A kind of ergosterol chromatography oil process units
Technical field
The utility model is related to pharmaceutical production equipment technical field, particularly a kind of ergosterol chromatography oil process units.
Background technology
Ergosterol, also known as ergosterol, is one of steroid, and ergosterol is the precursor for producing calciferol,
It is the intermediate for producing hormone medicine.When calciferol is produced using ergosterol, its art production process is more complicated,
Technique productions condition is also higher, and each operation has considerable influence to the yield of intermediate.
Ergosterol chromatography oil is using an important intermediateness during ergosterol production calciferol, by wheat
The ergosterol chromatography oil that sterol conversion oil in angle is carried out dissolving, chromatographed, obtained after reduced pressure concentration, production ergosterol chromatography oil is
The important step of calciferol is obtained, ergosterol chromatographs the yield of oil and quality to finally obtaining the dimension of high yield and quality
Raw element D2 has considerable influence, so, the ergosterol for how obtaining higher yields and quality is insignificant.In production ergosterol
During chromatography oil, as the requirement of technique productions condition is higher, production ergosterol chromatography oil also has larger difficulty and chooses
War, main cause is that existing process units cannot meet technique productions condition, and these technique productions conditions mainly include following
Aspect:
1st, feed liquid is when being chromatographed, it is necessary to keep the plateau of tomography devices, and this is accomplished by strictly controlling various things
The feed speed of material, is difficult to provide sufficient, stable feed to set of tomography devices in prior art, so as to have influence on chromatography
The normal operation of equipment, leads to not preferably be chromatographed;
2nd, there are higher cleannes to require to produce ergosterol, not only require in process of production process units with compared with
High cleannes, when equipment cleaning is carried out, it is also desirable to thoroughly clean in the equipment stoppage in transit stage;
3rd, when carrying out dispensing and mixing, it is desirable to which feed liquid is sufficiently mixed, whole dissolves, agitator tank is had higher
Require.
Utility model content
Goal of the invention of the present utility model is:Chromatograph for existing ergosterol and be difficult to chromatography in oily process units
Equipment provides sufficient, stable material and supplies so as to cause tomography devices chromatograph out the chromatographic solution of higher yields and quality,
Cause the problem for having a strong impact on chromatography oil production, there is provided a kind of ergosterol chromatography oil process units, the process units is by changing
The combination mounting means of change equipment, solves
The problem of product condition, makes feed liquid when being chromatographed, and various materials are supplied to tomography devices with strict even pace, while having
Effect ensure that the abundance of feed, tomography devices is normally run, and obtain the chromatography oil of better quality and yield.
To achieve these goals, the technical solution adopted in the utility model is:
A kind of ergosterol chromatography oil process units, including supply arrangement, tomography devices and stirring concentration kettle, the chromatography
Equipment includes charging aperture and discharging opening, and the supply arrangement is connected with supply lines, the supply lines and tomography devices charging aperture
Connection, the discharging opening of the tomography devices are connected with discharging pipeline, and the discharging pipeline is communicated to stirring concentration kettle, and the supply sets
Standby installation site is higher than tomography devices, and difference in height is in more than 3m, makes material in the mode of flowing automatically to tomography devices feed.
For supplying various materials to tomography devices, material is mainly the important intermediate ergot of calciferol to supply arrangement
Sterol conversion fluid, material are chromatographed in tomography devices, and the feed liquid after chromatography enters stirring concentration kettle, and feed liquid is in stirring concentration
Reduced pressure concentration in kettle, obtains ergosterol chromatography oil.The setting height(from bottom) of supply arrangement is arranged in into the installation higher than tomography devices
The position of height, makes material in the mode of flowing automatically to tomography devices feed, it is ensured that tomography devices obtain sufficient smoothly feed, make layer
Desorption device is unaffected in chromatography process, keeps preferable working condition, so as to obtain the layer of better quality and yield
Analysis liquid, is that the sub chromatography oil that is concentrated under reduced pressure to give in stirring concentration kettle of lower sequence carries out adequate preparation, and the high-order arrangement of supply arrangement is sharp
With the feed liquid liquid level automatic voltage regulation in equipment.
