CN208494186U - A kind of lipid reactor according - Google Patents

A kind of lipid reactor according Download PDF

Info

Publication number
CN208494186U
CN208494186U CN201820800340.6U CN201820800340U CN208494186U CN 208494186 U CN208494186 U CN 208494186U CN 201820800340 U CN201820800340 U CN 201820800340U CN 208494186 U CN208494186 U CN 208494186U
Authority
CN
China
Prior art keywords
agitating shaft
cylinder
stirring
lipid
cover
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN201820800340.6U
Other languages
Chinese (zh)
Inventor
朱瑶俊
孙成
佘奥
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CHANGZHOU KINYOND PHARMACEUTICAL MANUFACTURING Co Ltd
Original Assignee
CHANGZHOU KINYOND PHARMACEUTICAL MANUFACTURING Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by CHANGZHOU KINYOND PHARMACEUTICAL MANUFACTURING Co Ltd filed Critical CHANGZHOU KINYOND PHARMACEUTICAL MANUFACTURING Co Ltd
Priority to CN201820800340.6U priority Critical patent/CN208494186U/en
Application granted granted Critical
Publication of CN208494186U publication Critical patent/CN208494186U/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Abstract

The utility model discloses a kind of lipid reactor according, belong to field of pharmaceutical equipment, being intended to provide one kind enables raw material and the well-mixed lipid reactor according of dispersion liquid, the encapsulation rate of liposome is poor caused by solve the problems, such as because of raw material and dispersion liquid undercompounding, its drip irrigation device is as follows, a kind of lipid reactor according, including rack, cylinder is installed in the rack, cover is equipped with above the cylinder, the cover is equipped with feed inlet, the bottom of the cylinder is equipped with discharge port, it is characterized in that: being rotatably connected to agitating shaft in the middle part of the cover, the upper end of the agitating shaft is equipped with the driving assembly of driving agitating shaft rotation, the cover is equipped with fixed frame, the driving component is mounted on fixed frame;Mixing component is fixedly connected on the agitating shaft, the mixing component is located in cylinder, and the agitating shaft, which is located at below mixing component, is fixedly connected with gas injection assembly.The formation that the utility model is suitable for liposome is reacted.

