CN208071272U - The automatic Kaifeng feeding system of aseptic medicine packaging - Google Patents

The automatic Kaifeng feeding system of aseptic medicine packaging Download PDF

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Publication number
CN208071272U
CN208071272U CN201820455005.7U CN201820455005U CN208071272U CN 208071272 U CN208071272 U CN 208071272U CN 201820455005 U CN201820455005 U CN 201820455005U CN 208071272 U CN208071272 U CN 208071272U
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China
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unit
frame
main
cylinder
feeding
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CN201820455005.7U
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何国强
陈跃武
康国利
董书平
李晓瑞
李福�
李�浩
马敏肖
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AUSTAR PHARMACEUTICAL EQUIPMENT (SHIJIAZHUANG) Co Ltd
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AUSTAR PHARMACEUTICAL EQUIPMENT (SHIJIAZHUANG) Co Ltd
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Abstract

The utility model provides a kind of automatic Kaifeng feeding system of aseptic medicine packaging, including PLC control unit, main body frame, filter element, over cap unit, open interior cap unit, weighing unit, feed intake unit, the PLC control unit is connected with main body frame, the filter element is mounted on main body frame top, cap unit over described opens interior cap unit, weighing unit, the unit that feeds intake and is sequentially connected and connects, and it is all fixed in main body frame, weighing unit, which is located at, to be opened below interior cap unit, and rollgang is provided between cap unit and Kai Nei cap units over described.The present apparatus, which only needs sterile Aluminum Bottle being put into designated position, can be automatically performed the process of Aluminum Bottle uncap, feed intake, weighed; whole process is completed under the protection of A grades of parts RABS; and the process that feeds intake is simple, convenient and efficient; the process that feeds intake all closed docking, and the closed docking of position can be completed by controlling height and the vibrations of sterile Aluminum Bottle and completely fed intake.

