CN207367459U - A kind of flexibility people oesophagus, Stomach duodenum and small intestine Integrated Model - Google Patents
A kind of flexibility people oesophagus, Stomach duodenum and small intestine Integrated Model Download PDFInfo
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- CN207367459U CN207367459U CN201721013356.4U CN201721013356U CN207367459U CN 207367459 U CN207367459 U CN 207367459U CN 201721013356 U CN201721013356 U CN 201721013356U CN 207367459 U CN207367459 U CN 207367459U
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Abstract
The utility model discloses a kind of flexible people's oesophagus, Stomach duodenum and small intestine Integrated Model, it includes connected in sequence having oesophagus model, stomach model, duodenum model and small intestine model made of elastic material, multiple through holes have been separately formed on stomach model, duodenum model and small intestine model, each lead to the hole site is bonded with a secretor respectively, is connected inside the connected model of secretor；The elastic and oesophagus of true people of each cast material, Stomach duodenum and small intestine elastically keep it is consistent.The utility model makes flexible people's esophagus, stomach and duodenum mould using 3-D scanning and the method for 3D printing, small intestine mould is prepared using the method for machinery, then flexible people's esophagus, stomach and duodenum model is made by overmolded, and secretor of arranging on Stomach duodenum and small intestine, the model has quasi- real physiological architectural characteristic and size, there is the series of advantages such as digestive juice secretion and flexible, can be used in Bionic digestion experiment, improve the accuracy of experiment.
Description
Technical field
The utility model belongs to human digestive organ's simulation technical field, specifically, the utility model is related to a kind of soft
Property people oesophagus, Stomach duodenum and small intestine Integrated Model, in being tested for Bionic digestion, improve the accuracy of experiment.
Background technology
External people's Bionic digestion system is the equipment that the digestive system of people and digestion process are imitated in vitro, from engineering
Angle is set out, and external Bionic digestion system can be regarded as the dynamic being made of one or more soft biochemical reactors
System.It is most important wherein to establish complete external bionical people's oesophagus, Stomach duodenum and small intestine model.Due to low cost, just
It is prompt, efficiently, the features such as being limited without ethics and being easy to local or specificity sampling, external Bionic digestion system has partly substituted clinical
Or zoopery, in the bioavailability of food nutrient composition, medicament slow release, the digestion stability of allergen, probiotics
Many important achievements in research are obtained in the research of digestion survival rate etc., are widely used in food, pharmacy, medical treatment, environment
Etc. multiple research fields.Researchers carry out on the road towards more actualization to optimizing external stomach bionic system
Many beneficial explorations, wherein, bionical extremely pass weight is carried out to the morphosis, motion mode and digestive environments of true digestive system
Will, i.e., can be detected by these three bionic patterns, complicated and unstable state peptic digest system being disassembled into and
The biochemical reactor system of analysis；These three bionic patterns not only directly determine digestive juice (containing digestive ferment) feeding manner,
Reactant (food materials etc.) and the hybrid mode of digestive juice and the discharge method of reaction product, and have impact on reactant and entirely disappearing
Change the crushing effect and digestion effect in road.Therefore, it is hair to Bionic conflguration, motion biomimetics and bionical optimize of digestive environments
The key for opening up external bionic system studies a question.And it is to carry out to build accurate real external people's oesophagus, Stomach duodenum and small intestine
The basic link of these work, and a most important link.
Bionic digestion experiment is carried out to human organ, it usually needs make some relevant digestive system models, assign at the same time
The action certain to digestive system model, makes it have the digestive function of human organ, for carrying out grinding for digestion
Study carefully.Digestive organs model and the function possessed by real human digestive organ that the research of digestive system uses are carried out at present
There are larger difference, it is impossible to imitates the true digestive system of human body completely, therefore when carrying out scientific research, can produce perhaps
More incredible experiment gathered data, is unfavorable for scientific research.
Utility model content
Therefore, the technical problem that the utility model is solved is to be made with quasi- real physiological architectural characteristic and size
Digestion model, in being tested for Bionic digestion, improves the accuracy of experiment.Therefore, the utility model provides a kind of flexible people
Oesophagus, Stomach duodenum and small intestine Integrated Model.
The utility model provides a kind of flexible people's oesophagus, Stomach duodenum and small intestine Integrated Model, it is included sequentially
Connection has oesophagus model, stomach model, duodenum model and small intestine model, the stomach model, ten made of elastic material
Multiple through holes have been separately formed on two duodenum 12 models and small intestine model, each lead to the hole site is bonded with a secretor respectively,
It is connected inside the connected model of secretor；Elastic and the oesophagus of true people, the Stomach duodenum of each cast material
It is consistent with elastically keeping for small intestine.
