CN206603845U - A kind of mouse anesthesia device - Google Patents
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- 206010002091 Anaesthesia Diseases 0.000 title claims abstract description 90
- 230000037005 anaesthesia Effects 0.000 title claims abstract description 89
- 239000003153 chemical reaction reagent Substances 0.000 claims abstract description 22
- 239000003193 general anesthetic agent Substances 0.000 claims abstract description 11
- 229940124326 anaesthetic agent Drugs 0.000 claims abstract 2
- 238000002474 experimental method Methods 0.000 abstract description 8
- 241001465754 Metazoa Species 0.000 abstract description 7
- 238000010171 animal model Methods 0.000 abstract description 4
- 208000010513 Stupor Diseases 0.000 abstract 1
- 241000699666 Mus <mouse, genus> Species 0.000 description 25
- 230000003444 anaesthetic effect Effects 0.000 description 15
- 241000699670 Mus sp. Species 0.000 description 9
- 238000000034 method Methods 0.000 description 5
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 230000008569 process Effects 0.000 description 4
- 238000007789 sealing Methods 0.000 description 4
- 239000003595 mist Substances 0.000 description 3
- 239000006199 nebulizer Substances 0.000 description 3
- 230000009471 action Effects 0.000 description 2
- 229940035674 anesthetics Drugs 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 238000011084 recovery Methods 0.000 description 2
- 239000002699 waste material Substances 0.000 description 2
- 229920000742 Cotton Polymers 0.000 description 1
- 206010033799 Paralysis Diseases 0.000 description 1
- 241000555745 Sciuridae Species 0.000 description 1
- 229910000831 Steel Inorganic materials 0.000 description 1
- 238000000889 atomisation Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000002695 general anesthesia Methods 0.000 description 1
- 239000003983 inhalation anesthetic agent Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000005381 potential energy Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000012827 research and development Methods 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 239000010959 steel Substances 0.000 description 1
- 230000032258 transport Effects 0.000 description 1
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Abstract
Description
技术领域technical field
本实用新型属于实验动物麻醉技术领域，尤其涉及一种小鼠麻醉装置。The utility model belongs to the technical field of experimental animal anesthesia, in particular to a mouse anesthesia device.
背景技术Background technique
实验小鼠的麻醉是医药研发实验、医学基础研究实验经常遇到的，然而乙醚/异丙烷等挥发性麻醉剂没有专供使用的麻醉器，而是用烧杯、标本缸等填充棉花自制简易麻醉器，这种简易麻醉剂浪费麻醉剂，而且麻醉剂量和麻醉深度不易掌握控制，挥发性麻醉剂又有快速麻醉快速苏醒的特点，小鼠经常在实验操作时苏醒，又需要再次麻醉，浪费时间，降低实验效率。The anesthesia of experimental mice is often encountered in medical research and development experiments and basic medical research experiments. However, there is no dedicated anesthesia device for volatile anesthetics such as ether/isopropane. Instead, a simple anesthesia device is made by filling cotton with beakers and specimen cylinders. , this simple anesthetic is a waste of anesthetic, and the anesthetic dose and depth of anesthesia are not easy to control, and the volatile anesthetic has the characteristics of rapid anesthesia and quick recovery. Mice often wake up during experimental operations, and need to be anesthetized again, wasting time and reducing experimental efficiency. .
申请号为201410161665.0的中国专利申请公开了一种小鼠麻醉器，包括麻醉剂层(15)及鼠笼(2)，两者间有中央孔，中央孔嵌有单向阀(3)，单向阀(3)下设钢丝网(12)；麻醉剂层(15)具有密封盖(5)，密封盖(5)侧旁设旋塞(6)，密封盖(5)中部设有中孔，贯穿中孔由上至下设调节螺母(7)、顶杆(11)及单向阀(3)；鼠笼(2)下端设底座(1)，鼠笼(2)与底座(1)壁上各设有旋转后重叠成鼠笼洞(14)的孔槽。使用时旋转底座(1)，鼠笼洞打开，小鼠头部伸入鼠笼(2)进行麻醉，使小鼠快速进入麻醉期。但是该麻醉器依然没有解决小鼠麻醉后快速苏醒，需要多次麻醉，浪费时间的问题。The Chinese patent application with the application number 201410161665.0 discloses a mouse anesthesia device, which includes an anesthetic agent layer (15) and a mouse cage (2). There is a central hole between them, and a one-way valve (3) is embedded in the central hole. A steel wire mesh (12) is set under the valve (3); the anesthetic agent layer (15) has a sealing cover (5), and a cock (6) is arranged on the side of the sealing cover (5). The hole is provided with adjusting nut (7), ejector rod (11) and check valve (3) from top to bottom; Base (1) is established at the lower end of squirrel cage (2), and each It is provided with the hole slots overlapping into mouse cage holes (14) after being rotated. When in use, the base (1) is rotated to open the mouse cage hole, and the head of the mouse is inserted into the mouse cage (2) for anesthesia, so that the mouse quickly enters the anesthesia period. However, the anesthesia device still does not solve the problem of rapid recovery of mice after anesthesia, the need for multiple anesthesia, and a waste of time.
