CN207276627U - A kind of bio-pharmaceutical fermentation tank - Google Patents
A kind of bio-pharmaceutical fermentation tank Download PDFInfo
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- CN207276627U CN207276627U CN201721286866.9U CN201721286866U CN207276627U CN 207276627 U CN207276627 U CN 207276627U CN 201721286866 U CN201721286866 U CN 201721286866U CN 207276627 U CN207276627 U CN 207276627U
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- tank body
- sleeve
- tank
- fermentation
- heating wire
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- 238000000855 fermentation Methods 0.000 title claims abstract description 33
- 230000004151 fermentation Effects 0.000 title claims abstract description 33
- 229960000074 biopharmaceutical Drugs 0.000 title claims abstract description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 47
- 238000010438 heat treatment Methods 0.000 claims abstract description 17
- 239000007788 liquid Substances 0.000 claims description 4
- 239000000945 filler Substances 0.000 claims 3
- 230000002093 peripheral effect Effects 0.000 claims 1
- 238000005485 electric heating Methods 0.000 abstract description 5
- 244000005700 microbiome Species 0.000 abstract description 5
- 241000894006 Bacteria Species 0.000 abstract description 4
- 238000001816 cooling Methods 0.000 abstract description 3
- 230000000694 effects Effects 0.000 abstract description 3
- 208000015181 infectious disease Diseases 0.000 abstract description 3
- 239000000463 material Substances 0.000 abstract description 3
- 238000003756 stirring Methods 0.000 description 6
- 238000000034 method Methods 0.000 description 3
- 230000000813 microbial effect Effects 0.000 description 3
- 238000010586 diagram Methods 0.000 description 2
- 230000001954 sterilising effect Effects 0.000 description 2
- 238000004659 sterilization and disinfection Methods 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000009423 ventilation Methods 0.000 description 1
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- Apparatus Associated With Microorganisms And Enzymes (AREA)
Abstract
本实用新型涉及一种生物制药发酵罐，本实用新型罐体内设有套筒，套筒与罐体之间形成环形腔体，环形腔体内设电热丝，发酵前首先往环形腔体加水开启电热丝进行加热，水沸腾后蒸汽经透气孔进入罐体内壁对罐体内部进行高温杀菌，能有效对罐体内部进行灭菌，防止发酵时杂菌的感染，对于发酵过程中有温度需求的微生物，也可在发酵过程中开启电热丝进行加热，温度传感器感应罐体内部的温度，将信号传至控制器，控制器控制电热丝功率调节，实现自动控制，对于发酵过程中产热的微生物，可以通过螺纹冷水管进行降温，螺纹冷水管设置于套筒上，可以直接与发酵物料接触，降温效果好。
The utility model relates to a biopharmaceutical fermentation tank. A sleeve is arranged in the tank body of the utility model. An annular cavity is formed between the sleeve and the tank body. An electric heating wire is arranged in the annular cavity. Before fermentation, water is firstly added to the annular cavity to turn on the electric heating. After the water boils, the steam enters the inner wall of the tank through the vent hole to sterilize the inside of the tank at high temperature, which can effectively sterilize the inside of the tank and prevent the infection of miscellaneous bacteria during fermentation. For microorganisms that have temperature requirements during fermentation , the heating wire can also be turned on during the fermentation process for heating, the temperature sensor senses the temperature inside the tank, and the signal is transmitted to the controller, and the controller controls the power adjustment of the heating wire to realize automatic control. The temperature is lowered through the threaded cold water pipe. The threaded cold water pipe is set on the sleeve, which can directly contact the fermentation material, and the cooling effect is good.
Description
技术领域technical field
本实用新型涉及一种生物制药发酵罐，属于生物工程技术领域。The utility model relates to a biopharmaceutical fermenter, which belongs to the technical field of bioengineering.