Description

The automatic Kaifeng feeding system of aseptic medicine packaging
Technical field
The utility model is related to aseptic medicine production fields, and packing automatic Kaifeng more particularly, to a kind of aseptic medicine feeds intake System.
Background technology
In drug production process, to meet the regulation of GMP, it is often necessary to the sterile technique to feed intake be taken to carry out drug life Production especially in aseptic powdery during feeding intake, needs to use sterile charging technology.Technological process prepared by aseptic injection The generally preparation Yu processing, preparation, embedding, inspection of bulk pharmaceutical chemicals and packaging.Non-final sterilising prods use non-final sterilizing side The aseptic subpackaged injection of formula production, drug usually thermo-labile and that terminal sterilization cannot be carried out, so must especially emphasize Sterile working in drug production process.The sterile working in its production operation area should be strictly separated with non-sterile operation, Suo Youcong The material utensil that non-sterile operating space enters sterile working area has to pass through stringent sterilization, and producers should be by sterile procedures requirement Into the net program of pedestrian.
The preparation of sterile bulk drug and processing are a links important in aseptic powder injection injection production process.Current state The storage and transhipment of interior sterile bulk drug carry out in the sterile Aluminum Bottle of sealing.Enter powder needle split-charging after sterile Aluminum Bottle is sterilized Between, carry out dosing operation.Existing sterile feeding method is manually to open Aluminum Bottle outer cover and interior rubber plug, people under local-laminar protection Work docking turns over bucket and carries out the relevant operation that feeds intake, and laminar flow is a kind of air purification for the clean environment providing partial vertical one-way flow Unit ensures the cleanliness factor for reaching technological requirement in workspace.Local-laminar can play a certain protective role, but laminar flow Operation have it is inconvenient for operation, personnel's disturbing factor is more, comparatively laborious feature, in addition, for it is certain feed intake process time compared with Long product carries out the Manual material feeding still risk with larger microbial contamination using laminar flow, and personnel are in the process of uncapping In there are inconvenient for operation, the problems such as waste environment easy to pollute, the intensity that feeds intake is big.
The implementation of new edition GMP, proposes pharmacy corporation high requirement, and specified in more detail has been done to drugs manufacture equipment.It is required that straight It contacts the assembly after pharmaceutical packing material, utensil sterilizing and the transhipment under non-fully sealed position and storage is necessary It is A grades of environment;Transhipment and storage after immediate packaging materials, utensil sterilizing in closed container can be B Grade environment, the operation of high pollution risk are preferably completed in isolated operation device.And current domestic sterile powder feeding apparatus, exhausted big portion Divide without RABS and the function that feeds intake can not be automatically performed, is still maintained at level hand-manipulated.Based on present in sterile production The risk of product microbial contamination cannot be satisfied new edition GMP requirement, therefore develops and meet the sterile Aluminum Bottles of GMP requirements and uncap throwing Expect RABS (limitation disengaging barrier system).To promote the international competitiveness of China's medical product.
Utility model content
The utility model provides a kind of automatic Kaifeng feeding system of aseptic medicine packaging, solves that its technical solution is as follows It is described:
A kind of automatic Kaifeng feeding system of aseptic medicine packaging, including PLC control unit, main body frame, filter element, open Outer cap unit, open interior cap unit, weighing unit, feed intake unit, the PLC control unit is connected with main body frame, the mistake Filter unit and be mounted on main body frame top, it is described over cap unit, open interior cap unit, weighing unit, the unit that feeds intake and be sequentially connected Connect, and be all fixed in main body frame, weighing unit, which is located at, to be opened below interior cap unit, it is described over cap unit and Kai Nei cap units Between be provided with rollgang.
Lid cylinder over cap unit includes over described, over lid lifting cylinder, revolution telescopic cylinder, finger cylinder, solid Surely take lid cylinder, it is described over lid cylinder, revolution telescopic cylinder, it is fixed take lid cylinder to be mounted on main body frame, be respectively used to The outer aluminium lid of sterile Aluminum Bottle is uncapped, turn, is removed, it is described over lid lifting cylinder lid cylinders with over connect, use In the outer aluminium lid for tearing sterile Aluminum Bottle, the finger cylinder is connected with revolution telescopic cylinder, tears sterile Aluminum Bottle for turn Outer aluminium lid.