Description

A kind of lipid reactor according
Technical field
The utility model relates to reactor, in particular to a kind of lipid reactor according.
Background technique
Reactor is the container physically or chemically reacted, by the structure design and parameter configuration to container, realizes technique It is required that heating, evaporation, cooling and low high speed mixed function, be widely used in petroleum, chemical industry, rubber, pesticide, dyestuff, The industries such as medicine and food.
Existing medicinal liposome two-phase dispersion method production technology is all using organic solvent to phosphatide, sterol and liposoluble Property active matter dissolved, then recycle organic solvent with boulton process, and formed and be enclosed with the rouge of liposoluble active composition Plastid.The production process of this method needs to stir mixed raw material and dispersion liquid, will affect lipid if stirring is uneven The encapsulation rate of body, to influence the quality of drug.
Utility model content
The purpose of the utility model is to provide a kind of lipid reactor according, and having enables raw material to be sufficiently mixed with dispersion liquid The advantages of.
The above-mentioned technical purpose of the utility model has the technical scheme that
A kind of lipid reactor according, including rack are equipped with cylinder in the rack, are equipped with cover above the cylinder, The cover is equipped with feed inlet, and the bottom of the cylinder is equipped with discharge port, is equipped with mixing component, the stirring in the cylinder Component and cover are rotatablely connected, and gas injection assembly, the gas injection assembly and stirring group are equipped with below the mixing component Part coaxial arrangement, the mixing component top are equipped with the driving assembly of driving mixing component and gas injection assembly rotation.
By using above-mentioned technical proposal, driving assembly driving mixing component and gas injection assembly are rotated, and are stirred Component can be stirred the intracorporal raw material of cylinder with dispersion liquid, be sufficiently mixed raw material and dispersion liquid, thus after improving mixing Encapsulation rate of the liposome of formation during following process, and then improve the quality of drug.Gas injection assembly can be into one The disturbance for walking raw material and dispersion liquid in reinforced tube, to further increase the mixed effect of raw material and dispersion liquid.
Further, the mixing component includes agitating shaft, installation sleeve and the stirring with installation sleeve coaxial arrangement Ring, the agitating shaft are fixedly connected with driving assembly and are rotatablely connected with cover, and the installation sleeve is fixedly connected with agitating shaft;
Several stirring blades, several stirring blades are equipped in the annular region that the installation sleeve and stirring ring are formed Along installation sleeve outer wall circumference array and be obliquely installed, it is described stirring blade one end fixed with installation sleeve, the other end with stir Ring is mixed to fix;
The stirring ring periphery is uniformly provided with staggered stirring blade up and down.
By using above-mentioned technical proposal, agitating shaft rotation be able to drive stirring blade and stirring blade simultaneously to raw material with Dispersion liquid is stirred, stir blade be obliquely installed when both being capable of increasing stirring and the contact surface between raw material and dispersion liquid The disturbance in raw material and dispersion liquid axial direction is accumulated and can be enhanced, the intracorporal raw material of cylinder and dispersion liquid circulation stirring are enable, thus So that the mixing effect of raw material and dispersion liquid is more uniform, to further increase the mixed effect of raw material and dispersion liquid.
Further, agitating shaft periphery Circle-Array shows several rectangular stirring frames, and the stirring frame is located at stirring Above ring.
By using above-mentioned technical proposal, stirring frame also can simultaneously be stirred raw material and dispersion liquid when agitating shaft rotates It mixes, stirring frame can further enhance the raw material of cylinder internal upper part and the longitudinal of dispersion liquid disturbs, and make the intracorporal raw material of cylinder and divide Dispersion liquid, which is able to carry out, to be sufficiently stirred, to improve the mixing efficiency and mixed effect of raw material and dispersion liquid.
Further, vertical scraper plate, side and cylinder of the scraper plate far from stirring frame are equipped on the outside of the stirring frame Inner wall contradict.
By using above-mentioned technical proposal, the inner wall of scraper plate side and cylinder is contradicted, and scraper plate is rotated together with stirring frame When rotation scraping is carried out to cylinder inboard wall, make the inner wall of cylinder be less prone to raw material or dispersion liquid wall built-up or residual it is existing As enabling raw material to be sufficiently mixed with dispersion liquid, to improve packet of the liposome formed after mixing during following process Envelope rate, and then improve the quality of drug.
Further, outer its axisymmetrical of lateral edge of the agitating shaft is equipped with defoaming plate, and the defoaming plate is located at stirring frame Top;
The defoaming plate lower end surface is fixedly connected with several defoaming sticks being uniformly arranged along its length.
