CN205084759U - Be applied to dry -type thermostat of bacterium endotoxin checkout facility - Google Patents

Abstract

The utility model discloses a dry-type constant temperature instrument used in bacterial endotoxin inspection tests, which comprises a shell, and a metal heating block is embedded in the upper part of the shell, and a test tube hole is arranged on the metal heating block. A thin-film resistor is arranged at the bottom of the metal heating block for heating, a semiconductor digital sensor is embedded inside the metal heating block for monitoring temperature, and a temperature display screen is also arranged on the housing. The utility model solves the problem of uneven heat distribution in the thermostat in the traditional water bath heating by adopting the high-density aluminum alloy extruded heating block; solves the temperature control of the water bath box by adopting advanced heating film heating and digital temperature control technology problem, improve the accuracy of temperature control.

Description

A Dry Thermostat Applied to Bacterial Endotoxin Inspection Test

technical field

The utility model relates to the field of bacterial toxin inspection instruments, in particular to a dry-type constant temperature instrument used in bacterial endotoxin inspection tests.

Background technique

Bacterial endotoxin is an exogenous pyrogen, and most of the injectable drugs included in the Pharmacopoeia need to control the content of bacterial endotoxin. Bacterial endotoxin inspection test refers to the method of using Limulus reagent to detect the bacterial endotoxin content of Gram-negative bacteria. Bacterial endotoxin will specifically activate Limulus reagent, cause a multi-level enzymatic reaction of Limulus reagent, activate coagulation enzyme, and coagulate Coagulation protein or chromogenic groups are produced under the action of enzymes, and the concentration of bacterial endotoxin is determined by visually observing whether a solid, non-slip gel is formed or by using a photometer to measure the turbidity of the reagent or the generation of chromogenic groups. Finally, make a judgment on whether the endotoxin content of the test product is qualified. When carrying out the bacterial endotoxin test, it is usually necessary to control the reaction temperature of the LAL reagent and the test product at 37±1°C and incubate at a constant temperature for 60±2 minutes.

The existing constant temperature equipment is heated by the water bath in the water bath box, but this method has the following problems: First, because the heat capacity of water as the heating medium is relatively high, there is a large delay in temperature control, which often exceeds 37±1°C Due to the slow heat conduction, the heat distribution in different areas is uneven, which affects the accuracy of the test. The current solution is to use a metered thermometer to monitor the temperature of the constant temperature equipment, but this method increases the work of the operator. There is no way to quickly correct the situation where the temperature is out of range. Second, during the operation of the water bath, condensed water will be formed on the top of the chamber. This gel water dripping into the reaction test tube will cause pollution. The current solution is to seal each reaction test tube and then enter the constant temperature equipment to keep the temperature, but There are problems with this method, because the LAL reagent is very sensitive to bacterial endotoxin. If the LAL reagent is not placed in a constant temperature device for incubation in time after it contacts the test product, it will lead to false positive/false negative results, and increase the need for sealing operations. time consuming. Third, the general water bath tank does not have a timing device, so it is necessary to prepare a timing device separately, but there are problems in this method, and non-specialized timers are easy to lose and confuse the test.

Contents of the invention

The dry thermostat used in the bacterial endotoxin inspection test of the utility model is exquisite in design, easy to operate, can precisely control the temperature of the constant temperature equipment, and can set the timing of the test without sealing the reaction test tube.

In order to solve the above technical problems, the technical solution adopted by the utility model is: a dry-type thermostat applied to the bacterial endotoxin inspection test, which includes a shell, and a metal heating block is embedded in the upper part of the shell. A test tube hole is provided on the metal heating block, a thin film resistor is provided at the bottom of the metal heating block for heating, a semiconductor digital sensor is embedded inside the metal heating block for monitoring the temperature, and a temperature display screen.

Further, a timer button, a timer indicator light and a display button are embedded on the housing.

Further, the number of test tube holes on the metal heating block is at least one. It should be noted that the test tube hole is drilled on the metal block.

Further, a time display screen is embedded on the housing.

Further, a status indicator light is embedded on the housing.

The utility model discloses a dry-type constant temperature instrument used in bacterial endotoxin inspection test, which mainly has the following advantages:

1) The utility model solves the problem of uneven heat distribution in the thermostat in the traditional water bath heating by adopting a high-density aluminum alloy extruded heating block;

2) By adopting advanced heating film heating and digital temperature control technology, the temperature control problem of the water bath box is solved, and the accuracy of temperature control is improved;

3) Through the use of 3 independent timing devices and time display screens, each timing device has an independent timing buzzer sound, which can be used to time 3 tests at the same time, and the next time can be reasonably arranged through the countdown displayed on the time display screen Test, which solves the problem of the need to configure additional timers and the confusion of multiple tests at the same time;

4) The dry-type thermostat is heated by a metal block and will not produce condensed water. By installing a unique light-shielding and dust-proof cover, the problem that the reaction test tube needs to be sealed during use is solved, making the test operation more convenient and fast, improving efficiency and avoiding The operation time is too long and the result is abnormal.