Described to open interior cap unit include vacuum cup, lifting cylinder, fixing bracket, and the vacuum cup is solid with lifting cylinder Fixed connection, lifting cylinder are fixedly connected with fixing bracket, and fixing bracket is fixedly connected with main body frame.
The weighing unit includes weighing unit, weighing sensor, fixing bracket, and weighing unit is fixed with weighing sensor to be connected It connects, weighing sensor is fixedly connected with fixing bracket, and fixing bracket is fixedly connected with main body frame.
The unit that feeds intake includes sterile baiting valve, slewing equipment, lifting gear, docking facilities, the sterile baiting valve It is fixedly connected with docking facilities, slewing equipment is fixedly connected with docking facilities, and lifting gear and slewing equipment and main body frame are solid Fixed connection.
The filter element includes plenum chamber, wind turbine, H14 high efficiency filter layers, homogenizing plate, in the plenum chamber, on to Under be disposed with wind turbine, H14 high efficiency filter layers, homogenizing plate.
The sterile baiting valve includes valve body, sealing ring, flap, actuator, and sealing ring is fixedly connected with valve body, flap with Valve body is hinged, and actuator is fixedly connected with flap, and valve body is fixedly connected with fixed arm.
The slewing equipment includes fixed arm, pivoted arm, power unit, fixed frame, and fixed arm is fixedly connected with pivoted arm, pivoted arm Hinged with power unit, power unit is fixedly connected with fixed frame, and fixed frame is fixedly connected with main body frame.
The lifting gear includes fixed frame, crane, driving member, power plant, and driving member is fixedly connected with fixed frame, Crane is fixedly connected with driving member, and power plant is fixedly connected with driving member, and fixed frame is fixedly connected with main body frame.
It is provided with electric terminal case below main body frame.
Package unit is completed under the effect of PLC control unit 1, is intervened without personnel, whole device is by top blower fan filtering Device group 3 provides sterile laminar flow protection, meets GMP requirements.
Compared with prior art, the present apparatus has the advantages that:
The sterile Aluminum Bottle that the present apparatus provides is uncapped charging device, and 1. pass through the 0.22 μm of offer of the sterile high efficiency particulate air filter group in top The clean environment of partial vertical one-way flow;2. people and object is separated by equipment blocking device, avoid interference from human factor;3. Automatic lid closing/opening is carried out to aseptic packaging Aluminum Bottle by providing sterile Aluminum Bottle hood-opening device to equipment, collects waste automatically;4. logical Sterile Aluminum Bottle, production are held in the setting for crossing the interface of sterile Aluminum Bottle discharge port, production containers feeding port and sterile feed valves both ends Device connects to form sealing system, reduces the risk of microbial contamination in the production process that feeds intake;5. package unit is controlled by PLC, entirely It is automatically performed the uncapping, feed intake of sterile Aluminum Bottle, weighing process;
The present apparatus, which only needs sterile Aluminum Bottle being put into designated position, can be automatically performed the work of Aluminum Bottle uncap, feed intake, weighed Sequence, it is whole to be completed under the protection of A grades of parts RABS, and the process that feeds intake is simple, convenient and efficient, the process that feeds intake is all closed right It connects, and the closed docking of position can be completed by controlling height and the vibrations of sterile Aluminum Bottle and completely fed intake.Device meets GMP It is required that keeping personnel and material completely isolated, the influence of operating personnel can be reduced to greatest extent, and environment is to production in reduction sterile production The risk of product microbial contamination, high degree of automation improve production efficiency, reduce labor intensity.
Description of the drawings
Figure 1A is the front schematic view of the automatic Kaifeng feeding system of aseptic medicine packaging;
Figure 1B is the side schematic view of the automatic Kaifeng feeding system of aseptic medicine packaging;
Fig. 2 is sterile Aluminum Bottle structure chart;
Fig. 3 is the structure chart of fan filter group;
Fig. 4 is out the schematic diagram of outer cover structure;
Fig. 5 is out the schematic diagram of interior cap unit;
Fig. 6 is the schematic diagram of weighing unit;
Fig. 7 is the structural schematic diagram of sterile baiting valve;
Fig. 8 is the structural schematic diagram of slewing equipment;
Fig. 9 is the structural schematic diagram of lifting gear;
Figure 10 be over lid mechanism front view;