背景技术Background technique
发酵罐作为生物制药过程中一个重要的设备，其发酵的效率以及发酵的质量都对产品很大的影响，当前应用于生物制药的发酵装置在工业上仍然是较为简单传统的，易受环境影响，而在微生物发酵工艺中，关键的一个工艺环节就是发酵过程必须没有杂菌的感染，同时微生物发酵对温度比较敏感，高温或低温都会影响发酵效率，有的微生物发酵过程产热导致温度升高，如不能进行冷却也会影响发酵效率。As an important equipment in the biopharmaceutical process, the fermentation tank has a great influence on the fermentation efficiency and quality of the product. The fermentation equipment currently used in biopharmaceutical industry is still relatively simple and traditional, and is easily affected by the environment. , and in the microbial fermentation process, a key process link is that the fermentation process must not be infected by bacteria. At the same time, microbial fermentation is sensitive to temperature. High or low temperature will affect the fermentation efficiency. Some microbial fermentation processes produce heat and cause temperature rise. , If it cannot be cooled, it will also affect the fermentation efficiency.
实用新型内容Utility model content
针对以上技术问题，本实用新型目的在于提供一种生物制药发酵罐。In view of the above technical problems, the purpose of this utility model is to provide a biopharmaceutical fermenter.
本实用新型所述的生物制药发酵罐，包括罐体、电机、搅拌轴、搅拌叶、加料口，罐体内设有套筒，套筒与罐体之间形成环形腔体，环形腔体内设电热丝，套筒的中上部设一圈均匀分布的透气孔，罐体外壳设有第一加水口、第一出水口、第二加水口、第二出水口，第一加水口、第一出水口均与环形腔体内部连通，紧贴套筒内壁设有螺旋冷水管，螺旋冷水管进水端与第二加水口连通，螺旋冷水管出水端与第二出水口连通，罐体外壳上设有液位计。The biopharmaceutical fermentation tank described in the utility model includes a tank body, a motor, a stirring shaft, a stirring blade, and a feeding port. A sleeve is arranged in the tank body, and an annular cavity is formed between the sleeve and the tank body, and an electric heater is arranged in the annular cavity. The middle and upper part of the sleeve is provided with a circle of evenly distributed ventilation holes, and the shell of the tank body is provided with a first water inlet, a first water outlet, a second water inlet, a second water outlet, a first water inlet, and a first water outlet. Both are connected with the interior of the annular cavity, and a spiral cold water pipe is arranged close to the inner wall of the sleeve. liquid level gauge.
罐体设有加料孔。The tank body is provided with feeding holes.
罐体底部设排料口。There is a discharge port at the bottom of the tank.
套筒内壁上设有温度传感器，温度传感器与外部控制器连接，控制器与电热丝连接。A temperature sensor is arranged on the inner wall of the sleeve, the temperature sensor is connected with an external controller, and the controller is connected with the heating wire.
本实用新型与现有技术相比，具有以下有益效果。Compared with the prior art, the utility model has the following beneficial effects.
本实用新型罐体内设有套筒，套筒与罐体之间形成环形腔体，环形腔体内设电热丝，发酵前首先往环形腔体加水开启电热丝进行加热，水沸腾后蒸汽经透气孔进入罐体内壁对罐体内部进行高温杀菌，能有效对罐体内部进行灭菌，防止发酵时杂菌的感染，对于发酵过程中有温度需求的微生物，也可在发酵过程中开启电热丝进行加热，温度传感器感应罐体内部的温度，将信号传至控制器，控制器控制电热丝功率调节，实现自动控制，对于发酵过程中产热的微生物，可以通过螺纹冷水管进行降温，螺纹冷水管设置于套筒上，可以直接与发酵物料接触，降温效果好。The tank body of the utility model is provided with a sleeve, and an annular cavity is formed between the sleeve and the tank body. An electric heating wire is arranged in the annular cavity. Before fermentation, water is firstly added to the annular cavity to turn on the electric heating wire for heating. Enter the inner wall of the tank to sterilize the inside of the tank at high temperature, which can effectively sterilize the inside of the tank and prevent the infection of miscellaneous bacteria during fermentation. For microorganisms that have temperature requirements during the fermentation process, the heating wire can also be turned on during the fermentation process. Heating, the temperature sensor senses the temperature inside the tank and transmits the signal to the controller. The controller controls the power adjustment of the heating wire to realize automatic control. For the heat-producing microorganisms in the fermentation process, the temperature can be cooled through the threaded cold water pipe. The threaded cold water pipe is set On the sleeve, it can be directly in contact with the fermentation material, and the cooling effect is good.
