spaced by altitude range for 0.5-2 millimeters,
It is formed by the strip groove structural arrangement that distance range is 1-3 millimeters deep, wherein ditch piston ring land is equipped with extra projection or groove
To increase surface area；Wherein tooth array is formed by sawtooth unit repeated arrangement, and the sawtooth unit is successively arranged from top to bottom
The different V-type tooth of 3-6 length, the length of 3-6 V-type tooth are gradually reduced from top to bottom.
As shown in Fig. 3, when adsorption structure is tooth array, tooth array is made of more than two sawtooth units, each
Sawtooth unit includes three V-type teeth being arranged from top to bottom；When in use, blood to be processed is added in test tube, additional amount is
5-10 milliliters；Test tube is shaken, comes into full contact with sample in test tube with the adsorption structure on inboard wall of test tube；Test tube of toppling over that treated
Interior liquid, the excretion somatocyst bubble substance in sample is attached on the adsorption structure on inboard wall of test tube at this time；Use phosphate buffer
Tube wall is carefully cleaned multiple times；Appropriate excretion body cracking is added to test tube in step 4 and RNA extracts reagent Trizol, or is added
Heparin hydrolase or 8 mol/L sodium chloride solutions dissociation excretion body carry out analysis of protein；It is settled by nucleic acid and obtains nucleic acid object
Matter, or pass through antibody binding assay protein ingredient and content.
Embodiment 3:
The utility model extracts excretion body particle size results in fetal calf serum with ultracentrifugation method and is compared as follows:
As shown in Fig. 5, using excretion body particle diameter distribution obtained by existing ultracentrifugation method as schemed, what this method obtained
Excretion body partial size be (median ± s.d., nm) 71.0 ± 8.1, using as cuvette construction recorded in above-described embodiment 1 it is separated
Excretion body grain size distribution it is as shown in Fig. 6, excretion body partial size be (median ± s.d., nm) 73.4 ± 9.4；Using as above
It is as shown in Fig. 7 to state the separated excretion body grain size distribution of cuvette construction in embodiment 2, is (median ± s.d., nm)
73.8±9.7。
From the above results, excretion body is separated using cuvette construction recorded in the application, can largely guaranteed outer
It secretes somatocyst bubble not to be damaged, disintegrate-quality increases relative to ultracentrifugation method.
The utility model extracts excretion body purity result in fetal calf serum with ultracentrifugation method and is compared as follows:
Wherein excretion bulk concentration calculation method is as follows: concentration standards concentration is denoted as " C1 ", the dilution times of concentration standards
Number scale is " D1 "；Sample to be tested concentration is denoted as " C2 ", and the extension rate of sample to be tested is denoted as " D2 "；Concentration standards detect particle
Number scale is " Q1 ", and product to be tested detection granule number is denoted as " Q2 ", and product to be tested blank control detection granule number is denoted as " Q3 ", then (C1/
D1)/(C2/D2)=Q1/ (Q2-Q3), (C1=2.30x10^11/ml, D1=400, D2=100, Q1=6122, Q3Surpass from=
713, Q3Embodiment 1-2=816).
It is that green is glimmering that attached drawing 8, which is using excretion bulk concentration FITC-SS two dimension scatter plot obtained by existing ultracentrifugation method,
Light-scattering light two dimension scatter plot, gained excretion bulk concentration are 3.78x10^10 (a/ml), and attached drawing 9 is using 1 pilot scale of embodiment
The separated excretion bulk concentration FITC-SS two dimension scatter plot of pipe structure, gained excretion bulk concentration is 4.91x10^10 (a/ml), attached
Figure 10 is using the separated excretion bulk concentration FITC-SS two dimension scatter plot of cuvette construction in embodiment 2, and gained excretion bulk concentration is
(5.15x10^10 a/ml).
From the above results, the separation of excretion body acquired in documented technical solution concentration is not less than now in the application
Some ultracentrifugation methods.