Figure 11 be over lid mechanism left view.
Specific implementation mode
The problem of for being pointed out in background technology, the utility model are intended to provide a kind of sterile Aluminum Bottle and uncap charging device, A kind of RABS can be such that sterile Aluminum Bottle is automatically performed and uncap, and collect waste, form sealing docking system with production containers automatically, Completion accurately feeds intake, and reduces personnel's disturbing factor in the production process that feeds intake, reduces the risk of microbial contamination.
In order to achieve the above objectives, the technical solution adopted in the utility model is as follows:
As shown in FIG. 1A and 1B, a kind of sterile Aluminum Bottle is uncapped charging device, including:
PLC control unit 1, main body frame 2, FFU fan filters group 3, open interior cap unit 4, rollgang 5, over cover Cylinder 6, over lid lifting cylinder 7, revolution telescopic cylinder 8, finger cylinder 9, fixed take lid cylinder 10, outer cover collection box 11, electricity Gas terminal box 12, weighing unit 13, sterile baiting valve 14, slewing equipment 15, lifting gear 16, docking facilities 17.
Based on the device is by main body frame 2, PLC control unit 1 is connect with main body frame 2, FFU fan filters group 3 It is installed on 2 top of main body frame, interior cap unit 4 is opened and is connected with main body frame 2, rollgang 5 is fixedly connected with main body frame 2, Over lid cylinder 6 be connected with main body frame 2, over the lid cylinder 6 with over of lid lifting cylinder 7 be fixedly connected, turn round telescopic cylinder 8 It is fixedly connected with main body frame 2, finger cylinder 9 is fixedly connected with revolution telescopic cylinder 8, and fixation takes lid cylinder 10 and main body frame 2 are fixedly connected, and outer cover collection box 11 is fixedly connected with main body frame 2, and 10 lower section of lid cylinder, sterile baiting valve 14 are taken positioned at fixed Be fixedly connected with docking facilities 17, slewing equipment 15 is fixedly connected with docking facilities 17, lifting gear 16 and slewing equipment 15 and Main body frame 2 is fixedly connected, and electric terminal case 12 is located at 2 lower section of main body frame, and weighing unit 13 is fixed with main body frame 2 to be connected It connects, positioned at opening the lower section of interior cap unit 7.
As shown in Fig. 2, the sterile Aluminum Bottle includes outer aluminium lid 18, interior rubber plug cover 19 and bottle 20, interior rubber plug cover 19 is filled in Bottle opening 20, outer aluminium lid 18 fasten interior rubber plug cover 19 and bottle.
As shown in figure 3, the filter element uses fan filter group, structure includes plenum chamber 21, wind turbine 22, H14 High efficiency filter layer 23, homogenizing plate 24 in the plenum chamber 21, are disposed with wind turbine 22, H14 high efficiency filter layers from top to bottom 23, homogenizing plate 24, so for filtering air.
As shown in figure 4, in conjunction with Figure 10 and Figure 11, it is described in cap unit, over lid cylinder 6 be connected with main body frame 2, Over the lid cylinder 6 with over of lid lifting cylinder 7 be fixedly connected, specifically, over lid cylinder 6 front end with over lid promoted gas Cylinder 7 be connected, over lid lifting cylinder 7 front end be connected hook, revolution telescopic cylinder 8 be fixedly connected with main body frame 2, finger gas Cylinder 9 is fixedly connected with 8 front end of revolution telescopic cylinder, and fixation takes lid cylinder 10 to be fixedly connected with main body frame 2.
After Aluminum Bottle is put into out the rollgang designated position of interior cap unit 4, start PLC, fixation takes lid cylinder 10 with annular Fixed frame after starting action, is adjacent to Aluminum Bottle bottleneck position and fixes Aluminum Bottle, over lid lifting cylinder 7 act, by the outer aluminium of Aluminum Bottle The lid draw ring of lid 18 lifts, over lid cylinder 6 act, aluminium lid draw ring is torn into certain position, rotary cylinder 8 carries out back rotation Make, finger cylinder 9 is moved at the breach of outer aluminium lid 18, finger cylinder 9 act, outer aluminium lid 18 is strutted, over lid cylinder 6 Action, outer aluminium lid 18 is moved integrally, and is detached from Aluminum Bottle, will be outer under the action of fixing and taking lid cylinder 10 after outer aluminium lid 18 is detached from For aluminium lid 18 under the shifting of lid lifting cylinder 7, outer aluminium lid 18 enters outer cover collection box 11, and all cylinders reset, and open next Cycle.
As shown in figure 5, described, to open interior cap unit include vacuum cup 25, lifting cylinder 26, fixing bracket 27, the vacuum Sucker 25 is fixedly connected with lifting cylinder 26, and lifting cylinder 26 is fixedly connected with fixing bracket 27, fixing bracket 27 and body frame Frame 2 is fixedly connected.
