CN207153616U - A kind of semi-automatic multi-channel solid phase peptide synthesizer - Google Patents
A kind of semi-automatic multi-channel solid phase peptide synthesizer Download PDFInfo
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- CN207153616U CN207153616U CN201720324361.0U CN201720324361U CN207153616U CN 207153616 U CN207153616 U CN 207153616U CN 201720324361 U CN201720324361 U CN 201720324361U CN 207153616 U CN207153616 U CN 207153616U
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- mixing
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- cylinder
- peptide synthesizer
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Abstract
It the utility model is related to Solid-phase Polypeptide mixing appliance technology, especially a kind of semi-automatic multi-channel solid phase peptide synthesizer, including bar shaped bearing base, the bar shaped bearing base upper surface is provided with mixing casing, described mixing casing upper surface one end is provided with feeding mechanism, lower surface is provided with one group of No.1 fixed pedestal in the blending bin body, each No.1 fixed pedestal upper surface is equipped with vacuum cup, each vacuum cup upper surface is connected with the miniature electric rotating machine of the upward No.1 of round end, rotating circular disc is set with each miniature electric rotating machine round end of No.1, the cylinder mixing drum being connected with upper surface in blending bin body is set with each rotating circular disc side surface.The beneficial effects of the utility model are that operation is more convenient, and solid phase mixing works well, and can be carried out continuously mixing, saves the time, improve efficiency, may be repeated stirring, the device to stir.
Description
Technical field
Solid-phase Polypeptide mixing appliance technology is the utility model is related to, more particularly to a kind of semi-automatic multi-channel solid phase is more
Peptide synthesizer.
Background technology
The solid phase synthetic instrument of polypeptide is exactly that the polypeptide of solid-state and the polypeptide of liquid are agitated or rotated via nitrogen stock to stir
The device of broken mixing.
Common solid phase synthetic instrument can only carry out rotation process once, and speed is constant, or via nitrogen
Agitating from bottom to top is effectively mixed, and its synthetic effect is bad, and easily glues glutinous inwall, and bad cleaning, discharge is not
Convenient, once stirring content is less, and if necessary to be largely stirred, the time is long, less efficient, and charging effect is not
It is good, therefore in order to solve these situations, it is necessary to design a kind of new synthesizer.
Utility model content
The purpose of this utility model be in order to solve less efficient, the bad shortcoming of charging effect present in prior art,
A kind of and semi-automatic multi-channel solid phase peptide synthesizer proposed.
To achieve these goals, the utility model employs following technical scheme：
Design a kind of semi-automatic multi-channel solid phase peptide synthesizer, including bar shaped bearing base, the bar shaped bearing base
Upper surface is provided with mixing casing, and described mixing casing upper surface one end is provided with feeding mechanism, and lower surface is set in the blending bin body
There is one group of No.1 fixed pedestal, each No.1 fixed pedestal upper surface is equipped with vacuum cup, each vacuum cup
Upper surface is connected with the miniature electric rotating machine of the upward No.1 of round end, on each miniature electric rotating machine round end of No.1
Rotating circular disc is set with, is set with each rotating circular disc side surface and is mixed with the cylinder that upper surface is connected in blending bin body
Cylinder is closed, each rotating circular disc upper surface is equipped with the helical rotation leaf mutually overlapped with corresponding cylinder mixing drum side surface
Piece, the discharge port on one of them described cylinder mixing drum upper end side surface is embedded with the discharge port and another cylinder
The No.1 conduit being connected inside mixing drum, total discharge port is provided with another described cylinder mixing drum upper end side surface, it is described
It is embedded with total discharge port and is provided with and one group through the discharge conduit of mixing casing right lateral surface, the blending bin body front surface
One group of corresponding vertical strip gab of cylinder mixing drum, horizontal bearing circular shaft each is equipped with the vertical strip gab,
The oscillating rod across mixing casing front face, each oscillating rod end face are set with each horizontal bearing circular shaft
The tong that is connected with the miniature electric rotating machine of corresponding No.1 is provided with, is set with described in one group on the end face of oscillating rod two and position
In the external horizontal fix bar of blending bin.
Preferably, the feeding mechanism is by being opened in the No.1 circular open of mixing casing upper surface one end, being inlaid in No.1
Column sealed cylinder in circular open, multiple No. two circular opens being opened at the center of column sealed cylinder side surface, be inlaid in it is every
Folding shape feed pipe in individual No. two circular opens, the wide-mouth carrying bucket for being sleeved on each folding shape feed pipe upper surface collectively form
's.