The utility model there is acquisition to facilitate timely compared with the prior art and design, structurally reasonable, easy to operate etc. aobvious
The advantages of work.
Claims (8)
1. a kind of test tube for the acquisition of blood excretion body, is equipped with test tube main body, it is characterised in that inboard wall of test tube, which has, uses liver
Specific surface area made of plain modified macromolecule material increases 10 times or more of adsorption structure, and adsorption structure is arranged in test tube lower part.
2. a kind of test tube for the acquisition of blood excretion body according to claim 1, it is characterised in that the adsorption structure
For porous structure or tooth array or FRACTAL ADSORPTION structure or class small intestine wall construction.
3. a kind of test tube for the acquisition of blood excretion body according to claim 1, it is characterised in that be additionally provided in test tube
Convenient for accelerating the groove structure of blood blood cell discharge, the top that adsorption structure is arranged in of the groove structure, in groove structure
Groove equipped with two or more around inboard wall of test tube setting, groove extend to test tube by the top of adsorption structure along test tube central axes
Mouthful.
4. a kind of test tube for the acquisition of blood excretion body according to claim 3, it is characterised in that the groove structure
6-16 V-groove being uniformly arranged around inboard wall of test tube, the boss surface between adjacent groove are convexly curved, convenient for plus
Fast blood or blood cell discharge.
5. a kind of test tube for the acquisition of blood excretion body according to claim 1, it is characterised in that have light in test tube
Sliding bottom surface.
6. a kind of test tube for the acquisition of blood excretion body according to claim 1, it is characterised in that the adsorption structure
In class small intestine wall construction refer to that inboard wall of test tube is equipped with the policae circulane that specific surface area increases 10 times or more.
7. a kind of test tube for the acquisition of blood excretion body according to claim 2, it is characterised in that the adsorption structure
In tooth array by altitude range be 0.5-2 millimeter interval cone cell teeth, by distance range be 1-3 millimeters deep bar shaped
Groove structure rearranges, and wherein ditch piston ring land is equipped with extra projection or groove to increase surface area；Wherein tooth array is by sawtooth
Unit repeated arrangement is formed, and the sawtooth unit is successively arranged the different V-type tooth of 3-6 length, 3-6 V-type tooth from top to bottom
Length be gradually reduced from top to bottom.
8. a kind of test tube for the acquisition of blood excretion body according to claim 2, it is characterised in that the adsorption structure
In porous structure in pore diameter range be 0.05-0.5mm, hole depth range is 0.05-0.1mm, aperture shape is circular hole or ellipse
Round hole or square hole or elongate holes or tri-angle-holed or pentagon hole or hexagonal hole.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201821358760.XU CN208888247U (en) | 2018-08-22 | 2018-08-22 | Test tube for the acquisition of blood excretion body |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201821358760.XU CN208888247U (en) | 2018-08-22 | 2018-08-22 | Test tube for the acquisition of blood excretion body |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN208888247U true CN208888247U (en) | 2019-05-21 |
Family
ID=66509626
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201821358760.XU Withdrawn - After Issue CN208888247U (en) | 2018-08-22 | 2018-08-22 | Test tube for the acquisition of blood excretion body |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN208888247U (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109116010A (en) * | 2018-08-22 | 2019-01-01 | 威海纽兰生物科技有限公司 | Test tube and excretion body separation method for the acquisition of blood excretion body |
-
2018
- 2018-08-22 CN CN201821358760.XU patent/CN208888247U/en not_active Withdrawn - After Issue
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109116010A (en) * | 2018-08-22 | 2019-01-01 | 威海纽兰生物科技有限公司 | Test tube and excretion body separation method for the acquisition of blood excretion body |
| CN109116010B (en) * | 2018-08-22 | 2023-11-21 | 威海纽兰生物科技有限公司 | Test tube for blood exosome collection and exosome separation method |
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