实用新型内容Utility model content
针对现有技术的不足，本实用新型提供一种小鼠麻醉装置，所述小鼠麻醉装置能够实现定时定量释放麻醉剂，雾化麻醉剂提高麻醉效果，而且麻醉操作一体化，节省实验时间，提高实验效率。Aiming at the deficiencies of the prior art, the utility model provides a mouse anesthesia device, which can release anesthesia in a fixed and quantitative manner, atomize the anesthesia to improve the anesthesia effect, and integrate anesthesia operation, save experiment time and improve experiment efficiency. efficiency.
本实用新型的技术方案如下：一种小鼠麻醉装置，所述装置包括麻醉试剂瓶1、与试剂瓶1底部相连的输送管7，与输送管7相连的麻醉盒10，以及位于输送管7出口处的雾化器6，所述麻醉盒10的顶部设有气孔9，麻醉盒10的侧边设有双手操作孔11；在输送管末端设置雾化器6，可以将麻醉剂超声雾化为微小的雾滴，提高麻醉效果，缩短麻醉时间。The technical scheme of the utility model is as follows: a mouse anesthesia device, the device includes an anesthesia reagent bottle 1, a delivery tube 7 connected to the bottom of the reagent bottle 1, an anesthesia box 10 connected to the delivery tube 7, and an anesthesia box located in the delivery tube 7 The atomizer 6 at the exit, the top of the anesthesia box 10 is provided with an air hole 9, and the side of the anesthesia box 10 is provided with a two-handed operation hole 11; the atomizer 6 is set at the end of the delivery tube, and the anesthetic agent can be ultrasonically atomized into Tiny mist droplets improve the anesthesia effect and shorten the anesthesia time.
所述输送管7靠近试剂瓶1处设有流量调节器，便于开启和停止麻醉剂输送。The delivery pipe 7 is provided with a flow regulator near the reagent bottle 1, which is convenient for starting and stopping the delivery of the anesthetic.
进一步地，所述试剂瓶1与雾化器6之间设有定时定量控制器5，所述定时定量控制器5包括流量监控器2、定时器3、阀门4和控制器8，其中，流量监控器2、定时器3和阀门4均与控制器8相连，流量监控器2和阀门4均设置在输送管7上。Further, a timing and quantitative controller 5 is provided between the reagent bottle 1 and the atomizer 6, and the timing and quantitative controller 5 includes a flow monitor 2, a timer 3, a valve 4 and a controller 8, wherein the flow The monitor 2, the timer 3 and the valve 4 are all connected to the controller 8, and the flow monitor 2 and the valve 4 are all arranged on the delivery pipe 7.
进一步地，所述气孔9和操作孔11上均设有相应的盖子。Further, the air holes 9 and the operation holes 11 are provided with corresponding covers.
进一步地，所述输送管7与麻醉盒10连接处设有固定胶圈进行密封。Further, a fixed rubber ring is provided at the joint between the delivery tube 7 and the anesthesia box 10 for sealing.
本实用新型的工作原理如下：本实用新型在麻醉试剂瓶1的底部连接输送管7，输送管7与麻醉盒10连接，并且输送管7与麻醉盒10的连接处设置有超声波雾化器6，试剂瓶的液面高于麻醉盒中输送管出口，利用势能差，输送管7将麻醉剂输送至雾化器6内，超声雾化后喷入麻醉盒10中，麻醉盒中的小鼠吸入麻醉剂后陷入麻痹状态，实验人员将手伸入麻醉盒中进行实验操作，此时将输送管的阀门关掉即可，该装置将麻醉剂雾化，加快麻醉效果，但由于吸入麻醉的作用时间较短，数分钟后小鼠会清醒，又需要再次打开阀门释放麻醉剂继续麻醉。The working principle of the present utility model is as follows: the utility model connects the conveying pipe 7 at the bottom of the anesthesia reagent bottle 1, and the conveying pipe 7 is connected with the anesthesia box 10, and the junction of the conveying pipe 7 and the anesthesia box 10 is provided with an ultrasonic nebulizer 6 , the liquid level of the reagent bottle is higher than the outlet of the delivery tube in the anesthesia box, using the potential energy difference, the delivery tube 7 transports the anesthetic to the atomizer 6, sprays it into the anesthesia box 10 after ultrasonic atomization, and the mice in the anesthesia box inhale The anesthesia fell into a paralyzed state. The experimenter put his hand into the anesthesia box for experimental operation. At this time, the valve of the delivery tube can be turned off. The device atomizes the anesthetic to speed up the anesthesia effect, but the action time of inhalation anesthesia is longer After a few minutes, the mice will wake up and need to open the valve again to release the anesthetic to continue anesthesia.