Ratio between the oesophagus of each moulded dimension and true man, Stomach duodenum and small intestine is 1:1.
The secretor is the silicone tube that outside diameter is 2mm, internal diameter 1mm, length are 300~400mm.
Two sides of stomach wall of the stomach model respectively form multiple through holes, the major papilla position of the duodenum model
A through hole is at least molded, the secretor is fixed in the corresponding through hole one by one, at the insertion end port of the secretor
Less than or equal to the stomach model and the inner surface of duodenum model.
Two sides of stomach wall of the stomach model respectively form 12 through holes
The duodenal inside forms annular fold.
Used elastic material is silica gel material, its tensile strength is 4~6kgf/cm2, elongation at break for 300~
800%, tear resistance is 20~30kgf/cm2, linear contraction is≤0.5%.
It is fixedly connected respectively by adhesive-layer between the oesophagus model, stomach model, duodenum model and small intestine model.
Technical solutions of the utility model, have the following advantages that：
The utility model makes flexible people's esophagus, stomach and duodenum mould using 3-D scanning and the method for 3D printing,
Small intestine mould is prepared using the method for machinery, then using flexible elastic material by overmolded be made flexible people's oesophagus, stomach and
Duodenum model, and secretor of arranging on Stomach duodenum and small intestine, then by obtained flexible people's oesophagus, stomach, ten
Structure connects in sequence for two duodenum 12 and small intestine, has produced the one of flexible people's oesophagus, Stomach duodenum and small intestine
Change model, which has quasi- real physiological architectural characteristic and size, has the function of digestive juice secretion and flexibility one system of grade
Row advantage, can be used in Bionic digestion experiment, improve the accuracy of experiment.
Brief description of the drawings
, below will be right in order to illustrate more clearly of the utility model embodiment or technical solution of the prior art
Embodiment or attached drawing needed to be used in the description of the prior art are briefly described, it should be apparent that, describe below
In attached drawing be the utility model some embodiments, for those of ordinary skill in the art, do not paying creativeness
On the premise of work, other attached drawings can also be obtained according to these attached drawings.
Fig. 1 is people's esophageal-gastric-Duodeno- small intestine silica gel model schematic diagram in the utility model；
Fig. 2 is the stomach model internal structure schematic diagram in Fig. 1；
Fig. 3 is the duodenum model structure schematic diagram in Fig. 1；
Fig. 4 is the small intestine model structure schematic diagram in Fig. 1；
Fig. 5 is the small intestine lamps structure schematic diagram of Fig. 4.
In figure：
1- oesophagus models；2- stomach models；3- duodenum models, 31- annular folds；4- small intestine models, 41- fine hair；5-
Poly (methyl methacrylate) plate, 51- apertures；6- secretors.
Embodiment
The technical solution of the utility model is clearly and completely described below in conjunction with attached drawing, it is clear that described
Embodiment is the utility model part of the embodiment, instead of all the embodiments.Based on the embodiment in the utility model, sheet
Field those of ordinary skill all other embodiments obtained without making creative work, belong to this practicality
Novel protected scope.
As shown in Figure 1, the utility model provides a kind of flexible people's oesophagus, Stomach duodenum and small intestine Integrated Model,
It includes oesophagus model 1, stomach model 2, duodenum model 3 and small intestine model 4 connected in sequence, stomach model 2, duodenum mould
Be separately formed multiple through holes in type 3 and small intestine model 4, each lead to the hole site is bonded with a secretor 6 respectively, secretor 6 with
It is connected inside its model connected；Each equal resilient material of model is made, the elastic and oesophagus of true people of each cast material,
Stomach duodenum is consistent with elastically keeping for small intestine.Oesophagus model 1, stomach model 2, duodenum model 3 and small intestine model 4 it
Between sequentially pass through adhesive-layer and be fixedly connected, keep the elasticity at link position between model.
The utility model has produced the integration of flexible people's oesophagus, Stomach duodenum and small intestine by 3D printer
Model, the model have quasi- real physiological architectural characteristic and size, have the function of digestive juice secretion and flexible etc. a series of
Advantage, can be used in Bionic digestion experiment, improve the accuracy of experiment.