Preferably, the No.1 conduit is provided with electromagnetic valve.
Preferably, one of them described cylinder mixing drum mutually overlaps with column sealed cylinder lower surface, the column sealed cylinder
Spacing collar is provided with the junction of No.1 circular open.
Preferably, the quantity of multiple No. two circular opens is 3-6, multiple No. two circular opens angularly position
In on same circumference.
Preferably, it is equipped with one group of automatically controlled promotion between lower surface in each the No.1 fixed pedestal and blending bin body
Bar.
Preferably, it is provided with one group of compression spring between horizontal fix bar and No.1 bar shaped the bearing base upper surface.
The utility model proposes a kind of semi-automatic multi-channel solid phase peptide synthesizer, beneficial effect is：This is semi-automatic
Multi-channel solid phase peptide synthesizer operation is more convenient, and solid phase mixing works well, and can be carried out continuously mixing, save the time, carry
High efficiency, stirring is may be repeated, the device to stir.
Brief description of the drawings
Fig. 1 be the utility model proposes a kind of semi-automatic multi-channel solid phase peptide synthesizer structural representation；
Fig. 2 be the utility model proposes a kind of semi-automatic multi-channel solid phase peptide synthesizer top plan view；
Fig. 3 be the utility model proposes a kind of semi-automatic multi-channel solid phase peptide synthesizer side view.
In figure：1st, bar shaped bearing base；2nd, casing is mixed；3rd, No.1 fixed pedestal；4th, vacuum cup；5th, No.1 Miniature
Rotating motor；6th, rotating circular disc；7th, cylinder mixing drum；8th, helical rotation blade；9th, No.1 conduit；10th, discharge conduit；11st, it is horizontal
Carry circular shaft；12nd, oscillating rod；13rd, tong；14th, horizontal fix bar；15th, column sealed cylinder；16th, shape feed pipe is rolled over；17th, wide-mouth
Carrying bucket；18th, electromagnetic valve；19th, spacing collar；20th, automatically controlled catch bar；21st, compression spring.
Embodiment
Below in conjunction with the accompanying drawing in the utility model embodiment, the technical scheme in the embodiment of the utility model is carried out
Clearly and completely describing, it is clear that described embodiment is only the utility model part of the embodiment, rather than whole
Embodiment.
Such as Fig. 1-3, a kind of semi-automatic multi-channel solid phase peptide synthesizer, including bar shaped bearing base 1, the bar shaped carrying
The upper surface of pedestal 1 is provided with mixing casing 2, and described mixing casing 2 upper surface one end is provided with feeding mechanism, described to mix in casing 2
Lower surface is provided with one group of No.1 fixed pedestal 3, and each upper surface of No.1 fixed pedestal 3 is equipped with vacuum cup 4, Mei Gesuo
State the upper surface of vacuum cup 4 and be connected with the miniature electric rotating machine 5 of the upward No.1 of round end, each miniature rotation of No.1
Rotating circular disc 6 is set with the round end of motor 5, is set with each side surface of rotating circular disc 6 with mixing upper table in casing 2
The cylinder mixing drum 7 that face is connected, each upper surface of rotating circular disc 6 are equipped with and the corresponding side surface of cylinder mixing drum 7
The mutually helical rotation blade 8 of overlap joint, the discharge port on one of them described upper end side surface of cylinder mixing drum 7, the discharge port
The interior No.1 conduit 9 being embedded with being connected inside another cylinder mixing drum 7, another described upper end side of cylinder mixing drum 7
Total discharge port is provided with surface, is embedded with total discharge port and passes through the discharge conduit 10 of the mixing right lateral surface of casing 2,
2 preceding surface of the mixing casing is provided with the one group vertical strip gab corresponding with one group of cylinder mixing drum 7, each described vertical
Horizontal bearing circular shaft 11 is equipped with strip gab, is set with each horizontal bearing circular shaft 11 across mixing casing 2
The oscillating rod 12 of front face, each end face of oscillating rod 12 are connected provided with electric rotating machine 5 miniature with corresponding No.1
Tong 13, be set with 12 liang of end faces of oscillating rod described in one group and the horizontal fix bar 14 outside mixing casing 2；It is described
Feeding mechanism is close by No.1 circular open, the cylinder being inlaid in No.1 circular open for being opened in mixing casing 2 upper surface one end
Sealed tube 15, multiple No. two circular opens being opened at the column sealed side surface center of cylinder 15, it is inlaid in each No. two circular opens
Interior folding shape feed pipe 16, it is sleeved on what the wide-mouth carrying bucket 17 of each upper surface of folding shape feed pipe 16 collectively formed；Described one
Number conduit 9 is provided with electromagnetic valve 18；One of cylinder mixing drum 7 mutually overlaps with the column sealed lower surface of cylinder 15, institute
The junction for stating column sealed cylinder 15 and No.1 circular open is provided with spacing collar 19, and the quantity of multiple No. two circular opens is
3-6, multiple No. two circular opens are angularly on same circumference；Each No.1 fixed pedestal 3 and blending bin
One group of automatically controlled catch bar 20 is equipped with body 2 between lower surface；The horizontal fix bar 14 and the upper table of No.1 bar shaped bearing base 1
One group of compression spring 21 is provided between face.