Used as preferred version of the present utility model, the supply arrangement is 4m with the setting height(from bottom) difference of tomography devices.By height
Degree difference is set to 4m, and the feed pressure in supply arrangement can be made more stable, it is ensured that the feed liquid to tomography devices conveying is more put down
Surely, pressure oscillation is less, makes the technique productions condition of tomography devices reach bigger optimization.
As preferred version of the present utility model, the supply arrangement include ergosterol conversion liquid storage tank, benzene basin and
It is high that ethanol basin, equal vertical, and ergosterol conversion liquid storage tank, benzene basin and ethanol basin are arranged in same level
Degree.Ergosterol conversion liquid storage tank, benzene basin and ethanol basin are set, and different material are conveyed to tomography devices, make ergosterol
Chromatography, obtains chromatographic solution, each basin is arranged in sustained height, make the pressure of every kind of feed liquid identical, while to tomography devices
The feed liquid of conveying uniform pressure, various feed liquids are steady, even into tomography devices.
As preferred version of the present utility model, be separately provided in the ergosterol conversion liquid storage tank input,
The liquor inlet and material liquid outlet of output feed liquid, is additionally provided with respirator and vacuum equipment in the angle sterol conversion liquid storage tank.
Arrange respirator, can keep in general ergosterol convert liquid storage tank seal, make ergosterol conversion fluid with it is outer
Boundary completely cuts off, and keeps the cleannes which is higher, when needing to adjust the pressure in ergosterol conversion liquid storage tank, can pass through respirator
Automatically the external and internal pressure of aeration regulation equilibrium conversion liquid storage tank, plays safeguard protection effect to ergosterol conversion liquid storage tank, together
When prevent extraneous dirty air from entering in conversion liquid storage tank, turned to conveying in ergosterol conversion liquid storage tank using vacuum equipment
Change liquid material, also allow for keeping the high level of cleanliness inside ergosterol conversion liquid storage tank, meet production ergosterol chromatography oil
Higher cleannes requirement, solves the problems, such as that existing equipment is difficult to meet cleannes requirement.
Used as preferred version of the present utility model, the benzene for being separately provided for being input into, exporting benzene on the benzene basin enters
Mouth and benzene outlet, are additionally provided with respirator and vacuum equipment on the benzene basin.Respirator is set, can be kept in general
The seal of benzene basin, makes material benzene be hedged off from the outer world, keeps the cleannes which is higher, is needing to adjust the pressure in benzene basin
When, the external and internal pressure of benzene basin can be balanced by the automatic aeration regulation of respirator, play safeguard protection effect to benzene basin, while
Prevent extraneous dirty air from entering in benzene basin, using vacuum equipment to conveying benzene material in benzene basin, also allow for keeping benzene
High level of cleanliness inside basin, meets the higher cleannes of production ergosterol chromatography oil and requires, solve existing equipment difficult
To meet the problem of cleannes requirement.
As preferred version of the present utility model, it is separately provided for being input on the ethanol basin, exports ethanol
Ethanol import and nol outlet, are additionally provided with respirator and vacuum equipment on the ethanol basin.Respirator is set, in general feelings
The seal of ethanol basin can be kept under condition, is made material ethanol be hedged off from the outer world, is kept the cleannes which is higher, needing to adjust
During pressure in ethanol basin, the external and internal pressure of ethanol basin can be balanced by the automatic aeration regulation of respirator, to ethanol basin
Safeguard protection effect is played, while preventing extraneous dirty air from entering in ethanol basin, using vacuum equipment to ethanol basin
Interior conveying ethanol material, also allows for keeping the high level of cleanliness inside ethanol basin, meets production ergosterol chromatography oil higher
Cleannes require, solve the problems, such as that existing equipment is difficult to meet cleannes requirement.
Used as preferred version of the present utility model, the tomography devices are the complete set of equipments for including a plurality of chromatographic column, a plurality of
Chromatographic column is connected in parallel and is vertically arranged, and is provided with ball valve per chromatographic column two ends described in bar, is respectively arranged in chromatography column inlet
With chromatography column outlet, to supply lines, supply lines are respectively communicated to often for the material liquid outlet, benzene outlet and nol outlet Correspondent
Bar chromatographs column inlet, and the chromatography column outlet Correspondent per chromatographic column described in bar is to the pipeline that discharges.