Preferably, the ratio between the oesophagus of each moulded dimension and true man, Stomach duodenum and small intestine is 1:1, more favorably
Carry out the digestion experiment of people to the oesophagus, Stomach duodenum and small intestine model that imitate true man in scientific research personnel.
Above-mentioned secretor 6 is the silicone tube that outside diameter is 2mm, internal diameter 1mm, length are 300~400mm.This practicality is new
Type preferably uses the silicone tube of 350mm.
The utility model respectively forms multiple through holes in two sides of stomach wall of stomach model 2, is preferably 12 through holes, ten
The major papilla position of two duodenum 12 models 3 is at least molded a through hole, and secretor 6 is fixed in corresponding through hole one by one, secretor 6
It is less than or equal to the inner surface of stomach model 2 and duodenum model 3 at insertion end port.Certainly, it is not limited to here in stomach model 2
Both sides are respectively molded 12 through holes, and merely just preferable scheme, can also respectively set in the both sides of stomach model 2 and be more or less than
12 through holes, the technical solution that number of openings here will not protect the utility model are construed as limiting.
More have preferably, annular fold 31 is formed in duodenal inside, as shown in Fig. 3 and Fig. 1, more realistically mould
Intend the duodenum function of true people.
Elastic material is preferably silica gel material used by the utility model, its tensile strength is 4~6kgf/cm2, fracture
Elongation is 300~800%, and tear resistance is 20~30kgf/cm2, linear contraction is≤0.5%.
Specifically, the preparation method of flexible people's oesophagus, Stomach duodenum and small intestine Integrated Model, includes the following steps：
【S1】The inside and outside structure of the oesophagus of people, Stomach duodenum and small intestine is scanned, oesophagus mould, stomach mould is made
Tool, duodenum mould and small intestine mould.
Scan the inside and outside structure of the esophagus, stomach and duodenum of people respectively using spatial digitizer, pass through three-dimensional
Modeling software is by the image modeling scanned and preserves the picture into STL forms；3-D view is input in 3D printer, according to
Oesophagus mould, stomach mould and the duodenum mould of secondary obtained people.
The preparation of oesophagus mould：
According to the oesophagus physiological data of true people, the mean outside diameter for determining oesophagus is 20mm, mean inside diameter 15.6mm,
And there are three narrow positions, wherein the first narrow positions is located at the origin or beginning of esophagus, i.e. pharynx and the junction of esophagus；Second narrow
Narrow portion position is below esophagus entrance at 7cm；3rd narrow positions is located at esophagogastric intersection.The utility model is according to food
The internal diameter and outer diameter of pipe, produce the mould of the silica gel plate of a plane first, and slot length is 250mm in the mould, wide
Spend for π * oesophaguses overall diameter=62.8mm.Required silica gel amount is 250x62.8x2.2mm3=345.4 milliliters.
Stomach mould preparation method：
The inside and outside structure of true stomach is scanned using spatial digitizer, three-dimensionalreconstruction is carried out with 3 d modeling software,
And preserve the STL forms into 3D printer identification.Successively printed with 3D printer.Wherein stomach mould is made of four parts,
Including internal model and external mold, internal model and external mold have two parts assembled respectively.
The preparation method of duodenum mould：
Using the true duodenal inside and outside structure of spatial digitizer scanning people, refer to according to the 12 of true people
Intestines data, it is 70mm, internal diameter 50mm to determine duodenal outside diameter, and has annular fold.
The utility model produces the mould of the silica gel plate of a plane according to duodenal internal diameter and outer diameter first
Tool, the interior slot length of the mould is 250mm, and width is π * duodenums overall diameter=219.8mm.Required silica gel amount is
250x219.8x10mm3=549.5 milliliters.
The preparation method of small intestine mould：
As shown in figure 5, according to the small intestine structure size of the obtained true people of spatial digitizer, on poly (methyl methacrylate) plate 5
The smooth aperture 51 with certain intervals, diameter and depth is stamped, small intestine mould is made.
【S2】The uniform smearing release agent on mould, elastic liquid material is cast on mould, through de- after its curing
Oesophagus model, stomach model, duodenum model and small intestine model is made in mould respectively, and carries out after surface cleaning drying processing,
Respectively as shown in Figures 2 to 4.
Prepare silicon rubber liquid：
Calculate between the internal model of institute's molding jig and external mold reserve void space and bionical people's oesophagus to be manufactured, stomach,
The volume of duodenum and small intestine, prepares liquid silica gel, and liquid silica gel and crosslinking agent are mixed and defoamed, and obtains uncrosslinked
Liquid silica gel, the volume for liquid of casting are equal with soft elastic container material volume to be manufactured.Certain the utility model can be with
Using other elastomeric materials.