Embodiment 1：In the present embodiment, programmable Series Controller and two motors are installed first at the present apparatus free time
Driver and starting switch, by taking the controller of MAM-200 models as an example, four lead-out terminals of the model controller are passed through
Input of the wire respectively with two motor drivers, electromagnetic valve and starting switch is connected, and those skilled in the art are by two electricity
The terminals for the motor that machine driver is carried by wire electric rotating machine miniature with No.1 and automatically controlled catch bar are connected, ability
After domain personnel are by controller programming, the job order of each electrical part of fully controllable system, concrete operating principle is as follows：Blending bin
Body 2 is fixedly connected on the upper surface of No.1 bar shaped bearing base 1, first justifies the solid-state operation thing for needing to be operated via No.1
Shape opening is entered in one of cylinder mixing drum 7, spacing collar 19 is installed in No.1 circular open, by column sealed cylinder
15 are fixed in spacing collar 19, then by the liquid article for needing to operate via wide-mouth carrying bucket 17 and the work of folding shape feed pipe 16
Entered with lower in column sealed cylinder 15, now automatically controlled catch bar 20 carries out elevating movement by advance control, drives No.1 to consolidate
Determine pedestal 3 and carry out descending operation, the No.1 electric rotating machine 5 of the upper surface of No.1 fixed pedestal 3 and rotating circular disc 6 are promoted corresponding
Cylinder mixing drum 7 in, now by control the miniature electric rotating machine 5 of No.1 rotated.Drive rotating circular disc 6 and rotate
The helical rotation blade of the upper surface of disk 6 is effectively mixed to the liquid phase of inside and the polypeptide of solid phase, after having mixed, electricity
Magnet valve door is opened, and is entered via No.1 conduit 9 in another cylinder tempering tank 7, now repeatedly aforesaid operations, is had again
The mixing of effect, it is allowed to mixing thoroughly, is mixed via at the row of discharge conduit 10 outside casing 2, No.1 fixed pedestal 3 is inhaled by vacuum
Disk 4 is attached with the miniature electric rotating machine of No.1, can be by manually swinging up and down horizontal fixation if being not desired to carry out automatic lifting
Bar 14 drives tong 13 to carry out descending operation by the cooperation between horizontal bearing circular shaft 11 and oscillating rod 12, drives No.1 miniature
Electric rotating machine 5 carries out descending operation, is rotated into the mixing of row solid-liquid automatically carrying out the above-mentioned miniature electric rotating machine 5 of No.1, is entering
Row discharge, the compression spring 21 between horizontal fix bar 14 and the upper surface of No.1 bar shaped bearing base 1 ensure in horizontal fix bar
14, which carry out descending operation, carries out Auxiliary support.
Embodiment 2：Vacuum cup 4 can be replaced gluing seat, equally can also reach the effect of active link, other structures with
Embodiment 1 is identical.
It is described above, the only preferable embodiment of the utility model, but the scope of protection of the utility model is not
This is confined to, any one skilled in the art is in the technical scope that the utility model discloses, according to this practicality
New technical scheme and its utility model design are subject to equivalent substitution or change, should all cover in protection model of the present utility model
Within enclosing.