附图说明Description of drawings
图1、本实用新型一实施例结构示意图；Fig. 1, the structural representation of an embodiment of the utility model;
图2、图1中套筒上所设置的透气孔结构示意图；Fig. 2, the schematic diagram of the vent hole structure arranged on the sleeve in Fig. 1;
图3、图1中螺旋冷水管结构示意图。Figure 3, the schematic diagram of the structure of the spiral cold water pipe in Figure 1.
图中：1、罐体2、加料孔3、搅拌轴4、电机5、加料口6、电热丝7、温度传感器8、螺旋冷水管9、第一出水口10、排料口11、搅拌叶12、套筒13、液位计14、第一加水口15、透气孔16、第二出水口17、第二加水口。In the figure: 1, tank body 2, feeding hole 3, stirring shaft 4, motor 5, feeding port 6, heating wire 7, temperature sensor 8, spiral cold water pipe 9, first water outlet 10, discharge port 11, stirring blade 12. Sleeve 13, liquid level gauge 14, first water inlet 15, vent hole 16, second water outlet 17, second water inlet.
具体实施方式Detailed ways
下面结合实施例和说明书附图对本实用新型做进一步说明。Below in conjunction with embodiment and accompanying drawing, the utility model is further described.
如图1-3所示，本实用新型所述的生物制药发酵罐，包括罐体1、电机4、搅拌轴3、搅拌叶11、加料口5，罐体1内设有套筒12，套筒12与罐体1之间形成环形腔体，环形腔体内设电热丝6，套筒12的中上部设一圈均匀分布的透气孔15，罐体1外壳设有第一加水口14、第一出水口9、第二加水口17、第二出水口16，第一加水口14、第一出水口9均与环形腔体内部连通，紧贴套筒12内壁设有螺旋冷水管8，螺旋冷水管8进水端与第二加水口17连通，螺旋冷水管8出水端与第二出水口16连通，罐体1外壳上设有液位计13。As shown in Figures 1-3, the biopharmaceutical fermentation tank described in the utility model includes a tank body 1, a motor 4, a stirring shaft 3, a stirring blade 11, and a feeding port 5. A sleeve 12 is arranged in the tank body 1, and the sleeve An annular cavity is formed between the cylinder 12 and the tank body 1, and a heating wire 6 is arranged in the annular cavity, and a circle of uniformly distributed air holes 15 is arranged on the middle and upper part of the sleeve 12, and the shell of the tank body 1 is provided with a first water inlet 14, a second The first water outlet 9, the second water inlet 17, the second water outlet 16, the first water inlet 14, and the first water outlet 9 are all connected to the inside of the annular cavity, and a spiral cold water pipe 8 is arranged close to the inner wall of the sleeve 12. The water inlet end of the cold water pipe 8 communicates with the second water inlet 17, the water outlet end of the spiral cold water pipe 8 communicates with the second water outlet 16, and a liquid level gauge 13 is arranged on the shell of the tank body 1 .
罐体1设有加料孔2。The tank body 1 is provided with a feeding hole 2 .
罐体1底部设排料口10。A discharge opening 10 is provided at the bottom of the tank body 1 .