为了定时定量持续麻醉小鼠，本实用新型在试剂瓶与雾化器之间设有定时定量控制器5，定时定量控制器5包括流量监控器2、定时器3、阀门4和控制器8，其中，流量监控器2、定时器3和阀门4均与控制器8相连，流量监控器2和阀门4均设置在输送管7上，经过预实验预估小鼠麻醉清醒时间，在定时器3上设定下次释放麻醉剂的时间，当到达预定时间时，定时器将信号转换为数字信号后传递至控制器，控制器8(如单片机)控制阀门打开；当流量监控器监控到设定剂量时，流量监控器将信号转换为数字信号，传递至控制器，控制器控制阀门关闭，此过程可反复多次使用，按实验需求进行操作，实现了定时定量释放麻醉剂，便于小鼠在实验过程中一直处于麻醉状态。In order to regularly anesthetize mice quantitatively, the utility model is provided with a timing quantitative controller 5 between the reagent bottle and the atomizer, and the timing quantitative controller 5 includes a flow monitor 2, a timer 3, a valve 4 and a controller 8, Among them, the flow monitor 2, the timer 3 and the valve 4 are all connected to the controller 8, and the flow monitor 2 and the valve 4 are all arranged on the delivery pipe 7. After pre-experimental estimation, the wake-up time of the mouse anesthetized, the timer 3 Set the time for the next release of the anesthetic agent, when the predetermined time is reached, the timer converts the signal into a digital signal and transmits it to the controller, and the controller 8 (such as a single-chip microcomputer) controls the opening of the valve; when the flow monitor monitors the set dose When the flow monitor converts the signal into a digital signal, it is transmitted to the controller, and the controller controls the valve to close. This process can be used repeatedly, and the operation is performed according to the experimental requirements, realizing the fixed and quantitative release of anesthetics, which is convenient for mice during the experiment. was kept under anesthesia.
与现有技术相比，本实用新型具有以下有益效果：Compared with the prior art, the utility model has the following beneficial effects:
1、本实用新型提供的麻醉装置主要用于动物(小鼠)实验中吸入性全身麻醉，可持续性麻醉动物，便于实验操作，降低重复麻醉消耗的人力物力；1. The anesthesia device provided by the utility model is mainly used for inhalational general anesthesia in animal (mouse) experiments, which can sustainably anesthetize animals, facilitate experimental operations, and reduce the manpower and material resources consumed by repeated anesthesia;
2、本实用新型提供的装置可调控麻醉使用剂量，以及麻醉的释放时间。能够有效减少动物麻醉中，由于人为误差所造成的动物麻醉过量死亡，同时能够在实验操作中，保证实验动物维持麻醉状态，为实验的顺利进行提供便利条件；2. The device provided by the utility model can regulate the dosage of anesthesia and the release time of anesthesia. It can effectively reduce the animal anesthesia overdose death caused by human error during animal anesthesia, and at the same time, it can ensure that the experimental animals maintain an anesthesia state during the experimental operation, and provide convenient conditions for the smooth progress of the experiment;
3、超声波雾化器可加大液体麻醉剂的利用率，操作盒的密闭性则保证了麻醉剂的浓度一直维持在较高水平；3. The ultrasonic atomizer can increase the utilization rate of the liquid anesthetic, and the airtightness of the operation box ensures that the concentration of the anesthetic is maintained at a high level;
4、双手操作孔和气孔的设计，可以在排出麻醉剂并为实验动物提供充足空气的情况下，无需转移动物，直接在麻醉盒中进行实验操作。4. The design of the two-hand operation hole and the air hole can directly carry out the experimental operation in the anesthesia box without transferring the animal under the condition of exhausting the anesthetic and providing sufficient air for the experimental animal.