By using above-mentioned technical proposal, the bubble generated in raw material and dispersion liquid mixed process can be stabbed by defoaming stick It is broken, mix raw material with dispersion liquid more preferably, thus encapsulation rate when improving liposomal encapsulated.
Further, the gas injection assembly includes gas storage ring and air nozzle;
The gas storage ring is fixed and is connected to agitating shaft lower end, and several air nozzle circumference array are in the outer of gas storage ring Week;
For the agitating shaft in hollow, the upper end of the agitating shaft is rotatably connected to lock chamber, the lock chamber and agitating shaft Inner cavity connection, the side wall of the lock chamber is communicated with air inlet pipe;
Escape pipe is fixedly connected on the cover, the escape pipe is connected to cylinder.
By using above-mentioned technical proposal, compressed gas enters the inner cavity of agitating shaft through air inlet pipe, subsequently into gas storage ring, Compressed gas in gas storage ring is sprayed from air nozzle, enhances the disturbance of raw material and dispersion liquid, is made the intracorporal raw material of cylinder and is divided Dispersion liquid, which is able to carry out, to be sufficiently mixed, to improve the mixing efficiency and mixed effect of raw material and dispersion liquid.
Further, the opening of the air nozzle is in being staggered up and down, the emanated stream of air nozzle it is oppositely oriented.
By using above-mentioned technical proposal, this unique design method can make air-flow while up and down eddy flow, This makes it possible to enhancings simultaneously to be located at raw material and dispersion liquid disturbance above and below gas storage ring, make the intracorporal raw material of cylinder and dispersion Liquid, which is able to carry out, to be sufficiently mixed, to improve the mixing efficiency and mixed effect of raw material and dispersion liquid.
Further, the aperture of the air nozzle is 2mm~5mm.
By using above-mentioned technical proposal, the aperture of air nozzle, which is set as 2mm~5mm, can guarantee compressed gas through jet Mouth has biggish blast pressure after spraying, to enable the intracorporal raw material of cylinder to come into full contact with dispersion liquid, to improve original The mixing efficiency and mixed effect of material and dispersion liquid.
Further, a lateral contract of the air nozzle far from tubular axis.
By using above-mentioned technical proposal, compressed gas is more concentrated from the gas pressure after air nozzle ejection, further Improve the mixing efficiency and mixed effect for improving raw material and dispersion liquid.
Further, observation window is provided on the cover, the cover side opposite with observation window is provided with illumination Lamp.
By using above-mentioned technical proposal, under the irradiation of headlamp, material can be clearly seen from observation window Situation is mixed, it is easy to operate without opening cover.
In conclusion the utility model has the following beneficial effects:
1. using mixing component, so that raw material is sufficiently mixed with dispersion liquid, improve the mixing of raw material and dispersion liquid Efficiency and mixed effect;
2. using gas injection assembly, it is more fully mixed raw material with dispersion liquid, further improves raw material and divide The mixing efficiency and mixed effect of dispersion liquid.
Detailed description of the invention
Fig. 1 is in embodiment for embodying the connection relationship diagram between cylinder, cover and agitating shaft;
Fig. 2 is to close in embodiment for embodying the connection between installation sleeve, stirring blade, stirring ring and stirring blade It is schematic diagram.
In figure, 1, rack;2, cylinder;21, discharge port;3, cover;31, feed inlet;32, observation window;33, headlamp;34, Fixed frame;4, mixing component;41, installation sleeve;42, ring is stirred;421, blade is stirred;422, stirring blade;43, lock chamber; 5, agitating shaft;51, stirring frame;511, scraper plate;52, plate is defoamed;521, stick is defoamed;6, gas injection assembly;61, gas storage ring;62, Air nozzle;63, air inlet pipe;64, escape pipe;7, driving assembly;71, motor;72, speed reducer.
Specific embodiment
The utility model is described in further detail below in conjunction with attached drawing.
Wherein identical components are presented with like reference characters.It should be noted that word used in the following description Language "front", "rear", "left", "right", "up" and "down" refer to the direction in attached drawing, word " bottom surface " and " top surface ", "inner" and "outside" refers respectively to the direction towards or away from geometric center of specific component.
A kind of lipid reactor according is equipped with cylinder 2 in rack 1, is equipped with above cylinder 2 as shown in Figure 1, including rack 1 Cover 3 is provided with observation window 32 on cover 3, and the side opposite with observation window 32 of cover 3 is provided with headlamp 33, and cover 3 is located at Feed inlet 31 is equipped with by observation window 32, the bottom of cylinder 2 is equipped with discharge port 21.
As shown in Figure 1, cover 3 is equipped with fixed frame 34, be rotatably connected to agitating shaft 5 in the middle part of cover 3, agitating shaft 5 it is upper End is equipped with the driving assembly 7 that driving agitating shaft 5 rotates, and driving assembly 7 is mounted on fixed frame 34.Driving assembly 7 includes electricity The rotor of machine 71 and speed reducer 72, motor 71 is connect by speed reducer 72 with agitating shaft 5, under the driving effect of motor 71, is made Agitating shaft 5 rotates, and is stirred to raw material and dispersion liquid.