套筒12内壁上设有温度传感器7，温度传感器7与外部控制器连接，控制器与电热丝6连接。A temperature sensor 7 is provided on the inner wall of the sleeve 12 , the temperature sensor 7 is connected to an external controller, and the controller is connected to the heating wire 6 .
本实用新型发酵前首先通过第一加水口14往环形腔体加水开启电热丝6进行加热，水沸腾后蒸汽经透气孔15进入罐体1内壁对罐体1内部进行高温杀菌，能有效对罐体1内部进行灭菌，防止发酵时杂菌的感染，对于发酵过程中有温度需求的微生物，也可在发酵过程中开启电热丝6进行加热，温度传感器7感应罐体1内部的温度，将信号传至控制器，控制器控制电热丝6功率调节，实现自动控制，对于发酵过程中产热的微生物，可以通过螺纹冷水管8进行降温，螺纹冷水管8设置于套筒12上，可以直接与发酵物料接触，降温效果好。Before the fermentation of the utility model, first add water to the annular cavity through the first water inlet 14 and turn on the electric heating wire 6 for heating. After the water boils, the steam enters the inner wall of the tank body 1 through the vent hole 15 to carry out high-temperature sterilization inside the tank body 1, which can effectively sterilize the tank body. Sterilization is carried out inside the tank body 1 to prevent the infection of miscellaneous bacteria during fermentation. For microorganisms with temperature requirements during the fermentation process, the heating wire 6 can also be turned on for heating during the fermentation process. The temperature sensor 7 senses the temperature inside the tank body 1, and the The signal is transmitted to the controller, and the controller controls the power adjustment of the heating wire 6 to realize automatic control. For the heat-producing microorganisms in the fermentation process, the temperature can be lowered through the threaded cold water pipe 8. The threaded cold water pipe 8 is arranged on the sleeve 12 and can be directly connected with the The fermented materials are in contact with each other, and the cooling effect is good.
Claims (4)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201721286866.9U CN207276627U (en) | 2017-09-30 | 2017-09-30 | A kind of bio-pharmaceutical fermentation tank |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201721286866.9U CN207276627U (en) | 2017-09-30 | 2017-09-30 | A kind of bio-pharmaceutical fermentation tank |
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| Publication Number | Publication Date |
|---|---|
| CN207276627U true CN207276627U (en) | 2018-04-27 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201721286866.9U Expired - Fee Related CN207276627U (en) | 2017-09-30 | 2017-09-30 | A kind of bio-pharmaceutical fermentation tank |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108485917A (en) * | 2018-05-22 | 2018-09-04 | 湖州南浔优恒工程咨询有限公司 | A kind of bioengineering fermentation tank |
| CN110923125A (en) * | 2019-12-19 | 2020-03-27 | 张镇伟 | Biological feed fermentation device |
| CN112300899A (en) * | 2020-11-10 | 2021-02-02 | 衡阳市凯信化工试剂股份有限公司 | Fermentation device for processing chemical reagent |
| CN113292590A (en) * | 2021-05-21 | 2021-08-24 | 江西国化实业有限公司 | Separation device for preparing trimethylsilyl trifluoromethanesulfonate and using method |
-
2017
- 2017-09-30 CN CN201721286866.9U patent/CN207276627U/en not_active Expired - Fee Related
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108485917A (en) * | 2018-05-22 | 2018-09-04 | 湖州南浔优恒工程咨询有限公司 | A kind of bioengineering fermentation tank |
| CN110923125A (en) * | 2019-12-19 | 2020-03-27 | 张镇伟 | Biological feed fermentation device |
| CN112300899A (en) * | 2020-11-10 | 2021-02-02 | 衡阳市凯信化工试剂股份有限公司 | Fermentation device for processing chemical reagent |
| CN113292590A (en) * | 2021-05-21 | 2021-08-24 | 江西国化实业有限公司 | Separation device for preparing trimethylsilyl trifluoromethanesulfonate and using method |
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Granted publication date: 20180427 Termination date: 20180930 |