附图说明Description of drawings
图1为实施例1提供的小鼠麻醉装置的结构示意图；Fig. 1 is the structural representation of the mouse anesthesia device that embodiment 1 provides;
图2为实施例2提供的小鼠麻醉装置的结构示意图；Fig. 2 is the structural representation of the mouse anesthesia device that embodiment 2 provides;
图中标记：1-试剂瓶，2-流量监控器，3-定时器，4-阀门，5-定时定量控制器，6-雾化器，7-输送管，8-控制器，9-气孔，10-麻醉盒，11-操作孔。Markings in the figure: 1-reagent bottle, 2-flow monitor, 3-timer, 4-valve, 5-timing quantitative controller, 6-atomizer, 7-transport tube, 8-controller, 9-air hole , 10-anesthesia box, 11-operation hole.
具体实施方式detailed description
下面结合附图和具体实施例对本实用新型的技术方案做进一步详细说明。实施例1The technical scheme of the utility model will be described in further detail below in conjunction with the accompanying drawings and specific embodiments. Example 1
如图1所示，一种小鼠麻醉装置，所述装置包括麻醉试剂瓶1、与试剂瓶1底部相连的输送管7，与输送管7相连的麻醉盒10，以及位于输送管7出口处的雾化器6，雾化器6与电源连接，所述麻醉盒10的顶部设有气孔9，麻醉盒10的侧边设有双手操作孔11，输送管上设有流量调节器，本实施例中流量调节器为阀门4，气孔9和操作孔11上均设有相应的盖子；输送管7与麻醉盒10连接处设有固定胶圈进行密封。为了保证麻醉剂顺利流出，可将试剂瓶1的摆放位置抬高。As shown in Figure 1, a kind of mouse anesthesia device, described device comprises anesthesia reagent bottle 1, the delivery tube 7 that links to each other with reagent bottle 1 bottom, the anesthesia box 10 that links to each other with delivery tube 7, and is positioned at delivery tube 7 outlets. The atomizer 6 is connected to the power supply, the top of the anesthesia box 10 is provided with an air hole 9, the side of the anesthesia box 10 is provided with a two-hand operation hole 11, and the delivery tube is provided with a flow regulator. In the example, the flow regulator is the valve 4, and the air hole 9 and the operation hole 11 are provided with corresponding covers; the connection between the delivery tube 7 and the anesthesia box 10 is provided with a fixed rubber ring for sealing. In order to ensure that the anesthetic agent flows out smoothly, the placement position of the reagent bottle 1 can be raised.
所述小鼠麻醉装置的使用过程如下：小鼠麻醉将小鼠放入麻醉盒10中，把足量麻醉剂倒入试剂瓶1中，麻醉剂顺着输送管7流出，在雾化器6的作用下被雾化成微小雾滴，进入小鼠麻醉盒内进行麻醉。待小鼠麻醉后，打开盒顶上气孔9的盖子，实验人员经双手操作孔11进行接下来的实验操作。The use process of the described mouse anesthesia device is as follows: the mouse is anesthetized and the mouse is put into the anesthesia box 10, and a sufficient amount of anesthetic is poured into the reagent bottle 1, and the anesthetic flows out along the delivery tube 7, and the effect of the nebulizer 6 is It is atomized into tiny mist droplets and enters the mouse anesthesia box for anesthesia. After the mouse is anesthetized, the cover of the air hole 9 on the top of the box is opened, and the experimenter performs the next experimental operation through the hole 11 with both hands.
实施例2Example 2
如图2所示，一种小鼠麻醉装置，所述装置包括麻醉试剂瓶1、与试剂瓶1底部相连的输送管7，与输送管7相连的麻醉盒10，以及位于输送管7出口处的雾化器6，雾化器6与电源连接，所述麻醉盒10的顶部设有气孔9，麻醉盒10的侧边设有双手操作孔11，输送管上设有阀门4，为了保证麻醉剂顺利流出，可将试剂瓶1的摆放位置抬高。As shown in Figure 2, a kind of mouse anesthesia device, described device comprises anesthesia reagent bottle 1, the delivery tube 7 that links to each other with reagent bottle 1 bottom, the anesthesia box 10 that links to each other with delivery tube 7, and is positioned at delivery tube 7 outlets. The atomizer 6 is connected to the power supply, the top of the anesthesia box 10 is provided with an air hole 9, the side of the anesthesia box 10 is provided with a two-hand operation hole 11, and the delivery tube is provided with a valve 4, in order to ensure that the anesthetic agent The smooth outflow can raise the placement position of the reagent bottle 1.