As shown in Fig. 2, being fixedly connected with mixing component 4 on agitating shaft 5, and mixing component 4 is located at cylinder 2(referring to Fig. 1) It is interior.Mixing component 4 includes installation sleeve 41 and the stirring ring 42 with the coaxial arrangement of installation sleeve 41.Installation sleeve 41 and agitating shaft 5 are fixedly connected, and are equipped with several stirring blades 421, several agitating paddles in the annular region of installation sleeve 41 and the stirring formation of ring 42 Piece 421 is along 41 outer wall circumference array of installation sleeve and is obliquely installed, and one end and the installation sleeve 41 for stirring blade 421 are fixed, separately One end and stirring ring 42 are fixed.Stirring 42 periphery of ring is uniformly provided with staggered stirring blade 422 up and down.It stirs blade 421 and stirs It mixes blade 422 while raw material and dispersion liquid is stirred, raw material can be enhanced and divide by stirring blade 421 and stirring blade 422 Disturbance in dispersion liquid axial direction enables raw material in cylinder 2 and dispersion liquid circulation stirring, so that raw material and dispersion liquid stir Mix that effect is more uniform, to further increase the mixed effect of raw material and dispersion liquid.
As shown in Fig. 2, in order to make cylinder 2(referring to Fig. 1) internal upper part raw material and dispersion liquid be more fully mixed, agitating shaft 5 periphery Circle-Arrays show several rectangular stirring frames 51, and stirring frame 51 is located at 42 top of stirring ring.Stirring frame 51 can be further Enhance raw material and the longitudinal of dispersion liquid disturbs, is able to carry out the raw material in cylinder 2 with dispersion liquid and is sufficiently stirred, to improve The mixing efficiency and mixed effect of raw material and dispersion liquid.
As shown in Fig. 2, being equipped with vertical scraper plate 511, side and cylinder of the scraper plate 511 far from stirring frame 51 on the outside of stirring frame 51 Body 2(is referring to Fig. 1) inner wall contradict.Scraper plate 511 makes cylinder with rotation scraping is carried out to 2 inner wall of cylinder when stirring frame 51 rotates The inner wall of body 2 is less prone to the wall built-up and residual phenomena of raw material or dispersion liquid, and raw material is enable to be sufficiently mixed with dispersion liquid, from And encapsulation rate of the liposome formed after mixing during following process is improved, and then improve the quality of drug.
As depicted in figs. 1 and 2, agitating shaft 5, which is located at below mixing component 4, is fixedly connected with gas injection assembly 6.Gas spray Penetrating component 6 includes gas storage ring 61 and air nozzle 62, and for agitating shaft 5 in hollow, the upper end of agitating shaft 5 is rotatably connected to lock chamber 43, Lock chamber 43 is connected to the inner cavity of agitating shaft 5, and the side wall of lock chamber 43 is communicated with air inlet pipe 63.It is fixedly connected with out on cover 3 Tracheae 64 and escape pipe 64 is connected to cylinder 2.Gas storage ring 61 is fixed and is connected to 5 lower end of agitating shaft, several 62 circumference of air nozzle Array in the periphery of gas storage ring 61, the opening of air nozzle 62 in being staggered up and down, the emanated stream of air nozzle 62 it is oppositely oriented, The aperture of air nozzle 62 is 2mm~5mm, a lateral contract of the air nozzle 62 far from 2 axis of cylinder.Agitating shaft 5 rotates, jet Mouth 62 can also rotate with it, to make air-flow in air nozzle 62 at injection twist, be conducive to enhance raw material and dispersion liquid Disturbance.
As shown in Fig. 2, 5 its axisymmetrical of outer lateral edge of agitating shaft is equipped with defoaming plate 52, defoaming plate 52 is located at stirring frame 51 Top.Defoaming 52 lower end surface of plate is fixedly connected with several defoaming sticks 521 being uniformly arranged along its length.Defoam 521 energy of stick It is enough to poke the bubble generated in raw material and dispersion liquid mixed process, mix raw material with dispersion liquid more preferably, to improve lipid Encapsulation rate when body is encapsulated.
Specific implementation process: being passed through compressed gas in air inlet pipe 63, and the agitated axis 5 of compressed gas enters gas storage ring 61, Then it is sprayed from air nozzle 62, air is driven out of out of cylinder 2, raw material and dispersion liquid are put into cylinder 2, motor from feed inlet 31 The rotor rotation of 71 work, motor 71 drives agitating shaft 5 to rotate, and the rotation of agitating shaft 5 drives stirring blade 421, stirring ring 42, stirs Blade 422 and stirring frame 51 is mixed to rotate, in cylinder 2 raw material and dispersion liquid be stirred, meanwhile, scraper plate 511 and disappear It steeps stick 521 also to rotate and rotate with agitating shaft 5, scraper plate 511 clears up the inner wall of cylinder 2 in real time, and defoaming stick 521 can The foam generated to liposome reactor reaction process is eliminated in time.In the process, air inlet pipe 63 is continually fed into compression Gas stops being passed through compressed gas to air inlet pipe 63, make in gas storage ring 61 not after liposome is completely exhausted out from discharge port 21 It tends to have raw material and dispersion liquid enters.
This specific embodiment is only the explanation to the utility model, is not limitations of the present invention, ability Field technique personnel can according to need the modification that not creative contribution is made to the present embodiment after reading this specification, but As long as all by the protection of Patent Law in the scope of the claims of the utility model.