Claims (7)
1. a kind of semi-automatic multi-channel solid phase peptide synthesizer, including bar shaped bearing base (1), it is characterised in that the bar shaped
Bearing base (1) upper surface is provided with mixing casing (2), and described mixing casing (2) upper surface one end is provided with feeding mechanism, described mixed
Mould assembling body (2) interior lower surface is provided with one group of No.1 fixed pedestal (3), and each No.1 fixed pedestal (3) upper surface is equipped with
Vacuum cup (4), each vacuum cup (4) upper surface are connected with the miniature electric rotating machine of the upward No.1 of round end
(5) rotating circular disc (6), is set with each miniature electric rotating machine of No.1 (5) round end, each rotating circular disc (6)
The cylinder mixing drum (7) being connected with mixing casing (2) interior upper surface, each rotating circular disc (6) are set with side surface
Upper surface is equipped with the helical rotation blade (8) mutually overlapped with corresponding cylinder mixing drum (7) side surface, one of them described circle
Discharge port on post mixing drum (7) upper end side surface, is embedded with the discharge port and the internal phase of another cylinder mixing drum (7)
The No.1 conduit (9) of connection, total discharge port, total excretion are provided with another described cylinder mixing drum (7) upper end side surface
It is intraoral be embedded with and through mixing casing (2) right lateral surface discharge conduit (10), it is described mixing casing (2) preceding surface be provided with
One group of corresponding vertical strip gab of one group of cylinder mixing drum (7), each it is equipped with level in the vertical strip gab and holds
Circular shaft (11) is carried, the oscillating rod across mixing casing (2) front face is set with each horizontal bearing circular shaft (11)
(12), each oscillating rod (12) end face is provided with the tong being connected with the miniature electric rotating machine of corresponding No.1 (5)
(13), it is set with described in one group on the end face of oscillating rod (12) two and is located at the horizontal fix bar (14) of mixing casing (2) outside.
A kind of 2. semi-automatic multi-channel solid phase peptide synthesizer according to claim 1, it is characterised in that the charger
Structure mixes the No.1 circular open, the column sealed cylinder being inlaid in No.1 circular open of casing (2) upper surface one end by being opened in
(15) multiple No. two circular opens at column sealed cylinder (15) side surface center, are opened in, are inlaid in each No. two circular opens
Interior folding shape feed pipe (16), it is sleeved on what the wide-mouth carrying bucket (17) of each folding shape feed pipe (16) upper surface collectively formed.
A kind of 3. semi-automatic multi-channel solid phase peptide synthesizer according to claim 1, it is characterised in that the No.1
Conduit (9) is provided with electromagnetic valve (18).
A kind of 4. semi-automatic multi-channel solid phase peptide synthesizer according to claim 1, it is characterised in that one of institute
State cylinder mixing drum (7) mutually to overlap with column sealed cylinder (15) lower surface, the column sealed cylinder (15) and No.1 circular open
Junction be provided with spacing collar (19).
5. a kind of semi-automatic multi-channel solid phase peptide synthesizer according to claim 2, it is characterised in that multiple described two
The quantity of number circular open is 3-6, and multiple No. two circular opens are angularly on same circumference.
6. a kind of semi-automatic multi-channel solid phase peptide synthesizer according to claim 1, it is characterised in that each described one
Number fixed pedestal (3) is equipped with one group of automatically controlled catch bar (20) between casing (2) interior lower surface with mixing.
7. a kind of semi-automatic multi-channel solid phase peptide synthesizer according to claim 1, it is characterised in that described horizontal solid
One group of compression spring (21) is provided between fixed pole (14) and No.1 bar shaped bearing base (1) upper surface.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201720324361.0U CN207153616U (en) | 2017-03-30 | 2017-03-30 | A kind of semi-automatic multi-channel solid phase peptide synthesizer |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201720324361.0U CN207153616U (en) | 2017-03-30 | 2017-03-30 | A kind of semi-automatic multi-channel solid phase peptide synthesizer |
Publications (1)
| Publication Number | Publication Date |
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| CN207153616U true CN207153616U (en) | 2018-03-30 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201720324361.0U Active CN207153616U (en) | 2017-03-30 | 2017-03-30 | A kind of semi-automatic multi-channel solid phase peptide synthesizer |
Country Status (1)
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| CN (1) | CN207153616U (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11319339B2 (en) | 2018-08-08 | 2022-05-03 | Hunan University Of Science And Engineering | Multi-channel peptide synthesizer and operating method thereof |
-
2017
- 2017-03-30 CN CN201720324361.0U patent/CN207153616U/en active Active
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11319339B2 (en) | 2018-08-08 | 2022-05-03 | Hunan University Of Science And Engineering | Multi-channel peptide synthesizer and operating method thereof |
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