As preferred version of the present utility model, the oily process units of ergosterol chromatography also include being arranged at tomography devices with
Chromatographic solution collecting tank between stirring concentration kettle, the chromatographic solution collecting tank are arranged side by side with tomography devices, and are in same installation
Highly.Arrangement chromatographic solution collecting tank, is easy to collect the chromatographic solution that tomography devices are discharged, and the chromatographic solution that tomography devices are chromatographed is timely
Enter chromatographic solution collecting tank to be collected, make tomography devices play chromatography in the more chromatography state of saturation, at utmost
Effect, chromatographic solution are also allowed for after being collected separately to stirring concentration kettle supply chromatographic solution.
As preferred version of the present utility model, on the chromatographic solution collecting tank, respirator is additionally provided with, the respirator cloth
It is placed at the top of chromatographic solution collecting tank, the chromatographic solution collecting tank is additionally coupled to vacuum equipment.Arrange at the top of chromatographic solution collecting tank
Respirator, can keep the seal of collecting tank in general, make chromatographic solution collecting tank be hedged off from the outer world, needing regulating course
When analysing the pressure in liquid collecting tank, collecting tank external and internal pressure can be balanced by the automatic aeration regulation of respirator, chromatographic solution is collected
Tank plays safeguard protection effect, while preventing extraneous dirty air from entering in collecting tank, carries out chromatographic solution using vacuum equipment
Collect, also allow for keeping the high level of cleanliness inside chromatographic solution collecting tank, meet the higher cleaning of production ergosterol chromatography oil
Degree requirement, solves the problems, such as that existing equipment is difficult to meet cleannes requirement.
As preferred version of the present utility model, heat-insulation layer is additionally provided with the outer surface of the stirring concentration kettle, the guarantor
There is between warm layer and stirring concentration kettle outer surface gap, the gap forms independent with inside extraneous and stirring concentration kettle
Closing space, is provided with the air inlet for being input into steam and the exhaust outlet for discharging steam in the closing space, it is described enter
, near stirring concentration kettle upper end, the exhaust outlet is near stirring concentration kettle lower end for gas port.Take the stirring of this version dense
Contracting kettle, conveys steam by air inlet to stirring concentration kettle, and acceleration obtains stirring ergot fusel chromatography oil, air inlet in concentration kettle
Near stirring concentration kettle upper end, make steam full of in whole confined space, improve steam utilization efficiency, it is abundant to stirring concentration kettle
Exhaust outlet is arranged in the position near stirring concentration kettle lower end, is easy to steam to discharge by heating, simultaneously as steam is to stirring
Concentration kettle heating rear portion branch condenses into liquid state, also allows for hole exhaust outlet and discharges.
In sum, as a result of above-mentioned technical proposal, the beneficial effects of the utility model are:
The 1st, the setting height(from bottom) of supply arrangement is arranged in the position of the setting height(from bottom) higher than tomography devices, makes material to flow automatically
Mode is to tomography devices feed, it is ensured that tomography devices obtain sufficient smoothly feed, makes the tomography devices will not in chromatography process
It is affected, keeps preferable working condition, so as to obtain the chromatographic solution of better quality and yield, is that lower sequence is concentrated in stirring
Chromatography oil being concentrated under reduced pressure to give in kettle and carrying out adequate preparation, the high-order arrangement of supply arrangement is automatic using the feed liquid liquid level in equipment
Voltage stabilizing;
2nd, convert in angle sterol and respirator is set on liquid storage tank, benzene basin and ethanol basin, can keep in general
The seal of basin, makes material be hedged off from the outer world, and keeps the cleannes which is higher, when needing to adjust the pressure in basin, energy
The external and internal pressure of basin is balanced by the automatic aeration regulation of respirator, safeguard protection effect is played to basin, while preventing the external world
Dirty air is entered in basin, conveys material using vacuum equipment into basin, also allows for keeping the height inside basin clear
It is clean, meet the higher cleannes of production ergosterol chromatography oil and require, solve existing equipment and be difficult to meet cleannes requirement
Problem;
3rd, heat-insulation layer is provided with the outer surface of stirring concentration kettle, shape between the heat-insulation layer and stirring concentration kettle outer surface
Into closing space, air inlet and exhaust outlet are set in closing space, steam are conveyed to stirring concentration kettle by air inlet, is accelerated
Obtain stirring ergot fusel chromatography oil in concentration kettle, air inlet makes steam be full of whole confined air near stirring concentration kettle upper end
In, steam utilization efficiency is improved, is fully heated to stirring concentration kettle, exhaust outlet is arranged near stirring concentration kettle lower end
Position, is easy to steam to discharge, simultaneously as steam condenses into liquid state to stirring concentration kettle heating rear portion branch, also allows for hole
Exhaust outlet is discharged.