Claims (10)

1. a kind of lipid reactor according, including rack (1), it is equipped with cylinder (2) on the rack (1), above the cylinder (2) Equipped with cover (3), the cover (3) is equipped with feed inlet (31), and the bottom of the cylinder (2) is equipped with discharge port (21), special Sign is: being rotatably connected to agitating shaft (5) in the middle part of the cover (3), the upper end of the agitating shaft (5) is equipped with driving agitating shaft (5) The driving assembly (7) of rotation, the cover (3) are equipped with fixed frame (34), and the driving component (7) is mounted on fixed frame (34) On;
It is fixedly connected with mixing component (4) on the agitating shaft (5), the mixing component (4) is located in cylinder (2), described to stir It mixes axis (5) and is located at below mixing component (4) and be fixedly connected with gas injection assembly (6).
2. a kind of lipid reactor according according to claim 1, it is characterized in that: the mixing component (4) includes installation set Cylinder (41), the stirring ring (42) with installation sleeve (41) coaxial arrangement, the installation sleeve (41) and agitating shaft (5) are fixed and are connected It connects;
Several stirring blades (421), Ruo Gansuo are equipped in the annular region that the installation sleeve (41) and stirring ring (42) are formed Stirring blade (421) is stated along installation sleeve (41) outer wall circumference array and to be obliquely installed, one end of stirring blade (421) with Installation sleeve (41) is fixed, and the other end and stirring ring (42) are fixed;
Stirring ring (42) periphery is uniformly provided with staggered stirring blade (422) up and down.
3. a kind of lipid reactor according according to claim 2, it is characterized in that: the agitating shaft (5) periphery circumference array There are several rectangular stirring frames (51), the stirring frame (51) is located above stirring ring (42).
4. a kind of lipid reactor according according to claim 3, it is characterized in that: being equipped with vertically on the outside of the stirring frame (51) Scraper plate (511), the scraper plate (511) far from stirring frame (51) side and cylinder (2) inner wall contradict.
5. a kind of lipid reactor according according to claim 4, it is characterized in that: its axis of the agitating shaft (5) outer lateral edge It is symmetrically arranged with defoaming plate (52), defoaming plate (52) is located at the top of stirring frame (51);
Described defoaming plate (52) lower end surface is fixedly connected with several defoaming sticks (521) being uniformly arranged along its length.
6. a kind of lipid reactor according according to claim 1, it is characterized in that: the gas injection assembly (6) includes storage Compression ring (61) and air nozzle (62);
The gas storage ring (61) is fixed and is connected to agitating shaft (5) lower end, and several air nozzle (62) circumference array are in gas storage The periphery of ring (61);
For the agitating shaft (5) in hollow, the upper end of the agitating shaft (5) is rotatably connected to lock chamber (43), the lock chamber (43) it is connected to the inner cavity of agitating shaft (5), the side wall of the lock chamber (43) is communicated with air inlet pipe (63);
It is fixedly connected with escape pipe (64) on the cover (3), the escape pipe (64) is connected to cylinder (2).
7. a kind of lipid reactor according according to claim 6, it is characterized in that: the opening of the air nozzle (62) is in up and down Be staggered, the emanated stream of the air nozzle (62) it is oppositely oriented.
8. a kind of lipid reactor according according to claim 7, it is characterized in that: the aperture of the air nozzle (62) is 2mm ~5mm.
9. a kind of lipid reactor according according to claim 8, it is characterized in that: the air nozzle (62) is far from cylinder (2) The lateral contract of the one of axis.
10. a kind of lipid reactor according as claimed in any of claims 1 to 9, it is characterized in that: the cover (3) On be provided with observation window (32), the cover (3) and observation window (32) opposite side are provided with headlamp (33).
CN201820800340.6U 2018-05-25 2018-05-25 A kind of lipid reactor according Active CN208494186U (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201820800340.6U CN208494186U (en) 2018-05-25 2018-05-25 A kind of lipid reactor according