试剂瓶1与雾化器6之间设有定时定量控制器5，所述定时定量控制器5包括流量监控器2、定时器3、阀门4和控制器8，控制器8可采用单片机来控制，其中，流量监控器2、定时器3和阀门4均与控制器8相连，流量监控器2和阀门4均设置在输送管7上。A timing and quantitative controller 5 is arranged between the reagent bottle 1 and the atomizer 6, and the timing and quantitative controller 5 includes a flow monitor 2, a timer 3, a valve 4 and a controller 8, and the controller 8 can be controlled by a single-chip microcomputer , wherein the flow monitor 2, the timer 3 and the valve 4 are all connected to the controller 8, and the flow monitor 2 and the valve 4 are all set on the delivery pipe 7.
所述麻醉装置的使用过程如下：The use process of described anesthesia device is as follows:
1、小鼠麻醉：将小鼠放入麻醉盒10中，把足量麻醉剂(乙醚或其他麻醉剂)倒入试剂瓶1，通过流量监控器2观察麻醉用量，当用量达到要求值时，关闭定时定量控制器5，麻醉剂在雾化器6的作用下被雾化成微小雾滴，经输送管7进入小鼠麻醉盒内进行麻醉，待小鼠麻醉后，打开盒顶负压盖9，实验人员经双手操作孔11进行麻醉操作。1. Mouse anesthesia: put the mouse into the anesthesia box 10, pour a sufficient amount of anesthetic (ether or other anesthetic) into the reagent bottle 1, observe the amount of anesthesia through the flow monitor 2, and when the amount reaches the required value, turn off the timer Quantitative controller 5, the anesthetic agent is atomized into tiny mist droplets under the action of nebulizer 6, and enters the mouse anesthesia box through the delivery tube 7 for anesthesia, after the mouse is anesthetized, open the negative pressure cover 9 on the top of the box, and the experimenter The anesthesia operation is performed through the two-hand operation hole 11 .
2、小鼠持续麻醉：经过预实验预估小鼠麻醉清醒时间，在定时器3上设定下次释放麻醉剂的时间，当到达预定时间时，信号传递至控制器8，控制器控制阀门打开；当流量达到需要剂量时，信号传递至控制器8，控制器控制阀门关闭，此过程可反复多次使用，按实验需求进行操作。2. Continuous anesthesia of mice: After pre-experimental estimation, the wake-up time of mice anesthesia is estimated, and the time for the next release of anesthetic is set on the timer 3. When the predetermined time is reached, the signal is transmitted to the controller 8, and the controller controls the valve to open ; When the flow reaches the required dose, the signal is transmitted to the controller 8, and the controller controls the valve to close. This process can be used repeatedly and operated according to the experimental requirements.
以上所述仅为本实用新型的较佳实施例而已，并不用以限制本实用新型，凡在本实用新型的精神和原则之内所作的任何修改、等同替换和改进等，均应包含在本实用新型的保护范围之内。The above descriptions are only preferred embodiments of the present utility model, and are not intended to limit the present utility model. Any modifications, equivalent replacements and improvements made within the spirit and principles of the present utility model shall be included in this utility model. within the scope of protection of utility models.
本实用新型的技术方案在以下基金项目的支持下完成，基金项目：国家自然科学基金资助项目(No:81060134；81371835；31560051；81560596)；云南省自然基金项目(No.2010CD221，2011FB244，2012FB011，2013FZ057，2014FA011,2014FB001)。The technical scheme of the utility model is completed under the support of the following fund projects, fund projects: National Natural Science Foundation of China (No: 81060134; 81371835; 31560051; 81560596); 2013FZ057, 2014FA011, 2014FB001).
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| CN201621301167.2U Expired - Fee Related CN206603845U (en) | 2016-11-30 | 2016-11-30 | A kind of mouse anesthesia device |
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| Country | Link |
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| CN (1) | CN206603845U (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112315620A (en) * | 2020-12-09 | 2021-02-05 | 斯贝福（北京）生物技术有限公司 | Gas anesthesia device for braking small animals |
-
2016
- 2016-11-30 CN CN201621301167.2U patent/CN206603845U/en not_active Expired - Fee Related
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112315620A (en) * | 2020-12-09 | 2021-02-05 | 斯贝福（北京）生物技术有限公司 | Gas anesthesia device for braking small animals |
| CN112315620B (en) * | 2020-12-09 | 2023-06-30 | 斯贝福（北京）生物技术有限公司 | Gas anesthesia device for small animal braking |
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