Description of the drawings
Fig. 1 is structural representation of the present utility model.
Structural representations of the Fig. 2 for the stirring concentration kettle in Fig. 1.
Mark in figure:1- stirs concentration kettle, 2- tomography devices, 21- charging apertures, 22- discharging openings, 23- chromatographic columns, 3- feed
Pipeline, 4- discharging pipelines, 5- supply arrangements, 51- ergosterols conversion liquid storage tank, 52- benzene basins, 53- ethanol basins, 6- material
Liquid import, 7- material liquid outlets, 8- respirators, 9- vacuum equipments, 10- benzene imports, the outlet of 11- benzene, 12- ethanol imports, 13- ethanol
Outlet, 14- ball valves, 15- chromatography column inlets, 16- chromatography column outlets, 17- chromatography collecting tanks, 18- heat-insulation layers, 19- air inlets,
20- exhaust outlets, 30- closing spaces, 31- agitating devices, 311- supporting parts, 312- agitating plates, 32- rotary power units.
Specific embodiment
Below in conjunction with the accompanying drawings, the utility model is described in detail.
In order that the purpose of this utility model, technical scheme and advantage become more apparent, below in conjunction with accompanying drawing and enforcement
Example, is further elaborated to the utility model.It should be appreciated that specific embodiment described herein is only to explain this
Utility model, is not used to limit the utility model.
Embodiment
As shown in figure 1, the oily process units of ergosterol chromatography, including supply arrangement 5, tomography devices 2 and stirring concentration kettle
1, the tomography devices 2 include charging aperture 21 and discharging opening 22, and the supply arrangement 5 is connected with supply lines 3, the supply lines
3 are connected with 2 charging aperture 21 of tomography devices, and the discharging opening 22 of the tomography devices 2 is connected with discharging pipeline 4, and the discharging pipeline 4 connects
Pass to stirring concentration kettle 1, the installation site of the supply arrangement is higher than tomography devices 2, and difference in height is in more than 3m, make material with
Gravity flow mode is to 2 feed of tomography devices.
For supplying various materials to tomography devices 2, material is mainly the important intermediate wheat of calciferol to supply arrangement 5
Angle sterol conversion fluid, material are chromatographed in tomography devices 2, and the feed liquid after chromatography enters stirring concentration kettle 1, and feed liquid is in stirring
Reduced pressure concentration in concentration kettle 1, obtains ergosterol chromatography oil.The setting height(from bottom) of supply arrangement is arranged in higher than tomography devices
The position of setting height(from bottom), makes material in the mode of flowing automatically to tomography devices feed, it is ensured that tomography devices obtain sufficient smoothly feed,
Tomography devices is unaffected in chromatography process, keep preferable working condition, so as to obtain better quality and yield
Chromatographic solution, be that lower sequence is concentrated under reduced pressure to give chromatography oil in stirring concentration kettle and carries out adequate preparation, supply arrangement high position cloth
Put, using the feed liquid liquid level automatic voltage regulation in equipment.
Supply arrangement 5 is 4m with the setting height(from bottom) difference of tomography devices 2, difference in height is set to 4m, can be made in supply arrangement
Feed pressure it is more stable, it is ensured that to tomography devices 2 conveying feed liquid it is more steady, pressure oscillation is less, makes tomography devices 2
Technique productions condition reach bigger optimization.
Supply arrangement 5 includes ergosterol conversion liquid storage tank 51, benzene basin 52 and ethanol basin 53, equal vertical, institute
State ergosterol conversion liquid storage tank 51, benzene basin 52 and ethanol basin 53 and be arranged in same level height, ergosterol is set and is turned
Change liquid storage tank 51, benzene basin 52 and ethanol basin 53, different material is conveyed to tomography devices 2, chromatograph ergosterol, obtain layer
Each basin is arranged in sustained height, makes the pressure of every kind of feed liquid identical by analysis liquid, while conveying uniform pressure to tomography devices
Feed liquid, various feed liquids are steady, even into tomography devices.