The mechanical property parameters of wherein silica gel material are:Tensile strength is 40kgf/cm, elongation at break for 300~
600%, tear resistance is 20~30kgf/cm, and linear contraction is≤0.5%.
The wherein preparation method of oesophagus model and duodenum model：The oesophagus of the people obtained according to 3-D scanning and ten
The inside/outside diameter size of two duodenum 12, the oesophagus mould with plane silica gel plate structure is produced by 3D printer and silica gel material respectively
Tool and duodenum mould, the length of its mould is respectively oesophagus and duodenal length, and the width of mould is oesophagus and ten
The outside diameter girth of two duodenum 12；Two silica gel plates are successively smeared into binding agent on two sides along its length, after curing respectively
Oesophagus model is made and duodenum model, the structure chart of duodenum model are as shown in Figure 3.
The preparation method of small intestine model specifically includes：Shaping has certain intervals, diameter and depth on poly (methyl methacrylate) plate
Smooth aperture, small intestine mould is made；The smearing release agent on organic glass board mold, small intestine is cast in by elastic liquid material
On mould, its curing and demolding being treated, and carrying out after surface cleaning drying processing, small intestine preliminary cast is made；By small intestine preliminary cast
Binding agent is successively smeared on two sides along its length, small intestine model is made after curing, as shown in Figure 4.
The preparation method of stomach model specifically includes：3D printer is according to the inside and outside size of 3-D scanning income earner's stomach
Print the internal model and external mold of stomach mould；Distinguish smearing release agent to the inner surface of the outer surface of internal model and external mold；In internal model and outside
Elastic liquid material is poured into a mould in the gap that mould is formed, left and right two parts stomach model is made after the demoulding after its curing, through table
Carry out drying processing after the cleaning of face；Two parts stomach model after drying successively is smeared viscous on two sides along its length
Agent is tied, stomach model is made after curing, as shown in Figure 2.
Silicon rubber is pressed 1:1 mass ratio is mixed, and vacuumizes 10 minutes until all bubbles all disappear.It is clear at the same time
Each mould is washed, and releasing agent is uniformly coated on each mould, is then poured into the desired amount in each mould respectively, wherein oesophagus mould
Tool, duodenum mould and small intestine mould inject in the desired amount, stomach mould (about 650ml) untill filling.Silicon rubber will be poured into
Each mould of glue is put into when drying 3 is small in the baking oven less than 40 ° and takes out, and mould is taken out up to each model.
【S3】Punched respectively on stomach model, duodenum model and small intestine model, flexible pipe is inserted and fixed in hole
As secretor.Secretor is preferably the silicone tube that outside diameter is 2mm, internal diameter 1mm, length are 300~400mm.
Obtained stomach model and duodenum model and small intestine model are punched with card punch, silicone tube is inserted in the hole simultaneously
Bonded with glue, silicone tube can protrude a part, wait and have one's hair trimmed after gluing close to stomach wall, while ensure that silicone tube is not blocked up by glue
Plug, and it is no more than the inner surface of stomach model, duodenum model and small intestine model at the port of insertion end.It is small that 3 are placed after gluing
When, then each silicone tube each leads into water miscible red liquid dyestuff, checks the conducting situation of secretor；Then by stomach
Secretor be integrated on a thicker pipe, every pipe is blocked with the solid electric wire of certain length in advance, prevents glue
Flow into secretor, wait and pulled out again after gluing, and be passed through water miscible red liquid dyestuff, check whether leakage and blocking.
Each model successively smears silicone adhesive agent, every layer of silicone adhesive agent in the junction of two sides along its length
Hardening time for 2.5~3.5 it is small when, smear 5~7 layers；The outlet of mould one end is closed, is injected from its other end water-soluble
Red liquid detection of fuel mould whether leakage.
12 holes are made a call to two sides of stomach wall of stomach model are each using the card punch of 5mm, in the big breast of duodenum model
At least respectively made a hole on head position and small intestine model, secretor is fixed in corresponding hole one by one, at the port of its insertion end
It is connected no more than stomach model and the inner surface of duodenum model, and with the inside of the stomach model and duodenum model.
【S4】The oesophagus model of bionical people, stomach model, duodenum model and small intestine model are pressed into structure using adhesive
Order is got up using silicone adhesive, up to Integrated Model, while checks whether leakage.