As shown in fig. 6, the weighing unit includes weighing unit 28, weighing sensor 29, fixing bracket 30, weighing unit 28 with Weighing sensor 29 is fixedly connected, and weighing sensor 29 is fixedly connected with fixing bracket 30, and fixing bracket 30 is solid with main body frame 2 Fixed connection.
As shown in fig. 7, the sterile baiting valve includes valve body 31, sealing ring 32, flap 33, actuator 34, sealing ring 32 It is fixedly connected with valve body 31, flap 33 is hinged with valve body 31, and actuator 34 is fixedly connected with flap 33, valve body 31 and fixed arm 35 It is fixedly connected.
As shown in figure 8, the slewing equipment includes fixed arm 35, pivoted arm 36, power unit 37, fixed frame 38, fixed arm 35 are fixedly connected with pivoted arm 36, and pivoted arm 36 and power unit 37 are hinged, and power unit 37 is fixedly connected with fixed frame 38, fixed frame 38 are fixedly connected with main body frame 2.
As shown in figure 9, the lifting gear includes fixed frame 39, crane 40, driving member 41, power plant 42, transmission Part 41 is fixedly connected with fixed frame 39, and crane 40 is fixedly connected with driving member 41, and power plant 42 and driving member 41 are fixed and connected It connects, fixed frame 39 is fixedly connected with main body frame 2.
Operation principle
Sterile Aluminum Bottle is transferred to after sterilizing between packing feeds intake, and bucket is manually put into the device designated position, opens PLC journeys Sequence, sterile Aluminum Bottle it is fixed take lid cylinder 10 to act under fasten, over lid lifting cylinder 7 outer cover 18 is lifted, over lid cylinder 6 Lid acts over progress, and in 6 mechanism of lid cylinder, finger cylinder 9 is uncapped in the case where revolution telescopic cylinder 8 acts on Action, after the completion of uncapping, fixation takes lid cylinder 10 to remove outer aluminium lid 18 into outer cover collection box 11, completion of uncapping.
Aluminum Bottle, which enters, takes inner cover station, opens the action of interior cap unit 4, Aluminum Bottle inner cover is taken out, weighing unit 13 takes weight, aluminium Bottle delivers into the station that feeds intake automatically by the auxiliary roller-way for opening interior cap unit 4, by Aluminum Bottle and nothing under the effect of docking facilities 17 The 14 closed docking of bacterium baiting valve is promoted under the effect of elevating mechanism 16, and the rotary motion under the effect of slewing equipment 15 realizes aluminium The overturning of bottle, for bottleneck by being changed to upwards downwards, the closed docking production containers under the effect of elevating mechanism 16 open sterile baiting valve 14, unlatching feeds intake, and the completion that feeds intake is weighed automatically into opening interior cap unit 4, and the medicament in Aluminum Bottle all finishes at this time, is only claimed Empty bottle weight is measured, Aluminum Drum is transferred out of RABS, uncaps, feeds intake, weighing is fully completed automatically.
Package unit is completed under the effect of sequence 1PLC control units, is intervened without personnel, whole device is by top wind turbine mistake Filter group 3 provides sterile laminar flow protection, meets GMP requirements.
Compared with prior art, the present apparatus has the advantages that:
The sterile Aluminum Bottle that the present apparatus provides is uncapped charging device, and 1. pass through the 0.22 μm of offer of the sterile high efficiency particulate air filter group in top The clean environment of partial vertical one-way flow;2. people and object is separated by equipment blocking device, avoid interference from human factor;3. Automatic lid closing/opening is carried out to aseptic packaging Aluminum Bottle by providing sterile Aluminum Bottle hood-opening device to equipment, collects waste automatically;4. logical Sterile Aluminum Bottle, production are held in the setting for crossing the interface of sterile Aluminum Bottle discharge port, production containers feeding port and sterile feed valves both ends Device connects to form sealing system, reduces the risk of microbial contamination in the production process that feeds intake;5. package unit is controlled by PLC, entirely It is automatically performed the uncapping, feed intake of sterile Aluminum Bottle, weighing process;
The present apparatus, which only needs sterile Aluminum Bottle being put into designated position, can be automatically performed the work of Aluminum Bottle uncap, feed intake, weighed Sequence, it is whole to be completed under the protection of A grades of parts RABS, and the process that feeds intake is simple, convenient and efficient, the process that feeds intake is all closed right It connects, and the closed docking of position can be completed by controlling height and the vibrations of sterile Aluminum Bottle and completely fed intake.Device meets GMP It is required that keeping personnel and material completely isolated, the influence of operating personnel can be reduced to greatest extent, and environment is to production in reduction sterile production The risk of product microbial contamination, high degree of automation improve production efficiency, reduce labor intensity.