It is separately provided for being input into, exporting the liquor inlet 6 of feed liquid in ergosterol conversion liquid storage tank 51 and feed liquid goes out
Mouth 7, is additionally provided with respirator 8 and vacuum equipment 9 in the angle sterol conversion liquid storage tank 51, arranges respirator 8, in ordinary circumstance
The lower seal that ergosterol can be kept to convert liquid storage tank 51, makes ergosterol conversion fluid be hedged off from the outer world, keeps which higher
Cleannes, when needing to adjust the pressure in ergosterol conversion liquid storage tank 51, can be balanced by 8 automatic aeration regulation of respirator
The external and internal pressure of conversion liquid storage tank, plays safeguard protection effect to ergosterol conversion liquid storage tank 51, while preventing extraneous dirty
Air enter conversion liquid storage tank in, using vacuum equipment 9 to ergosterol conversion liquid storage tank 51 in convey conversion fluid material,
It is easy to keep the high level of cleanliness inside ergosterol conversion liquid storage tank, meets the higher cleannes of production ergosterol chromatography oil
Require, solve the problems, such as that existing equipment is difficult to meet cleannes requirement.
It is separately provided for being input into, exporting the benzene import 10 of benzene and benzene outlet 11, the benzene basin 52 on benzene basin 52
On be additionally provided with respirator 8 and vacuum equipment 9, respirator 8 is set, the seal of benzene basin 52 can be kept in general,
Make material benzene be hedged off from the outer world, keep the cleannes which is higher, when needing to adjust the pressure in benzene basin 52, can be by breathing
The external and internal pressure of 8 automatic aeration regulation of device balance benzene basin 52, plays safeguard protection effect, while preventing the external world to benzene basin 52
Dirty air is entered in benzene basin 52, using vacuum equipment to conveying benzene material in benzene basin 52, also allows for keeping benzene basin
The high level of cleanliness of inside, meets the higher cleannes of production ergosterol chromatography oil and requires, solve existing equipment and be difficult to completely
The problem that sufficient cleannes are required.
It is separately provided for being input into, exporting ethanol import 12 and the nol outlet 13 of ethanol on ethanol basin 53, it is described
Respirator 8 and vacuum equipment 9 is additionally provided with ethanol basin 53, and respirator 8 is set, ethanol basin can be kept in general
53 seal, makes material ethanol be hedged off from the outer world, keeps the cleannes which is higher, is needing to adjust the pressure in ethanol basin 53
The external and internal pressure of ethanol basin 53 during power, can be balanced by 8 automatic aeration regulation of respirator, and safe guarantor is played to ethanol basin 53
Shield is acted on, while preventing extraneous dirty air from entering in ethanol basin 53, is conveyed into ethanol basin 53 using vacuum equipment 9
Ethanol material, also allows for keeping the high level of cleanliness inside ethanol basin 53, meets higher clear of production ergosterol chromatography oil
Cleanliness requirement, solves the problems, such as that existing equipment is difficult to meet cleannes requirement.
Tomography devices 2 are the complete set of equipments for including a plurality of chromatographic column 23, and a plurality of chromatographic column 23 is connected in parallel and is vertically arranged,
Ball valve 14 is provided with per 23 two ends of chromatographic column described in bar, is respectively arranged in chromatography column inlet 15 and chromatography column outlet 16, it is described
, to supply lines 3, supply lines 3 are respectively communicated to every chromatographic column 23 for material liquid outlet 7, benzene outlet 11 and 13 Correspondent of nol outlet
Entrance, 16 Correspondent of chromatography column outlet per chromatographic column described in bar 23 is to the pipeline 4 that discharges.
The oily process units of ergosterol chromatography also includes the chromatographic solution being arranged between tomography devices 2 and stirring concentration kettle 1
Collecting tank 17, the chromatographic solution collecting tank 17 are arranged side by side with tomography devices 2, and are in same setting height(from bottom), and arrangement chromatographic solution is received
Collection tank 17, is easy to collect the chromatographic solution that tomography devices 2 are discharged, and the chromatographic solution that tomography devices 2 are chromatographed enters chromatographic solution receipts in time
Collection tank 17 is collected, and makes tomography devices 2 play chromatography effect, chromatography in the more chromatography state of saturation, at utmost
Liquid is also allowed for after being collected separately to the stirring supply chromatographic solution of concentration kettle 1.