Obviously, the above embodiments are merely examples for clarifying the description, and the restriction not to embodiment.It is right
For those of ordinary skill in the art, can also make on the basis of the above description it is other it is various forms of change or
Change.There is no necessity and possibility to exhaust all the enbodiments.And the obvious change thus extended out or
Among the protection domain that variation is created still in the utility model.
Claims (8)
1. a kind of flexibility people oesophagus, Stomach duodenum and small intestine Integrated Model, it includes connected in sequence having elastic material
Manufactured oesophagus model, stomach model, duodenum model and small intestine model, it is characterised in that the stomach model, duodenum mould
Multiple through holes are separately formed on type and small intestine model, each lead to the hole site is bonded with a secretor, the secretion respectively
Manage and be connected inside connected model；The elastic and oesophagus of true people of each cast material, Stomach duodenum and small intestine
Elastically keep consistent.
2. flexibility people oesophagus, Stomach duodenum and small intestine Integrated Model according to claim 1, it is characterised in that each
Ratio between the oesophagus of moulded dimension and true man, Stomach duodenum and small intestine is 1:1.
3. flexibility people oesophagus according to claim 1 or 2, Stomach duodenum and small intestine Integrated Model, its feature exist
In the secretor is the silicone tube that outside diameter is 2mm, internal diameter 1mm, length are 300~400mm.
4. flexibility people oesophagus according to claim 1 or 2, Stomach duodenum and small intestine Integrated Model, its feature exist
In two sides of stomach wall of the stomach model respectively form multiple through holes, and the major papilla position of the duodenum model is at least
A through hole is molded, the secretor is fixed in the corresponding through hole one by one, is less than at the insertion end port of the secretor
Equal to the stomach model and the inner surface of duodenum model.
5. flexibility people oesophagus, Stomach duodenum and small intestine Integrated Model according to claim 4, it is characterised in that institute
Two sides of stomach wall for stating stomach model respectively form 12 through holes.
6. flexibility people oesophagus, Stomach duodenum and small intestine Integrated Model according to claim 5, it is characterised in that institute
State duodenal inside and form annular fold.
7. flexibility people oesophagus, Stomach duodenum and small intestine Integrated Model according to claim 6, it is characterised in that institute
For the elastic material used for silica gel material, its tensile strength is 4~6kgf/cm2, elongation at break is 300~800%, tear-resistant
Intensity is 20~30kgf/cm2, linear contraction is≤0.5%.
8. flexibility people oesophagus, Stomach duodenum and small intestine Integrated Model according to claim 7, it is characterised in that institute
State and be fixedly connected respectively by adhesive-layer between oesophagus model, stomach model, duodenum model and small intestine model.
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109333883A (en) * | 2018-09-29 | 2019-02-15 | 江南大学 | A kind of bionical ileum and preparation method thereof |
| CN109333882A (en) * | 2018-09-29 | 2019-02-15 | 江南大学 | A kind of bionical jejunum and preparation method thereof |
| WO2019034008A1 (en) * | 2017-08-14 | 2019-02-21 | 中粮营养健康研究院有限公司 | Method for fabricating integrated model of flexible human esophagus, stomach, duodenum, and small intestine, and dynamic in vitro biomimetic digestive system thereof |
| CN109615994A (en) * | 2019-01-25 | 2019-04-12 | 胡岳 | A kind of medical instruments and equipment development real training human body Bionics Bone bone model production method |
| CN110070774A (en) * | 2019-04-15 | 2019-07-30 | 四川大学华西医院 | A kind of ultrasonic simulation device for guiding nasointestinal tube to dispose |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019034008A1 (en) * | 2017-08-14 | 2019-02-21 | 中粮营养健康研究院有限公司 | Method for fabricating integrated model of flexible human esophagus, stomach, duodenum, and small intestine, and dynamic in vitro biomimetic digestive system thereof |
| CN109333883A (en) * | 2018-09-29 | 2019-02-15 | 江南大学 | A kind of bionical ileum and preparation method thereof |
| CN109333882A (en) * | 2018-09-29 | 2019-02-15 | 江南大学 | A kind of bionical jejunum and preparation method thereof |
| CN109615994A (en) * | 2019-01-25 | 2019-04-12 | 胡岳 | A kind of medical instruments and equipment development real training human body Bionics Bone bone model production method |
| CN110070774A (en) * | 2019-04-15 | 2019-07-30 | 四川大学华西医院 | A kind of ultrasonic simulation device for guiding nasointestinal tube to dispose |
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