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201820800340.6U CN208494186U (en) 2018-05-25 2018-05-25 A kind of lipid reactor according

Publications (1)

Publication Number Publication Date
CN208494186U true CN208494186U (en) 2019-02-15

Family

ID=65293752

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201820800340.6U Active CN208494186U (en) 2018-05-25 2018-05-25 A kind of lipid reactor according

Country Status (1)

Country Link
CN (1) CN208494186U (en)

Similar Documents

Publication Publication Date Title
CN106475021A (en) A kind of gas-liquid mixed reactor of the chemical industry with gas concentration unit
CN210425878U (en) Bipyramid drying device
CN208494023U (en) Two-dimensional mixing machine
CN208642443U (en) A kind of lithium battery electrolytes agitating device
CN207002460U (en) A kind of pharmaceutical factory equipment for separating liquid from solid
CN211913790U (en) Reation kettle that stirring effect is good
CN111389246A (en) Shear mixing part and vacuum mixer using same
CN208494186U (en) A kind of lipid reactor according
CN206285849U (en) A kind of liquid preparation feedway and pipeline kneading machine
CN108499390A (en) A kind of antisiludging injecting type mixing apparatus of chemical industry feed liquid
CN206381996U (en) A kind of hydrogenation reaction cauldron
CN212882111U (en) Solid-liquid mixing device
CN204079968U (en) A kind of fermentor tank with guide shell
CN103240019A (en) Circulating liquid medicine granule disperser
CN203899522U (en) Efficient rotary liquid mixing device
CN206996587U (en) A kind of reactor for mixing liquid
CN207237355U (en) Continous way infiltration apparatus
CN208406681U (en) A kind of novel dispensing tank
CN207708999U (en) It is sufficiently mixed the high-speed mixer of material
CN204865655U (en) Feed mixer
CN109277072A (en) Aqueous Adhesives reaction kettle
CN211133603U (en) Nitrogen stirring device for stirring surfactant
CN211837855U (en) Reation kettle agitating unit for pharmacy
CN211537417U (en) Powder-liquid proportioning machine for false tooth manufacturing
CN210934819U (en) Matching liquid stirring device based on purple bamboo salt product

Legal Events

Date Code Title Description
GR01 Patent grant
GR01 Patent grant