Claims (10)

1. a kind of automatic Kaifeng feeding system of aseptic medicine packaging, it is characterised in that:Including PLC control unit, main body frame, mistake Filter unit, over cap unit, open interior cap unit, weighing unit, feed intake unit, the PLC control unit is connected with main body frame Connect, the filter element be mounted on main body frame top, it is described over cap unit, open interior cap unit, weighing unit, feed intake unit It is sequentially connected and connects, and be all fixed in main body frame, weighing unit, which is located at, to be opened below interior cap unit, cap unit and is opened over described It is provided with rollgang between interior cap unit.
2. the automatic Kaifeng feeding system of aseptic medicine packaging according to claim 1, it is characterised in that:Sheet over described Member include over lid cylinder, over lid lifting cylinder, revolution telescopic cylinder, finger cylinder, fixation take lid cylinder, covered over described Cylinder, revolution telescopic cylinder, fixation take lid cylinder to be mounted on main body frame, are respectively used to carry out the outer aluminium lid of sterile Aluminum Bottle Uncap, turn, remove, it is described over lid lifting cylinder lid cylinders with over connect, the outer aluminium lid for tearing sterile Aluminum Bottle, The finger cylinder is connected with revolution telescopic cylinder, the outer aluminium lid for sterile Aluminum Bottle of tearing for turn.
3. the automatic Kaifeng feeding system of aseptic medicine packaging according to claim 1, it is characterised in that:It is described to open interior sheet Member includes vacuum cup, lifting cylinder, fixing bracket, and the vacuum cup is fixedly connected with lifting cylinder, lifting cylinder with consolidate Fixed rack is fixedly connected, and fixing bracket is fixedly connected with main body frame.
4. the automatic Kaifeng feeding system of aseptic medicine packaging according to claim 1, it is characterised in that:The weighing unit Including weighing unit, weighing sensor, fixing bracket, weighing unit is fixedly connected with weighing sensor, weighing sensor and fixed branch Frame is fixedly connected, and fixing bracket is fixedly connected with main body frame.
5. the automatic Kaifeng feeding system of aseptic medicine packaging according to claim 1, it is characterised in that:The unit that feeds intake Including sterile baiting valve, slewing equipment, lifting gear, docking facilities, the sterile baiting valve is fixedly connected with docking facilities, is returned Rotary device is fixedly connected with docking facilities, and lifting gear is fixedly connected with slewing equipment and main body frame.
6. the automatic Kaifeng feeding system of aseptic medicine packaging according to claim 1, it is characterised in that:The filter element Including plenum chamber, wind turbine, H14 high efficiency filter layers, homogenizing plate, in the plenum chamber, it is disposed with wind turbine, H14 from top to bottom High efficiency filter layer, homogenizing plate.
7. the automatic Kaifeng feeding system of aseptic medicine packaging according to claim 5, it is characterised in that:The sterile blanking Valve includes valve body, sealing ring, flap, actuator, and sealing ring is fixedly connected with valve body, and flap is hinged with valve body, actuator and valve Valve is fixedly connected, and valve body is fixedly connected with fixed arm.
8. the automatic Kaifeng feeding system of aseptic medicine packaging according to claim 5, it is characterised in that:The slewing equipment Including fixed arm, pivoted arm, power unit, fixed frame, fixed arm is fixedly connected with pivoted arm, and pivoted arm and power unit are hinged, power Unit is fixedly connected with fixed frame, and fixed frame is fixedly connected with main body frame.
9. the automatic Kaifeng feeding system of aseptic medicine packaging according to claim 5, it is characterised in that:The lifting gear Including fixed frame, crane, driving member, power plant, driving member is fixedly connected with fixed frame, and crane and driving member are fixed and connected It connects, power plant is fixedly connected with driving member, and fixed frame is fixedly connected with main body frame.
10. the automatic Kaifeng feeding system of aseptic medicine packaging according to claim 1, it is characterised in that:Under main body frame Side is provided with electric terminal case.
CN201820455005.7U 2018-04-02 2018-04-02 The automatic Kaifeng feeding system of aseptic medicine packaging Active CN208071272U (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201820455005.7U CN208071272U (en) 2018-04-02 2018-04-02 The automatic Kaifeng feeding system of aseptic medicine packaging

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201820455005.7U CN208071272U (en) 2018-04-02 2018-04-02 The automatic Kaifeng feeding system of aseptic medicine packaging

Publications (1)

Publication Number Publication Date
CN208071272U true CN208071272U (en) 2018-11-09

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Family Applications (1)

Application Number Title Priority Date Filing Date
CN201820455005.7U Active CN208071272U (en) 2018-04-02 2018-04-02 The automatic Kaifeng feeding system of aseptic medicine packaging

Country Status (1)

Country Link
CN (1) CN208071272U (en)

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