Respirator 8 is additionally provided with chromatographic solution collecting tank 17, and the respirator 8 is arranged at the top of chromatographic solution collecting tank 17, institute
State chromatographic solution collecting tank 17 and be additionally coupled to vacuum equipment 9, respirator 8 is set at the top of chromatographic solution collecting tank 17, in ordinary circumstance
The lower seal that can keep collecting tank, makes chromatographic solution collecting tank 17 be hedged off from the outer world, and is needing to adjust in chromatographic solution collecting tank 17
Pressure when, can by 8 automatic aeration regulation of respirator balance collecting tank external and internal pressure, safety is played to chromatographic solution collecting tank 17
Protective effect, while preventing extraneous dirty air from entering in collecting tank, carries out chromatographic solution collection using vacuum equipment, also allows for
The high level of cleanliness inside chromatographic solution collecting tank 17 is kept, the higher cleannes of production ergosterol chromatography oil is met and is required, solution
Existing equipment of having determined is difficult to meet the problem of cleannes requirement.
As shown in Fig. 2 being provided with agitating device 31 in stirring concentration kettle 1, agitating device 31 includes supporting part 311 and connection
Agitating plate 312 on supporting part 311, the supporting part 311 are connected with rotary power unit 32, and agitating plate 312 is with supporting part
311 rotate in the presence of rotary power unit 32, and the plate face of the agitating plate 312 is parallel to esterification tank axis so as to plate face
Become contact surface of the agitating plate 312 when rotating with feed liquid.
Agitating device is set, and more full and uniform when making to be stirred inside stirring concentration kettle 1, existing agitating device is adopted
, used as rotation section, round bar is essentially identical in all directions with the contact area of feed liquid for round bar, it is impossible to fully stir feed liquid
Mix, roll so that material is difficult to be concentrated by evaporation, so as to have influence on concentration speed, it is impossible to quickly obtain the layer of higher concentration
Condensate oil, using the agitating device of this programme, its agitating plate use with the contact area ratio of chromatographic solution in a rotational direction round steel or
Bigger with the contact area of feed liquid when pipe is stirred, larger plate face will promote feed liquid to be stirred, and feed liquid is fully turned over
Rolling, reaching fully makes chromatographic solution rapid evaporation, the purpose of rapid concentration.
Heat-insulation layer 18 is additionally provided with the outer surface of stirring concentration kettle 1, the heat-insulation layer 18 and 1 outer surface of stirring concentration kettle it
Between there is gap, the gap formed with it is extraneous and stir closing space 30 independent inside concentration kettle, in the closing space
The air inlet 19 for being input into steam and the exhaust outlet 20 for discharging steam is provided with, the air inlet 19 is near stirring concentration
The stirring concentration kettle of this version is taken, by air inlet near 1 lower end of stirring concentration kettle in 1 upper end of kettle, the exhaust outlet 20
Mouth obtains ergot fusel in stirring concentration kettle and chromatographs oil to stirring concentration kettle conveying steam, acceleration, and air inlet is concentrated near stirring
Kettle upper end, makes steam full of in whole confined space, improves steam utilization efficiency, fully heat to stirring concentration kettle, will exhaust
Mouth is arranged in the position near stirring concentration kettle lower end, is easy to steam to discharge, simultaneously as steam is to stirring after concentration kettle heating
Part can condense into liquid state, also allow for hole exhaust outlet and discharge.
By the oily process units of ergosterol chromatography of the present embodiment, the setting height(from bottom) of supply arrangement is arranged in higher than layer
The position of the setting height(from bottom) of desorption device, makes material in the mode of flowing automatically to tomography devices feed, it is ensured that tomography devices obtain sufficient flat
Steady feed, makes tomography devices be unaffected in chromatography process, keeps preferable working condition, more high-quality so as to obtain
The chromatographic solution of amount and yield, is that the sub chromatography oil that is concentrated under reduced pressure to give in stirring concentration kettle of lower sequence carries out adequate preparation, and supply sets
Standby high-order arrangement, using the feed liquid liquid level automatic voltage regulation in equipment.
Preferred embodiment of the present utility model is the foregoing is only, it is not to limit the utility model, all at this
Any modification, equivalent and improvement made within the spirit and principle of utility model etc., should be included in the utility model
Protection domain within.