Description of drawings

Below in conjunction with accompanying drawing, the utility model is further described.

Fig. 1 is the structural representation of a kind of dry-type constant temperature instrument that is applied to bacterial endotoxin inspection test of the present utility model;

In the figure: 1. Shading dust cover; 2. Fast metal heating; 3. Temperature display; 4. Timing button; 5. Timing indicator; 6. Time display; 7. Status indicator; 8. Display button; 9. Shell.

detailed description

In order to illustrate the technical features of this solution, the utility model will be described in detail below through specific implementation methods and in conjunction with the accompanying drawings.

The shading and dustproof cover 1 is connected to the upper side of the housing 9, and can be opened and covered. The metal heating block 2 is embedded in the upper part of the casing 9, and a test tube hole is arranged on the metal heating block. The bottom of the metal heating block 2 is provided with a thin film resistor for heating, and a semiconductor digital sensor is embedded inside the metal heating block 2 for monitoring the temperature. The housing 9 is embedded with a temperature display screen 3, which displays the temperature of the instrument in the state of use, and displays the set temperature in the state of temperature setting.

Timing button 4 and timing indicator light 5 have 3 groups and are embedded on the housing 9, press timing button 4 once, timing indicator light 5 is bright green, and the timer that is pressed button starts counting. Indicator light 5 is bright red when timing ends, and buzzer sounds, and this timing will be canceled, only need press this timing button 4 once and get final product.

A time display screen 6 is embedded on the housing 9, which displays the set time of each stall timer under the standby state; displays the set time of each stall timer under the time setting state; displays the set time of each stall timer under the use state time left;

A status indicator 7 is embedded on the housing 9, and the red light indicates that the instrument is heating; when the temperature display 6 shows 37.0°C, the status indicator 7 flashes intermittently, indicating that the instrument is in a constant temperature state;

The display button 8 is embedded on the surface of the shell, press this button to switch and display the set time of each timer; when all three timers are in the timing state, press this button to switch and display the remaining time of each timer When displaying the remaining time of the second and third gear timers, the corresponding timing indicator lights 5 green lights and flashing, when showing the remaining time of the first gear timer, the corresponding timing indicator lights 5 green lights are on but not flashing.

The dry thermostat used in the bacterial endotoxin inspection test of the utility model is heated by the thin film resistance arranged at the bottom of the metal heating block 2, and the temperature is monitored by the semiconductor digital sensor embedded in the metal heating block 2 for precise temperature control. , the temperature control accuracy reaches 37±0.2°C, and the temperature difference between the holes of the test tube is ≤0.1°C. At the same time, the temperature display screen 3 is set to display the current working temperature, and the status indicator light 7 indicates the heating state of the instrument; Cover 1 prevents external ash and direct sunlight. In addition, because the instrument is heated by metal, there is no condensation water problem similar to that in water bath heating. There is no need to seal the reaction test tube during the test; by setting 3 sets of timers, 3 test tubes can be tested at the same time. The test in progress is timed and beeped.

Apparently, the above-mentioned embodiments of the present utility model are only examples for clearly illustrating the present utility model, rather than limiting the implementation manner of the present utility model. For those of ordinary skill in the art, other changes or changes in different forms can be made on the basis of the above description. It is not necessary and impossible to exhaustively list all the implementation manners here. All modifications, equivalent replacements and improvements made within the spirit and principles of the utility model shall be included in the protection scope of the claims of the utility model.

Claims (6)

1. A dry-type thermostat applied to bacterial endotoxin inspection test, characterized in that: it comprises a housing (9), and a metal heating block (2) is embedded in the upper part of the housing (9). The metal heating block (2) is provided with a test tube hole, and a thin-film resistor is provided at the bottom of the metal heating block for heating, and a semiconductor digital sensor is embedded inside the metal heating block (2) for monitoring the temperature. The body (9) is also provided with a temperature display screen (3). 2. A dry-type thermostat applied to bacterial endotoxin inspection test according to claim 1, characterized in that: a light-shielding and dust-proof cover (1) is provided on the upper side of the housing (9). 3. A dry-type thermostat applied to bacterial endotoxin inspection tests according to claim 1, characterized in that: a timing button (4) and a timing indicator ( 5) and the display button (8). 4. A dry-type thermostat applied to bacterial endotoxin inspection tests according to claim 1, characterized in that: the number of test tube holes on the metal heating block (2) is at least one. 5. A dry-type thermostat applied to bacterial endotoxin inspection tests according to any one of claims 1 to 4, characterized in that: a time display screen ( 6). 6. A dry-type thermostat applied to bacterial endotoxin inspection test according to claim 5, characterized in that: a status indicator light (7) is embedded in the housing (9).